CN-121971080-A - Integrated polarization spectrum device for noninvasive blood glucose measurement and blood glucose measurement method

CN121971080ACN 121971080 ACN121971080 ACN 121971080ACN-121971080-A

Abstract

The invention relates to a polarization spectrum device, in particular to an integrated polarization spectrum device for noninvasive blood glucose measurement and a blood glucose measurement method, which solve the technical problems of low optical parameter dimension, complex algorithm processing, overfitting and the like of the conventional noninvasive blood glucose measurement device, and lower blood glucose measurement precision. According to the integrated polarization spectrum device for noninvasive blood glucose measurement, the polarization signal and the multispectral signal are respectively obtained by adopting the polarization path and the spectrum path, compared with a traditional blood glucose measurement method, the optical information dimension is effectively improved, and efficient complementation of spectrum information and polarization information can be realized, so that the accuracy of blood glucose measurement is improved. The invention also provides a blood glucose measurement method, which adopts the LSTM neural network to predict the blood glucose, so that the problem of overfitting of the traditional BP neural network to the high-dimensional polarization spectrum information can be avoided, and the accuracy of blood glucose prediction is improved.

Inventors

LI CHENXI
YU WEIXING
CHEN YUWEI
QIN JIANQIN
MENG QINGYANG

Assignees

中国科学院西安光学精密机械研究所

Dates

Publication Date: 20260505
Application Date: 20251226

Claims (10)

