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CN-121971347-A - Penetration-promoting composition containing sweet wormwood herb and having skin cell repairing and relieving effects, and preparation method and application thereof

CN121971347ACN 121971347 ACN121971347 ACN 121971347ACN-121971347-A

Abstract

The invention relates to a sweet wormwood-containing penetration-promoting composition with skin cell repairing and relieving effects, and a preparation method and application thereof, and belongs to the technical field of cosmetics. The research of the invention finds that the anti-inflammatory effect is limited only by inhibiting the upstream anti-inflammatory path of the NF- κB channel, and the anti-inflammatory effect can be obviously enhanced by blocking the downstream conduction chain while inhibiting the NF- κB channel. Based on the above, the invention suppresses the upstream anti-inflammatory path and simultaneously reduces the recruitment and infiltration of inflammatory cells, blocks the downstream conduction chain and synergistically improves the anti-inflammatory effect through the sweet wormwood extract and the wang spring extract. In addition, the invention also cooperates with oat kernel oil, jasmine flower oil and squalane to promote the solubility of fat-soluble active substances on one hand, and on the other hand, the invention can participate in repairing, stabilizing and optimizing the lipid structure of skin horny layer, synchronously open skin fat-soluble channels and more efficiently transport active substances, thereby realizing excellent effects of relieving, repairing and stabilizing.

Inventors

  • LI MENGJIE
  • LIU YUFEI
  • PAN TING
  • HU XIN
  • GONG CHENGYI
  • WANG LILI
  • GAO HONGQI

Assignees

  • 上海林清轩化妆品集团股份有限公司

Dates

Publication Date
20260505
Application Date
20260408

Claims (10)

  1. 1. A sweet wormwood-containing penetration-promoting composition with skin cell repairing and soothing effects is characterized by comprising, by weight, 1-3 parts of plant extract active substances, 23-54 parts of fat-soluble carriers and 1-5 parts of antioxidants; The plant extract active substance comprises sweet wormwood extract and flos mori extract, and the fat-soluble carrier comprises oat kernel oil, jasmine flower oil and squalane.
  2. 2. The composition according to claim 1, wherein the mass ratio of the extract of the verruca vulgaris and the extract of the sweet wormwood is 1-6:2-6.
  3. 3. The composition according to claim 1, wherein the mass ratio of oat kernel oil, jasmine oil to squalane is 10-15:0.1-0.3:10-40.
  4. 4. The composition of claim 1, wherein the antioxidant is selected from one or more of tocopherols, pentaerythritol tetrakis (bis-t-butylhydroxyhydrocinnamate).
  5. 5. The composition of claim 1, wherein the artemisia annua extract has a deoxyartemisinin content of >1.5%, an artemisinic acid content of >0.5% and a dihydroartemisinic acid content of >0.5%.
  6. 6. A process for preparing a penetration enhancing composition having skin cell repair soothing effect comprising sweet wormwood according to any one of claims 1 to 5, which comprises the following steps: Step one, weighing oat kernel oil, jasmine flower oil and squalane, and uniformly stirring to obtain a fat-soluble carrier; weighing the sweet wormwood herb extract, adding the sweet wormwood herb extract into a fat-soluble carrier, and uniformly stirring to obtain a mixture 1; weighing the extract of the flos mori, adding the extract into the mixture 1, and uniformly stirring to obtain a mixture 2; and step four, weighing the antioxidant, adding the antioxidant into the mixture 2, and uniformly stirring to obtain the antioxidant.
  7. 7. The method according to claim 6, wherein the stirring speed is 200-400rpm/min for 5-30min.
  8. 8. Use of an artemisia annua-containing penetration-enhancing composition having skin cell repair and relief efficacy according to any one of claims 1to 5 in the preparation of cosmetics.
  9. 9. The use according to claim 8, wherein the cosmetic comprises 0.1-10 wt% of the sweet wormwood-containing penetration-promoting composition with skin cell repair and relief effects.
  10. 10. The use according to claim 8, wherein the cosmetic is one of an aqueous, an oil, an emulsion, a mask liquid, a cream, a sun protection product.

