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CN-121971353-A - Pearl powder preparation process for whitening effect and application thereof

CN121971353ACN 121971353 ACN121971353 ACN 121971353ACN-121971353-A

Abstract

The invention discloses a process for preparing pearl powder for whitening and application thereof, which belongs to the technical field of cosmetics, wherein pearl is pretreated and crushed to obtain coarse powder, water and dispersing agent are added to be ground to obtain nano slurry, active ingredients and auxiliary materials are mixed to prepare solution, the solution is mixed and homogenized with swelling suspending agent, and the solution is homogenized again, and is subjected to freeze drying, crushing and sieving to obtain the whitening pearl powder. The pearl powder preparation process for whitening effect and the application thereof adopt the dual mechanism of nanometer particle size and moisture retention and permeation promotion to greatly promote transdermal absorption, and the systemic process optimization such as whole-course low-temperature control, pH dual adjustment, suspension aid post-addition and secondary homogenization is adopted to effectively ensure the stability and system uniformity of active ingredients, and meanwhile, the product safety is ensured through gradient purification.

Inventors

  • ZHENG BAOQUAN
  • ZHAO LING
  • Zheng jinxin
  • SUN BIN
  • ZHENG FEI

Assignees

  • 恢春丹生物科技(海南)有限公司

Dates

Publication Date
20260505
Application Date
20260313

Claims (10)

  1. 1. A preparation process of pearl powder for whitening is characterized by comprising the following steps: Step one, pearl pretreatment and crushing to obtain coarse powder; step two, mixing the coarse powder obtained in the step one with deionized water, adding a dispersing agent, and grinding to obtain nano pearl slurry; Dissolving dipotassium glycyrrhizinate, magnesium ascorbyl phosphate, sodium hyaluronate, trehalose, preservative and pH regulator in deionized water, uniformly stirring, and regulating pH to obtain an auxiliary material solution; Step four, mixing the nano pearl slurry obtained in the step two with the auxiliary material solution obtained in the step three, and homogenizing to obtain mixed slurry; step five, adding a swelling suspending agent into the mixed slurry obtained in the step four, uniformly stirring, and homogenizing to obtain uniform and stable slurry; And step six, freeze-drying the slurry obtained in the step five, crushing, and sieving to obtain the whitening pearl powder.
  2. 2. The process for preparing pearl powder for whitening skin according to claim 1, wherein said pearl pretreatment comprises washing the pearl with fresh water without core, performing enzymolysis with complex enzyme, washing with deionized water to neutrality, and drying.
  3. 3. The process for preparing the pearl powder for whitening according to claim 2, wherein the compound enzyme is papain and neutral protease which are mixed according to a mass ratio of 1:1, the enzyme consumption is 0.5-2% of the pearl mass, the enzymolysis temperature is 45-55 ℃, the pH is regulated to 6.5-7.5 by 0.1-1 mol/L dilute hydrochloric acid or sodium hydroxide solution for 2-4 hours, and the temperature is raised to 80-90 ℃ for inactivation for 10-15 min after enzymolysis.
  4. 4. The process for preparing pearl powder for whitening according to claim 1, wherein in the first step, the pearl powder is crushed by an air flow crusher at-10 ℃ to 0 ℃ until the grain diameter D90 is less than or equal to 20 μm.
  5. 5. The process for preparing the pearl powder for whitening according to claim 1, wherein in the second step, the mass ratio of the coarse powder to the deionized water is 1:3-5, the dispersing agent is sodium polyacrylate, the adding amount is 0.1-0.5% of the mass of the coarse powder, the grinding temperature is less than or equal to 10 ℃, the grinding temperature is less than or equal to 300nm, the particle size D90 is less than or equal to 300nm, and the solid content of the nano pearl slurry is 25-35%.
  6. 6. The process for preparing the pearl powder for whitening according to claim 1, wherein in the third step, the preservative is a compound mixture of p-hydroxyacetophenone and 1, 2-hexanediol, the mass ratio of the p-hydroxyacetophenone to the 1, 2-hexanediol is 1:0.5-2, the pH regulator is citric acid and/or sodium citrate, the pH is regulated to 5.5-6.5, and the whole process is carried out in dark place, wherein the temperature is less than or equal to 15 ℃.
  7. 7. The process for preparing the pearl powder for whitening according to claim 1, wherein in the fourth step, the solid content is adjusted to 25-35% after mixing, the homogenization treatment is performed at 5-15 ℃, the pressure is 80-100 MPa, and the homogenization is performed for 2-3 times.
  8. 8. The process for preparing the pearl powder for whitening according to claim 1, wherein in the fifth step, the suspending agent is xanthan gum or sodium carboxymethylcellulose, and the homogenization treatment pressure is 50-70 MPa, and the homogenization is carried out for 1 time.
  9. 9. The process for preparing the pearl powder for whitening according to claim 1, wherein in the sixth step, the pre-freezing temperature of freeze drying is-40 to-50 ℃, the sublimation temperature is-20 to 0 ℃, the vacuum degree is less than or equal to 10Pa, and the moisture is less than or equal to 3%.
  10. 10. Use of a whitening pearl powder prepared by a process for preparing a pearl powder for whitening effect according to any one of claims 1 to 9 in a whitening skin care product.