1. The integrated polarization spectrum device for noninvasive blood glucose measurement is characterized by comprising a light source module (1), a miniature polarizer module (2), a miniature analyzer module (4), a detector module (5), an electric control module (6) and a data processing module (7); The light source module (1) comprises an integrated light source lamp panel (8), wherein the integrated light source lamp panel (8) comprises M polarized sub-light sources and N spectrum sub-light sources, the polarized sub-light sources and the spectrum sub-light sources are used for respectively generating polarized path detection light beams and spectrum path detection light beams, the wavelengths of the M polarized sub-light sources are the same, the wavelengths of the N spectrum sub-light sources are different, wherein M, N are integers, and M is equal to N=1:2; The miniature polarizer module (2) is arranged on an emergent light path of the integrated light source lamp panel (8) and is used for regulating and controlling the polarization state of the polarized path detection light beam to generate polarized light with a set polarization state and irradiating the polarized light to a human body target (3) to be detected; The miniature analyzer module (4) and the detector module (5) are sequentially arranged along a transmission light path of the reflected light of the human body target (3) to be detected, and the miniature analyzer module (4) is used for detecting the polarization state of the reflected light of the polarization path of the human body target to be detected; The output end of the detector module (5) is connected with the input end of the data processing module (7) and is used for detecting polarization information in the polarized light of the human body target (3) to be detected and spectrum information in the spectrum light of the human body target to be detected, so as to obtain a polarization signal and a multispectral signal; The output end of the electric control module (6) is respectively connected with the control ends of the M polarized sub-light sources, the N spectrum sub-light sources, the micro polarizer module (2), the micro analyzer module (4) and the detector module (5) and is used for realizing the on-off control of the M polarized sub-light sources and the N spectrum sub-light sources, the polarization state regulation and control of the micro polarizer module (2) and the micro analyzer module (4) and the triggering of the detector module (5).
2. The integrated polarization spectrum device for noninvasive blood glucose measurement of claim 1, wherein the transmission directions of the polarization path detection light beam and the spectrum path detection light beam are denoted as Z directions, the direction perpendicular to the Z directions along the horizontal plane is denoted as Y directions, and the direction perpendicular to the Z directions along the vertical plane is denoted as X directions; The M polarized sub-light sources and the N spectrum sub-light sources are respectively positioned on an XZ plane and a YZ plane.
3. The integrated polarized spectrum device for noninvasive blood glucose measurement according to claim 2, wherein the detector module (5) comprises a polarized sub-detector (51) and a spectrum sub-detector (52), the miniature analyzer module (4) and the polarized sub-detector (51) are sequentially arranged along a transmission light path of polarized light reflected by a human body target (3) to be measured, and the spectrum sub-detector (52) is arranged on the transmission light path of the polarized light reflected by the human body target (3) to be measured.
4. The integrated polarization spectrum device for noninvasive blood glucose measurement of claim 1, wherein the transmission directions of the polarization path detection beam and the spectrum path detection beam are denoted as Z directions, the direction perpendicular to the X direction along the horizontal plane is denoted as Y directions, and the direction perpendicular to the X direction along the vertical plane is denoted as Z directions; the M polarized sub-light sources and the N spectrum sub-light sources are uniformly distributed on an XY plane in a ring array structure.
5. The integrated polarization spectrum device for noninvasive blood glucose measurement of claim 4, wherein the light source module (1) further comprises a light homogenizer (9); The light homogenizing device (9) is arranged on an emergent light path of the integrated light source lamp panel (8) and is positioned between the integrated light source lamp panel (8) and the miniature polarizer module (2), the light homogenizing device (9) comprises M+N micro lenses which are uniformly distributed in an annular array structure, and the spatial positions of the M+N micro lenses are in one-to-one correspondence with the M polarized sub-light sources and the N spectrum sub-light sources.
6. The integrated polarization spectrum device for noninvasive blood glucose measurement according to any one of claims 1 to 5, wherein the miniature polarizer module (2) comprises a first integrated polarizer (10), the first integrated polarizer (10) comprises H first sub-polarizers uniformly distributed in a ring-shaped array structure, the polarization states of the H first sub-polarizers are different, and the control ends of the H first sub-polarizers are respectively connected with the output end of the electronic control module (6), wherein H is an integer and H is more than or equal to 4; the miniature analyzer module (4) comprises a second integrated polarizer (11), the second integrated polarizer (11) comprises H second sub-polarizers which are uniformly distributed in an annular array structure, the polarization states of the H second sub-polarizers are different, and the control ends of the H second sub-polarizers are respectively connected with the output end of the electric control module (6).
7. The integrated polarization spectrum device for noninvasive blood glucose measurement of claim 6, wherein the polarization states of H=4, 4 of the first sub-polarizers are respectively 0 degree linear polarization, 45 degree linear polarization, 90 degree linear polarization and right-hand circular polarization, and the polarization states of 4 of the second sub-polarizers are respectively 0 degree linear polarization, 45 degree linear polarization, 90 degree linear polarization and right-hand circular polarization; Or the polarization states of the H=6, the polarization states of the 6 first sub-polarizers are respectively 0 degree linear polarization, 45 degree linear polarization, 90 degree linear polarization, 135 degree linear polarization, right-hand circular polarization and left-hand circular polarization, and the polarization states of the 6 second sub-polarizers are respectively 0 degree linear polarization, 45 degree linear polarization, 90 degree linear polarization, 135 degree linear polarization, right-hand circular polarization and left-hand circular polarization.
8. The integrated polarized spectrum device for noninvasive blood glucose measurement of claim 7, wherein the polarized sub-light source and the spectral sub-light source are the same or different, and are respectively a near infrared LED or LD, the wavelengths of the M polarized sub-light sources are the same, the values of the M polarized sub-light sources are 630nm-700nm, the wavelengths of the N spectral sub-light sources are different, the values of the N polarized sub-light sources are 850nm-930nm, and the wavelengths of the M polarized sub-light sources are 1300nm-1650nm; The first integrated polarizer (10) and the second integrated polarizer (11) are the same and are one of a polarized super surface, a liquid crystal polarizer, a traditional polarizer and a wave plate; the detector module (5) adopts a planar array type detector.
9. A blood glucose measuring method using the integrated polarization spectrum device for noninvasive blood glucose measurement according to any one of claims 1 to 8, characterized by comprising the steps of: Step 1, sending a trigger signal to a detector module (5) through an electric control module (6) to enable the detector module to start working, simultaneously controlling N spectrum sub-light sources to sequentially generate spectrum path detection light beams through the electric control module (6), irradiating the spectrum path detection light beams to a human body target (3) to be detected through an empty miniature polarizer module (2), detecting spectrum information carried in spectrum path reflected light of the human body target to be detected by the detector module (5), sequentially obtaining N spectrum signals, and sending the N spectrum signals to a data processing module (7); Simultaneously, the micro polarizer module (2) and the micro analyzer module (4) are regulated and controlled by the electronic control module (6) to be respectively in H polarization states to form H multiplied by H polarization state combinations, and then the polarization information of each polarization state combination is detected by the detector module (5) to obtain polarization signals of the H multiplied by H polarization state combinations and sent to the data processing module (7), wherein the polarization signals are obtained by the following steps: step 2.1, the micro polarizer module (2) regulates the polarization state of the polarized path detection light beam to form polarized light irradiation with a set polarization state to a human body target (3) to be detected; step 2.2, receiving reflected light of a polarization path of a human body object (3) to be detected by a miniature polarization analyzer module (4), and detecting the polarization state of the reflected light to obtain reflected polarized light of a polarization state combination; step 2.3, detecting polarization information carried in the reflected polarized light of the polarization state combination by a detector module (5) to obtain a polarization signal of the polarization state combination; And 3, processing the N spectrum signals and the polarization signals of the H multiplied by H polarization state combination by a data processing module (7) to obtain integrated polarization spectrum information, and then calculating the blood glucose concentration based on the integrated polarization spectrum information to finish blood glucose measurement.
10. The method of claim 9, wherein step 3 comprises: Step 3.1, respectively calculating near infrared absorption coefficients alpha 1 -α N of N spectrum signals according to the lambert beer law; Step 3.2, calculating a human body polarization parameter f 1 -f 16 according to a Mueller matrix disassembly principle by using polarization signals combined by H multiplied by H polarization states; Step 3.3, performing dimension reduction on the human body polarization parameter f 1 -f 16 through measurement and learning to obtain a dimension reduction polarization parameter p 1 -p 4 ; And 3.4, inputting the near infrared absorption coefficients alpha 1 -α N and the dimension-reducing polarization parameters p 1 -p 4 of the N spectrum signals into an LSTM neural network to predict the blood glucose concentration, obtaining the blood glucose concentration and finishing blood glucose measurement.

