Search

CN-121971411-A - Aqueous gel-carrying eye mask and preparation method and application thereof

CN121971411ACN 121971411 ACN121971411 ACN 121971411ACN-121971411-A

Abstract

The invention relates to a liquid medicine-carrying gel eye patch, a preparation method and application thereof, belonging to the technical field of eye care and pharmaceutical preparations. The eye patch comprises a hydrogel matrix and active ingredients uniformly dispersed in the hydrogel matrix, wherein the active ingredients comprise salvianolic acid B and geniposide, and the mass ratio of the salvianolic acid B to the geniposide is 4:1-1.5:1. The aqueous gel-carrying eye mask provided by the invention takes gelatin and chitosan as matrixes, a hydrogel network is formed by genipin crosslinking, and salvianolic acid B and geniposide are loaded as active ingredients. Salvianolic acid B can inhibit inflammatory factor release, improve microcirculation and promote cornea repair, and geniposide has remarkable anti-inflammatory, antioxidant and neuroprotective effects, and can be used for treating xerophthalmia. The eye patch has good biocompatibility, adhesiveness and drug release performance, can effectively relieve dry eye symptoms, has simple preparation process, and is suitable for large-scale production.

Inventors

  • ZHANG PENG
  • Li Jiaweijie

Assignees

  • 沈阳药科大学

Dates

Publication Date
20260505
Application Date
20260126

Claims (10)

  1. 1. The eye patch is characterized by comprising a hydrogel matrix and active ingredients uniformly dispersed in the hydrogel matrix, wherein the active ingredients comprise salvianolic acid B and geniposide, and the mass ratio of the salvianolic acid B to the geniposide is 4:1-1.5:1.
  2. 2. The hydrogel eye patch of claim 1, wherein the mass ratio of salvianolic acid B to geniposide is 4:1-2:1.
  3. 3. The hydrogel eye patch of claim 2, wherein the mass ratio of salvianolic acid B to geniposide is 3:1.
  4. 4. The hydrogel eye mask of claim 1, wherein the hydrogel matrix is a hydrogel prepared from gelatin, chitosan, carboxymethyl chitosan, sodium alginate, sodium hyaluronate, sodium carboxymethyl cellulose, polyvinyl alcohol, poloxamer 407, or any two or more thereof.
  5. 5. The hydrogel eye patch of claim 4 wherein the hydrogel matrix is a hydrogel of gelatin crosslinked with chitosan.
  6. 6. The method for preparing the aqueous gel-carrying eye mask according to any one of claims 1 to 5, wherein phenolic acid B and geniposide are added into a raw material solution for preparing the hydrogel, and a cross-linking agent is added for cross-linking reaction, so that the aqueous gel-carrying eye mask is obtained after curing.
  7. 7. The method of claim 6, wherein the gelatin solution is mixed with the chitosan solution, salvianolic acid B and geniposide are added to the obtained mixed solution, the genipin cross-linking agent is added, the mixture is injected into a mold, the mixture is cured for 6 hours at room temperature, and the aqueous gel-loaded eye mask is obtained after demolding.
  8. 8. The method of claim 7, wherein the 12.5% gelatin solution and the 2% chitosan solution are mixed according to a volume ratio of 3:1, salvianolic acid B and geniposide are added into the mixed solution to make the concentration of salvianolic acid B0.375% and the concentration of geniposide 0.125%, and geniposide cross-linking agent is added to make the concentration of geniposide 0.1%, and the mixture is injected into a mold, cured at room temperature for 6 hours, and then the aqueous gel eye mask is obtained after demolding.
  9. 9. Use of the aqueous gel-loaded eye patch of any one of claims 1-5 for the preparation of a medicament for the relief or treatment of dry eye.
  10. 10. Use of a liquid-loaded hydrogel eye patch according to any one of claims 1-5 for the preparation of a medicament for extending the time of eye moisturization.

