CN-121971498-A - Composition for improving skin color multiple times and application thereof

Abstract

The invention provides a composition for improving skin color multiple times, which comprises an inonotus obliquus extract and pterostilbene, wherein the mass ratio of the inonotus obliquus extract to the pterostilbene is 10:1-1:10. In the combination, the combination of the inonotus obliquus extract and the pterostilbene has synergistic effect on the inhibition of ABTS free radicals, melanin generation and inflammatory factors, and can be used for preparing products for inhibiting melanin generation, resisting inflammation, resisting oxidation and resisting saccharification.

Inventors

• XU KE
• YANG LIYUAN
• HUI YUANYUAN
• Qiu shuo
• WANG DAN
• LEI LEI

Assignees

• 科笛生物医药(无锡)有限公司

Dates

Publication Date

20260505

Application Date

20251231

Claims (11)

1. 1. A composition for improving skin color comprises Inonotus obliquus extract and pterostilbene, wherein the mass ratio of Inonotus obliquus extract to pterostilbene is 10:1-1:10.
2. 2. The composition of claim 1, wherein pterostilbene is pterostilbene pure, pterocarpus marsupium bark extract, or Pterocarpus marsupium extract.
3. 3. The composition of claim 1, wherein the inonotus obliquus extract is an inonotus obliquus water extract.
4. 4. The composition of claim 1 or 3, wherein the inonotus obliquus extract is prepared by subcritical water extraction.
5. 5. Use of a composition according to claim 1 for the preparation of a product for inhibiting melanogenesis.
6. 6. Use of the composition of claim 1 for the preparation of a product for inhibiting inflammatory factors.
7. 7. The use according to claim 5, wherein the inflammatory factor is TNF- α and/or IL-6.
8. 8. Use of the composition of claim 1 for the preparation of a product for anti-glycation.
9. 9. Use of the composition of claim 1 for the preparation of a product for oxidation resistance.
10. 10. Use according to any one of claims 5 to 9, said product being an external skin product.
11. 11. The composition according to claim 1, which is a cosmetic or pharmaceutical product, wherein the total content of the inonotus obliquus extract and pterostilbene in the composition is 0.01-40% by mass.

Description

Composition for improving skin color multiple times and application thereof Technical Field The invention relates to the field of natural pharmaceutical chemistry, in particular to a composition with multiple effects of synergistically whitening and removing Huang Tuigong for improving skin color and application thereof. Background The skin is used as the largest functional organ of a human body, the skin color state of the skin directly reflects the health level of the body, and the uniform and transparent skin color is an important representation of skin health. However, due to multiple factors such as aging, ultraviolet irradiation, exposure to environmental pollutants, skin color abnormality such as blackening, yellowing, reddening, etc., the aesthetic appearance and consumer life experience are seriously affected. The abnormal skin color is formed by different factors, namely, black in skin color is mainly caused by abnormal melanin pigmentation, factors such as ultraviolet rays, inflammatory stimulus and the like, can activate melanin synthesis paths of melanocytes, promote transfer of melanosomes to keratinocytes to cause excessive skin pigmentation, yellow and dark skin color is accumulated in skin tissues mainly caused by advanced glycosylation end products generated by skin saccharification reaction, skin oxidative stress reaction caused by photoaging and environmental pollutants destroys normal metabolic functions of skin cells to cause the skin color to lose gloss, and skin color redness is closely related to skin barrier function damage, and skin inflammation caused by external stimulus destroys integrity of skin barrier to cause telangiectasia or permeability increase and is manifested by symptoms such as red blood wires, skin sensitive redness and the like. At present, research on skin color improvement in the fields of cosmetics and skin care is mainly focused on single whitening efficacy, namely, the problem of skin color blackening is improved by inhibiting melanin synthesis, blocking melanosome transfer and other ways, but comprehensive skin color improvement compositions capable of simultaneously achieving three effects of blackening, yellowing and reddening are still relatively deficient, and the demands of consumers on comprehensive optimization of skin colors are difficult to meet. Pterostilbene is an effective component derived from plants such as pterocarpus santalinus, blueberry, grape or Pterocarpus marsupium, is a natural polyphenol compound, has a certain effect on treatment of cancers, hypertension and hyperlipidemia, and has good effects in treatment and protection of skin diseases. Pterostilbene has high melanin inhibiting effect in skin external preparation, and can be used as whitening active ingredient in cosmetics. Inonotus obliquus, also called Fuscoporia obliqua, has a chemical name Inonotus obliquus (Fr.) Pilat, belongs to fungus of genus Inonotus in family Hymenochaetaceae, is a medicinal fungus parasitized on bark of arbor such as Betula obliqua, is mainly distributed in 40-50 ° North latitude region, has various pharmacological activities of regulating sugar metabolism, enhancing immunity, resisting oxidation and resisting tumor, and has been applied to pharmaceutical and food industries. Because the inonotus obliquus extract has the functions of resisting oxidation, controlling oil and the like, cosmetics such as cleansing foam containing the inonotus obliquus extract are on the market at present. However, there is no clear report about the effect of inonotus obliquus extract on improvement of skin color. Disclosure of Invention Technical problem to be solved by the invention The invention provides a composition for improving skin color multiple times, which can regulate the skin color from multiple angles of whitening, fading red and removing yellow. The inonotus obliquus extract and pterostilbene combination not only can cooperate with antioxidation, yellowing removal, inflammation resistance and reddening resistance, but also can improve the inhibition of the pterostilbene on the melanin content in melanocytes, thereby enhancing the whitening effect. The invention discloses that the combination of the inonotus obliquus extract and pterostilbene can synergistically inhibit ABTS free radical, melanin generation and inflammatory factors for the first time. Based on the discovery, the novel application of the composition in the field of cosmetics is further expanded. Technical proposal for solving the technical problems The invention provides a composition for improving skin color, which comprises an inonotus obliquus extract and pterostilbene, wherein the mass ratio of the inonotus obliquus extract to the pterostilbene is 10:1-1:10. In one embodiment of the present invention, the total content of the inonotus obliquus extract and pterostilbene in the composition is 0.01-40%, preferably 0.1% -40%, more preferably 1% -40%, for example, may be 5%, 10%, 15%, 20%, 25%,