CN-121971326-A - Composition containing organic acid and used for preventing alopecia and based on cacumen biotae extract and application thereof

Abstract

The invention discloses an organic acid-containing alopecia preventing composition based on a cacumen biotae extract, which comprises the cacumen biotae extract and an organic acid as alopecia preventing active ingredients, wherein the acid is succinic acid or malic acid or a combination of the succinic acid and the malic acid. The invention also provides application of the alopecia preventing composition in regulating energy metabolism of hair follicles and preventing alopecia. The composition containing the biota orientalis leaf extract, the succinic acid and the malic acid can promote the activity of hair papilla cells, enhance the energy metabolism of cells, recover the functions of oxidatively damaged hair follicles and recover the energy metabolism of oxidatively damaged hair follicles, thereby having good effects of preventing and treating alopecia, stimulating hair growth and having few toxic and side effects.

Inventors

• Xu Yaohao
• HU GENHUA
• LIU JIASHUO
• XIE LI
• YUAN YUXI

Assignees

• 广州环亚化妆品科技股份有限公司

Dates

Publication Date

20260505

Application Date

20251231

Claims (10)

1. 1. An anti-hair loss composition containing an organic acid based on a cacumen Platycladi extract, characterized by comprising a cacumen Platycladi extract and an organic acid as an anti-hair loss active ingredient, wherein the organic acid is succinic acid or malic acid or a combination of both.
2. 2. The composition for preventing alopecia based on an organic acid of claim 1, wherein the weight ratio of the cacumen Platycladi extract to succinic acid or malic acid is 1 (0.001-1).
3. 3. The composition for preventing alopecia based on an organic acid of a cacumen Platycladi extract according to claim 1, wherein the weight ratio of cacumen Platycladi extract, succinic acid and malic acid is 1 (0.001-1): 0.001-1.
4. 4. The composition for preventing alopecia based on an organic acid containing extract of Platycladus orientalis according to claim 1, wherein the composition for preventing alopecia comprises the following components, by mass, 0.1% of the extract of Platycladus orientalis, 0.0001-0.1% of succinic acid, and 0.0001-0.1% of malic acid.
5. 5. The organic acid-containing hair loss preventing composition based on a cacumen Platycladi extract according to claim 1, wherein the composition is a pharmaceutical composition or a cosmetic composition.
6. 6. The organic acid-containing hair loss preventing composition based on a cacumen Platycladi extract according to claim 1, wherein the cosmetic composition comprises any one of shampoo, hair cream, hair wax, hair gel, hair conditioner, spray, anti-hair loss essence, refined spray, pre-wash gel.
7. 7. Use of an organic acid-containing anti-hair loss composition based on an extract of biota orientalis leaves according to any one of claims 1 to 6 for regulating energy metabolism of hair follicles.
8. 8. Use of the composition for preventing alopecia comprising an organic acid based on an extract of biota orientalis leaves as claimed in any one of claims 1 to 6.
9. 9. The use according to claim 8, wherein the hair loss is oxidative damage type hair loss.
10. 10. The use according to claim 8, wherein said preventing hair loss comprises at least one of preventing hair loss, treating hair loss, and stimulating hair growth.

Description

Composition containing organic acid and used for preventing alopecia and based on cacumen biotae extract and application thereof Technical Field The invention belongs to the technical field of cosmetics, in particular to the technical field of hair cleaning and nursing products, and particularly relates to an anti-hair loss composition containing cacumen biotae, succinic acid and malic acid and application thereof. Background The occurrence of hair loss is closely related to the local microenvironment of hair follicles and the state of energy metabolism. Hair follicles act as highly dynamic regenerative tissues, and require maintenance of extremely high cell proliferation rates during the growth phase, while hair papilla cells are the core regulatory centers that maintain the stability of the hair follicle growth cycle. Oxidative damage type alopecia (Oxidative Damage-induced Alopecia, ODA) refers to hair follicle degenerative changes caused by excessive accumulation of scalp local active oxygen (such as hydrogen peroxide) under the action of various exogenous and endogenous factors such as ultraviolet radiation, environmental pollution, dyeing and scalding chemical stimulus and psychological pressure, etc., which causes hair follicle to be in a continuous oxidative stress state. Oxidative damage is considered to be one of the important mechanisms of hair loss occurrence, and its core is that oxidative stress causes cell dysfunction and decrease in cell viability, thereby causing weakening of hair follicle growth and maintenance ability. Other types of hair loss, such as androgenic hair loss, can also be eventually manifested as hair loss due to impaired cell viability triggered by different damaging factors. In contrast, oxidative damage type alopecia belongs to non-hormone-dependent alopecia, and can directly reflect the influence of cell state change on physiological functions of hair follicles, so that the oxidative damage type alopecia has important and wide research value, and can be used as a classical research model to explore the action effect of the alopecia preventing component. Hydrogen peroxide is one of the core reactive oxygen molecules, and its abnormal accumulation in the hair follicle area directly disrupts cellular homeostasis. Hydrogen peroxide can penetrate cell membranes to enter into papilla cells and hair mother cells to cause mitochondrial dysfunction, directly cause mitochondrial function reduction and ATP generation capacity reduction, cause cell cycle arrest, apoptosis and the like. Sustained oxidative damage to hair follicles eventually leads to hair follicle miniaturization, impaired keratinocyte barrier, and advanced hair follicle entry into telogen. Hydrogen peroxide is therefore considered a key mediator that promotes oxidative stress, inflammatory response, and hair follicle degeneration. Thus, there is a need to re-activate mitochondrial function against mitochondrial dysfunction, through key substances in the energy metabolic pathways, to autonomously counteract oxidative damage caused by hydrogen peroxide through oxidative phosphorylation, restoring mitochondrial energy production function and ATP levels. Succinic acid can directly enter a tricarboxylic acid cycle, and is converted into fumaric acid under the action of succinic dehydrogenase, and meanwhile, the electron transfer intermediate FADH2 is generated. FADH2 is a transient intermediate and is difficult to exist for a long time in vitro, and FADH2 produced during succinic acid change can be directly used as a substrate of a complex II, so that oxidative phosphorylation is directly started, and the electron transfer chain of mitochondria is integrally enhanced from an initial stage. Malic acid accelerates efficient transfer of cytoplasmic NADH reducing power into the interior of mitochondria by promoting malate-aspartate shuttle. As an important path for transferring reduction equivalent, the shuttle system enables exogenous malic acid to push the circulation speed of oxaloacetic acid and aspartic acid, so that mitochondria can continuously obtain NADH and metabolic substrates, the energy production process can continuously obtain substrate supplementation, and cells can maintain stable and sufficient metabolic flow in a longer time scale, thereby avoiding the condition of insufficient energy supply or failure. Succinic acid and malic acid act on the start and the supplementary stages of energy metabolism, respectively, forming a complementary metabolic promotion combination. The succinic acid strengthens the starting end and the initial electronic input of the electronic transmission chain, and the malic acid ensures the subsequent reducing force and the continuous supply of the substrate, and the two together construct a metabolism support system which can not only rapidly promote energy metabolism, but also maintain stable output in time. The synergistic promotion of ATP synthesis speed and overall circulation