Description

Penetration-promoting composition containing sweet wormwood herb and having skin cell repairing and relieving effects, and preparation method and application thereof Technical Field The invention belongs to the technical field of cosmetics, and relates to a sweet wormwood-containing penetration-promoting composition with skin cell repairing and relieving effects, and a preparation method and application thereof. Background The traditional skin anti-inflammatory technology only depends on the upstream anti-inflammatory action of the sweet wormwood herb extract to inhibit the NF- κB pathway, however, even if the upstream inflammatory mediators are reduced, the residual inflammatory signals activate vascular endothelial cells to enable the vascular endothelial cells to express adhesion proteins highly, thereby recruiting leukocytes to infiltrate into skin tissues to aggravate local inflammatory injury, and meanwhile, the local inflammation is at risk of spreading to surrounding skin and even the whole body, so that the problem of skin anti-inflammatory is still limited only by the sweet wormwood herb extract. In addition, the low solubility of plant extracts such as sweet wormwood and the like in cosmetics and the low penetration of the plant extracts on skin are always technical pain points which are difficult to overcome by the raw materials, and molecular treatment technologies are mostly adopted in the industry, but the technical difficulties are high, the development period is long, the equipment investment is high, and the actual application rate is low. For example, in patent application CN117898989a of Shanghai household, one or more of raspberry seed oil, perilla seed oil, safflower seed oil and sweet wormwood extract are used as a barrier repair composition, but the inhibition effect of sweet wormwood extract on skin inflammation is not explored, patent application CN120554246A, CN120554247a of Yunnan Bei Taini discloses preparation and efficacy of dihydroartemisinin and sweet wormwood acid, but the single anti-inflammatory action mechanism of dihydroartemisinin/sweet wormwood acid is single, the anti-inflammatory effect is not improved by compounding other anti-inflammatory components, and in addition, bei Taini also discloses a preparation method of dihydrosweet wormwood acid inclusion in patent application CN120754278A, although the solubility of dihydroartemisia apiacea is effectively improved, the cyclodextrin used as a wrapping material is a skin sense sticky polymer material, and adverse effect is caused on the use feeling of cosmetics. Therefore, how to significantly improve the skin anti-inflammatory effect of the sweet wormwood herb extract and improve the solubility and skin penetration of the sweet wormwood herb extract in cosmetics is a technical problem to be solved in the field. Disclosure of Invention In order to solve the technical problems, the invention provides a sweet wormwood-containing penetration-promoting composition with skin cell repairing and relieving effects, and a preparation method and application thereof. The research of the invention finds that the anti-inflammatory effect is limited only by inhibiting the upstream anti-inflammatory path of the NF- κB path, and the anti-inflammatory effect can be obviously enhanced by blocking the downstream conduction chain of the cytokinin HMGB1 and DAMPs signals while inhibiting the NF- κB path. Based on the above, the invention suppresses the upstream anti-inflammatory path (i.e. intervenes in the inflammation starting and signal amplifying) and simultaneously reduces the recruitment and infiltration of inflammatory cells, suppresses inflammatory factors, blocks the diffusion of inflammation and downstream conduction chains, and synergistically improves the anti-inflammatory effect by the extract of the flos mori and the extract of the sweet wormwood. In addition, the invention also cooperates with oat kernel oil, jasmine flower oil and squalane to promote the solubility of fat-soluble active substances on one hand, and on the other hand, the invention can participate in repairing, stabilizing and optimizing the lipid structure of skin horny layer, synchronously open skin fat-soluble channels and more efficiently transport active substances, thereby realizing excellent effects of relieving, repairing and stabilizing. The aim of the invention can be achieved by the following scheme: In a first aspect, the invention provides a sweet wormwood-containing penetration-promoting composition with skin cell repairing and soothing effects, which comprises, by weight, 1-3 parts of plant extract active substances, 23-54 parts of fat-soluble carriers and 1-5 parts of antioxidants; The plant extract active substance comprises sweet wormwood extract and flos mori extract, and the fat-soluble carrier comprises oat kernel oil, jasmine flower oil and squalane. As one embodiment of the invention, the mass ratio of the extract of the verruca plana t