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CN-121971400-A - Glucosamine sulfate capsule and application thereof in preventing joint degeneration after sports injury

CN121971400ACN 121971400 ACN121971400 ACN 121971400ACN-121971400-A

Abstract

The invention relates to the technical field of medicines, and particularly discloses a glucosamine sulfate capsule and application thereof in preventing joint degeneration after sports injury, wherein the content of the capsule is prepared from raw materials comprising glucosamine sulfate sodium chloride double salt, corn starch, lactose, talcum powder, magnesium stearate and chondroitin sulfate-chitosan nano-composite; the chondroitin sulfate-chitosan nanocomposite is introduced, so that the problems of moisture absorption easiness and poor stability commonly existing in the traditional glucosamine sulfate preparation are solved, the chondroitin sulfate-chitosan nanocomposite and active ingredients of the main medicine are subjected to good interaction, and a micro-protection structure is formed on the surface of particles, so that the physical and chemical stability of a final product is enhanced, the influence of environmental humidity can be effectively resisted in the production, storage and subsequent use processes, good fluidity and uniformity of contents are maintained, and long-term stability of the quality of the product is ensured.

Inventors

  • TANG WENXING
  • SHEN YUNTONG
  • LI ZEWEI

Assignees

  • 广州琥瑞医药科技发展有限公司

Dates

Publication Date
20260505
Application Date
20260306

Claims (10)

  1. 1. The glucosamine sulfate capsule is characterized in that the capsule is prepared from 400 parts of glucosamine sulfate sodium chloride double salt, 40-60 parts of corn starch, 40-60 parts of lactose, 10-20 parts of talcum powder, 3-8 parts of magnesium stearate and 15-25 parts of chondroitin sulfate-chitosan nano-composite.
  2. 2. A glucosamine sulfate capsule according to claim 1, wherein the content is prepared by a process comprising the steps of: a. Sieving glucosamine sulfate sodium chloride double salt, corn starch and lactose with a sieve with a pore diameter of 0.81mm respectively; b. Preparing chondroitin sulfate-chitosan nanocomposite powder; c. mixing the sieved material in the step a with the nanocomposite powder obtained in the step b for the first time to obtain a premixed material; d. sieving the premixed material by using a screen with the aperture of 0.81mm to obtain a sieved material; e. finally mixing talcum powder, magnesium stearate and the sieved material to obtain a total mixed material; f. the total mix is filled into a capsule shell.
  3. 3. A glucosamine sulfate capsule according to claim 2, wherein the chondroitin sulfate-chitosan nanocomposite is prepared by a process comprising the steps of: i. Dissolving chitosan in an acetic acid solution with the volume fraction of 1% to prepare a chitosan solution with the mass volume concentration of 0.5-5.0 mg/mL; ii. Dissolving chondroitin sulfate in deionized water to prepare a chondroitin sulfate solution with the mass volume concentration of 0.5-5.0 mg/mL; iii, slowly dropwise adding the chondroitin sulfate solution into the chitosan solution under continuous magnetic stirring, wherein the mass ratio of chitosan to chondroitin sulfate is 5:1-1:5; iv, after the dripping is finished, continuously stirring for 30-60 min to obtain a milky semitransparent chondroitin sulfate-chitosan nanocomposite suspension; and v, drying the suspension to obtain chondroitin sulfate-chitosan nanocomposite powder.
  4. 4. A glucosamine sulfate capsule as described in claim 3, wherein in said step iii, the mass ratio of chitosan to chondroitin sulfate is 1:1.
  5. 5. The glucosamine sulfate capsule of claim 2, wherein in step a and step d, the sieving is performed in a fixed vacuum granulator with a rotation speed of 400-800 rpm.
  6. 6. A glucosamine sulfate capsule according to claim 2, wherein in step c, the first mixing is performed at a speed of 12rpm for 20-30min.
  7. 7. A glucosamine sulfate capsule according to claim 2, wherein in step e, the final mixing speed is 12rpm for 5-10min.
  8. 8. The glucosamine sulfate capsule of claim 2, wherein in step f, the capsule is filled by a metering disc with the thickness of 15.4mm, the filling speed is 95-105 revolutions per minute, and the filling amount of the capsule content is 0.390-0.422 g.
  9. 9. The glucosamine sulfate capsule of claim 2, wherein the capsule is packaged by aluminum plastic, the molding temperature of the aluminum plastic package is 110-135 ℃, the heat sealing heating temperature is 180-230 ℃, and the molding pressure is 0.5-0.6 MPa.
  10. 10. Use of a glucosamine sulfate capsule as defined in any one of claims 1-9 in the manufacture of a medicament for preventing joint degeneration after sports injury.

