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CN-121971483-A - Iodophor compound composition for sterilization and processing technology thereof

CN121971483ACN 121971483 ACN121971483 ACN 121971483ACN-121971483-A

Abstract

The invention discloses an iodophor compound composition for sterilization and a processing technology thereof, which relate to the technical field of sterilization, the invention takes xanthan gum to be added into deionized water, stirred until the xanthan gum is completely dissolved, cooled, added with glycerin, amino-polyethylene glycol-polyacrylic acid segmented copolymer, stirring until the povidone iodine is completely dissolved, adding povidone iodine, stirring until the povidone iodine is completely dissolved, adding microcapsule solution, adding deionized water, stirring, keeping away from light, standing, and filtering to obtain the sterilizing iodophor compound composition. Povidone iodine can destroy bacterial proteins and nucleic acids by providing free iodine for oxidation, so that broad-spectrum sterilization is realized, thymol and eugenol can inhibit key enzyme activities by destroying bacterial cell membranes and cell walls, tannic acid can form a compound on cell membranes by combining with proteins so as to destroy membrane functions of the cell membranes, and the synergistic effect of the thymol and eugenol can improve the sterilization effect of the iodophor compound composition for sterilization.

Inventors

  • XU RONG
  • XU FENG
  • CHEN YU

Assignees

  • 江苏德鲁克生物科技有限公司

Dates

Publication Date
20260505
Application Date
20251231

Claims (9)

  1. 1. A processing technology of an iodophor compound composition for sterilization is characterized by comprising the following steps: Adding sodium alginate and calcium chloride into deionized water, stirring until the sodium alginate and the calcium chloride are completely dissolved to obtain a mixed solution, adding the core material solution into the shell material solution, stirring, adding the core material solution into the mixed solution, solidifying, centrifuging, washing, adding the core material solution into the deionized water, and dispersing to obtain a microcapsule solution; Adding polyacrylic acid into deionized water, uniformly mixing, adding methoxy polyethylene glycol ammonium, uniformly stirring, adding 1- (3-dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride and N-hydroxysuccinimide, regulating the pH value by using sodium hydroxide, stirring, dialyzing, and freeze-drying to obtain an amino-polyethylene glycol-polyacrylic acid segmented copolymer; And thirdly, adding xanthan gum into deionized water, stirring until the xanthan gum is completely dissolved, cooling, adding glycerol, amino-polyethylene glycol-polyacrylic acid segmented copolymer, stirring until the mixture is completely dissolved, adding povidone iodine, stirring until the mixture is completely dissolved, adding microcapsule solution, adding deionized water, stirring, keeping away from light, standing, and filtering to obtain the iodophor compound composition for sterilization.
  2. 2. The processing technology of the iodophor compound composition for sterilization, which is disclosed in claim 1, is characterized in that the preparation method of the core material solution is that core material, emulsifying agent and polyglycerin fatty acid ester are added into deionized water, and dispersed for 4-6min under the condition of the rotating speed of 11000-13000rpm, so as to obtain the core material solution, wherein the core material is any one or more of thymol, eugenol, carvacrol, menthol, tannic acid, gallic acid, ferulic acid and citric acid.
  3. 3. The processing technology of the iodophor compound composition for sterilization, as claimed in claim 1, is characterized in that the preparation method of the shell material solution is that quaternary ammonium salt chitosan, carboxylated nanocellulose and glycerol are added into glacial acetic acid water solution, and the mixture is uniformly mixed to obtain the shell material solution.
  4. 4. The process for preparing the sterilizing iodophor compound composition according to claim 3, wherein the preparation method of the quaternary ammonium salt chitosan is characterized in that chitosan is added into glacial acetic acid water solution, stirred until the chitosan is completely dissolved at 50-60 ℃, glycidyl trimethyl ammonium chloride and bisdecanyl dimethyl ammonium chloride are added, stirred, centrifuged for 9-11min at the rotating speed of 4500-5500rpm, dialyzed for 2-4d and freeze-dried, and the quaternary ammonium salt chitosan is obtained.
  5. 5. The process for preparing a sterilizing iodophor compound composition according to claim 1, wherein the pH value is adjusted to 5.0-6.0.
  6. 6. The process for preparing the sterilizing iodophor compound composition according to claim 4, wherein the volume ratio of the glycidyl trimethyl ammonium chloride to the bisdodecyl dimethyl ammonium chloride is (7-14): 1.
  7. 7. The processing technology of the iodophor compound composition for sterilization, which is characterized in that the mass ratio of the quaternary ammonium salt chitosan to the carboxylated nanocellulose to the glycerol to the glacial acetic acid aqueous solution is (0.8-1.2), 0.1-0.3, 0.05-0.1 and 90-110.
  8. 8. The processing technology of the iodophor compound composition for sterilization according to claim 1, wherein the pH value of the mixed solution is 5.0-6.0, and the mass percentage of sodium alginate in the mixed solution is 0.1-1 wt%.
  9. 9. An iodophor formulation for sterilization as claimed in any one of claims 1 to 8 the iodophor compound composition for sterilization is prepared by a processing technology of the composition.

