CN-121971504-A - Traditional Chinese medicine composition for treating hyperuricemia and application thereof

Abstract

The invention discloses a traditional Chinese medicine composition for treating hyperuricemia and application thereof, and belongs to the technical field of traditional Chinese medicines. The preparation method of the traditional Chinese medicine composition comprises the steps of mixing ganoderma lucidum spore powder and idesia polycarpa fruit powder according to the mass part ratio of 10-90:90-10, extracting by using a supercritical CO 2 fluid extraction technology to obtain an extraction phase, decompressing and analyzing to separate out an extract, and drying to obtain the traditional Chinese medicine composition powder. The invention provides a traditional Chinese medicine composition compounded by ganoderma lucidum spore oil and idesia oil, which is proved by cell experiments and animal experiments to be capable of obviously inhibiting uric acid synthesis and reabsorption, thereby reducing serum uric acid level and improving renal function injury caused by hyperuricemia, can be used as a functional raw material for preparing products for treating hyperuricemia or improving renal injury caused by hyperuricemia, and has the advantages of easily available raw materials, low cost, high safety and good development and application value.

Inventors

• WANG YING
• SUN YUANYUAN
• XU YANG
• HU MINYAN
• XU JUAN
• WU XUEQIAN

Assignees

• 浙江农林大学

Dates

Publication Date

20260505

Application Date

20260403

Claims (10)

1. 1. A traditional Chinese medicine composition for treating hyperuricemia is characterized by comprising the steps of mixing ganoderma lucidum spore powder and idesia fruit powder according to a mass ratio of 10-90:90-10, extracting by using a supercritical CO 2 fluid extraction technology to obtain an extraction phase, then decompressing and analyzing to separate out an extract, and drying to obtain the traditional Chinese medicine composition powder.
2. 2. The traditional Chinese medicine composition according to claim 1, wherein the ganoderma lucidum spore powder and idesia fruit powder are mixed according to a mass ratio of 20-50:50-80.
3. 3. The traditional Chinese medicine composition according to claim 2, wherein the ganoderma lucidum spore powder and idesia fruit powder are mixed according to a mass ratio of 40:60.
4. 4. The composition of claim 1, wherein the extraction pressure is 25-35 MPa, the supercritical CO 2 fluid is used in an amount of 20-40 times the weight of the mixed powder, the CO 2 flow rate is 20 kg/h, and the extraction temperature is 45-55 ℃.
5. 5. The composition of claim 4, wherein the extraction pressure is 25-30 MPa and the supercritical CO 2 fluid is used in an amount of 20-30 times the weight of the mixed powder and the extraction temperature is 50 ℃.
6. 6. The traditional Chinese medicine composition according to claim 1, wherein the resolving pressure is 4-10 MPa and resolving temperature is 40-50 ℃.
7. 7. The composition of claim 6, wherein the resolving pressure is 6 MPa and the resolving temperature is 40-45 ℃.
8. 8. The traditional Chinese medicine composition according to claim 1, wherein the drying is freeze drying.
9. 9. Use of a Chinese medicinal composition according to any one of claims 1-8 for the preparation of a product for the treatment of hyperuricemia or for the amelioration of renal damage caused by hyperuricemia.
10. 10. The use according to claim 9, wherein the product is a pharmaceutical product comprising an effective dose of the Chinese medicinal composition according to any one of claims 1 to 8 and a pharmaceutically acceptable carrier.

Description

Traditional Chinese medicine composition for treating hyperuricemia and application thereof Technical Field The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating hyperuricemia or improving renal injury caused by hyperuricemia and application thereof. Background Hyperuricemia (HUA) is a chronic metabolic disease characterized by abnormally elevated serum uric acid levels, and is a fundamental factor in the development of gout. Uric acid is the final product of purine metabolism in the body, and elevated uric acid levels may be associated with dietary, genetic and renal functions. With the improvement of living conditions, the incidence of HUA increases year by year and the age of onset tends to be younger due to abnormal purine metabolism caused by diet. In addition, long-term HUA aggravates kidney metabolic function, and is prone to cause kidney damage. Therefore, effective control of the HUA is of great importance for improving the health status of residents. According to the mechanism of action of HUA formation, a series of uric acid lowering drugs such as uric acid production inhibiting drugs (allopurinol, febuxostat), uric acid reabsorption inhibiting drugs (benzbromarone and probenecid), uric acid lowering auxiliary drugs (sodium bicarbonate) and gout acute episode relief drugs (colchicine and nonsteroidal anti-inflammatory drugs) have been developed clinically. Although the medicines can effectively reduce serum uric acid level or relieve gout symptoms, the medicines have the limitations of single action target point, liver and kidney toxicity caused by long-term administration, long-term and even life-long administration and the like, such as gastrointestinal tract reaction and acute renal failure caused by allopurinol, abnormal liver function caused by febuxostat, increased risk of cardiovascular events, increased risk of stone formation caused by tribromone and Levenard, acute gout attack easily induced by Prickii, liver and kidney injury caused by colchicine, bone marrow transplantation and the like, so that the HUA treatment effect is not ideal. Therefore, the search for a medicine for treating HUA with low side effects and definite curative effects is still a public health problem which needs to be solved in the field. The traditional Chinese medicine theory considers hyperuricemia as the symptom of the deficiency and the excess, is caused by spleen deficiency and kidney deficiency, and the traditional Chinese medicine treatment of hyperuricemia is based on the etiology and pathogenesis, and relieves the symptoms of patients and reduces organ injury through dialectical treatment. Clinically, the main treatment methods include tonifying liver and kidney, strengthening spleen and stomach, eliminating dampness and removing stasis, clearing heat and promoting diuresis and removing turbidity, and activating blood and dissolving stasis, for example, decoction for resolving dampness and reducing turbidity is commonly used for promoting serum uric acid excretion and reducing serum uric acid level. The traditional Chinese medicine has good curative effect on hyperuricemia, high safety and less adverse reaction, and can better guide clinical medication from the aspect of syndrome differentiation treatment of the whole concept (Liu Xuan. Traditional Chinese medicine for treating hyperuricemia and relevant disease pathogenesis and research progress. Sub-traditional medicine, 2025, 21 (3): 251-256). The Ganoderma spore powder is micro germ cells ejected from the fold of the fungus cover in the mature period of Ganoderma growth, and Ganoderma spore oil composed of triterpene compounds, fatty acid and sterol is one of its active components, and has effects of regulating immunity, resisting tumor, protecting liver, resisting aging and protecting cardiovascular system. Idesia is a woody oil tree species with high oil content, and idesia fruits and seeds contain various chemical components beneficial to human bodies, such as oleic acid, linoleic acid, vitamin E, flavone, phytosterol and the like, and have important development values in the fields of food and medical care. Modern pharmacological researches have shown that idesia has the effects of anti-inflammatory, antioxidant, hypolipidemic, cardiovascular and cerebrovascular protecting and anti-obesity. At present, no substantial evidence exists that ganoderma lucidum spore oil or idesia oil has the function of reducing uric acid, and no report of preparing uric acid-reducing products by compounding the ganoderma lucidum spore oil or idesia oil is found. Disclosure of Invention The invention aims to provide a traditional Chinese medicine composition for treating hyperuricemia, which has low side effect and definite curative effect, and is applied to the development of related products for treating hyperuricemia and improving renal injury caused by hyperuricemia. I