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CN-121971318-A - Scalp repair composition containing epidermis repair polysaccharide and saccharomycete lysate

CN121971318ACN 121971318 ACN121971318 ACN 121971318ACN-121971318-A

Abstract

The invention relates to the technical field of daily chemical products and cosmetics, in particular to a scalp repair composition containing epidermis repair polysaccharide and saccharomycete lysate. The skin repair polysaccharide comprises, by mass, 1% -5% of skin repair polysaccharide, 1% -5% of saccharomycetes lysate, 1% -10% of PEG-5 triglyceride triisostearate and the balance of cosmetically acceptable matrix. The polysaccharide is mannans with weight average molecular weight of 6.15X10 6 Da obtained by Paenibacillus sp.1538 fermentation. According to the invention, the compatibility difficulty of high polymer polysaccharide easy flocculation is effectively overcome by compounding the specific ultrahigh polymer polysaccharide with the saccharomyces cerevisiae extract and introducing the PEG-5 triglyceride triisostearate with low irritation. The composition can form a film instantly, deeply resist inflammation, relieve and repair scalp physical barrier, has excellent synergistic effect, and radically solves the problem of scalp chemical irritation and damage caused by traditional surfactants.

Inventors

  • TANG YONG
  • HU YAN
  • XIAO JUN

Assignees

  • 广东万翔宝诚实业有限公司

Dates

Publication Date
20260505
Application Date
20260401

Claims (10)

  1. 1. A scalp repair composition comprising an epidermis repair polysaccharide and a yeast lysate, characterized by comprising the following raw materials in mass percent: 1% -5% of epidermis repairing polysaccharide; 1% -5% of saccharomycete lysate; 1-10% of PEG-5 glycerate triisostearate; a cosmetically acceptable base, the balance; Wherein the epidermis repairing polysaccharide is mannans with weight average molecular weight of 6.15X10 6 Da obtained by fermenting Paenibacillus sp.1538 strain, the mannans are connected with D-mannose and D-glucose through beta-1, 3 and beta-1, 4 glycosidic bonds to form a main chain structure, and the HLB value of the PEG-5 glycerate triisostearate is 8-10; The epidermis repairing polysaccharide, the saccharomycete lysate and the PEG-5 triglyceride triisostearate are compounded to form a homogeneous system, which is used for inhibiting the release of pro-inflammatory factors caused by chemical stimulation and repairing the physical barrier of the scalp.
  2. 2. Scalp repair composition comprising epidermis repair polysaccharide and yeast lysate according to claim 1, characterized in that the yeast lysate is derived from saccharomyces cerevisiae, the yeast lysate raw material comprises 96.0% yeast fermentation lysate filtrate, 3.5% 1, 2-pentanediol and 0.5% 1, 2-hexanediol by mass percentage, and the active matter content of the raw material is not less than 2g/kg, pH value is 5.0-7.5.
  3. 3. A scalp repair composition comprising a skin repair polysaccharide and a yeast lysate according to claim 1, wherein the PEG-5 glyceryl triisostearate has an acid value of 8mgKOH/g or less, a saponification value of 139-159mgKOH/g, and a colorless to pale yellow transparent liquid at 25 ℃.
  4. 4. A scalp repair composition comprising a skin repair polysaccharide and a yeast lysate according to claim 1, wherein the cosmetically acceptable base comprises glycerin and deionized water.
  5. 5. Scalp repair composition comprising epidermis repair polysaccharide and saccharomycete lysate according to claim 1, characterized in that the chemical stimulus is in particular scalp cytotoxicity and barrier damage induced by surfactants in washing-type cosmetics.
  6. 6. A method of preparing a scalp repair composition comprising an epidermis repair polysaccharide and a yeast lysate according to any one of claims 1 to 5, comprising the steps of: s1, preparing epidermis repairing polysaccharide, namely preparing a seed culture medium by using purified water, inoculating Paenibacillus sp.1538 for seed culture, adjusting pH, filtering, inoculating a fermentation culture medium for fermentation, obtaining fermentation liquor, precipitating, centrifugally extracting polysaccharide precipitate, drying, redissolving the dried matter in the purified water, filtering to obtain filtrate, adding an antiseptic system into the filtrate, and uniformly stirring to obtain the epidermis repairing polysaccharide; S2, prefabricating PEG-5 glyceryl ether and isostearic acid, namely putting the PEG-5 glyceryl ether and the isostearic acid into a reaction kettle according to the molar ratio, slowly heating to ensure that materials are uniformly mixed, then heating to the reaction temperature to carry out multi-stage temperature control dehydration esterification reaction, monitoring the acid value and saponification value to reach the standard, and discharging to obtain the product; And S3, compounding the composition, namely weighing PEG-5 glyceryl triisostearate, a polyol humectant and the balance of deionized water according to the mass percent of the formula, heating to 60-65 ℃, uniformly stirring to form transparent matrix liquid, cooling to below 40 ℃, adding the epidermis repairing polysaccharide and the saccharomycete lysate prepared in the step S1, and uniformly stirring to form homogeneous liquid to obtain the scalp repairing composition.
  7. 7. The method for preparing a scalp repair composition comprising epidermis repair polysaccharide and yeast lysate according to claim 6, wherein in S1, the fermentation process comprises inoculating seed liquid obtained by seed culture into a fermenter containing fermentation medium according to a volume ratio of 5% -8%, fermenting at 30-35 deg.C, ventilation of 0.5-1.0vvm, stirring speed of 200-300rpm, and maintaining pH of the system between 6.5-7.0 during fermentation for 48-72 hours.
  8. 8. The method for preparing a scalp repair composition comprising epidermis repair polysaccharide and yeast lysate according to claim 6, wherein in S1, the polysaccharide precipitate is extracted by precipitation and centrifugation and dried, and the fermentation broth is centrifuged at 5000rpm for 15 minutes to collect supernatant, 3-4 times volume of absolute ethanol is added for alcohol precipitation, and after standing for 8-12 hours, the polysaccharide precipitate is collected by centrifugation, washed with absolute ethanol, and dried to constant weight at 50-60 ℃ in a vacuum drying oven.
  9. 9. The method for preparing a scalp repair composition containing epidermis repair polysaccharide and saccharomycete lysate according to claim 6, wherein in S2, PEG-5 glyceryl ether and isostearic acid are put into a reaction kettle according to a molar ratio of 1:3.05, and p-toluenesulfonic acid and hypophosphorous acid with a total mass of 0.2% are added, and the multi-stage temperature-controlled dehydration esterification reaction is carried out by heating to 120-140 ℃ under normal pressure for 1-2 hours, then heating to 180-200 ℃ and controlling the vacuum degree of the system between-0.08 MPa and-0.095 MPa for 6-8 hours.
  10. 10. The method for preparing a scalp care composition comprising a skin care polysaccharide and a yeast lysate according to claim 6, wherein in S3, the stirring speed is set to 150-200rpm when the PEG-5 glyceryl triisostearate, the polyol humectant and the deionized water are mixed, and the stirring time is maintained for 15-20 minutes after the skin care polysaccharide and the yeast lysate are added at a reduced temperature.

