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CN-121971084-A - Epileptic infant brain oxygen monitoring method based on near infrared gating ICCD imaging technology

CN121971084ACN 121971084 ACN121971084 ACN 121971084ACN-121971084-A

Abstract

The invention discloses a brain oxygen monitoring method for epileptic children patients based on a near infrared gating ICCD imaging technology, and belongs to the technical field of medical monitoring and brain function imaging. The method comprises the steps of emitting pulses to the head of an epileptic child through a laser, returning photons after reaching brain tissues, setting an acquisition interval of a near infrared gating ICCD detector to acquire a plurality of brain frame images, acquiring light intensity of each pixel point in the plurality of brain frame images to establish a light intensity response curve, extracting photon flight parameters to invert absorption coefficients and scattering coefficients corresponding to each pixel point, fitting oxygenated hemoglobin concentration and reduced hemoglobin concentration corresponding to each pixel point, calculating oxygen saturation, and generating brain oxygen saturation images for brain oxygen monitoring. The invention remarkably improves the space coverage, imaging efficiency and quantitative accuracy of brain oxygen monitoring, and provides a powerful visual tool for the location of epileptogenic foci and preoperative brain function assessment of children epilepsy.

Inventors

  • YE WEN

Assignees

  • 西北妇女儿童医院

Dates

Publication Date
20260505
Application Date
20260407

Claims (6)

  1. 1. The brain oxygen monitoring method for the epileptic children based on the near infrared gating ICCD imaging technology is characterized by being realized based on a near infrared gating ICCD detector and a laser; the brain oxygen monitoring method comprises the following steps: Setting the acquisition interval of the near infrared gating ICCD detector, and acquiring photons returned after the laser emits pulses to the head of the epileptic infant to obtain a plurality of brain frame images of the epileptic infant; acquiring the light intensity of each pixel point in a plurality of brain frame images, and establishing a light intensity response curve of each pixel point; Performing Gaussian fitting on the light intensity response curve of each pixel point, and extracting photon flight parameters corresponding to each pixel point; Inverting the absorption coefficient and the scattering coefficient corresponding to each pixel point by adopting a time distribution model and combining a diffusion approximation theory according to the photon flight parameters; fitting the concentration of oxygenated hemoglobin and the concentration of reduced hemoglobin corresponding to each pixel point according to the absorption coefficient and the scattering coefficient; calculating oxygen saturation corresponding to each pixel point according to the oxygenated hemoglobin concentration and the reduced hemoglobin concentration; Generating an oxygen saturation image of the brain of the epileptic infant according to the oxygen saturation corresponding to each pixel point, and monitoring the brain oxygen according to the oxygen saturation image.
  2. 2. The method for monitoring brain oxygen of epileptic children based on the near infrared gating ICCD imaging technology as set forth in claim 1, wherein the photon flight parameters comprise: photon average arrival time, half-width of light intensity response curve and area enclosed by light intensity response curve and coordinate axis.
  3. 3. The method for monitoring brain oxygen of epileptic children based on the near infrared gating ICCD imaging technology of claim 1, wherein the method is characterized in that according to the photon flight parameters, a time distribution model is adopted to invert the absorption coefficient and the scattering coefficient corresponding to each pixel point by combining a diffusion approximation theory, and the method is specifically as follows: establishing a diffusion equation of photon propagation based on a diffusion approximation theory; setting a simulated absorption coefficient and a simulated scattering coefficient, and adopting a time distribution model to carry out forward simulation solution on the diffusion equation so as to obtain photon flight simulation parameters; constructing an objective function based on the photon flight parameters and the photon flight simulation parameters; iterative updating is carried out on the simulated absorption coefficient and the simulated scattering coefficient by adopting an optimization algorithm; And calculating the objective function value updated by each iteration until the objective function converges, and obtaining the absorption coefficient and the scattering coefficient corresponding to each pixel point.
  4. 4. The brain oxygen monitoring method for epileptic children based on the near infrared gate ICCD imaging technology of claim 1, wherein the method is characterized by fitting the concentration of oxygenated hemoglobin and the concentration of reduced hemoglobin corresponding to each pixel point according to the absorption coefficient and the scattering coefficient, and specifically comprises the following steps: fitting the absorption coefficient and the scattering coefficient corresponding to each pixel point by adopting a dual-wavelength method; Correcting the optical path corresponding to each pixel point according to the scattering coefficient; establishing a dual-wavelength absorption equation based on a beer-lambert law according to the corrected optical path and the absorption coefficient; And solving the dual-wavelength absorption equation to obtain the oxygenated hemoglobin concentration and the reduced hemoglobin concentration corresponding to each pixel point.
  5. 5. The method for monitoring cerebral oxygen of epileptic children based on the near infrared gate ICCD imaging technology of claim 1, wherein the method for calculating the oxygen saturation corresponding to each pixel point according to the oxyhemoglobin concentration and the reduced hemoglobin concentration is characterized by comprising the following steps: Obtaining total hemoglobin concentration corresponding to each pixel point according to the sum of the oxygenated hemoglobin concentration and the reduced hemoglobin concentration corresponding to each pixel point; and obtaining the oxygen saturation corresponding to each pixel point according to the ratio of the oxygenated hemoglobin concentration to the total hemoglobin concentration corresponding to each pixel point.
  6. 6. The method for monitoring brain oxygen of epileptic children based on the near infrared gate ICCD imaging technology of claim 1, wherein after generating the brain oxygen saturation image of epileptic children according to the oxygen saturation corresponding to each pixel point, the method further comprises the steps of: Setting a region of interest in an epileptic infant brain oxygen saturation image; and carrying out spatial registration on the brain oxygen saturation images of the epileptic children according to the set region of interest, and generating brain region oxygen saturation mapping images of the epileptic children brain.

