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CN-121971343-A - Mild anti-aging liposome skin care composition suitable for sensitive muscles and application thereof

CN121971343ACN 121971343 ACN121971343 ACN 121971343ACN-121971343-A

Abstract

The invention relates to a mild anti-aging liposome skin care composition suitable for sensitive muscles and application thereof, and belongs to the technical field of cosmetics. According to the liposome skin care composition, a specific spatial structure is adopted, namely PDRN is wrapped in an inner water phase of a liposome, the white birch bark extract and the semen lablab album extract are embedded in a phospholipid bilayer of the liposome, VII type collagen is anchored on the outer surface of the phospholipid bilayer of the liposome, and a multi-target synergistic regulation and control skin cell ubiquitination system is realized, so that protein steady state is systematically recovered, and the effects of resisting skin photoaging and the early aging comprehensively in the aspects of tightening, resisting wrinkles, relieving and repairing, improving skin elasticity, protecting and brightening skin color and the like are achieved.

Inventors

  • ZHANG JIANHUA
  • LIU SHICHAO
  • GUO WENJIAO

Assignees

  • 溪木源生物科技集团有限公司

Dates

Publication Date
20260505
Application Date
20260313

Claims (10)

  1. 1. A liposome skin care composition is characterized by comprising the following raw materials of (0.1-3): 0.5-5): 0.1-2): 0.01-2: (0.01-3): 0.1-1 and (0.01-1) as well as (VII) and (10.1-3) as raw materials of behenyl trimethyl ammonium chloride, hydrogenated soybean lecithin, cholesterol, PDRN, VII type collagen, white birch bark extract and ash green soybean seed extract.
  2. 2. The liposomal skin care composition of claim 1, wherein the weight ratio of behenyl trimethyl ammonium chloride, hydrogenated soy lecithin, cholesterol, PDRN, type VII collagen, birch bark extract, and green soybean seed extract is (0.3-1.5): 1-3): 0.3-1.5): 0.01-1.5): 0.5-2: 0.05-0.8.
  3. 3. The liposomal skin care composition according to claim 1, wherein the weight ratio of behenyl trimethyl ammonium chloride, hydrogenated soy lecithin, cholesterol, PDRN, type VII collagen, birch bark extract, and green soybean seed extract is (0.5-1): 1.5-2.5): 0.5-0.8): 0.3-1): 0.5-1): 1-2: 0.1-0.5.
  4. 4. A method of preparing a liposomal skin care composition according to any one of claims 1-3 comprising the steps of: S1, dissolving behenyl trimethyl ammonium chloride, 1/2 dosage of hydrogenated soybean lecithin and 1/2 dosage of cholesterol in absolute ethyl alcohol, removing the ethanol by rotary evaporation to form a lipid film, dissolving PDRN in preheated ultrapure water to obtain a hydration medium, mixing the hydration medium and the lipid film, stirring until the lipid film is fully hydrated to obtain a crude suspension, and treating the crude suspension by using a liposome extruder to obtain clarified cationic core liposome suspension; S2, dissolving the rest hydrogenated soybean lecithin, the rest cholesterol, the white birch bark extract and the green soybean seed extract in absolute ethyl alcohol, performing rotary evaporation to remove the ethyl alcohol to form a composite lipid film, adding the cationic core liposome suspension obtained in the step S1, and stirring and mixing to obtain a mixed system; S3, dissolving VII type collagen in ultrapure water to obtain a collagen solution, dropwise adding the collagen solution into the mixed system prepared in the S2, and stirring and mixing to obtain a mixed suspension; S4, transferring the mixed suspension obtained in the step S3 to an ultrafiltration centrifuge tube, centrifuging, discarding the filtrate, and adding ultrapure water to resuspend and precipitate to obtain the liposome skin care composition.
  5. 5. The method according to claim 4, wherein the spin evaporation in step S1 is reduced pressure rotary evaporation in a water bath at 50-60 ℃ for 35-50min, the stirring is magnetic stirring in a water bath at 50-60 ℃ and a rotating speed of 200-300r/min for 50-80min, and the treatment of the crude suspension by a liposome extruder is carried out such that the crude suspension is passed through a polycarbonate membrane with a pore size of 400 nm times and then through a polycarbonate membrane with a pore size of 200 nm times.
  6. 6. The method according to claim 4, wherein the stirring and mixing in the step S2 is performed by magnetic stirring at a water bath of 55-65 ℃ and a rotational speed of 200-400 rpm for 40-80min.
  7. 7. The method according to claim 4, wherein the stirring and mixing in the step S3 is performed at room temperature at a rotation speed of 200-400r/min for 25-40min.
  8. 8. The method according to claim 4, wherein the ultrafiltration tube has a molecular weight cut-off of 100kDa in step S4 and is centrifuged at 3000 to 5000 Xg for 8 to 15min.
  9. 9. Use of a liposomal skin care composition according to any one of claims 1-3 in the preparation of a cosmetic.
  10. 10. The use according to claim 9, wherein the cosmetic is a lotion, an emulsion, a cream, a mask or a lyophilized powder.