Description

Scalp repair composition containing epidermis repair polysaccharide and saccharomycete lysate Technical Field The invention relates to the technical field of daily chemical products and cosmetics, in particular to a scalp repair composition containing epidermis repair polysaccharide and saccharomycete lysate. Background With the increase of life rhythm and environmental pressure, the problems of scalp microecological imbalance such as scalp desquamation, sebum abnormality, scalp itching, erythema, pimple and the like are increasingly serious. Various surfactants (cationic, anionic, zwitterionic or nonionic), bacteriostats or hair dyes are inevitably added to modern washing and caring products. These chemical components tend to thin the stratum corneum or reduce water saturation while cleaning the scalp, stimulating the scalp cells to produce inflammatory factors, causing apoptosis and scaling, i.e., chemical stimulation damage. Currently, in order to improve the scalp problems, the scalp care products on the market mostly adopt single active ingredients (such as panthenol, ceramide and the like) for basic moisturizing, or use chemical anti-dandruff ingredients (such as zinc pyrithione ZPT) for inhibiting malassezia, but the methods have the defects of high irritation and easy initiation of drug resistance. In recent years, attempts have been made in the industry to modulate scalp micro-ecology using bio-fermentation techniques and polysaccharides. For example, chinese patent CN118453491B discloses a scalp care solution containing a probiotic fermentation product, which is mainly used for basic repair by fermentation filtrate of saccharomyces cerevisiae and the like, and, for example, chinese patent CN114681362a discloses a shampoo for improving scalp microecology, which attempts to compound and use common polysaccharide and a surfactant such as amino acid. In addition, fermentation of Paenibacillus (Paenibacillus) and polysaccharide extraction (e.g., CN 109666603B) have been primarily disclosed in the industrial and agricultural fields. However, the prior art still suffers from the following significant drawbacks when dealing with complex scalp chemical irritation injuries: Firstly, the conventional yeast ferment or probiotic extract used in the prior art can only provide basic amino acid and nutrient substances, lacks the capability of instantly constructing a physical defense barrier on the surface of damaged scalp, secondly, the conventional polysaccharide component used in the existing formula cannot form a film quickly in an elution system due to uneven molecular weight distribution or low molecular weight, and has limited deep repairing effect, and thirdly, has the most troublesome compatibility problem. When trying to combine the yeast extract with high bioactivity and ultra-high molecular weight polysaccharide with film forming property, flocculation, delamination or inactivation is very easy to occur in the traditional washing and protecting matrix, and fourth, the traditional washing and protecting matrix per se lacks blocking capability for chemical stimulation injury, and the cleaning process still can cause secondary micro injury to fragile scalp. Based on the above, the technical problem to be solved by the invention is to provide a scalp care composition which can form a film instantly and physically, go deep into the gene layer, resist inflammation and relieve, and has excellent system stability and ultra-low irritation. The composition needs to overcome the problem of compatibility stability of ultra-high molecular weight polysaccharide in a complex washing and caring system, and radically solves the problems of scalp barrier damage and microecological imbalance caused by the traditional surfactant. Disclosure of Invention The present invention is directed to a scalp repair composition comprising an epidermis repair polysaccharide and a yeast lysate, which solves the problems set forth in the background art. In order to achieve the above object, the present invention provides a scalp repair composition comprising epidermis repair polysaccharide and yeast lysate, comprising the following raw materials by mass percent: 1% -5% of epidermis repairing polysaccharide; 1% -5% of saccharomycete lysate; 1% -10% of PEG-5 glycerate triisostearate; a cosmetically acceptable base, the balance. Further, the epidermis repairing polysaccharide is microbial polysaccharide (manna) obtained by fermenting a strain Paenibacillus sp.1538, and the weight average molecular weight of the epidermis repairing polysaccharide is 6.15 multiplied by 10 6 Da. The polysaccharide is mainly formed by connecting D-mannose and D-glucose through beta-1, 3 and beta-1, 4 glycosidic bonds to form a main chain structure. Further, the yeast lysate is derived from saccharomyces cerevisiae (Saccharomyces cerevisiae), and comprises 96.0% of yeast fermentation lysate filtrate, 3.5% of 1, 2-pentanediol and 0.5% of 1, 2-hexanediol by mass