CN-121971466-A - Composition for preventing or treating oral diseases

Abstract

The present invention relates to a composition for preventing or treating oral diseases, which comprises one compound selected from the group consisting of sclareolide, astragaloside I and brassinolide, or a pharmaceutically acceptable salt thereof, as an active ingredient. The composition of the present invention has excellent antibacterial activity against bacteria causing caries and periodontal disease, and inhibits PGE2 as a marker of pain and inflammation in a concentration-dependent manner, and is excellent in effect of inhibiting gingivitis formation, effect of inhibiting dental hypersensitivity symptoms and effect of removing halitosis, so that it has high degree of use as a pharmaceutical external composition for preventing or improving one or more oral diseases selected from the group consisting of caries, periodontal disease, dental hypersensitivity and halitosis. In addition, the composition of the present invention can be used as a pharmaceutical composition and a food composition.

Inventors

• LIU DINGXIAN
• LI XIANGHE

Assignees

• 株式会社LG生活健康

Dates

Publication Date

20260505

Application Date

20180528

Claims (10)

1. 1. A pharmaceutical composition for preventing or improving oral diseases, wherein, Comprises one compound selected from sclareolide, astragaloside I and brassinolide or pharmaceutically acceptable salt thereof as effective ingredient.
2. 2. The pharmaceutical composition according to claim 1, wherein, The oral disease is at least one selected from the group consisting of dental caries, periodontal disease, toothache, dental hypersensitivity and halitosis.
3. 3. The pharmaceutical composition according to claim 2, wherein, The dental caries is a disease caused by Streptococcus mutans.
4. 4. The pharmaceutical composition according to claim 2, wherein, The periodontal disease is periodontitis or gingivitis.
5. 5. The pharmaceutical composition according to claim 2, wherein, The periodontal disease is a disease caused by Porphyromonas gingivalis.
6. 6. The pharmaceutical composition according to claim 1, wherein, The external medicine is used for oral cavity.
7. 7. The pharmaceutical composition according to claim 6, wherein, The pharmaceutical external composition is one or more dosage forms selected from the group consisting of toothpaste, mouth rinse, mouth cleaner, chewing gum, candy, oral spray, oral ointment, oral desensitizer, oral rinse, and gum massage cream.
8. 8. A pharmaceutical composition for preventing or treating oral diseases, wherein, Comprises one compound selected from sclareolide, astragaloside I and brassinolide or pharmaceutically acceptable salt thereof as effective ingredient.
9. 9. A food composition for preventing or improving oral diseases, wherein, Comprises one compound selected from the group consisting of sclareolide, astragaloside I and brassinolide or a pharmaceutically acceptable salt thereof as an active ingredient.
10. 10. An oral composition, wherein, Comprises one compound selected from the group consisting of sclareolide, astragaloside I and brassinolide or a permissible salt thereof as an active ingredient.

Description

Composition for preventing or treating oral diseases The present application is a divisional application of an application patent application with the name of "composition for preventing or treating oral diseases" which is invented for the application of 2018, 5, 28, 201880094107.3 and LG living health of the applicant. Technical Field The present invention relates to a composition for preventing or treating oral diseases, which comprises a natural compound as an active ingredient, and more particularly, to a pharmaceutical external composition having a preventive or ameliorating effect on caries, periodontal disease, toothache, dental hypersensitivity and halitosis. The present invention also relates to a pharmaceutical composition, a food composition, and an oral composition each containing a natural compound as an active ingredient. Background Healthy teeth can be one of five blessing and are important factors in determining quality of life. Caries (DENTAL CAVITIES, tooth decay) and periodontal disease (periodontal disease, wind teeth) among oral diseases are known as various clinical symptoms causing pain, chewing dysfunction, destruction of periodontal tissues, halitosis, tooth sensitivity, and the like, and cause loss of teeth, as diseases with high worldwide incidence, and the cause elements of oral diseases are further increasing due to changes in dietary life. It is well known that more than about 600 to 800 microorganisms exist in the human mouth and these microorganisms are controlled by enzymes such as salivary lysozyme (lysozyme). The nutrient and moisture rich oral environment provides good growth conditions for microorganisms and the tongue or plaque (dental plaque) provides an ideal habitat for the microorganisms. Some of these microorganisms are causative organisms, and cause diseases such as caries, periodontal disease and tooth sensitivity (dentin hypersensitivity) and halitosis. As a method for inhibiting proliferation of oral pathogenic bacteria that inhabit dental plaque to cause caries, periodontal disease, halitosis and tooth sensitivity, there are antibacterial agents, and various antibacterial preparations containing antibiotics having bactericidal and bacteriostatic actions on oral pathogenic bacteria have been developed as inhibitors and therapeutic agents for tooth decay, periodontal disease, dental pulp and periapical infection. However, antibiotics have the disadvantage of being difficult to use for a long period of time and only as therapeutic agents, since they can have systemic side effects on our body, as well as the potential for the appearance of intraoral resistant bacteria and secondary infections (superinfection). Further, as an antibacterial agent used as an oral cleaner, sanguinarine (Sangquinarine), li Shide (Listerine), peroxide (Peroxide), chlorhexidine (chlorexidine) and the like are known, and sanguinarine has disadvantages that the effect on bacteria in the oral cavity is not clear and the therapeutic effect on periodontal disease is more clear and the price is high, and the main component of Li Shide is ethanol, which has a certain antibacterial effect but only shows a short-term effect in the oral cavity and may have a harmful effect on tissues when used for a long time. In addition, peroxide added for whitening effect in recent years is toxic to bacteria, but also toxic to human tissues, so that there is a problem in safety, and peroxide-resistant bacteria are occasionally present in bacteria. In addition, chlorhexidine is the most excellent of the preparations for inhibiting the formation of dental plaque and preventing and treating periodontal diseases known so far, however, chlorhexidine causes not only the problem of irritation to tissues, staining and denaturation of tissues, particularly, side effects such as strong pungent taste and heavy smell, but also secondary infection, and is carcinogenic, and thus has a disadvantage of being unable to be used for a long period of time for the purpose of treatment or particularly prevention, such as limited use for pregnant women. In addition, since compounds synthesized artificially by chemical reaction may have side effects such as cytotoxicity and accumulation in human body, it is now required to investigate pharmacological activities of natural compounds having low risk of side effects in terms of safety. Disclosure of Invention Problems to be solved by the invention The present inventors have studied to find a natural material which has an excellent effect of preventing and improving dental caries, periodontal disease, toothache, dental hypersensitivity and halitosis, without worrying about the above-mentioned side effects. As a result, it was found that a natural compound which can be safely and assuredly used in vivo, shows an antibacterial effect on bacteria causing caries and periodontal disease, a toothache relieving effect by PGE2 inhibiting effect, gingivitis formation inhibiting effect, tooth aller