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CN-121971320-A - Repair composition based on mussel mucin and application of repair composition in skin barrier repair

CN121971320ACN 121971320 ACN121971320 ACN 121971320ACN-121971320-A

Abstract

The invention relates to the technical field of repair compositions, and discloses a repair composition based on mussel mucin and application thereof in skin barrier repair, wherein the composition is in the form of a composition and consists of the following components in parts by weight: mussel mucin-zinc composite microcapsule, modified carboxymethyl chitosan, palmitic acid isolactone, pH response type ceramide slow-release system, simethicone, cetostearyl alcohol, calcium ion activator, auxiliary repair factor, behenpolyether-25, caprylic/capric triglyceride, glyceryl monostearate, pentanediol, citric acid, phenoxyethanol/ethylhexyl glycerol, trehalose, beta-glucan and purified water; the whole technical scheme realizes synergy through functional complementation and process optimization of each component, can rapidly reduce the trans-epidermal water loss, improve the water content of the skin cuticle, can radically repair the damaged skin barrier structure, and remarkably improves the resistance and stability of the skin.

Inventors

  • CUI HAITAO
  • CHEN LEI
  • JIANG LEI
  • LI NANNAN
  • SHI JINXIU

Assignees

  • 合肥贝壳派创新科技有限公司

Dates

Publication Date
20260505
Application Date
20260313

Claims (10)

  1. 1. The repair composition based on mussel mucin is characterized by comprising, by weight, 15-25 parts of mussel mucin-zinc composite microcapsules, 5-15 parts of modified carboxymethyl chitosan, 0.1-0.3 part of palmitic acid iso-lactone, 3-8 parts of a pH responsive ceramide slow release system, 2-5 parts of simethicone, 5-10 parts of cetostearyl alcohol, 1-3 parts of a calcium ion activator, 2-4 parts of an auxiliary repair factor, 1-3 parts of behenyl alcohol polyether, 2-4 parts of caprylic/capric triglyceride, 1-2 parts of glyceryl monostearate, 2-3 parts of pentanediol, 0.1-0.2 part of citric acid, 0.5-1 part of phenoxyethanol/ethylhexyl glycerol, 0.2-0.6 part of trehalose, 0.1-0.3 part of beta-glucan and 30-40 parts of purified water.
  2. 2. The repair composition of claim 1 wherein the pH-responsive ceramide slow release system consists of a ceramide complex and a poly- β -amino ester in a mass ratio of 1 (1.2-1.8).
  3. 3. The repairing composition according to claim 2, wherein the ceramide complex consists of ceramide EOP, ceramide NP and ceramide AP according to a mass ratio of 1 (0.5-1.5): 0.8-1.2.
  4. 4. The repairing composition according to claim 1, wherein the pH responsive ceramide slow-release system is prepared by dissolving poly beta-amino ester in absolute ethyl alcohol, adding ceramide compound, performing ultrasonic dispersion for 10-15min under the power of 200-300W, and performing rotary evaporation at 45-55 ℃ to remove the ethyl alcohol.
  5. 5. The repair composition of claim 1 wherein the calcium activator consists of calcium gluconate and calmodulin in a mass ratio of (2-4): 1.
  6. 6. The repair composition of claim 1 wherein the auxiliary repair factor consists of panthenol and beta-glucan in a mass ratio of (1.5-2.5): 1.
  7. 7. The repair composition of claim 1, wherein the mussel mucin-zinc composite microcapsule is prepared by the following steps: adding mussel mucin and zinc ions according to the mass ratio (10-20) of 1 into Tris buffer solution with pH of 7.5-8.5, and slowly stirring for 30-40min at 2-8 ℃ to form a compound; b, adding sodium alginate solution with the mass fraction of 2-5% into the compound, uniformly stirring, and preparing a microcapsule primary product under the condition that the aperture of a nozzle is 0.1-0.3mm and the atomization pressure is 0.2-0.4 MPa; c, placing the microcapsule primary product into a calcium ion solution with the mass fraction of 1-3% for crosslinking and curing for 20-30min, thus obtaining the microcapsule primary product.
  8. 8. The repair composition of claim 1 wherein the modified carboxymethyl chitosan is prepared by the process of: S1, dissolving chitosan powder in 1-2% of dilute hydrochloric acid by mass fraction, and stirring until the chitosan powder is completely dissolved to prepare 3-5% of chitosan solution by mass fraction; S2, adding a sodium hydroxide solution with the mass fraction of 20-30% accounting for 20-30% of the mass of the chitosan into the chitosan solution, and performing alkalization treatment for 30-60min; s3, slowly dripping chloroacetic acid solution with the mass fraction of 40-50% at the rate of 0.5-1mL/min, and reacting for 2-4h at the temperature of 60-80 ℃; S4, adjusting the pH value of the reaction solution to 6.8-7.2 by using hydrochloric acid with the mass fraction of 5-10%, and filtering to remove insoluble matters; S5, separating and purifying by an ultrafiltration membrane with a molecular weight cutoff of 5000-8000 Da.
  9. 9. A repair composition according to any one of claims 1 to 7 for use in skin barrier repair.
  10. 10. A method of preparing a repair composition according to any one of claims 1 to 7, comprising the steps of: (1) Weighing the components according to a proportion, and respectively preparing a water phase component and an oil phase component; The preparation of water phase component includes dissolving modified carboxymethyl chitosan, pentanediol, citric acid, trehalose and beta-glucan in purified water, adding palmitic acid iso-lactone, stirring at 30-40 deg.c for 15-20min, adding behenyl alcohol polyether-25, and stirring for 5-10min to obtain water phase base liquid; preparing an oil phase component, namely mixing a pH response type ceramide slow release system, cetostearyl alcohol, simethicone, caprylic/capric triglyceride and glyceryl monostearate, and heating and stirring at 55-65 ℃ until the components are completely dissolved to prepare an oil phase base solution; (2) Slowly adding the oil phase base solution into the water phase base solution, stirring while maintaining the temperature at 55-65 ℃, stirring for 10-15min, and emulsifying at 10000-12000r/min for 15-20min to form a primary emulsion; (3) Cooling the primary emulsion to 30-40 ℃, adding mussel mucin-zinc composite microcapsules, and stirring at constant temperature for 1-2h; (4) Adding a calcium ion activator and an auxiliary repair factor, regulating the pH to 5.5-6.5 by using a citric acid-disodium hydrogen phosphate buffer solution, and uniformly stirring; (5) Adding phenoxyethanol/ethylhexyl glycerol, stirring at 50-60deg.C for dissolving, homogenizing under 20-30MPa for 2-3 times, homogenizing for 3-5min each time, cooling to room temperature, and packaging.