Description

Integrated polarization spectrum device for noninvasive blood glucose measurement and blood glucose measurement method Technical Field The invention relates to a polarization spectrum device, in particular to an integrated polarization spectrum device for noninvasive blood glucose measurement and a blood glucose measurement method. Background The number of diabetics continuously rises worldwide, but diabetes is not completely cured at present, and the patients need to effectively manage the blood sugar level of the patients through frequent blood sugar detection. In this context, blood glucose monitoring technology is increasingly receiving extensive attention from both academia and industry. Compared with the traditional invasive and minimally invasive blood glucose monitoring technology, the optical blood glucose measuring technology is used as a non-contact measuring method, has the remarkable advantages of non-invasiveness, convenience, user friendliness and the like, and has important application potential. Currently, there are many researches on measuring blood glucose by an optical regulation method, for example, chinese patent CN119949821a discloses an infrared multispectral blood glucose measuring device, which predicts blood glucose concentration by regulating a near infrared spectrum signal and utilizing a method of combining multi-level measurement learning-BP neural network (multi-layer feedforward network based on error counter propagation), chinese patent CN118806275A discloses a method of obtaining a polarized signal by regulating a polarization state through liquid crystal so as to predict blood glucose concentration, and chinese patent CN114041789a discloses a method of calculating a rotation angle by regulating a polarization state through an electric motor so as to predict blood glucose concentration. Although the blood glucose measurement method based on near infrared spectrum and polarization regulation has a certain effect in the blood glucose measurement field, the single near infrared spectrum technology has the fundamental problem of serious absorption spectrum overlapping, the polarization regulation blood glucose measurement method has the problem of too small polarization signal, and meanwhile, the high-dimensional optical signal processing is complex and easy to be overfitted, so that the high-precision blood glucose measurement under the background of huge population and complex human body is difficult to be satisfied. Disclosure of Invention The invention aims to solve the technical problems of low accuracy of blood glucose measurement caused by low optical information dimension, complex algorithm processing, overfitting and the like of the existing noninvasive blood glucose measurement device, and provides an integrated polarization spectrum device for noninvasive blood glucose measurement and a blood glucose measurement method. In order to achieve the above purpose, the invention adopts the following technical scheme: the integrated polarization spectrum device for noninvasive blood glucose measurement is characterized by comprising a light source module, a miniature polarizer module, a miniature analyzer module, a detector module, an electric control module and a data processing module; The light source module comprises an integrated light source lamp panel, the integrated light source lamp panel comprises M polarized sub-light sources and N spectrum sub-light sources, the polarized sub-light sources and the spectrum sub-light sources are used for respectively generating polarized path detection light beams and spectrum path detection light beams, the wavelengths of the M polarized sub-light sources are the same, the wavelengths of the N spectrum sub-light sources are different, wherein M, N are integers, and M is equal to n=1:2; the miniature polarizer module is arranged on an emergent light path of the integrated light source lamp panel and is used for regulating and controlling the polarization state of the polarized path detection light beam so as to generate polarized light with a set polarization state, and the polarized light irradiates a human body target to be detected; the miniature analyzer module and the detector module are sequentially arranged along a transmission light path of the reflected light of the human body target to be detected, and the miniature analyzer module is used for detecting the polarization state of the reflected light of the polarization path of the human body target to be detected; the output end of the detector module is connected with the input end of the data processing module and is used for detecting polarization information in the polarized light reflected by the target to be detected of the human body and spectrum information in the spectral light reflected by the target to be detected of the human body to obtain a polarization signal and a multispectral signal; The output end of the electric control module is respectively connecte