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CN-121971083-A - Body fluid composition dynamic monitoring system for senile chronic patients based on infrared spectrum analysis

CN121971083ACN 121971083 ACN121971083 ACN 121971083ACN-121971083-A

Abstract

The invention relates to the technical field of biomedical detection and monitoring, in particular to a body fluid component dynamic monitoring system for senile chronic patients based on infrared spectrum analysis, which comprises an optical detection module, a signal acquisition and preprocessing module, a data analysis and modeling module, a user interaction and communication module, a power management subsystem and a structure and environment compensation module. According to the invention, through infrared spectrum analysis and combination of a deep learning bioinformatics model and dynamic self-adaptive calibration, non-invasive, continuous, dynamic, accurate and reliable monitoring of critical biochemical components of body fluid of an aged chronic patient is realized, the compliance of users is improved, and the chronic disease management level is improved.

Inventors

  • LU JUAN
  • JIANG LIYE
  • WANG JUAN

Assignees

  • 凉山彝族自治州第二人民医院(凉山州民族药物研究所)

Dates

Publication Date
20260505
Application Date
20260407

Claims (9)

  1. 1. The utility model provides an old slow patient's body fluid composition dynamic monitoring system based on infrared spectrum analysis which characterized in that includes: The optical detection subsystem is used for capturing spectral information of body fluid components in tissues through interaction between infrared radiation in a wavelength range of 700 nanometers to 2500 nanometers and human skin; the signal acquisition and preprocessing subsystem is connected to the optical detection subsystem and is used for converting, amplifying, filtering, analog-to-digital converting and primary digital signal processing of the optical signals output by the optical detection subsystem; The data analysis and modeling subsystem is connected with the signal acquisition and preprocessing subsystem and is used for carrying out complex bioinformatics modeling and algorithm analysis on the preprocessed spectrum data so as to accurately quantify the concentration of the target body fluid component; the user interaction and communication subsystem is connected to the data analysis and modeling subsystem and is used for displaying monitoring results, receiving user instructions and realizing wireless data transmission with external equipment or a cloud platform; the power management subsystem is used for providing stable and reliable electric energy supply for the whole system; the structure and environment compensation module is used for providing physical support for the system, ensuring the stability of an optical interface and correcting the influence of environmental factors on a measurement result.
  2. 2. The system of claim 1, wherein the optical detection subsystem is disposed within a detection unit in close contact with human skin, the detection unit being made of a medical-grade biocompatible material and having a precise optical coupling structure, the optical detection subsystem comprising at least: An infrared light source array for emitting infrared light of a wavelength; the optical coupling module is arranged between the infrared light source array and the human skin and is used for realizing efficient incidence and emergence of infrared light; the infrared detector array is used for receiving infrared light scattered and emitted from the skin of the human body and converting the infrared light into an electric signal; The spectrum separation module is arranged between the optical coupling module and the infrared detector array and is used for selecting the wavelength of broadband infrared light scattered and emitted from the skin of the human body.
  3. 3. The system of claim 2, wherein the infrared light source array comprises a plurality of semiconductor infrared light emitting diodes having a narrow band emission spectrum, the semiconductor infrared light emitting diodes having a center wavelength of 700 nm to 2500 nm, the wavelength selection being based on a characteristic absorption peak of the body fluid component to be measured in the near infrared region.
  4. 4. The system of claim 2, wherein the optical coupling module comprises at least: The transparent window is made of single crystal sapphire glass with high infrared transmittance, the thickness of the transparent window is 0.5-1.0 mm, and broadband anti-reflection coatings are laid on the surfaces of two sides of the transparent window; The flexible medical grade silica gel gasket is formed by injection molding of a low-compression permanent deformation silica gel material with the hardness of Shore A20-30, and is used for tightly attaching the transparent window to the surface of the skin of the human body and filling microscopic uneven gaps of the skin; the micro-pressure sensor adopts a film piezoresistance type sensor array, and the effective sensing area of the micro-pressure sensor is matched with the contact area of the flexible medical grade silica gel gasket.
  5. 5. The system of claim 1, wherein the signal acquisition and preprocessing subsystem is disposed within an asic chip or a fpga chip, and specifically comprises: the analog front-end circuit is connected to the output end of the infrared detector array and is used for carrying out high-precision processing on weak current signals output by the detector; The analog-to-digital converter module is connected to the output end of the analog front-end circuit and is used for converting an analog voltage signal into a digital signal; And the digital signal processor module is connected to the output end of the analog-to-digital converter module and is used for carrying out primary processing and noise suppression on the digitized spectrum data.
  6. 6. The system of claim 1, wherein the data analysis and modeling subsystem is disposed within a high performance microcontroller, the data analysis and modeling subsystem comprising at least: The spectral feature extraction module is used for extracting spectral features directly related to the concentration of the target body fluid component from the preprocessed infrared spectral data; A bioinformatics model for mapping the extracted spectral features to accurate body fluid constituent concentration values; and the calibration and self-adaption module is used for realizing dynamic self-adaption calibration of the bioinformatics model so as to compensate individual physiological differences, long-term physiological changes and equipment drift.
  7. 7. The system of claim 6, wherein the bioinformatics model is a predictive model constructed based on a deep learning framework, the predictive model adopts a multi-layer feedforward neural network architecture and integrates a long-short-term memory network layer, and the bioinformatics model further introduces physiological parameters and environmental parameters acquired by the structure and environment compensation module as auxiliary input features.
  8. 8. The system of claim 1, wherein the structural and environmental compensation module comprises: The contact type thermistor array is integrated on the contact surface of the optical coupling module and is used for accurately measuring the skin surface temperature and the environment temperature; the gyroscope sensor is used for monitoring the motion state and the gesture of the equipment in real time, and identifying and distinguishing artifacts caused by the motion of a user; an ambient light sensor for measuring ambient background light intensity; humidity sensor for measuring skin surface humidity and ambient humidity.
  9. 9. The system of claim 1, wherein the user interaction and communication subsystem comprises at least: the display and input interface comprises a low-power-consumption organic light-emitting diode display screen, a high-sensitivity tactile feedback unit and a plurality of physical keys, and is used for displaying a monitored body fluid component concentration trend chart, historical data, system states, electric quantity information and early warning prompts in real time; The wireless communication module comprises a Bluetooth 5.0 low-power consumption communication module and a Wi-Fi 802.11n communication module, wherein the Bluetooth 5.0 module is used for carrying out short-distance wireless data transmission with a smart phone and a tablet personal computer of a user, the Wi-Fi 802.11n module is used for directly uploading monitoring data to a cloud health management platform, and the wireless communication module adopts an encryption transmission protocol and an identity verification mechanism and supports an OTA firmware upgrading function; The data storage module adopts an embedded NAND flash memory and is used for locally storing original spectrum data, preprocessing data, analysis results and system logs, and the data storage module has cyclic writing and power-down protection.