Description

Repair composition based on mussel mucin and application of repair composition in skin barrier repair Technical Field The invention relates to the technical field of repair compositions, in particular to a repair composition based on mussel mucin and application thereof in skin barrier repair, which can be applied to the effects of keeping wound skin moist and promoting wound healing and damaged skin repair. Is especially suitable for repairing non-chronic wound skin formed by laser, water light, fruit acid skin replacement, micro plastic operation, dermatitis, eczema, acne and the like. Background The skin barrier is used as a protective layer of skin and mainly consists of keratinocytes and intercellular lipids, and has the core functions of locking skin moisture and resisting invasion of external stimuli. Along with environmental changes, living habit changes and age increase, skin barriers are easy to damage, the problems of dryness, redness, accelerated water loss and the like are presented, and discomfort such as sensitivity, itching and the like can be caused when the skin barriers are serious, so that the research and development of skin barrier repair products are always the important direction in the field of skin care. At present, most of repairing products on the market realize repairing effects through conventional active ingredients, but obvious short plates are commonly existing. Some products adopt a mode of directly adding common active ingredients, the active ingredients are easy to be rapidly metabolized and difficult to continuously play a role due to poor stability of the ingredients and insufficient permeability of the skin, and some products pay attention to efficacy enhancement of single ingredients, but neglect cooperative coordination among the ingredients, have limited repairing effect and have weak pertinence. Meanwhile, few products are aimed at immediate effect, excessive irritating ingredients are added, and long-term use may increase skin burden and even further destroy skin barrier. In order to solve the problems of low utilization rate of active ingredients, non-lasting repairing effect, poor ingredient cooperativity and the like of the existing product, the skin barrier repairing composition which is reasonable in ingredient collocation, long-acting in active ingredients, remarkable in repairing effect, mild and safe is developed, and the urgent need of the current industry is met. Disclosure of Invention Aiming at the problems in the prior art, the invention provides a repair composition based on mussel mucin. The repair composition based on mussel mucin comprises, by weight, 15-25 parts of mussel mucin-zinc composite microcapsules, 5-15 parts of modified carboxymethyl chitosan, 0.1-0.3 part of palmitic acid iso-lactone, 3-8 parts of pH response type ceramide slow release system, 2-5 parts of simethicone, 5-10 parts of cetostearyl alcohol, 1-3 parts of calcium ion activator, 2-4 parts of auxiliary repair factor, 1-3 parts of behenyl alcohol polyether, 2-4 parts of caprylic/capric triglyceride, 1-2 parts of glyceryl monostearate, 2-3 parts of pentanediol, 0.1-0.2 parts of citric acid, 0.5-1 part of phenoxyethanol/ethylhexyl glycerol, 0.2-0.6 part of trehalose, 0.1-0.3 part of beta-glucan and 30-40 parts of purified water. As a further technical scheme, the pH response type ceramide slow-release system consists of a ceramide compound and poly beta-amino ester according to the mass ratio of 1 (1.2-1.8). As a further technical scheme, the ceramide compound consists of ceramide EOP, ceramide NP and ceramide AP according to the mass ratio of 1 (0.5-1.5) to 0.8-1.2. The preparation method of the pH response type ceramide slow-release system comprises the steps of dissolving poly beta-amino ester in absolute ethyl alcohol, adding a ceramide compound, performing ultrasonic dispersion for 10-15min under the power of 200-300W, and removing the ethyl alcohol by rotary evaporation at the temperature of 45-55 ℃. As a further technical scheme, the calcium ion activator consists of calcium gluconate and calmodulin according to a mass ratio of (2-4): 1. As a further technical scheme, the auxiliary repair factor consists of panthenol and beta-glucan according to a mass ratio of (1.5-2.5): 1. As a further technical scheme, the preparation method of the mussel mucin-zinc composite microcapsule comprises the following steps: adding mussel mucin and zinc ions according to the mass ratio (10-20) of 1 into Tris buffer solution with pH of 7.5-8.5, and slowly stirring for 30-40min at 2-8 ℃ to form a compound; b, adding sodium alginate solution with the mass fraction of 2-5% into the compound, uniformly stirring, and preparing a microcapsule primary product under the condition that the aperture of a nozzle is 0.1-0.3mm and the atomization pressure is 0.2-0.4 MPa; c, placing the microcapsule primary product into a calcium ion solution with the mass fraction of 1-3% for crosslinking and curing for 20