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CN-121971507-A - Composition for relieving eye strong light burn and preparation method thereof

CN121971507ACN 121971507 ACN121971507 ACN 121971507ACN-121971507-A

Abstract

The invention relates to the technical field of medical medicaments, and discloses a composition for relieving eye strong light burn and a preparation method thereof. The composition comprises, by weight, 0.5-3% of sodium fatty acid, 30-50% of corn starch, 25-45% of talcum powder, 1-4% of cresol, 5-15% of wild chrysanthemum flower, 0.05-0.5% of radix scutellariae, 0.01-0.1% of safflower, 0.1-1% of aqueous solvent and the balance of water. The preparation method comprises pulverizing the above materials, preparing water phase matrix containing aqueous solvent and sodium fatty acid, dry mixing corn starch, pulvis Talci and fine powder, mixing water phase and solid phase, adding cresol, homogenizing, regulating pH, and sterilizing to obtain paste or paste composition. The composition can effectively relieve ocular surface pain, lacrimation and foreign body sensation caused by strong light burn through physical protection, anti-inflammatory repair and antioxidant multi-way synergy.

Inventors

  • Dai Songsheng

Assignees

  • 戴松生

Dates

Publication Date
20260505
Application Date
20260109

Claims (10)

  1. 1. A composition for relieving eye strong light burn is characterized by comprising, by weight, 0.5-3% of fatty acid sodium, 30-50% of corn starch, 25-45% of talcum powder, 1-4% of cresol, 5-15% of wild chrysanthemum, 0.05-0.5% of radix scutellariae, 0.01-0.1% of safflower, 0.1-1% of aqueous solvent and the balance of water.
  2. 2. A composition for alleviating an ocular highlight as in claim 1, wherein said aqueous solvent is at least one of glycerin, propylene glycol or polyethylene glycol 400.
  3. 3. The composition for relieving eye strong light burn according to claim 1 or 2, wherein the composition comprises, by weight, 1.2% of fatty acid sodium, 38.7% of corn starch, 35% of talcum powder, 2.1% of cresol, 10% of wild chrysanthemum flower, 0.15% of scutellaria baicalensis, 0.03% of safflower, 0.3% of aqueous solvent and the balance of water.
  4. 4. A process for the preparation of a composition according to any one of claims 1 to 3, comprising the steps of: S1, preprocessing, namely respectively cleaning and drying wild chrysanthemum, baical skullcap root and safflower, and then crushing the wild chrysanthemum, the baical skullcap root and the safflower to pass through a 100-200-mesh sieve to obtain medicinal material fine powder; S2, preparing a water phase, namely adding the aqueous solvent into part of water, uniformly stirring to obtain a first mixed solution, dissolving sodium fatty acid in the rest water, heating to 0-70 ℃ and stirring until the sodium fatty acid is completely dissolved to obtain a second mixed solution, combining the first mixed solution and the second mixed solution, and carrying out heat preservation and stirring at 40-60 ℃ to obtain a water phase matrix; S3, solid phase mixing, namely mixing the corn starch, the talcum powder and the medicinal material fine powder obtained in the step S1 in dry mixing equipment for 15-30min to obtain a uniform solid phase mixture; S4, forming the composition, namely slowly adding the aqueous phase matrix into the solid phase mixture, stirring at the rotating speed of 200-500rpm, adding cresol, and continuously stirring until uniform paste or paste is formed; And S5, post-treatment, namely homogenizing the product obtained in the step S4, then adjusting the pH value to 6.5-7.5, and sterilizing to obtain the composition.
  5. 5. The method according to claim 4, wherein in step S2, the temperature of the heated and dissolved sodium fatty acid is 55-65 ℃ and the stirring time is 20-40min.
  6. 6. The method according to claim 4, wherein in step S3, the dry mixing apparatus is a three-dimensional motion mixer or a V-type mixer for 15-20min.
  7. 7. The method according to claim 4, wherein in step S5, the homogenizing treatment is performed by using a high shear emulsifying machine at 2000-4000rpm for 3-5min, and the sterilization is performed by using irradiation sterilization under conditions of 115-121 ℃ and 15-30min.
  8. 8. A composition for alleviating ocular intense light burns comprising the composition according to any one of claims 1-3 or a pharmaceutically acceptable physical form obtained according to the method of preparation of claims 4-7.
  9. 9. The composition of claim 8, wherein the composition is a powder or a paste.
  10. 10. Use of a composition according to any one of claims 1-3 or a composition obtained according to the method of preparation of claims 4-7 for the manufacture of a medicament for alleviating pain, tear and foreign body sensation caused by hard light burns on the eye.

