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CN-121971339-A - Swallowable oral care spray and preparation method thereof

CN121971339ACN 121971339 ACN121971339 ACN 121971339ACN-121971339-A

Abstract

The invention discloses a swallowable oral care spray and a preparation method thereof, and belongs to the technical field of oral care. The spray consists of an odor decomposition component (0.2-0.4% of persimmon fruit extract, 0.1-0.2% of phyllanthus emblica extract, and a mass ratio of 2:1), a microecological adjustment component (0.3-0.6% of fructo-oligosaccharide, 0.2-0.4% of galacto-oligosaccharide, 0.08-0.15% of sugarcane polyphenol, and a mass ratio of 2:1:0.3), a mucous membrane affinity component (0.08-0.15% of sodium hyaluronate, 0.03-0.06% of hydrolyzed hyaluronic acid, and 0.08-0.15% of aloe polysaccharide) and a moisturizing stable matrix. All edible components meet the food related standard, all components meet the cosmetic safety technical specification, contain no alcohol and no traditional preservative, and can be swallowed. The invention realizes the effects of radically improving the oral cavity peculiar smell, mildly adjusting the flora balance and relieving the mucosa discomfort through the triple synergistic effects of peculiar smell decomposition, microecology adjustment and mucosa affinity. The preparation method comprises the steps of temperature control dissolution, gradient charging, pre-dispersion hydration of hyaluronic acid, filtration filling and the like, and has definite process end point and good batch stability. The accelerated test proves that the product has good normal temperature storage stability.

Inventors

  • LI MINGYANG

Assignees

  • 北京名扬口腔门诊部有限公司

Dates

Publication Date
20260505
Application Date
20260226

Claims (5)

  1. 1. A swallowable oral care spray, characterized by comprising the following components in percentage by mass: the peculiar smell decomposition component comprises 0.2-0.4% of persimmon fruit extract and 0.1-0.2% of phyllanthus emblica extract, wherein the mass ratio of persimmon fruit extract to phyllanthus emblica extract is 2:1; the microecological regulating components comprise 0.3-0.6% of fructo-oligosaccharide, 0.2-0.4% of galacto-oligosaccharide and 0.08-0.15% of sugarcane polyphenol, wherein the mass ratio of the fructo-oligosaccharide, the galacto-oligosaccharide and the sugarcane polyphenol is 2:1:0.3; The mucosa affinity component comprises sodium hyaluronate (molecular weight 80-150W Da) 0.08-0.15%, hydrolyzed hyaluronic acid (molecular weight 1-5W Da) 0.03-0.06%, and aloe polysaccharide 0.08-0.15%; a moisturizing and stabilizing matrix, wherein the moisturizing and stabilizing matrix comprises 3.0-5.0% of glycerol, 1.5-2.5% of erythritol, 0.02-0.05% of vitamin E, 0.01-0.03% of EDTA disodium and purified water added to 100%; The pH value of the spray is 5.8-6.6, and the osmotic pressure is 250-350 mOsm/kg; The spray contains no alcohol, no benzoate preservative and no bacteriostat, all edible components meet the food related standards, and all components meet the requirements of cosmetic safety technical Specification.
  2. 2. The oral care spray of claim 1 wherein the molecular weight of the sodium hyaluronate is 80-150 kiloda and the molecular weight of the hydrolyzed hyaluronic acid is 1-5 kiloda.
  3. 3. The oral care spray of claim 1, wherein the spray is filled in brown bottles packaged with a vacuum check valve.
  4. 4. A method of preparing the oral care spray of any one of claims 1-3, comprising the steps of: (1) Adding glycerol, erythritol and EDTA disodium into purified water at 40-55deg.C, and stirring to dissolve completely to obtain matrix solution; (2) Cooling the matrix liquid to 30-40 ℃, sequentially adding fructo-oligosaccharide, galacto-oligosaccharide and sugarcane polyphenol, and stirring for 10-15 minutes until the matrix liquid is uniformly dispersed; (3) Premixing sodium hyaluronate and hydrolyzed hyaluronic acid with 10-15 times of glycerol to form slurry, slowly adding into the system of the step (2) under stirring, continuously stirring for 30min, standing for hydration for more than 2 hours, and taking sample detection that the light transmittance of 550nm wavelength is more than or equal to 98% as complete dissolution; (4) Pre-dissolving fructus kaki extract and fructus Phyllanthi extract with purified water at 35-40deg.C, respectively, adding into the system, and stirring; (5) Adding vitamin E, and stirring to disperse uniformly; (6) Cooling to room temperature, and adjusting pH to 5.8-6.6 with citric acid or sodium citrate; (7) Filtering with 0.22 μm filter membrane, standing for deaeration, and aseptically packaging in brown bottle packed with vacuum check valve.
  5. 5. The method of claim 4, wherein the stationary hydration of step (3) is replaced by slow stirring at 4-10 ℃ for 1 hour.