Description

Epileptic infant brain oxygen monitoring method based on near infrared gating ICCD imaging technology Technical Field The invention relates to the technical field of medical monitoring, in particular to a brain oxygen monitoring method for epileptic children based on a near infrared gate ICCD imaging technology. Background Epilepsy is one of the most common nervous system chronic diseases in childhood, and is an important treatment means for drug-refractory epileptic children, and surgical excision of the epileptogenic focus is critical to accurate positioning of the epileptogenic focus before surgery and clear definition of important brain functional areas. The functional near infrared spectrum (fNIRS) technology is used as a noninvasive, safe and relatively insensitive optical brain imaging technology, has unique advantages in preoperative evaluation of pediatric epilepsy, and is particularly suitable for infants and pediatric patients with low coordination degree. fNIRS by monitoring the change of the concentration of cerebral cortex hemoglobin, the cortical hemodynamic response caused by epileptic seizure and inter-seizure epileptic discharge can be effectively monitored, and the hemodynamic information different from electroencephalogram and functional magnetic resonance imaging is provided for epileptogenic focus positioning and brain functional area drawing. However, when the existing fNIRS technology system is applied to accurate brain oxygen monitoring and imaging of epileptic children, a series of inherent technical bottlenecks related to each other still face. First, in terms of spatial resolution and sampling density, the continuous wave (CW-fNIRS) system of clinical mainstream essentially relies on sparse arrangement of discrete fiber probes for measurement, and it is difficult to realize high-density, fully-covered continuous two-dimensional cortical imaging, which may lead to omission of local fine blood oxygen anomalies associated with the epileptogenic focus. In terms of signal quality and quantitative accuracy, the CW-fNIRS technology only measures light intensity attenuation, can not effectively separate absorption and scattering effects of tissues, a measurement result is easily interfered by shallow physiological noise such as scalp blood flow and the like, extraction of epileptic specific blood oxygen signals is affected, and although a time domain fNIRS (TD-fNIRS) system based on a time-dependent single photon counting technology can improve quantitative capability and depth discrimination capability through photon flight time distribution, the traditional TD system is limited by a single-point or low-channel scanning mode, and the problems of low sampling rate, complex and heavy system, sparse head coverage range and the like generally exist, so that the clinical requirements of rapid and large-scale bedside imaging are difficult to meet. Finally, in the aspects of technical development and system integration, the Single Photon Avalanche Diode (SPAD) array technology for improving the number of channels faces challenges of rapid increase of data volume, high real-time processing complexity, high system integration difficulty and the like caused by a single photon counting mode in practical application. In summary, in the field of brain oxygen monitoring of epileptic children, there is an urgent need for a fNIRS system that has high photon arrival time resolution, can express time response in a two-dimensional image form, and simultaneously has high spatial resolution, non-contact measurement and real-time imaging characteristics, so as to realize rapid, accurate and visual evaluation of brain blood oxygen dynamics of epileptic children. Disclosure of Invention The invention provides a brain oxygen monitoring method for epileptic children based on a near infrared gating ICCD imaging technology, which is realized based on a near infrared gating ICCD detector and a laser, wherein a pulse is emitted to the head of the epileptic children through the laser, photons return again after reaching brain tissues, the acquisition interval of the near infrared gating ICCD detector is set to acquire a plurality of brain frame images, the light intensity of each pixel point in the plurality of brain frame images is acquired to establish a light intensity response curve, the absorption coefficient and the scattering coefficient corresponding to each pixel point are inverted by extracting photon flight parameters, the concentration of oxyhemoglobin and the concentration of reduced hemoglobin corresponding to each pixel point are fitted, the oxygen saturation is calculated, and the brain oxygen saturation image is generated to perform brain oxygen monitoring. The invention remarkably improves the space coverage, imaging efficiency and quantitative accuracy of brain oxygen monitoring, and provides a powerful visual tool for the location of epileptogenic foci and preoperative brain function assessment of