Description

Composition for relieving eye strong light burn and preparation method thereof Technical Field The invention relates to the technical field of medical medicaments, in particular to a composition for relieving eye highlight burn and a preparation method thereof. Background Strong eye burn is common acute physical injury of ophthalmology, and is mostly caused by excessive ultraviolet and strong visible light radiation released by electric welding, ultraviolet disinfection, high-intensity outdoor light, specific industrial light sources and the like. The injury is mainly applied to ocular surface tissues such as cornea, conjunctiva and the like, and causes the necrosis and shedding of epithelial cells, tissue inflammatory reaction and nerve ending exposure, and the symptoms such as severe eye pain, photophobia, lacrimation, foreign body sensation, temporary blurred vision and the like are clinically presented, and if the injury is improper, secondary infection or delayed healing is possibly caused, so that the work and life of a patient are affected. At present, the clinical treatment and drug development for the acute ocular surface photodamage are focused on two aspects, namely, the use of artificial tears or lubricating gel and the like, aiming at relieving dryness and discomfort by supplementing tears and keeping the ocular surface moist, and the application of non-steroidal anti-inflammatory drugs or low-concentration glucocorticoid eye drops, so as to inhibit inflammatory response and relieve tissue edema. However, existing treatment regimens still have certain limitations. First, most artificial tear formulations have a short residence time on the ocular surface, and have limited physical barrier and protective effects against sustained stimulation of formation of a large amount of abnormal secretions and exposed nerve endings after acute burns, and are difficult to rapidly and permanently relieve severe pain and foreign body sensation. Secondly, although the pure anti-inflammatory drug can control partial inflammation, the promotion effect on acute edema, oxidative stress injury and subsequent epithelial repair of tissues in the early stage of burn is insufficient, and potential risks of increasing intraocular pressure, delaying wound healing and the like can exist SUMMARY OF THE PATENT FOR INVENTION In view of the foregoing, it is desirable to provide a composition for alleviating eye strong light burns and a preparation method thereof, so as to solve or alleviate the technical problems in the prior art. The technical scheme of the embodiment of the invention is that the composition for relieving eye strong light burn comprises, by weight, 0.5-3% of sodium fatty acid, 30-50% of corn starch, 25-45% of talcum powder, 1-4% of cresol, 5-15% of wild chrysanthemum flower, 0.05-0.5% of radix scutellariae, 0.01-0.1% of safflower, 0.1-1% of aqueous solvent and the balance of water. As an improvement, the aqueous solvent is at least one of glycerin, propylene glycol or polyethylene glycol 400. The modified corn flour comprises, by weight, 1.2% of sodium fatty acid, 38.7% of corn starch, 35% of talcum powder, 2.1% of cresol, 10% of wild chrysanthemum, 0.15% of scutellaria baicalensis, 0.03% of safflower, 0.3% of aqueous solvent and the balance of water. A method of preparing a composition for alleviating ocular glare burns comprising the steps of: S1, preprocessing, namely respectively cleaning and drying wild chrysanthemum, baical skullcap root and safflower, and then crushing the wild chrysanthemum, the baical skullcap root and the safflower to pass through a 100-200-mesh sieve to obtain medicinal material fine powder; s2, preparing a water phase, namely adding the aqueous solvent into part of water, uniformly stirring to obtain a first mixed solution, dissolving sodium fatty acid in the rest water, heating to 50-70 ℃ and stirring until the sodium fatty acid is completely dissolved to obtain a second mixed solution, combining the first mixed solution and the second mixed solution, and carrying out heat preservation and stirring at 40-60 ℃ to obtain a water phase matrix; S3, solid phase mixing, namely mixing the corn starch, the talcum powder and the medicinal material fine powder obtained in the step S1 in dry mixing equipment for 15-30min to obtain a uniform solid phase mixture; S4, forming the composition, namely slowly adding the aqueous phase matrix into the solid phase mixture, stirring at the rotating speed of 200-500rpm, adding cresol, and continuously stirring until uniform paste or paste is formed; And S5, post-treatment, namely homogenizing the product obtained in the step S4, then adjusting the pH value to 6.5-7.5, and sterilizing to obtain the composition. As a modification, in the step S2, the temperature of the heated and dissolved fatty acid sodium is 55-65 ℃ and the stirring time is 20-40min. As an improvement, in step S3, the dry mixing device is a three-dimensional motion mixer or a V-type mi