Description

Swallowable oral care spray and preparation method thereof Technical Field The invention belongs to the technical field of oral care, and particularly relates to a swallowable oral care spray and a preparation method thereof. Background Oral malodour, microecological imbalance and mucosal discomfort have become a high-frequency daily oral puzzles for modern people. The oral spray is a high frequency, as-needed product due to the portable and instant care characteristics. However, the following drawbacks and deficiencies are common to the products currently on the market: 1. the safety is not enough. The existing oral spray contains more alcohol, preservative, bacteriostat and other components, can not be swallowed, is easy to cause throat and stomach irritation due to incorrect swallowing, and can not be safely used for a long time by pregnant women, children and old people. 2. The efficacy is single and short. Most products only use essence to cover peculiar smell, cannot decompose a real odor-causing source, namely Volatile Sulfide (VSC), and are difficult to realize long-term freshness. 3. The microecological balance of the oral cavity is easy to be destroyed. The oral cavity spray mainly containing sterilizing components can influence harmful bacteria and simultaneously interfere with the balance of oral cavity primary flora, and is unfavorable for stable oral cavity environment after long-term use. 4. The mucosal affinity was ignored. The existing product is not fully considered to be matched with the osmotic pressure of the oral mucosa, and has irritation, dryness or acerbity after being used by partial people. 5. Lacks a synergistic design. Most of the commercial products are single components or simple combinations, and the multiple synergistic nursing effects of improving peculiar smell, regulating microecology and protecting mucous membrane are not realized. 6. The preparation process is rough. The dissolution, dispersion and hydration of high molecular components such as hyaluronic acid are not sufficiently controlled, and the problems of agglomeration, incomplete dissolution, poor batch stability and the like are easily caused. Disclosure of Invention The invention provides a swallowable oral care spray which consists of an odor decomposition component, a microecological regulation component, a mucous membrane affinity component and a moisturizing stable matrix. All edible components accord with food related standards, all components accord with the requirements of cosmetic safety technical standards, do not contain alcohol, benzoate and other traditional chemical preservatives, do not contain irritant bacteriostats, do not contain western medicine components, can be swallowed, and can be used by pregnant women, children and the old. 3.1 Formulation composition (mass percent) 1. Odor decomposing component 0.2-0.4% Of persimmon fruit extract 0.1-0.2% Of phyllanthus emblica extract The persimmon fruit extract and the phyllanthus emblica extract have the mass ratio of 2:1, and have synergistic improvement effect on simulated oral cavity odor precursor substances. 2. Microecological regulating component Fructo-oligosaccharide 0.3-0.6% Galacto-oligosaccharide 0.2-0.4% 0.08-0.15% Of sugarcane polyphenol The mass ratio of the fructo-oligosaccharide, the galacto-oligosaccharide and the sugarcane polyphenol is 2:1:0.3, and the fructo-oligosaccharide, the galacto-oligosaccharide and the sugarcane polyphenol have a synergistic regulation effect on the balance of the oral microenvironment, and are beneficial to maintaining the living environment of the oral primary beneficial bacteria. 3. Mucosal affinity component Sodium hyaluronate (molecular weight 80-150 Da) 0.08-0.15% Hydrolyzing hyaluronic acid (molecular weight 1-5W Da) 0.03-0.06% Aloe polysaccharide 0.08-0.15% 4. Moisture-retaining stabilization matrix Glycerol 3.0-5.0% Erythritol 1.5-2.5% Vitamin E0.02-0.05% EDTA disodium 0.01-0.03% Purified water was added to 100% The addition amount of EDTA disodium meets the limit requirement of cosmetic safety technical Specification, and the safety is reliable. 5. Product key control index pH:5.8–6.6 Osmotic pressure of 250-350 mOsm/kg, and more affinity with oral mucosa tissue fluid 3.2 Preparation method (1) Adding glycerol, erythritol and EDTA disodium into purified water at 40-55deg.C, and stirring to dissolve completely to obtain matrix solution. (2) Cooling the matrix liquid to 30-40deg.C, sequentially adding fructo-oligosaccharide, galacto-oligosaccharide and sugarcane polyphenol, and stirring for 10-15 min to disperse uniformly. (3) Fully premixing sodium hyaluronate and hydrolyzed hyaluronic acid with 10-15 times of glycerol by mass in advance to form slurry, slowly adding the slurry into the system in the step (2) under stirring, continuously stirring for 30 minutes, standing and hydrating for more than 2 hours, sampling and detecting that the light transmittance of 550nm wavelength reaches more than