Description

Iodophor compound composition for sterilization and processing technology thereof Technical Field The invention relates to the technical field of sterilization, in particular to an iodophor compound composition for sterilization and a processing technology thereof. Background Povidone iodine is a compound of povidone and iodine and is commonly used in the field of disinfection and sterilization, but in the application process, povidone iodine has limitation, on one hand, bacterial cell membranes inhibit povidone iodine from entering the inside of cells, and povidone iodine can destroy bacterial proteins and nucleic acids by providing free iodine oxidation to realize broad-spectrum sterilization, substances are required to be added to destroy protective barrier cell membranes of bacteria so as to ensure that the sterilization and bacteriostasis of povidone iodine are maximized, and on the other hand, povidone iodine has no other additional functions such as anti-inflammation, wound healing promotion and the like. In order to solve the problems, the invention provides an iodophor compound composition for sterilization and a processing technology thereof. Disclosure of Invention The invention aims to provide an iodophor compound composition for sterilization and a processing technology thereof, which are used for solving the problems in the prior art. In order to achieve the above purpose, the present invention provides the following technical solutions: Adding sodium alginate and calcium chloride into deionized water, stirring until the sodium alginate and the calcium chloride are completely dissolved to obtain a mixed solution, adding the core material solution into the shell material solution, stirring, adding the core material solution into the mixed solution, solidifying, centrifuging, washing, adding the core material solution into the deionized water, and dispersing to obtain a microcapsule solution; Adding polyacrylic acid into deionized water, uniformly mixing, adding methoxy polyethylene glycol ammonium, uniformly stirring, adding 1- (3-dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride and N-hydroxysuccinimide, regulating the pH value by using sodium hydroxide, stirring, dialyzing, and freeze-drying to obtain an amino-polyethylene glycol-polyacrylic acid segmented copolymer; And thirdly, adding xanthan gum into deionized water, stirring until the xanthan gum is completely dissolved, cooling, adding glycerol, amino-polyethylene glycol-polyacrylic acid segmented copolymer, stirring until the mixture is completely dissolved, adding povidone iodine, stirring until the mixture is completely dissolved, adding microcapsule solution, adding deionized water, stirring, keeping away from light, standing, and filtering to obtain the iodophor compound composition for sterilization. The optimized preparation method of the core material solution comprises the steps of adding the core material, the emulsifier and the polyglycerol fatty acid ester into deionized water, and dispersing for 4-6min at the rotating speed of 11000-13000rpm to obtain the core material solution, wherein the core material is one or more of thymol, eugenol, carvacrol, menthol, tannic acid, gallic acid, ferulic acid and citric acid. The optimized preparation method of the shell material solution comprises the steps of adding the quaternary ammonium salt chitosan, the carboxylated nanocellulose and the glycerol into the glacial acetic acid water solution, and uniformly mixing to obtain the shell material solution. The optimized preparation process includes adding chitosan into glacial acetic acid aqua, stirring at 50-60 deg.c to dissolve completely, adding glycidyl trimethyl ammonium chloride and bisdodecyl dimethyl ammonium chloride, stirring, centrifuging at 4500-5500rpm for 9-11min, dialyzing for 2-4d, and freeze drying to obtain quaternary ammonium salt chitosan. Preferably, the pH value is adjusted to 5.0-6.0. Preferably, the volume ratio of the glycidyl trimethyl ammonium chloride to the bisdodecyl dimethyl ammonium chloride is (7-14) 1. The optimized mass ratio of the quaternary ammonium salt chitosan, carboxylated nano cellulose, glycerol and glacial acetic acid aqueous solution is (0.8-1.2) (0.1-0.3) (0.05-0.1) (90-110). Preferably, the pH value of the mixed solution is 5.0-6.0, and the mass percentage of sodium alginate in the mixed solution is 0.1-1 wt%. Compared with the prior art, the invention has the beneficial effects that: 1. Preparing quaternary ammonium salt chitosan, under the weak acid condition, protonating free amino of chitosan to form positively charged amino, and making epoxy group of glycidol aldehyde trimethyl ammonium chloride produce ring-opening reaction to obtain the single-chain quaternary ammonium salt chitosan with more excellent water solubility and antibacterial property, using didecyl dimethyl ammonium chloride to make hydrophobic interaction or electrostatic adsorption and single-chain quaternary ammo