CN-121971313-A - Composition containing arginine/lysine polypeptide and preparation method and application thereof

Abstract

The invention relates to a composition containing arginine/lysine polypeptide, and a preparation method and application thereof, and belongs to the technical field of cosmetics. The composition is prepared by scientifically proportioning arginine/lysine polypeptide, medicinal rhubarb root extract, semiaquilegia root extract and ganoderma lucidum fermentation products, wherein the ganoderma lucidum fermentation products are obtained by adopting specific lactobacillus plantarum and lactobacillus paracasei to carry out liquid fermentation on ganoderma sinensis, and after the ganoderma lucidum fermentation products are compounded with the arginine/lysine polypeptide, the medicinal rhubarb root extract and the semiaquilegia root extract, the antioxidation capability of the composition can be synergistically improved, the expression of MMPs can be effectively inhibited, and the synthesis of collagen can be promoted, so that the composition has the effects of effectively tightening skin and reducing skin wrinkles.

Inventors

• LIU LU
• LIU TIANJIAO

Assignees

• 广州博士派生物科技有限公司

Dates

Publication Date

20260505

Application Date

20260407

Claims (10)

1. 1. The composition containing the arginine/lysine polypeptide is characterized by comprising the arginine/lysine polypeptide, a medicinal rhubarb root extract, a semiaquilegia root extract and a ganoderma lucidum fermentation product in a weight ratio of 2-3:1-2:0.5-1.5:0.1-1, wherein the ganoderma lucidum fermentation product is prepared by taking ganoderma sinensis as a raw material and carrying out mixed fermentation on lactobacillus plantarum and lactobacillus paracasei.
2. 2. The composition of claim 1, wherein the method of preparing the fermentation product of ganoderma sinensis comprises the steps of: s1, performing superfine grinding on dried ganoderma sinensis to obtain ganoderma sinensis micro powder, adding the ganoderma sinensis micro powder into a liquid fermentation medium, and sterilizing to obtain a fermentation substrate; s2, inoculating a mixed bacterial agent consisting of lactobacillus plantarum bacterial liquid and lactobacillus paracasei bacterial liquid with the volume ratio of 1:2-3 into the fermentation substrate obtained in the S1 for fermentation to obtain fermentation liquor; s3, centrifuging the fermentation liquor obtained in the step S2, filtering and sterilizing the supernatant, and freeze-drying to obtain the ganoderma sinensis fermentation product.
3. 3. The composition according to claim 2, wherein the fine powder of Ganoderma lucidum in step S1 has a particle size of 30-60 μm.
4. 4. The composition of claim 2, wherein the fermentation substrate in step S1 comprises 3wt% to 8wt% of the fine powder of ganoderma sinensis.
5. 5. The composition according to claim 2, wherein the mixed bacteria in step S2 are inoculated in an amount of 2-4% v/v, and the number of viable bacteria in the Lactobacillus plantarum bacteria solution and the Lactobacillus paracasei bacteria solution is the same and is 1X 10 7 -5×10 8 CFU/mL.
6. 6. The composition of claim 2, wherein the fermentation in step S2 is a resting fermentation at 30-37 ℃ for 20-30 hours.
7. 7. Use of the composition according to any one of claims 1 to 6 for the preparation of cosmetics having a tightening and anti-aging effect.
8. 8. The use according to claim 7, wherein the cosmetic is one of a lotion, an emulsion, a cream, a mask, a spray.
9. 9. A cosmetic having a tightening and anti-aging effect, characterized in that it contains the composition according to any one of claims 1 to 6.
10. 10. The cosmetic product of claim 9, wherein the composition is present in the cosmetic product in an amount of from 0.5wt% to 5wt%.

