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CN-121971302-A - Calamine suspension system and preparation method and application thereof

CN121971302ACN 121971302 ACN121971302 ACN 121971302ACN-121971302-A

Abstract

The invention discloses a calamine suspension system and a preparation method and application thereof, wherein the calamine suspension system comprises, by weight, 5-12 parts of a surfactant, 1.5-4 parts of a thickener, 0.01-0.5 part of calamine, 0.0001-0.02 part of zinc oxide, 0.1-1.5 parts of a pH regulator, 0.2-2 parts of a preservative and water to 100 parts, wherein the surfactant comprises sodium laureth sulfate and cocamidopropyl betaine, and the thickener comprises an acrylic acid (ester) copolymer and cocamidopropyl MEA. According to the invention, through compounding the specially adopted surfactant and the thickener, the calamine suspension system with the calamine addition amount of 0.5% can be successfully prepared, the calamine can be completely suspended in water, and the suspension system has good stability and no precipitation after being placed for 30 days at normal temperature.

Inventors

  • PENG YUN
  • DENG HAO

Assignees

  • 仁和全域(上海)大健康研究院有限公司

Dates

Publication Date
20260505
Application Date
20260204

Claims (10)

  1. 1. The calamine suspension system is characterized by comprising, by weight, 5-12 parts of a surfactant, 1.5-4 parts of a thickener, 0.01-0.5 part of calamine, 0.0001-0.02 part of zinc oxide, 0.1-1.5 parts of a pH regulator, 0.2-2 parts of a preservative and 100 parts of water; the surfactant comprises sodium laureth sulfate and cocamidopropyl betaine, and the thickener comprises acrylic acid (ester) copolymer and cocamide MEA.
  2. 2. The calamine suspension of claim 1, wherein the sodium laureth sulfate is 3-10 parts by weight and cocamidopropyl betaine is 1-4 parts by weight.
  3. 3. The calamine suspension system of claim 1 or 2, wherein the surfactant further comprises decyl glucoside, the weight fraction of decyl glucoside is 0-1 part.
  4. 4. A calamine suspension according to claim 3, wherein the weight ratio of sodium laureth sulfate to cocamidopropyl betaine in the surfactant is 2-4.5:1.
  5. 5. The calamine suspension system of claim 1, wherein the weight fraction of the acrylic copolymer is 0.5-2 parts, and the weight fraction of cocoamide MEA is 1-2.5 parts.
  6. 6. The calamine suspension of claim 5, wherein the weight ratio of acrylic copolymer to cocoamide MEA in the thickener is 0.6-1:1.
  7. 7. The calamine suspension system of claim 1, wherein the pH adjustor is selected from at least one of citric acid, sodium hydroxide.
  8. 8. The calamine suspension system of claim 1, wherein the preservative is selected from at least one of phenoxyethanol, sodium benzoate.
  9. 9. A process for the preparation of a calamine suspension according to any one of claims 1-8, comprising the steps of: s1, adding calamine and zinc oxide into water, and homogenizing to obtain a mixture a; s2, adding the acrylic acid (ester) copolymer into water, and uniformly stirring to obtain a mixture b; S3, adding a surfactant into water at normal temperature, and heating to 80-85 ℃ while stirring until the material is clear and transparent; s4, cooling to 60-65 ℃, adding the mixture b into the material body prepared in the step S3 for multiple times, stirring and homogenizing until the material body is completely dissolved; S5, cooling to 40 ℃, adding the mixture a into the material body prepared in the step S5, uniformly stirring, adding a preservative and a pH regulator, and continuously uniformly stirring; s6, cooling to 38 ℃, and vacuum defoaming and filtering to obtain the calamine suspension system.
  10. 10. Use of the calamine suspension according to any one of claims 1-8 for the preparation of a cosmetic, characterized in that the cosmetic is in the form of an aqueous formulation, an emulsion.