Description

Pearl powder preparation process for whitening effect and application thereof Technical Field The invention relates to the technical field of cosmetics, in particular to a preparation process and application of pearl powder for whitening. Background Pearl powder is used as a traditional cosmetic raw material, and has a medicinal history of more than two thousand years in China. According to the ancient books of medicine, such as Ben Cao gang mu, the pearl has the effects of relieving heart, strengthening eyes, enabling the coated face to be moist, improving color, removing facial spots, and the like. Modern researches show that the pearl powder is rich in various amino acids, trace elements and cutin proteins, can inhibit tyrosinase activity, reduce melanin generation, and has unique value in the aspects of whitening, spot lightening, anti-aging and the like. In recent years, with the increase of the demand of the cosmetic industry for natural functional components, the application of pearl powder in the field of skin care products is widely focused. However, the existing pearl powder products and processes have the following technical problems: Firstly, the absorption rate is low, the bioavailability is insufficient, the traditional pearl powder is mostly crushed by a mechanical crushing method, the particle size of the powder is large, the powder is difficult to absorb by skin, and the active ingredients cannot fully play a role. Secondly, the whitening component is single, and most of the currently marketed pearl powder products are used independently, so that the effect of inhibiting melanin formation and reducing formed melanin is difficult to realize. Thirdly, the active ingredients in the preparation process are easy to be destroyed, in the prior art, the enzymolysis method can improve the protein extraction rate, but the acid or enzyme treatment can destroy part of the active ingredients in the pearl. In the physical nanocrystallization process, if the natural mineral powder is ground together with other auxiliary materials, the grinding efficiency is reduced due to the existence of thermosensitive and viscous auxiliary materials, so that the particle size is uneven and active ingredients are degraded. Disclosure of Invention The invention aims to provide a pearl powder manufacturing process for whitening effect and application thereof, which greatly improves transdermal absorption by a dual mechanism of nanometer particle size and moisture retention and permeation promotion, and effectively ensures stability and uniformity of active ingredients and system through systematic process optimization such as whole-course low-temperature control, pH dual adjustment, suspension aid post-addition and secondary homogenization, and meanwhile ensures safety of products through gradient purification. In order to achieve the above purpose, the invention provides a process for preparing pearl powder for whitening, which comprises the following steps: Step one, pearl pretreatment and crushing to obtain coarse powder; step two, mixing the coarse powder obtained in the step one with deionized water, adding a dispersing agent, and grinding to obtain nano pearl slurry; Dissolving dipotassium glycyrrhizinate, magnesium ascorbyl phosphate, sodium hyaluronate, trehalose, preservative and pH regulator in deionized water, uniformly stirring, and regulating pH to obtain an auxiliary material solution; Step four, mixing the nano pearl slurry obtained in the step two with the auxiliary material solution obtained in the step three, and homogenizing to obtain mixed slurry; step five, adding a swelling suspending agent into the mixed slurry obtained in the step four, uniformly stirring, and homogenizing to obtain uniform and stable slurry; And step six, freeze-drying the slurry obtained in the step five, crushing, and sieving to obtain the whitening pearl powder. Further, the raw materials comprise, by mass, 60-90 parts of coarse powder, 2-8 parts of dipotassium glycyrrhizinate, 1-5 parts of magnesium ascorbyl phosphate, 0.5-3 parts of sodium hyaluronate, 1-5 parts of trehalose, 0.1-0.5 part of a dispersing agent, 0.1-1 part of a suspending agent and 0.1-1 part of a preservative. Preferably, in the first step, the pearl pretreatment comprises the steps of cleaning the coreless fresh water pearl, carrying out enzymolysis by using compound enzyme, washing the treated pearl to be neutral by using deionized water, and drying. Preferably, the compound enzyme is prepared by mixing papain and neutral protease according to a mass ratio of 1:1, wherein the enzyme consumption is 0.5-2% of the mass of the pearl, the enzymolysis temperature is 45-55 ℃, the pH is regulated to 6.5-7.5 by 0.1-1 mol/L dilute hydrochloric acid or sodium hydroxide solution for 2-4 hours, and the temperature is raised to 80-90 ℃ for inactivation for 10-15min after enzymolysis. Preferably, in the first step, an air flow pulverizer is adopted for pulverization, and