CN-121971373-A - Quick-drying medical ray protective cream and preparation method and application thereof

Abstract

The invention discloses quick-drying medical ray protective cream and a preparation method and application thereof, and by effectively combining a radiation-proof material with a specific film forming system, a strong protective film can be quickly formed on the surface of skin after the protective cream is coated, the ray shielding effect is better than that of an interventional protective glove, and meanwhile, safety and innocuity can be ensured because of no heavy metals such as lead and the like. The ointment can be directly smeared on skin, solves the problems of heavy and inflexible traditional lead gloves and the like, is particularly suitable for scenes such as interventional operations, can realize effective ray protection, and can not influence the operation of the operation process.

Inventors

• FANG CHAO
• ZHANG JING
• LU ZIJIE
• YI LI

Assignees

• 智元柏迈(浙江)科技有限公司

Dates

Publication Date

20260505

Application Date

20260119

Claims (7)

1. 1. The quick-drying medical ray protective paste is characterized by comprising the following components of 50-80 parts by weight of radiation protection materials, 2-7 parts by weight of film forming materials, 1-3 parts by weight of humectant and 7-27 parts by weight of volatile agents, wherein the film forming materials are one or more of polyvinylpyrrolidone, polyvinyl alcohol and hydroxypropyl methyl cellulose, the polymerization degree of the polyvinyl alcohol is 300-2500, the alcoholysis degree is 80-99%, the radiation protection materials are one or more of bismuth tungstate, barium sulfate, bismuth oxide, tungsten oxide and gadolinium oxide, and the particle size of the radiation protection materials is 30-75 mu m.
2. 2. The quick-drying medical radiation protective cream according to claim 1, wherein the humectant is one or more selected from glycerin, propylene glycol, sodium hyaluronate, and sorbitol.
3. 3. The quick-drying medical radiation protection cream according to claim 1, wherein the volatile agent is absolute ethyl alcohol.
4. 4. The quick-drying medical radiation protective cream according to claim 1, wherein the radiation protective material is 60-75 parts by weight.
5. 5. The method for preparing the quick-drying medical ray protective cream according to claim 1, wherein a film forming material is added into deionized water at 80-90 ℃, the mixture is stirred until the film forming material is completely dissolved, a transparent glue solution is formed, the mixture is cooled to room temperature, then a humectant and a volatile agent are added under the stirring condition, the mixture is uniformly mixed, then the radiation protective material is added, the mixture is stirred to form a uniform paste, and the quick-drying medical ray protective cream is obtained after defoaming.
6. 6. The method of claim 5, wherein the mass ratio of deionized water to volatile agent is 1:1.3-3.4.
7. 7. Use of the quick-drying medical radiation protective cream according to claim 1.

Description

Quick-drying medical ray protective cream and preparation method and application thereof Technical Field The invention belongs to the field of radiation protection medical instruments, and particularly relates to quick-drying medical ray protection cream as well as a preparation method and application thereof. Background Interventional radiology refers to a technique for diagnosing and treating diseases by performing aspiration injection, drainage or molding, perfusion, embolism and the like on a lumen, a blood vessel and the like through percutaneous needle puncture or catheter introduction under the monitoring and guiding of a medical imaging system. In the interventional diagnosis and treatment process, medical staff engaged in interventional diagnosis and treatment inevitably receive X-ray irradiation due to the operation of the same room in the near-desk, and the X-rays have accumulated effect on the damage of human bodies, so that the protection of the medical staff in the interventional diagnosis and treatment process is very important. At present, personal protective equipment such as lead clothes, lead neckerchiefs, lead glasses, lead caps and the like are commonly adopted in clinic, but the protection of hands is often ignored. Although researches show that the hand exposure dose can be obviously reduced by wearing the protective glove containing lead rubber in the interventional operation, the surgical glove is usually required to be worn on the inner layer and the disposable latex glove is covered on the outer layer due to the strict aseptic operation required by the interventional operation, and if the thick and heavy lead rubber glove is overlapped on the basis, the touch sensitivity and the operation flexibility of the hand are seriously weakened, the operation accuracy is influenced, so that the actual clinical application rate is extremely low. In recent years, some lightweight radiation protection gloves adopting heavy metals such as tungsten, bismuth and the like to replace lead appear on the market, and wearing comfort and operability are improved to a certain extent, but the radiation protection gloves are high in manufacturing cost, are mostly disposable and difficult to popularize in the conventional interventional diagnosis and treatment on a large scale. In addition, there have been radiation shielding skin care products such as ULTRABLOX X-ray attenuating creams, which achieve partial shielding of X-rays by forming a protective film containing heavy metal components on the skin surface. However, the product has obvious technical defects that on one hand, the film forming speed is low, the effective protection state can be achieved only by long waiting time, and the product is difficult to adapt to a fast-paced interventional operation flow, and on the other hand, in order to avoid influencing the operation hand feeling, the thickness of the coating is strictly limited, so that the actual shielding effectiveness is limited, and sufficient hand radiation protection cannot be provided. In summary, the prior art still has significant shortcomings in terms of protection effectiveness, operation flexibility, convenience in use and the like, and development of a novel hand radiation protection scheme is needed to practically guarantee occupational safety of interventional radiological medical staff. Disclosure of Invention Aiming at the problems, the application provides quick-drying medical ray protective paste, a preparation method and application thereof, wherein the protective paste adopts non-toxic inorganic functional filler with high atomic number as an X-ray shielding component, and a high molecular polymer with good water solubility and excellent film forming performance is combined as a flexible matrix. In the film forming process, the polymer is quickly adsorbed and enriched on the surfaces of a large number of radiation-proof particles, so that the local concentration of molecular chains of the polymer at the particle interface is obviously increased, and a stable physical cross-linked network is quickly formed. Meanwhile, the network builds a rich three-dimensional microporous structure, provides a high-efficiency channel for solvent volatilization, has a synergistic effect of multiple mechanisms, and remarkably shortens film forming time. The formed protective cream has excellent shielding effect on X-rays, can effectively reduce radiation exposure risk, has uniform texture, is easy to paint, and has the coated surface quickly dried to form a film, and the flexibility of hands is not affected. The film forming matrix is water soluble polymer material, so that the film can be easily cleaned by clean water or mild cleaning agent after use, and has no residue and no environmental pollution. The invention creatively utilizes the physical characteristics of the high-solid-content radiation-proof particles, reconstructs the traditional film forming path, does not depend on polymer