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CN-121971363-A - Composition and application thereof in preparation of oil-control acne-removal product for sensitive muscles

CN121971363ACN 121971363 ACN121971363 ACN 121971363ACN-121971363-A

Abstract

The invention belongs to the technical field of medicines and cosmetics, and relates to a composition and application thereof in preparation of an oil-control acne-removing product for sensitive muscles. The composition comprises, by weight, 0.01-0.5 parts of Norway spruce leaf extract, 0.01-0.5 parts of PCA zinc and 0.001-0.05 parts of bacillus fermentation product. The composition disclosed by the invention is simple in component types, and the components are mutually synergistic, so that propionibacterium acnes are effectively inhibited, and an excellent acne removing effect is realized.

Inventors

  • FU MAODONG
  • ZHENG YONG

Assignees

  • 济南美桔互联网科技有限公司

Dates

Publication Date
20260505
Application Date
20260330

Claims (10)

  1. 1. A composition is characterized by comprising, by weight, 0.01-0.5 part of Norway spruce leaf extract, 0.01-0.5 part of PCA zinc and 0.001-0.05 part of bacillus fermentation product.
  2. 2. The composition of claim 1, wherein the composition comprises, in parts by weight, 0.01-0.1 parts of Norway spruce leaf extract, 0.01-0.1 parts of zinc PCA, and 0.001-0.01 parts of bacillus fermentation product.
  3. 3. The composition of claim 1, wherein the composition is in the form of an aqueous solution, emulsion, paste, gel, powder, spray, oil, or patch.
  4. 4. The composition of claim 1, further comprising water, the norway spruce leaf extract being present in an aqueous solution at a mass fraction of 0.01-0.5%.
  5. 5. The composition of claim 1, further comprising a preservative, preferably comprising one or more of phenoxyethanol, p-hydroxyacetophenone, hexanediol, and ethylhexyl glycerol, preferably wherein the preservative comprises 0.5-1.5% by mass of the aqueous solution; Or, the water-based paint further comprises a chelating agent, wherein the chelating agent is preferably disodium EDTA, and the mass fraction of the chelating agent in the water solution is preferably 0.03-0.07%; or, the water-based paint further comprises a cosolvent, wherein the cosolvent is preferably one or more of butanediol and methyl propylene glycol, and the mass fraction of the cosolvent water solution is preferably 1.0-3.0%.
  6. 6. A method of preparing the composition of claim 1, comprising the steps of: The active ingredients are dissolved in water and mixed.
  7. 7. The process according to claim 6, wherein the active ingredients are dissolved in water and then mixed.
  8. 8. The method according to claim 6, wherein the dissolution of the cosolvent and the chelating agent in water is performed, and then the dissolution of the preservative and the active ingredient is performed, preferably, the dissolution temperature of the cosolvent and the chelating agent in water is 80-90 ℃, and preferably, the dissolution temperature of the preservative and the active ingredient is 40-50 ℃.
  9. 9. Use of a composition according to any one of claims 1to 5 for the preparation of a product for controlling oil and acne in sensitive muscles.
  10. 10. The use according to claim 9, wherein the product is a cosmetic or pharmaceutical product.

Description

Composition and application thereof in preparation of oil-control acne-removal product for sensitive muscles Technical Field The invention belongs to the technical field of medicines and cosmetics, and relates to a composition and application thereof in preparation of an oil-control acne-removing product for sensitive muscles. Background The disclosure of this background section is only intended to increase the understanding of the general background of the invention and is not necessarily to be construed as an admission or any form of suggestion that this information forms the prior art already known to those of ordinary skill in the art. Acne is a common chronic inflammation of sebaceous glands, and the pathological mechanism of the acne is complex, and mainly relates to excessive sebum secretion caused by sebaceous gland hyperfunction, catheter blockage caused by follicular orifice keratinization abnormality, abnormal proliferation of propionibacterium acnes and a series of inflammatory reactions caused by the abnormal proliferation of propionibacterium acnes. Based on the above, the ideal oil-control acne-removing product needs to have the capability of multi-target synergistic effect. In the existing market, active ingredients for controlling oil and removing acnes mainly comprise chemical synthesis, traditional natural extracts and trace elements. Among them, chemical synthesis components such as retinoids, benzoyl peroxide and salicylic acid have definite effects in dredging pores, inhibiting bacteria and exfoliating cutin, but have strong skin irritation, easily cause side effects such as dry desquamation and barrier damage, and severely limit the application of the chemical synthesis components in sensitive skin groups. In contrast, although traditional plant extracts such as tea tree oil, witch hazel extract and the like are mild, the traditional plant extracts often have the limitations of single acting target point, slow acting and insignificant efficacy, and are difficult to meet the treatment requirements of moderately severe acnes. To solve the contradiction between efficacy and mildness, the art has gradually adopted mild ingredients such as zinc pyrrolidone carboxylate (zinc PCA) which have both sebum-modulating and some antimicrobial capabilities. However, the oil control intensity and the anti-inflammatory effect of single PCA zinc are relatively limited, and particularly, the improvement capability of the single PCA zinc is insufficient for acne skin lesions accompanied with obvious inflammatory reaction, so that the expectation of consumers on the high-efficiency multi-effect acne removal product is difficult to realize. With the improvement of the consumption level, the market has urgent demands on products which can efficiently control oil and remove acnes and synchronously relieve, repair and maintain the stability of skin barriers, and particularly aims at the special skin of oiliness sensitive muscles. However, the existing products often have difficulty in achieving an ideal balance between powerful acne removal and mildness and no irritation. Therefore, developing a composition which has synergistic effect, excellent oil control and acne removal effects and excellent mildness, is truly suitable for sensitive skin and becomes a technical problem to be solved in the field. Disclosure of Invention In order to solve the defects of the prior art, the invention aims to provide a composition and application thereof in preparing an oil-control acne-removing product for sensitive muscles, wherein the composition is simple in component type and synergistic in component type, and effectively inhibits propionibacterium acnes, so that an excellent acne-removing effect is realized. In order to achieve the above purpose, the technical scheme of the invention is as follows: In the first aspect, the composition comprises, by weight, 0.01-0.5 parts of Norway spruce leaf extract, 0.01-0.5 parts of PCA zinc and 0.001-0.05 parts of bacillus fermentation product. Norway spruce leaf extract is an active ingredient complex extracted from Norway spruce (academic name: picea abies) leaves, and has effects of controlling oil, improving oily skin, and relieving inflammation. Zinc PCA is a zinc salt of Pyrrolidone Carboxylic Acid (PCA), in which zinc ions (Zn 2+) are combined with pyrrolidone carboxylate ions by ionic bonds in the chemical structure, thus forming a metal organic complex, which is mainly used for controlling oil, astringing and moisturizing. The Bacillus fermentation product is a compound mixture containing thallus, metabolite and culture medium components obtained by fermenting and culturing Bacillus strain and performing subsequent treatment (such as inactivation, filtration, centrifugation, extraction or concentration). According to the invention, by compounding the Norway spruce leaf extract, PCA zinc and bacillus fermentation products, a remarkable synergistic effect is generated on an a