Description

Body fluid composition dynamic monitoring system for senile chronic patients based on infrared spectrum analysis Technical Field The invention relates to the technical field of biomedical detection and monitoring, in particular to a body fluid component dynamic monitoring system for senile chronic patients based on infrared spectrum analysis. Background With the increasing trend of global population aging, and lifestyle changes, chronic diseases have become a major public health problem severely threatening the health and quality of life of the elderly. Effective management of common chronic diseases consists in the dynamic monitoring of real-time or near real-time changes in key biochemical components in body fluids. For a long time, the clinical detection of body fluid components has been mainly dependent on traditional laboratory biochemical analysis methods. These methods generally involve the collection of blood or urine samples, and the accurate quantification of various biochemical indicators such as blood glucose, electrolytes, creatinine, uric acid, blood lipids, etc., is achieved by complex reagent reactions, chromatographic separations, enzymatic or electrochemical detection, etc. However, with the continuous development of the related technology and the severe requirements of the senile chronic disease management on performance indexes, the conventional technical scheme gradually shows the limitation that the traditional scheme is difficult to surmount when dealing with the emerging requirement of dynamic, long-term and non-invasive monitoring of body fluid components. Based on the above, how to realize the technical scheme which can not only effectively overcome the inherent limitations of the prior art in terms of continuity, non-invasiveness, convenience and user compliance, but also meet the requirements of the dynamic monitoring of the body fluid components of the aged chronic patients on timeliness and data continuity becomes the technical problem to be solved urgently. Disclosure of Invention The invention aims to provide a body fluid composition dynamic monitoring system for senile chronic patients based on infrared spectrum analysis, which solves the inherent limitation problems of the prior art in terms of continuity, non-invasiveness, convenience and user compliance. The invention provides a body fluid composition dynamic monitoring system for senile chronic patients based on infrared spectrum analysis, which comprises the following components: The optical detection subsystem is used for capturing spectral information of body fluid components in tissues through interaction between infrared radiation in a wavelength range of 700 nanometers to 2500 nanometers and human skin; the signal acquisition and preprocessing subsystem is connected to the optical detection subsystem and is used for converting, amplifying, filtering, analog-to-digital converting and primary digital signal processing of the optical signals output by the optical detection subsystem; The data analysis and modeling subsystem is connected with the signal acquisition and preprocessing subsystem and is used for carrying out complex bioinformatics modeling and algorithm analysis on the preprocessed spectrum data so as to accurately quantify the concentration of the target body fluid component; the user interaction and communication subsystem is connected to the data analysis and modeling subsystem and is used for displaying monitoring results, receiving user instructions and realizing wireless data transmission with external equipment or a cloud platform; the power management subsystem is used for providing stable and reliable electric energy supply for the whole system; the structure and environment compensation module is used for providing physical support for the system, ensuring the stability of an optical interface and correcting the influence of environmental factors on a measurement result. In some embodiments, the optical detection subsystem is arranged inside a detection unit closely contacted with human skin, the detection unit is made of medical-grade biocompatible materials and has a precise optical coupling structure, and the optical detection subsystem at least comprises: An infrared light source array for emitting infrared light of a wavelength; the optical coupling module is arranged between the infrared light source array and the human skin and is used for realizing efficient incidence and emergence of infrared light; the infrared detector array is used for receiving infrared light scattered and emitted from the skin of the human body and converting the infrared light into an electric signal; The spectrum separation module is arranged between the optical coupling module and the infrared detector array and is used for selecting the wavelength of broadband infrared light scattered and emitted from the skin of the human body. In some embodiments, the infrared light source array comprises a plurality of semico