Description

Glucosamine sulfate capsule and application thereof in preventing joint degeneration after sports injury Technical Field The invention belongs to the technical field of medicines, and particularly relates to a glucosamine sulfate capsule and application thereof in preventing joint degeneration after sports injury. Background The glucosamine sulfate is taken as a natural amino monosaccharide, is an important component of the polyaminoglucose in the articular cartilage matrix and the synovial fluid, is widely applied to the treatment and symptom improvement of osteoarthritis clinically, and is also used for preventing the articular cartilage abrasion and the degenerative change caused by sports injury by a plurality of sports people. The existing glucosamine sulfate capsule preparation is generally prepared by taking stable double salt formed by the glucosamine sulfate capsule preparation and sodium chloride as active ingredients, adding diluents such as starch and lactose and lubricants such as magnesium stearate, and the like, and adopting a simple powder mixing and capsule filling process. However, in the prior art, the glucosamine sulfate sodium chloride double salt has certain hygroscopicity, is easy to absorb moisture in the production and storage processes, leads to poor powder fluidity and caking of contents, further leads to unstable filling quantity of capsules, changes dissolution behavior, can accelerate chemical degradation of active ingredients, influences long-term stability and validity period of products, has relatively single efficacy and lacks multi-target synergistic protection effect for preventing and repairing complex joint degeneration pathological processes after sports injury. Disclosure of Invention The invention aims to provide a glucosamine sulfate capsule and application thereof in preventing joint degeneration after sports injury, so as to solve the problems in the prior art. In order to achieve the above purpose, the present invention provides the following technical solutions: The glucosamine sulfate capsule is prepared from 400 parts of glucosamine sulfate sodium chloride double salt, 40-60 parts of corn starch, 40-60 parts of lactose, 10-20 parts of talcum powder, 3-8 parts of magnesium stearate and 15-25 parts of chondroitin sulfate-chitosan nano-composite. Preferably, the content is prepared by a method comprising the steps of: a. Sieving glucosamine sulfate sodium chloride double salt, corn starch and lactose with a sieve with a pore diameter of 0.81mm respectively; b. Preparing chondroitin sulfate-chitosan nanocomposite powder; c. mixing the sieved material in the step a with the nanocomposite powder obtained in the step b for the first time to obtain a premixed material; d. sieving the premixed material by using a screen with the aperture of 0.81mm to obtain a sieved material; e. finally mixing talcum powder, magnesium stearate and the sieved material to obtain a total mixed material; f. the total mix is filled into a capsule shell. Preferably, the chondroitin sulfate-chitosan nanocomposite is prepared by a method comprising the steps of: i. Dissolving chitosan in an acetic acid solution with the volume fraction of 1% to prepare a chitosan solution with the mass volume concentration of 0.5-5.0 mg/mL; ii. Dissolving chondroitin sulfate in deionized water to prepare a chondroitin sulfate solution with the mass volume concentration of 0.5-5.0 mg/mL; iii, slowly dropwise adding the chondroitin sulfate solution into the chitosan solution under continuous magnetic stirring, wherein the mass ratio of chitosan to chondroitin sulfate is 5:1-1:5; iv, after the dripping is finished, continuously stirring for 30-60 min to obtain a milky semitransparent chondroitin sulfate-chitosan nanocomposite suspension; and v, drying the suspension to obtain chondroitin sulfate-chitosan nanocomposite powder. Preferably, in the step iii, the mass ratio of chitosan to chondroitin sulfate is 1:1. Preferably, in the step a and the step d, the sieving is performed in a fixed vacuum granulator, and the rotating speed of the granulator is 400-800 rpm. Preferably, in the step c, the rotation speed of the first mixing is 12rpm, and the time is 20-30min. Preferably, in the step e, the final mixing speed is 12rpm, and the time is 5-10min. Preferably, in the step f, a metering disc with a thickness of 15.4mm is used for filling the capsules, the filling speed is 95-105 revolutions per minute, and the filling amount of the capsule content is 0.390-0.422 g. Preferably, the capsule is packaged by aluminum plastic, the molding temperature of the aluminum plastic package is 110-135 ℃, the heat sealing heating temperature is 180-230 ℃, and the molding pressure is 0.5-0.6 MPa. Use of a glucosamine sulfate capsule as described in any one of the preceding claims for the manufacture of a medicament for preventing joint degeneration following sports injury. Compared with the prior art, the invention has the beneficial