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CN-121971192-A - Bionic healing composite base station of tissue engineering support structure

CN121971192ACN 121971192 ACN121971192 ACN 121971192ACN-121971192-A

Abstract

The invention discloses a bionic healing composite base of a tissue engineering support structure, which relates to the field of bionic healing bases and comprises a base body, a threaded connection part, a conical gum penetrating part and a shaping end part, wherein the threaded connection part, the conical gum penetrating part and the shaping end part are sequentially arranged on the base body from bottom to top, the conical gum penetrating part is connected with the shaping end part through a connection mechanism, a butt joint platform is arranged at one end part of the conical gum penetrating part, which is close to the shaping end part, and a threaded short column is arranged on the surface of the butt joint platform. This bionical compound base station of tissue engineering supporting structure, through the setting can be dismantled between shaping tip and the toper portion of wearing gum through coupling mechanism for when red swelling inflammation appears in follow-up gum cuff portion, can take off the shaping tip alone and change, no longer need change the whole base station of healing, thereby be difficult for producing the influence to the stability of planting body, also can not cause the damage to planting body-bone initial stage faying face, and then be favorable to going on of patient's tooth planting work.

Inventors

  • XU XIAOWEI
  • WANG XIAOCHEN
  • Bian Bingtao

Assignees

  • 山东迈尔医疗科技有限公司

Dates

Publication Date
20260505
Application Date
20260408

Claims (10)

  1. 1. The bionic healing composite base of the tissue engineering support structure comprises a base body (1), a threaded connection part (101), a conical gum penetrating part (102) and a shaping end part (103) which are sequentially arranged on the base body (1) from bottom to top, and is characterized in that the conical gum penetrating part (102) is connected with the shaping end part (103) through a connecting mechanism; The conical gum penetrating part (102) is provided with a butt joint platform (2) near one side end part of the shaping end part (103), the surface of the butt joint platform (2) is provided with a screw short column (210), and the bottom of the shaping end part (103) is provided with an internal screw thread groove (211); The end of shaping tip (103) has seted up top groove (21), cylinder groove (22), axle groove (23) and below groove (24) in proper order along its axis direction, medial surface sliding connection in cylinder groove (22) has disc (25) that exert pressure, the top fixedly connected with of disc (25) that exert pressure goes up square (26), a word groove (213) has been seted up at the top of square (26), the bottom fixedly connected with connecting axle (27) of disc (25) that exert pressure, the bottom fixedly connected with of connecting axle (27) is square (28) down, butt joint groove (29) corresponding with square (28) down have been seted up on the surface of butt joint platform (2), install supporting spring (212) between disc (25) and cylinder groove (22) inner wall that exert pressure.
  2. 2. The biomimetic healing composite abutment of a tissue engineering scaffold structure according to claim 1, wherein the internal thread groove (211) has a specification adapted to the threaded stub (210).
  3. 3. The bionic healing composite abutment of a tissue engineering scaffold structure according to claim 2, wherein the upper square block (26) is slidably connected with the inner side surface of the upper groove (21), the shape and the specification of the upper square block (26) are matched with those of the upper groove (21), the lower square block (28) is slidably connected with the inner side surface of the lower groove (24), the shape and the specification of the lower square block (28) are matched with those of the lower groove (24) and the butt joint groove (29), and a reserved gap (3) is arranged between the bottom end of the lower square block (28) and the notch of the lower groove (24).
  4. 4. A composite abutment for biomimetic healing of a tissue engineering scaffold according to claim 3, wherein the connecting shaft (27) is a circular shaft, and the connecting shaft (27) is slidably connected with the inner side of the shaft groove (23).
  5. 5. The bionic healing composite abutment of the tissue engineering scaffold structure according to claim 4, wherein one end of the supporting spring (212) is fixedly connected with the bottom end of the inner wall of the cylindrical groove (22), the other end of the supporting spring (212) is fixedly connected with the supporting disc (4), a plurality of balls (41) are arranged at the top end of the supporting disc (4) at equal intervals in a circular ring shape, and the balls (41) are in rolling connection with the lower surface of the pressing disc (25).
  6. 6. The bionic healing composite abutment of a tissue engineering scaffold structure according to claim 1, wherein the end of the shaped end (103) is provided with a bionic scaffold layer (5), the bionic scaffold layer (5) comprises a supporting part (501) arranged on the end face of the shaped end (103) and a guiding part (502) arranged on the periphery of the shaped end (103), and a surface functional layer (51) is arranged outside the bionic scaffold layer (5).
  7. 7. The bionic healing composite abutment of the tissue engineering scaffold structure according to claim 6, wherein the bionic scaffold layer (5) takes PLGA/PCL blend as a matrix and is loaded with 10-20wt% of hydroxyapatite nanoparticles, and the bionic scaffold layer (5) has communication pores of a bionic haverse tube structure, the porosity is 60-80%, the pore diameter is 100-500 μm, and the pore communication rate is more than or equal to 90%.
  8. 8. The biomimetic healing composite abutment of a tissue engineering scaffold according to claim 7, wherein the thickness of the support portion (501) is 2mm and the thickness of the guide portion (502) is 100-500 μm.
  9. 9. The biomimetic healing composite abutment of a tissue engineering scaffold according to claim 8, wherein the surface functional layer (51) consists of a cationic short peptide coating and an automineralization induction system, wherein H (K) nS-RGD in the amino acid sequence of the cationic short peptide, wherein n=1-3, the coating thickness is 10-50 μm, and the automineralization induction system comprises ovalbumin, tannic acid, calcium phosphate ion composite framework.
  10. 10. The biomimetic healing composite scaffold of a tissue engineering scaffold according to claim 9, wherein the surface functional layer (51) is further loaded with 2-5wt% of antibacterial peptide LL-37, and is combined with H (K) nS-RGD peptide fragments by electrostatic action.

