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CN-121971387-A - Liquid liposome composition, preparation method thereof, oral preparation and application

CN121971387ACN 121971387 ACN121971387 ACN 121971387ACN-121971387-A

Abstract

The present disclosure provides a liquid liposome composition comprising a phospholipid, an oligosaccharide and water, wherein the weight ratio of oligosaccharide to phospholipid is from 4:1 to 21:1, further the composition further comprises an efficacy ingredient, further the composition further optionally comprises no or a bulking agent. The present disclosure also provides methods of preparing liquid liposome compositions, oral formulations, and uses of liquid liposome compositions in food and health products or for preparing pharmaceutical products. The liquid liposome composition has the advantages of physical stability, functional ingredient stability and the like.

Inventors

  • HU RONGHAI
  • CHEN WENRONG
  • FANG SUQIONG
  • CUI SHAOHUA

Assignees

  • 仙乐健康科技股份有限公司

Dates

Publication Date
20260505
Application Date
20260206

Claims (11)

  1. 1. A liquid liposome composition comprising a phospholipid, an oligosaccharide and water, wherein the weight ratio of said oligosaccharide to said phospholipid is from 4:1 to 21:1, Further, the composition further comprises an efficacy ingredient; further, the composition is optionally free of or comprises a filler.
  2. 2. The liquid liposome composition of claim 1, wherein the phospholipid is selected from the group consisting of a natural phospholipid, a synthetic phospholipid, and any combination thereof; Further, the phospholipid is a natural phospholipid; Further, the phospholipid is selected from the group consisting of soybean phospholipid, sunflower phospholipid, egg yolk phospholipid, and any combination thereof.
  3. 3. The liquid liposome composition of claim 1, wherein the oligosaccharide satisfies one or more of the following: (1) The oligosaccharide is selected from fructo-oligosaccharide, isomaltooligosaccharide, xylooligosaccharide, galactooligosaccharide, gentiooligosaccharide, palatinose, stachyose, raffinose, soy oligosaccharide, chitosan oligosaccharide, mannose oligomer, sucrose, maltose, lactose or any combination thereof, further the oligosaccharide is selected from fructooligosaccharide, galactooligosaccharide, xylooligosaccharide, stachyose, raffinose and any combination thereof; (2) The oligosaccharide comprises 2 to 10 monosaccharides.
  4. 4. The liquid liposome composition of claim 1, wherein the functional ingredient is selected from the group consisting of a liposoluble functional ingredient, a water-soluble functional ingredient, and any combination thereof; Further, the fat-soluble functional component is selected from fat-soluble animal extracts, fat-soluble plant extracts, fat-soluble vitamins, polyunsaturated fatty acids and combinations thereof, further, the fat-soluble functional component comprises one or more selected from astaxanthin, lutein esters, lycopene, garlicin, carotene, fucoxanthin, docosahexaenoic acid, coenzyme Q10, vitamin A, vitamin D, vitamin E, vitamin K, fish oil and algae oil, and/or, Further, the water-soluble functional component is selected from water-soluble plant extracts, water-soluble minerals, water-soluble vitamins, proteins or polypeptides, amino acids and combinations thereof, and further, the water-soluble functional component comprises one or more selected from dihydromyricetin, epigallocatechin gallate, vitamin VC group, vitamin VB group, pyrroloquinoline quinone, collagen, elderberry extract, lysine, arginine, glutathione, ferric pyrophosphate and magnesium threonate.
  5. 5. The liquid liposome composition of claim 1, wherein the filler comprises a polyol, Further, the bulking agent is selected from the group consisting of glycerol, maltitol, sorbitol, xylitol, mannitol, and any combination thereof.
  6. 6. The liquid liposome composition of any one of claims 1 to 5, wherein the liquid liposome composition comprises, based on the total weight of the liquid liposome composition: (1) 0.01 wt% to 20 wt% of an active ingredient; (2) 2 wt% to 10 wt% of a phospholipid; (3) 30 wt% to 70 wt% oligosaccharides; (4) 0 wt to 50 wt% of a filler, and (5) 10 Wt% to 40 wt% water.
  7. 7. A method of preparing the liquid liposome composition of any one of claims 1 to 6, comprising thoroughly mixing and homogenizing the components of the liquid liposome composition to prepare the liquid liposome composition.
  8. 8. The method as claimed in claim 7, comprising: (a) Thoroughly mixing and homogenizing the water-soluble components of the liquid liposome composition to form an aqueous phase mixture; (b) Fully mixing and homogenizing fat-soluble components in each component of the liquid liposome composition to form an oil phase mixture; (c) Adding the oil phase mixture into the water phase mixture, fully mixing and homogenizing, Thereby preparing the liquid liposome composition.
  9. 9. The method of claim 8, wherein the method satisfies one or more of: (1) The water phase mixture is prepared at the temperature of 20-60 ℃; (2) The oil phase mixture is prepared at the temperature of 30-70 ℃; (3) The liquid liposome composition is sterilized at a temperature of 85-100 ℃.
  10. 10. An oral preparation characterized by comprising the liquid liposome composition of any one of claims 1 to 6, further wherein the oral preparation is selected from the group consisting of food products, health products and pharmaceutical products.
  11. 11. Use of the liquid liposome composition of any one of claims 1 to 6 in food and health products or for the preparation of pharmaceutical products.