Description

Aqueous gel-carrying eye mask and preparation method and application thereof Technical Field The invention relates to a liquid medicine-carrying gel eye patch, a preparation method and application thereof, belonging to the technical field of eye care and pharmaceutical preparations. Background With the increase in the frequency of use of electronic devices and the change in living environment, the incidence of dry eye has been as high as 21-30%. Dry eye is a type of ocular surface disease that is accompanied by ocular discomfort and visual dysfunction due to decreased tear film stability caused by insufficient tear secretion, excessive tear evaporation, or abnormal tear composition. Patients mainly show uncomfortable symptoms such as dry eyes, fatigue, burning sensation, foreign body sensation and the like, and when serious, the patients can cause corneal epithelial damage to influence eyesight. The current treatment methods commonly used in clinic comprise artificial tears, anti-inflammatory drugs, immunosuppressants and the like. The artificial tear mainly has lubrication and moisture retention effects, but has short action time and needs to be frequently used, and the anti-inflammatory medicaments such as glucocorticoid and the like have side effects such as elevated intraocular pressure, cataract and the like after long-term use. Therefore, the development of a novel dry eye therapeutic agent which can act from multiple ways, has high safety and is convenient to use has important clinical significance. Salvianolic acid B is water soluble component extracted from Saviae Miltiorrhizae radix, and has various pharmacological activities. Studies show that salvianolic acid B can obviously inhibit the release of inflammatory factors such as TNF-alpha, IL-6 and the like, lighten ocular surface inflammatory response, and accelerate ocular surface tissue repair by improving microcirculation, promoting proliferation and migration of cornea epithelial cells. In addition, the salvianolic acid B has remarkable antioxidant activity, can remove oxygen free radicals, and can reduce the damage of oxidative stress to ocular surface tissues. The geniposide is an iridoid glycoside component extracted from gardenia fruits and has wide pharmacological actions. The gardenoside can inhibit activation of inflammatory signal channels such as NF- κB and the like to reduce the generation of inflammatory mediators, has an antioxidation effect to protect corneal epithelial cells from oxidative damage, and has a certain neuroprotection effect in recent years, and can possibly improve nerve abnormality accompanied by xerophthalmia. The existing gel eye mask mostly adopts a single active ingredient, has limited treatment effect, and can have biosafety problem due to the fact that a chemical cross-linking agent with higher concentration is often used. Disclosure of Invention The invention aims to provide a medicine-carrying hydrogel eye mask for treating xerophthalmia, and a preparation method and application thereof. The eye mask takes gelatin and chitosan as matrixes, takes the loaded salvianolic acid B and the gardenoside as active ingredients by optimizing the dosage of the cross-linking agent, and fully plays the synergistic treatment effect of the two. The eye patch comprises a hydrogel matrix and active ingredients uniformly dispersed in the hydrogel matrix, wherein the active ingredients comprise salvianolic acid B and geniposide, and the mass ratio of the salvianolic acid B to the geniposide is 4:1-1.5:1. Preferably, the mass ratio of the salvianolic acid B to the geniposide is 4:1-2:1, and most preferably, the mass ratio of the salvianolic acid B to the geniposide is 3:1. In the above technical scheme, the hydrogel matrix is hydrogel prepared from gelatin, chitosan, carboxymethyl chitosan, sodium alginate, sodium hyaluronate, sodium carboxymethylcellulose, polyvinyl alcohol, poloxamer 407 or any two or more of them. Preferably, the hydrogel matrix is a hydrogel obtained by crosslinking gelatin and chitosan. The invention also aims to provide a preparation method of the liquid medicine-carrying gel eye mask. A method for preparing the eye mask containing liquid medicine gel comprises adding phenolic acid B and geniposide into the raw material solution for preparing hydrogel, adding cross-linking agent for cross-linking reaction, and solidifying to obtain the eye mask containing liquid medicine gel. Preferably, the gelatin solution and the chitosan solution are mixed, the salvianolic acid B and the geniposide are added into the obtained mixed solution, the genipin cross-linking agent is added, the mixture is injected into a mould, the mixture is solidified for 6 hours at room temperature, and the aqueous gel-carrying eye mask is obtained after demoulding. Further, mixing gelatin solution with the concentration of 12.5% with chitosan solution with the concentration of 2% according to the volume ratio of 3:1, adding salvianolic aci