Description

Bionic healing composite base station of tissue engineering support structure Technical Field The invention relates to a bionic healing abutment technology, in particular to a bionic healing composite abutment of a tissue engineering scaffold structure. Background A biomimetic healing abutment is a material or structure used in the medical and bioengineering fields that aims to mimic the healing process of organisms in nature to promote tissue regeneration and repair. In the field of oral implantation, a bionic healing abutment is important for promoting osseointegration and improving implantation success rate. The healing abutment is generally made of titanium alloy and comprises a threaded connection part at the bottom, a conical gum penetrating part at the middle and a shaping end part at the top, which are generally designed in an integrated manner so as to facilitate the disassembly and assembly of the healing abutment. However, in the practical application process, when the healing abutment is required to be replaced due to inflammation caused by bacterial growth or other reasons between the shaped end of the healing abutment and the gingiva, the whole of the healing abutment is usually required to be removed from the implant, and then a new healing abutment is required to be replaced. However, the whole healing abutment is taken out, which not only easily damages the side wall in the gingival hole, but also disturbs the implant-bone initial stage joint surface, so that the osseointegration foundation is destroyed, and especially when the patient himself has rejection reaction or other reasons to frequently replace the healing abutment, the implant and the gingival hole are more easily damaged, thereby being unfavorable for the tooth planting work. Disclosure of Invention The invention aims to provide a bionic healing composite base station of a tissue engineering scaffold structure, which aims to solve the defects in the prior art. In order to achieve the aim, the invention provides the technical scheme that the bionic healing composite base of the tissue engineering support structure comprises a base body, a threaded connection part, a conical gum penetrating part and a shaping end part, wherein the threaded connection part, the conical gum penetrating part and the shaping end part are sequentially arranged on the base body from bottom to top, and the conical gum penetrating part is connected with the shaping end part through a connection mechanism; The conical gum penetrating part is provided with a butt joint platform near one side end part of the shaping end part, the surface of the butt joint platform is provided with a screw short column, and the bottom of the shaping end part is provided with an internal thread groove; The end of the shaping end is sequentially provided with an upper groove, a cylindrical groove, a shaft groove and a lower groove along the direction of the middle axis, the inner side surface of the cylindrical groove is slidably connected with a pressing disc, the top end of the pressing disc is fixedly connected with an upper square, the top of the upper square is provided with a straight groove, the bottom of the pressing disc is fixedly connected with a connecting shaft, the bottom end of the connecting shaft is fixedly connected with a lower square, the surface of the docking platform is provided with a docking groove corresponding to the lower square, and a supporting spring is arranged between the pressing disc and the inner wall of the cylindrical groove. Further, the specification of the internal thread groove is matched with the short thread column. Further, the upper square block is slidably connected with the inner side surface of the upper groove, the shape and the specification of the upper square block are matched with the inner side surface of the upper groove, the lower square block is slidably connected with the inner side surface of the lower groove, the shape and the specification of the lower square block are matched with the lower groove and the butt joint groove, and a reserved gap is formed between the bottom end of the lower square block and the notch of the lower groove. Further, the connecting shaft is a round shaft, and the connecting shaft is in sliding connection with the inner side surface of the shaft groove. Further, support spring one end and the bottom fixed connection of cylinder inslot wall, the other end fixedly connected with support disc of support spring, the top of support disc is the circular equidistance and is provided with a plurality of balls, ball and the disc lower surface roll connection that applies pressure. Further, the end part of the shaping end part is provided with a bionic support layer, the bionic support layer comprises a supporting part arranged on the end face of the shaping end part and a guiding part arranged on the periphery of the shaping end part, and a surface functional layer is arranged outside the bionic sup