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CN-121971351-A - Toothpaste capable of clearing fire and protecting gingiva and preparation method thereof

CN121971351ACN 121971351 ACN121971351 ACN 121971351ACN-121971351-A

Abstract

The invention relates to the technical field of oral care products, and particularly discloses a fire-clearing gum-protecting toothpaste and a preparation method thereof. The toothpaste prepared by the method has multiple synergistic effects that the antibacterial rate of helicobacter pylori for 24 hours is more than 99.97%, the sulfide content of 24 hours is less than or equal to 300 ppb, the lasting breath is realized, the oral mucosa irritation index is 0.0, the mildness and the no irritation are ensured, the viscosity of the final paste at 25 ℃ is precisely controlled within 60000-100000 mPa s, and meanwhile, the paste particle size D90 is less than or equal to 20 mu m, so that the technical problems of paste roughness, unsmooth extrusion, layered precipitation, pump head blockage and the like frequently occurring in pump type toothpaste are solved while the effects of clearing fire and protecting gingiva, strong antibacterial effect and lasting refreshing are realized.

Inventors

  • ZHOU JINMING

Assignees

  • 乐胃优品(广州)生物医药科技有限公司
  • 呀乐胃(广州)生物医药科技有限公司

Dates

Publication Date
20260505
Application Date
20260326

Claims (7)

  1. 1. The preparation method of the fire-clearing gum-protecting toothpaste is characterized by comprising the following steps of: (1) The cortex Ilicis Rotundae extract is prepared by pulverizing dried cortex Ilicis Rotundae medicinal materials to 40-60 mesh, adding 8-10 times of 70% -75% ethanol, reflux-extracting at 55-60deg.C for 2 times at constant temperature for 1.5-2 hr each time, mixing the filtered extractive solutions, micro-filtering with 0.22 μm ceramic membrane to remove impurities, gradient eluting with D101 macroporous adsorbent resin column, mixing antibacterial and antiinflammatory repairing components, concentrating under reduced pressure to relative density of 1.10-1.15 extract, drying under reduced pressure of 45-50deg.C and-0.08-0.09 MPa to obtain cortex Ilicis Rotundae extract; (2) Dry-mixing and premixing, namely taking 38-42% of hydrated silica, 1.0-1.4% of sodium carboxymethylcellulose and 0.15-0.25% of stevioside according to weight percentage, dry-mixing for 3-5min at 1500-2000r/min to prepare premix; (3) Preparing water phase, namely taking 20-24% of glycerin, 6-8% of sorbitol and the balance of deionized water, stirring and dissolving at 40-45 ℃ and 300-500r/min, adding 0.8-1.5% of the cortex rotundae officinalis extract, and continuously stirring for 10-15min until the solution is completely dispersed to prepare water phase suspension; (4) Homogenizing, namely slowly adding the premix into the aqueous phase suspension, stirring for 10min at 800-1000r/min, and homogenizing for 5-8min at high pressure of 3000-3500r/min to obtain primary paste; (5) Post-treatment, namely cooling the initial paste to 25-30 ℃, adding 1.8-2.2% of sodium lauroyl sarcosinate, 0.1-0.2% of sodium benzoate and 1.0-1.2% of spearmint essence, stirring at a low speed of 500r/min for 3-5min, and then vacuum degassing for 15-20min under the pressure of-0.09 to-0.10 MPa to obtain final paste; (6) Pump filling, namely filling the final paste at 25 ℃ plus or minus 2 ℃ and relative humidity of 40% -60% by adopting a quantitative pump filling machine at a filling pressure of 0.3-0.5MPa, and sealing to obtain the final paste; the gradient elution of the D101 macroporous adsorption resin column in the step (1) is sequentially eluting with 10% ethanol, 30% ethanol and 70% ethanol, and the antibacterial component eluted by 30% ethanol and the anti-inflammatory repair component eluted by 70% ethanol are combined according to the mass ratio of 3:2; And (3) when the post-treatment is carried out in the step (5), 0.5% -1.0% of licorice extract and 0.3% -0.5% of dendrobium candidum stem extract are synchronously added, and the mixture is mixed with sodium lauroyl sarcosinate.
  2. 2. The process according to claim 1, wherein the pH of the aqueous suspension in step (3) is controlled between 6.5 and 8.0.
  3. 3. The method according to claim 1, wherein the primary paste obtained after the high-pressure homogenization in the step (4) has a particle diameter D90≤20. Mu.m.
  4. 4. The process according to claim 1, wherein the final paste obtained in step (5) has a viscosity of 60000-100000 mpa.s at 25 ℃.
  5. 5. A gum-protecting toothpaste for clearing heat, characterized by being prepared by the preparation method of any one of claims 1-4.
  6. 6. The fire-clearing gum-protecting toothpaste according to claim 5, wherein the pH of the fire-clearing gum-protecting toothpaste is 6.5-8.0, the oral mucosa irritation index is 0.0, D90 is less than or equal to 20 μm, the viscosity is 60000-100000 mPa.s, the antibacterial rate of helicobacter pylori under the action of 24h at 50% concentration is more than 99.97%, and the sulfide content is less than or equal to 300ppb after the toothpaste is co-cultured with saliva for 24 h;
  7. 7. the fire-clearing and gingiva-protecting toothpaste according to claim 5, being a pump-type toothpaste.