Description

Liquid liposome composition, preparation method thereof, oral preparation and application Technical Field The present disclosure relates to the field of large health (such as food, health care products, and drug delivery), and in particular to a stable liquid liposome composition, and a preparation method, an oral preparation, and use thereof. Background Liposomes (liposome, LP) have been widely used in large health fields (such as food, health products and drug delivery) as a carrier system with a bilayer structure due to their good biocompatibility and encapsulation ability. Particularly, the liquid liposome product has a certain application potential in oral preparations due to the characteristics of convenient administration and processing. However, the existing common liquid liposome products still have significant defects in practical application. On the one hand, phospholipid is used as a main component material of liposome, is easy to hydrolyze or oxidatively decompose in a liquid environment to cause the damage of the structural integrity, and on the other hand, substances such as free fatty acid, lysophospholipid and the like generated after the phospholipid is degraded can cause unpleasant pungent flavor, can also cause the reduction of the physical stability of the product, cause the phenomena of precipitation, layering and the like, and seriously influence the shelf life and consumer experience of the product. Thus, there is a need in the art to develop liquid liposome products with improved properties. Disclosure of Invention The existing liposome technology has the problems of poor product stability, bad flavor in the shelf life of the product, no obvious specific bilayer structure of the liposome, and the like. The food field is used, and components which are not allowed to be added are used, such as cholesterol and the like, and do not accord with food safety and compliance. In view of the above and other drawbacks, the present disclosure provides a stable liquid liposome composition and a method for preparing the same. In one aspect, the present disclosure provides a liquid liposome composition comprising a phospholipid, an oligosaccharide, and water, wherein the weight ratio of the oligosaccharide to the phospholipid is from 4:1 to 21:1. In some embodiments, the composition further comprises an efficacy ingredient. In some embodiments, the composition is also optionally free of or comprises a filler. In some embodiments, the phospholipid is selected from the group consisting of natural phospholipids, synthetic phospholipids, and any combination thereof. In some embodiments, the phospholipid is a natural phospholipid. In some embodiments, the phospholipid is selected from the group consisting of soybean phospholipid, sunflower phospholipid, egg yolk phospholipid, and any combination thereof. In some embodiments, the oligosaccharide is selected from the group consisting of fructo-oligosaccharide, isomalto-oligosaccharide, xylo-oligosaccharide, galacto-oligosaccharide, gentio-oligosaccharide, palatinose (isomalto-oligosaccharide), stachyose, raffinose, soy oligosaccharide, chitosan oligosaccharide, mannooligosaccharide, sucrose, maltose, lactose, or any combination thereof. In some embodiments, the oligosaccharide is selected from the group consisting of fructooligosaccharides, galactooligosaccharides, xylooligosaccharides, stachyose, raffinose, and any combination thereof. In some embodiments, the oligosaccharide comprises 2 to 10 monosaccharides. In some embodiments, the functional ingredient is selected from the group consisting of a fat-soluble functional ingredient, a water-soluble functional ingredient, and any combination thereof. In some embodiments, the fat-soluble functional ingredient is selected from the group consisting of fat-soluble animal extracts, fat-soluble plant extracts, fat-soluble vitamins, polyunsaturated fatty acids, and combinations thereof. In some embodiments, the fat-soluble functional ingredient comprises one or more selected from astaxanthin, lutein esters, lycopene, garlicin, carotene, fucoxanthin, docosahexaenoic acid (DHA), coenzyme Q10, vitamin a, vitamin D, vitamin E, vitamin K, fish oil, and algae oil. In some embodiments, the water-soluble functional ingredient is selected from the group consisting of a water-soluble plant extract, a water-soluble mineral, a water-soluble vitamin, a protein or polypeptide, an amino acid, and combinations thereof. In some embodiments, the water-soluble functional ingredient comprises one or more selected from dihydromyricetin, epigallocatechin gallate (EGCG), vitamin VC group, vitamin VB group, pyrroloquinoline quinone (PQQ), collagen, elderberry extract, lysine, arginine, glutathione, ferric pyrophosphate, and magnesium threonate. In some embodiments, the filler comprises a polyol. In some embodiments, the bulking agent is selected from the group consisting of glycerol, maltitol, sorbitol, xylitol, mannitol, and any comb