CN-121971401-A - Propolis soft capsule for assisting in reducing blood sugar and preparation method thereof

Abstract

The invention discloses a propolis soft capsule for assisting in reducing blood sugar and a preparation method thereof, belonging to the technical field of soft capsule preparation. The propolis soft capsule comprises the following raw materials, by weight, 1-2 parts of a glue solution and 2-5 parts of a content. The process of the invention not only realizes the de-plasticizing agent of the soft capsule, the soft capsule is stable in storage and free from leakage, and has shorter disintegration time, but also has good freezing strength, toughness and strength after the glue solution is dried.

Inventors

• SUN HAIWEI
• HE XIAOYIN

Assignees

• 天津桂芝堂科技有限公司

Dates

Publication Date

20260505

Application Date

20260319

Claims (10)

1. 1. The propolis soft capsule for assisting in reducing blood sugar is characterized by comprising the following raw materials in parts by weight: 1-2 parts by weight of glue solution and 2-5 parts by weight of content.
2. 2. The propolis soft capsule for assisting in reducing blood sugar according to claim 1, wherein the preparation method of the gelatin solution comprises the following steps: Mixing and dispersing gelatin and water according to a weight ratio of 1:10-20 to obtain a dispersion liquid; mixing and stirring the dispersion liquid and modified starch according to the weight ratio of 1:0.1-0.4 to obtain modified gelatin; mixing and stirring modified gelatin and phospholipid according to the weight ratio of 1:0.03-0.06 to obtain phosphatized gelatin; and mixing, dissolving and removing the phosphatized gelatin and water according to the weight ratio of 1:0.8-1 to obtain the glue solution.
3. 3. The propolis soft capsule for assisting in reducing blood sugar according to claim 2, wherein the condition of mixing and dispersing gelatin and water comprises a temperature of 45-50 ℃, an ultrasonic power of 200-250W and a dispersing time of 5-8 min.
4. 4. The propolis soft capsule for assisting in reducing blood sugar according to claim 2, wherein the preparation method of the modified starch comprises the following steps: and mixing the starch, water and sodium periodate according to the weight part ratio of 1:20-30:0.4-0.6, and carrying out light-shielding reaction at 25-30 ℃ for 10-20 min to obtain the modified starch.
5. 5. The propolis soft capsule for assisting in reducing blood sugar according to claim 2, wherein the conditions of mixing and stirring the dispersion liquid and the modified starch comprise a temperature of 50-55 ℃ and a stirring time of 12-15 h.
6. 6. The propolis soft capsule for assisting in reducing blood glucose according to claim 2, wherein the phospholipid comprises soybean lecithin or egg yolk lecithin.
7. 7. The propolis soft capsule for assisting in reducing blood sugar according to claim 2, wherein the condition of mixing and stirring the modified gelatin and the phospholipid comprises the temperature of 50-55 ℃ and the stirring time of 2-3 hours.
8. 8. The propolis soft capsule for assisting in reducing blood sugar according to claim 2, wherein the process of mixing, dissolving and degassing the phosphatized gelatin and water comprises stirring at 60-65 ℃ until the phosphatized gelatin and water are completely dissolved, and then transferring the mixture to a vacuum degree of 0.06-0.07 MPa and a temperature of 60 ℃ for 3-4 min.
9. 9. The propolis soft capsule for assisting in reducing blood sugar according to claim 1, wherein the content is prepared by mixing beeswax, vitamin E and soybean oil according to a weight ratio of 1-2:0.1:14-15.
10. 10. A method for preparing the propolis soft capsule for assisting in reducing blood sugar according to any one of claims 1 to 9, characterized in that the method comprises the following steps: and (3) feeding 1-2 parts by weight of glue solution and 2-5 parts by weight of content into a pressing machine for pressing and drying to obtain the propolis soft capsule.