Description

Toothpaste capable of clearing fire and protecting gingiva and preparation method thereof Technical Field The invention relates to the technical field of oral care products, in particular to a heat-clearing gum-protecting toothpaste and a preparation method thereof. Background The toothpaste is a daily oral cleaning and nursing necessity, and as the consumer demands are upgraded, the herbal toothpaste with multiple effects of clearing fire, protecting gingiva, inhibiting bacteria, refreshing and the like becomes a research and development hot spot, and the pump type packaging is a main stream packaging form of high-end toothpaste because of convenient use, sanitation, environmental protection and gradual replacement of the traditional hose. The cortex rotundae officinalis is used as a traditional herbal raw material, has the effects of clearing heat and detoxicating, detumescence and relieving pain, inhibiting bacteria and resisting inflammation, is widely applied to functional oral care products, but the preparation of the cortex rotundae officinalis extract in the prior art mainly adopts a conventional ethanol reflux extraction process, only extracts active ingredients simply, does not carry out directional purification and targeted enrichment, has high impurity content and low active ingredient ratio, and is easy to cause active ingredient loss in the extraction process, so that the effects of clearing fire and protecting gingiva in toothpaste are greatly reduced. Meanwhile, the traditional preparation method of the pump type toothpaste is used for a plurality of times, a special process is not designed according to special requirements of pump type packaging on paste fluidity, stability and extrudability, the problems of uneven paste dispersion, excessively hard particles, layered precipitation after placement and the like often occur, blockage and unsmooth extrusion of a pump head are easily caused, poor cooperativity of functional components can be caused, the effect cannot be fully exerted, the problems of single formula collocation and weak cooperativity of the effect of the traditional fire-clearing gum-protecting toothpaste are solved, long-acting bacteriostasis, lasting freshness and mild gum-protecting multiple effects are difficult to realize at the same time, and part of products have oral mucosa irritation and cannot meet the long-term oral care requirements of consumers. Disclosure of Invention The invention aims to overcome the defects of the prior art, and provides a preparation method of a fire-clearing gum-protecting toothpaste, which is used for solving the technical problems that the conventional fire-clearing gum-protecting toothpaste is difficult to take into account long-acting bacteriostasis, lasting freshness and mildness and no irritation. In order to achieve the above purpose, the invention adopts the following technical scheme: the preparation method of the fire-clearing gum-protecting toothpaste comprises the following steps of: (1) The cortex Ilicis Rotundae extract is prepared by pulverizing dried cortex Ilicis Rotundae medicinal materials to 40-60 mesh, adding 8-10 times of 70% -75% ethanol, reflux-extracting at 55-60deg.C for 2 times at constant temperature for 1.5-2 hr each time, mixing the filtered extractive solutions, micro-filtering with 0.22 μm ceramic membrane to remove impurities, gradient eluting with D101 macroporous adsorbent resin column, mixing antibacterial and antiinflammatory repairing components, concentrating under reduced pressure to relative density of 1.10-1.15 extract, drying under reduced pressure of 45-50deg.C and-0.08-0.09 MPa to obtain cortex Ilicis Rotundae extract; (2) Dry-mixing and premixing, namely taking 38-42% of hydrated silica, 1.0-1.4% of sodium carboxymethylcellulose and 0.15-0.25% of stevioside according to weight percentage, dry-mixing for 3-5min at 1500-2000r/min to prepare premix; (3) Preparing water phase, namely taking 20-24% of glycerin, 6-8% of sorbitol and the balance of deionized water, stirring and dissolving at 40-45 ℃ and 300-500r/min, adding 0.8-1.5% of the cortex rotundae officinalis extract, and continuously stirring for 10-15min until the solution is completely dispersed to prepare water phase suspension; (4) Homogenizing, namely slowly adding the premix into the aqueous phase suspension, stirring for 10min at 800-1000r/min, and homogenizing for 5-8min at high pressure of 3000-3500r/min to obtain primary paste; (5) Post-treatment, namely cooling the initial paste to 25-30 ℃, adding 1.8-2.2% of sodium lauroyl sarcosinate, 0.1-0.2% of sodium benzoate and 1.0-1.2% of spearmint essence, stirring at a low speed of 500r/min for 3-5min, and then vacuum degassing for 15-20min under the pressure of-0.09 to-0.10 MPa to obtain final paste; (6) Pump filling, namely filling the final paste at 25 ℃ plus or minus 2 ℃ and relative humidity of 40% -60% by adopting a quantitative pump filling machine at a filling pressure of 0.3-0.5MPa,