Description

Composition containing arginine/lysine polypeptide and preparation method and application thereof Technical Field The invention relates to the technical field of cosmetics, in particular to a composition containing arginine/lysine polypeptide, and a preparation method and application thereof. Background Skin aging is a complex physiological and pathological process, mainly caused by the combined action of endogenous aging (INTRINSIC AGING) and exogenous aging (extrinsic aging). Endogenous aging is a natural aging process determined by genetic factors. With age, cellular DNA damage accumulates to cause cellular senescence, mitochondrial dysfunction reduces ATP supply, and thus affects proliferation and differentiation capacity of skin cells. Meanwhile, the synthesis level of extracellular matrix proteins such as collagen, elastin and the like in the dermis layer is reduced, degradation is accelerated, and finally skin structure degradation, thinning of the dermis nipple layer and elastic fiber fracture are caused, so that wrinkles are formed. Exogenous aging is mainly caused by environmental factors and lifestyle, including ultraviolet irradiation, PM2.5 pollution, stay up, psychological stress, etc., of which ultraviolet irradiation is the most dominant cause. Long-term uv radiation induces Reactive Oxygen Species (ROS), resulting in reduced collagen and elastic fibrosis of the skin, loss of elasticity and retractive force of the skin, and sagging. In order to cope with the aging mechanism, the cosmetic industry is continuously striving to develop skin care products with tightening and anti-aging effects, and the skin aging process is radically delayed through the synergistic effect of multiple targets and multiple paths. Arginine/lysine polypeptide (Arginine/Lysine Polypeptide) is an artificial synthetic polypeptide simulating conotoxin, can inhibit various Na + channels in a targeted manner and block neurotransmitter release, so that expressive muscles are relaxed, dynamic lines are reduced, and the artificial synthetic polypeptide has good anti-aging and wrinkle-removing effects. However, the mechanism of action of the single polypeptide component is relatively limited, and it is difficult to cover the complex network of skin aging in its entirety. Therefore, the cosmetic capable of enhancing the tightening and anti-aging effects through multi-target synergistic effect has important significance. Disclosure of Invention The invention aims to overcome the defects of the prior art and provide a composition containing arginine/lysine polypeptide, and a preparation method and application thereof. In order to achieve the above purpose, the technical scheme adopted by the invention is as follows: In a first aspect, the invention provides a composition containing arginine/lysine polypeptide, which comprises arginine/lysine polypeptide, medicinal rhubarb root extract, radix semiaquilegiae root extract and ganoderma sinensis fermentation product in a weight ratio of 2-3:1-2:0.5-1.5:0.1-1, wherein the ganoderma sinensis fermentation product is prepared by taking ganoderma sinensis as a raw material and carrying out mixed fermentation on lactobacillus plantarum and lactobacillus paracasei. The composition with the effects of tightening and resisting aging is prepared by scientifically proportioning arginine/lysine polypeptide, medicinal rhubarb root extract, semiaquilegia root extract and ganoderma lucidum fermentation products, each component in the composition can resist aging through a triple mechanism of instant anti-wrinkle, long-acting protection and deep restoration, wherein the arginine/lysine polypeptide can target and inhibit various Na + channels to block neurotransmitter release, thereby relaxing expressive muscles, reducing dynamic lines and realizing instant anti-wrinkle, the medicinal rhubarb root extract is rich in active ingredients such as anthraquinone, flavone, stilbene and tannin and the like, has the effects of resisting inflammation, resisting bacteria and the like, can be used for delaying the aging process by regulating and controlling a cell autophagy mechanism, the semiaquilegia root extract is rich in bioactive substances such as flavonoid compounds and saponin and the like, can neutralize free radicals, delay skin aging, reduce appearance of fine lines and wrinkles, simultaneously, has anti-inflammatory properties, can ease sensitive or stimulated skin, relieve red swelling and uncomfortable feeling, and the ganoderma lucidum is a ganoderma lucidum fungus, polysaccharide, and triterpenoid, can play roles of inhibiting and resisting aging through the oxidation and deep-aging by regulating the active ingredients such as amino acid, and the effects of resisting aging, and repairing the tissues and the aging can be realized. Furthermore, the ganoderma lucidum fermentation product provided by the invention is obtained by adopting specific lactobacillus plantarum and lactobacillus paracasei t