Description

Propolis soft capsule for assisting in reducing blood sugar and preparation method thereof Technical Field The invention belongs to the technical field of soft capsule preparation, and particularly relates to a propolis soft capsule for assisting in reducing blood sugar and a preparation method thereof. Background Propolis is a viscous glue substance formed by mixing components such as wax, enzymes, amino acids and the like secreted by bees. Propolis has complex composition, and contains bioactive substances such as flavonoids, terpenes, phenolic acids, etc. The propolis has wide application, and is mainly divided into the fields of medicine, health care products, cosmetics, food and the like. In the field of medicine, the propolis has definite medicinal value, is mainly used for treating gastric ulcer, dental ulcer, cervical erosion, herpes zoster, bovine dander, psoriasis, skin laceration pain, corn, burns and scalds and other diseases, and can be used for assisting in treating cardiovascular diseases, diabetes, tumors and other diseases. In addition, propolis can be used as natural antibacterial agent for preventing and treating bacterial, fungal and viral infections, such as respiratory tract infection, skin infection, etc. In the field of health products, propolis is a popular dietary supplement and is mainly used for enhancing immunity, resisting oxidation, delaying aging, regulating blood fat, protecting liver and the like. In the cosmetic field, propolis has antibacterial, antiinflammatory, antioxidant, and moisturizing effects, and is widely used in skin care products and cosmetics such as propolis facial cream, propolis emulsion, propolis facial mask, and propolis toothpaste. The active ingredients in propolis can inhibit bacterial growth on skin surface, reduce acne and inflammation, promote metabolism of skin cells, enhance skin elasticity and luster, delay skin aging, and improve skin dryness and roughness. In the field of foods, propolis can be used as a food additive for preserving, preserving and flavoring foods, such as propolis honey, propolis candy, propolis beverage, etc. The antibacterial component in propolis can inhibit the growth and reproduction of microorganisms in food, prolong the shelf life of food, and improve the taste and flavor of food. The propolis has complex active ingredients and has the characteristics of easy oxidation, pungent peculiar smell, difficult storage and the like, and the soft capsule is used as a high-quality carrier for dosage forms, so that the problems can be effectively solved, the efficacy of the propolis is fully exerted, and the quality and the administration experience of products are improved. The soft capsule mainly comprises two parts, namely rubber and content, which cooperate to ensure the stability of the content and realize convenient administration and effective absorption. The rubber is the "coat" of the soft capsule, mainly made up of film-forming material and plasticizer. The film forming material is core, and the most widely used film forming material is gelatin, and the plasticizer has the functions of increasing the elasticity and toughness of the gelatin, weakening the hydrogen bond self-crosslinking characteristic of the gelatin, avoiding the cracking of the gelatin, and commonly used glycerin, sorbitol, propylene glycol and the like. The contents are the core functional part of the soft capsule, and the forms thereof are mainly divided into three types, oily liquid, semisolid and suspension. The gelatin has wide application in preparing soft capsule, and has excellent biocompatibility, wide source and low cost, and has homogeneous colloid solution in water, high filming performance, high toughness and high elasticity, and is used to encapsulate the animal skin, bone and other side products. Although the plasticizer can regulate and control the flexibility of the capsule shell and avoid rupture, the long-term intake of the plasticizer can cause potential damage to organs such as human liver, kidney and the like, and does not accord with the development concept of 'natural, safe and green' modern health care products. Therefore, how to prepare the propolis into a soft capsule with stable structure without using plasticizer has important significance for green and healthy development of the soft capsule. Disclosure of Invention According to the defects of the prior art, the propolis soft capsule is obtained by mixing and pressing the prepared glue solution and the content, so that the technical problem in the background art is solved. Specifically, the technical scheme of the invention comprises the following contents: A propolis soft capsule for assisting in reducing blood sugar comprises the following raw materials in parts by weight: 1-2 parts by weight of glue solution and 2-5 parts by weight of content. Further, the preparation method of the glue solution comprises the following steps: Mixing and dispersing gelatin and water accor