Description

Calamine suspension system and preparation method and application thereof Technical Field The invention relates to the technical field of cosmetics, in particular to a calamine suspension system and a preparation method and application thereof. Background The calamine is mainly used for diminishing inflammation, relieving itching, astringing and protecting skin, and is suitable for various skin problems, such as eczema, allergic dermatitis, insect bite and the like. The main component of the calamine is zinc carbonate, which is usually used in the form of calamine lotion, and the formulation may also contain zinc oxide, glycerin and other components which act together to endow the calamine with multiple effects. Calamine is generally applied to oil-type cosmetics, and for water-type cosmetics, because the calamine has the defects of rapid sedimentation and difficult dispersion in the preparation and storage processes, the calamine is difficult to form a stable aqueous suspension, so that the application of calamine in cosmetics is limited. Disclosure of Invention Aiming at the defects of the prior art, the invention aims to provide a calamine suspension system and a preparation method and application thereof. The invention aims at realizing the following technical scheme: In a first aspect, the invention provides a calamine suspension system, which comprises, by weight, 5-12 parts of a surfactant, 1.5-4 parts of a thickener, 0.01-0.5 part of calamine, 0.0001-0.02 part of zinc oxide, 0.1-1.5 parts of a pH regulator, 0.2-2 parts of a preservative, and water to 100 parts; the surfactant comprises sodium laureth sulfate and cocamidopropyl betaine, and the thickener comprises acrylic acid (ester) copolymer and cocamide MEA. As a preferable scheme, the sodium laureth sulfate is 3-8 parts by weight and the cocamidopropyl betaine is 2-4 parts by weight. Preferably, the surfactant further comprises decyl glucoside, wherein the weight part of the decyl glucoside is 0-1 part. Preferably, in the surfactant, the weight ratio of sodium laureth sulfate to cocamidopropyl betaine is 2-4.5:1. Preferably, the weight portion of the acrylic copolymer is 0.5-1.5 portions, and the weight portion of the cocoamide MEA is 1-2.5 portions. Preferably, in the thickener, the weight ratio of the acrylic copolymer to the cocoamide MEA is 0.6-1:1. Preferably, the pH regulator is at least one selected from citric acid and sodium hydroxide. Preferably, the preservative is at least one selected from phenoxyethanol and sodium benzoate. In a second aspect, the present invention provides a process for the preparation of a calamine suspension according to the foregoing, comprising the steps of: s1, adding calamine and zinc oxide into water, and homogenizing to obtain a mixture a; s2, adding the acrylic acid (ester) copolymer into water, and uniformly stirring to obtain a mixture b; S3, adding a surfactant into water at normal temperature, and heating to 80-85 ℃ while stirring until the material is clear and transparent; s4, cooling to 60-65 ℃, adding the mixture b into the material body prepared in the step S3 for multiple times, stirring and homogenizing until the material body is completely dissolved; S5, cooling to 40 ℃, adding the mixture a into the material body prepared in the step S5, uniformly stirring, adding a preservative and a pH regulator, and continuously uniformly stirring; s6, cooling to 38 ℃, and vacuum defoaming and filtering to obtain the calamine suspension system. In a third aspect, the invention provides an application of the calamine suspension system in preparing cosmetics, wherein the formulations of the cosmetics are water aqua and emulsion. Preferably, the cosmetic comprises a cleaning skin care product and a washing product. Such as shampoo, bath lotion, facial cleanser, cleansing lotion, etc. Compared with the prior art, the invention has the following beneficial effects: According to the invention, through compounding the specially adopted surfactant and the thickener, the calamine suspension system with the calamine addition amount of 0.5% can be successfully prepared, the calamine can be completely suspended in water, and the suspension system has good stability and no precipitation after being placed for 30 days at normal temperature. Drawings Other features, objects and advantages of the present invention will become more apparent upon reading of the detailed description of non-limiting embodiments, given with reference to the accompanying drawings in which: FIG. 1 is a photograph of an immediate observation of the calamine suspension prepared in example 1 (left glass bottle) and comparative example 1 (right glass bottle); FIG. 2 is a photograph of the calamine suspension prepared in example 1 (left glass bottle) and comparative example 4 (right glass bottle) as viewed on standing for 3 days; FIG. 3 is a photograph of the calamine suspension prepared in example 2 (left glass bottle) and example 8 (right glass bot