Description

Mild anti-aging liposome skin care composition suitable for sensitive muscles and application thereof Technical Field The invention relates to the technical field of cosmetics, in particular to a mild anti-aging liposome skin care composition suitable for sensitive muscles and application thereof. Background The characterization of skin presage is a multi-dimensional, progressive biological process whose clinical appearance is far beyond the slight change in static fine lines and elasticity, and is more early and more commonly manifested as a deterioration in the overall texture of the skin. This includes darkening and unevenness of skin tone due to local melanin metabolic disorders, loss of penetration and glossiness due to disorder of stratum corneum turnover, and significant slowing of the rate of self-healing of skin after it is subjected to daily minor damage (e.g. uv radiation, mechanical abrasion). From the point of view of molecular cell biology, the root of these macroscopic manifestations can be traced back to an early, systematic imbalance in the steady-state network of proteins within the skin keratinocytes and dermal fibroblasts. Specifically, ubiquitin-proteasome systems, which are the cores for intracellular protein quality control, have reduced initial functional efficiency or recognize specific disorders, and proteins that cause misfolding, oxidative modification, or functional redundancy cannot be cleared in time to accumulate abnormally. The accumulation not only directly interferes with the activity cycle and degradation process of melanin metabolism key enzymes such as tyrosinase and the like to cause pigmentation regulation failure, but also can be used as an endogenous stress signal to cause the inflammatory pathways such as nuclear factor kappa B and the like to be in a continuously existing and low-intensity abnormal activation state, thereby triggering a chronic subclinical inflammatory state and damaging the update mechanisms such as mitochondrial function, autophagy and the like. This cascade of reactions, which is triggered by early dysfunctions of the protein quality control system, forms a common molecular basis for the loss of skin viability and the appearance of an "as-worn" state. Current mainstream cosmetic intervention strategies against the above-mentioned signs of early age have focused on direct effects on a single target downstream. Common protocols include the addition of high doses of vitamin C derivatives or nicotinamide, to achieve skin lightening by competitively inhibiting tyrosinase activity or blocking melanin transport, or the use of specific signal peptides to directly stimulate collagen synthesis. However, such approaches are essentially punctual interventions on specific pathways downstream of the aging complex network, failing to systematically regulate the ubiquitinated regulatory network, a core hub that maintains intracellular protein mass balance. Thus, while these components can improve specific appearance metrics in a short period of time, the global ability of the cells themselves to recognize, repair and clear damaged proteins cannot be fundamentally restored, the progressive senescence process driven by deregulation of the protein homeostasis network is poorly blocked, and the effects are often bottleneck and difficult to persist. Disclosure of Invention The invention aims to overcome the defects of the prior art and provide a mild anti-aging liposome skin care composition suitable for sensitive muscles and application thereof. In order to achieve the above purpose, the technical scheme adopted by the invention is as follows: In a first aspect, the invention provides a liposome skin care composition, which comprises the following raw materials of (0.1-3): 0.5-5): 0.1-2): 0.01-3: (0.01-1) and (0.01-1) as well as (7) as hydrogenated soybean lecithin, white birch bark extract and white green soybean seed extract. Based on the understanding of the primary and old core molecular mechanism of the skin, the invention provides a brand new strategy for synergistically regulating and controlling a cell ubiquitination system and a related network through multiple targets, wherein the primary and old problems of skin darkness, slow repair and the like are systematically resisted by jointly recovering and enhancing the protein steady state management capability of skin cells from multiple dimensions of damage protection, microenvironment stability, proteasome activation, ubiquitination regulation and the like. The active ingredients in the liposome skin care composition exert synergistic effects through the following specific mechanisms: The core role of Polydeoxyribonucleotides (PDRNs) is to intervene in DNA damage repair and inflammatory signaling. As a nucleotide precursor, it provides a DNA repair substrate for skin cells damaged by environmental stress, accelerating the recovery of genome integrity, thereby reducing abnormal activation of signal pathways