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CN-121971512-A - A composition with blood pressure lowering, liver protecting and anti-hangover effects

CN121971512ACN 121971512 ACN121971512 ACN 121971512ACN-121971512-A

Abstract

The invention relates to a composition with the effects of reducing blood pressure, protecting liver and dispelling the effects of alcohol, which comprises ginkgo leaf, kudzuvine root, eucommia bark, apocynum venetum, kelp and pepper. According to the invention, kelp and pepper are introduced as protecting and synergistic agents, so that the stomach passing rate of total flavone and puerarin can be obviously improved, and the effects of reducing blood pressure, dispelling alcohol and protecting liver of ginkgo leaf, kudzuvine root, eucommia bark and apocynum venetum are enhanced.

Inventors

  • Peng Zhaorong
  • WU FENHONG
  • Lei Jianxing
  • SHAO YUNXIAO

Assignees

  • 江西仁和康健科技有限公司
  • 仁和全域(上海)大健康研究院有限公司

Dates

Publication Date
20260505
Application Date
20260209

Claims (8)

  1. 1. A composition with the effects of reducing blood pressure, protecting liver and dispelling the effects of alcohol is characterized by comprising the following raw materials, by weight, 70-150 parts of ginkgo leaf, 70-150 parts of kudzuvine root, 60-120 parts of eucommia ulmoides, 60-120 parts of apocynum venetum, 40-90 parts of kelp and 7-15 parts of pepper.
  2. 2. The composition of claim 1, wherein the composition comprises, by weight, 90-130 parts of ginkgo leaf, 90-130 parts of kudzuvine root, 75-105 parts of eucommia bark, 75-105 parts of apocynum venetum, 53-78 parts of kelp and 9-13 parts of pepper.
  3. 3. The composition of claim 2, which is prepared from the following raw materials, by weight, 110 parts of ginkgo leaf, 110 parts of kudzuvine root, 90 parts of eucommia bark, 90 parts of apocynum venetum, 65 parts of kelp and 11 parts of pepper.
  4. 4. The composition of claim 1, further comprising 1-20 parts of an adjuvant.
  5. 5. The composition according to claim 4, wherein the auxiliary material comprises one or more of sugar alcohol, sucrose, corn starch and povidone K30.
  6. 6. The composition of claim 1, wherein the dosage form of the composition comprises one of a capsule, a tablet, a powder, and a granule.
  7. 7. A method for preparing the composition with the effects of reducing blood pressure, protecting liver and dispelling effects of alcohol according to any one of claims 1 to 6, which is characterized by comprising the following steps: (1) Removing impurities from folium Ginkgo, radix Puerariae, eucommiae cortex, herba Apocyni Veneti, thallus laminariae, and fructus Piperis, and pulverizing to 20-40 mesh respectively; (2) Weighing crushed ginkgo leaves, kudzuvine roots, eucommia ulmoides and peppers according to a formula, adding the ginkgo leaves, the kudzuvine roots, the eucommia ulmoides and the peppers into an ethanol solution for reflux extraction, filtering, discarding filter residues, combining the extracting solutions, and concentrating to a relative density of 1.08-1.16 to obtain an extracting solution 1; (3) Weighing crushed apocynum venetum and kelp according to a formula, adding water for boiling extraction, filtering, discarding filter residues, combining the extracting solutions, and concentrating to a relative density of 1.08-1.16 to obtain an extracting solution 2; (4) Placing the extract 1 and the extract 2 in a mixing tank, stirring uniformly, placing the mixture and auxiliary materials in a boiling dryer, drying until the water content is less than or equal to 3%, cooling, and sieving to obtain the composition.
  8. 8. The application of the composition with the effects of reducing blood pressure, protecting liver and dispelling alcohol in preparing health-care food for reducing blood pressure, dispelling alcohol and protecting liver according to any one of claims 1-6.

Description

A composition with blood pressure lowering, liver protecting and anti-hangover effects Technical Field The invention belongs to the technical field of traditional Chinese medicine products, and particularly relates to a composition with the effects of reducing blood pressure, protecting liver and dispelling effects of alcohol. Background In the prior scientific and technical researches and practical application, traditional Chinese medicines such as ginkgo leaves, kudzuvine roots, eucommia barks and apocynum venetum have been widely proved to have the effects of reducing blood pressure, dispelling effects and protecting liver, the core efficacy components of the traditional Chinese medicines are total flavonoids and puerarin respectively, and although the components have remarkable pharmacological effects, the traditional Chinese medicines have inherent defects in practical application, such as poor water solubility of the total flavonoids and puerarin, low permeability, difficulty in penetrating through biological membranes to enter blood circulation and directly influence the absorption efficiency of the traditional Chinese medicines in vivo, and in addition, the two components show instability in gastrointestinal tract environments and are easy to be metabolized and degraded, so that the bioavailability of the traditional Chinese medicines is low, and the full play of the efficacy of the traditional Chinese medicines is finally limited. Most of the products related to the traditional Chinese medicines in the market at present stay on the level of single component extracts, or only ginkgo leaves, kudzuvine roots and eucommia ulmoides are simply compounded and combined. However, such products do not offer an effective solution to the problems of bioavailability of the core ingredients described above. Meanwhile, auxiliary components capable of synergistic effect are not introduced into the products, so that the overall effect is further improved. Therefore, the actual effect of such products is often limited to the effect of a single ingredient or simply superimposed effects, and it is difficult to achieve a synergistic effect between multiple ingredients. The limitation makes the prior product not fully meet the requirements of the crowd with high blood pressure, alcohol effect dispelling and liver protecting on efficient health management, and the prior art still has a great improvement space. Disclosure of Invention The invention aims to solve the technical problem of providing a composition with the effects of reducing blood pressure, protecting liver and dispelling effects of alcohol, and the stomach passing rate of total flavonoids and puerarin can be obviously improved by introducing kelp and pepper as protecting and synergistic agents, so that the effects of reducing blood pressure, dispelling effects of alcohol and protecting liver of ginkgo leaves, kudzuvine root, eucommia bark and apocynum venetum are enhanced. The invention provides a composition with the effects of reducing blood pressure, protecting liver and dispelling effects of alcohol, which comprises the following raw materials, by weight, 70-150 parts of ginkgo leaf, 70-150 parts of kudzuvine root, 60-120 parts of eucommia ulmoides, 60-120 parts of apocynum venetum, 40-90 parts of kelp and 7-15 parts of pepper. More preferably, the wine comprises the following raw materials, by weight, 90-130 parts of ginkgo leaf, 90-130 parts of kudzuvine root, 75-105 parts of eucommia ulmoides, 75-105 parts of apocynum venetum, 53-78 parts of kelp and 9-13 parts of pepper. Most preferably, the traditional Chinese medicine composition comprises the following raw materials, by weight, 110 parts of ginkgo leaf, 110 parts of kudzuvine root, 90 parts of eucommia ulmoides, 90 parts of apocynum venetum, 65 parts of kelp and 11 parts of pepper. Further comprises 1-20g of auxiliary materials. Preferably, the auxiliary materials comprise one or more of sugar alcohol, sucrose, corn starch and povidone K30. Further, the formulation of the composition comprises one of capsules, tablets, powder and granules. The invention also provides a preparation method of the composition with the effects of reducing blood pressure, protecting liver and dispelling effects of alcohol, which comprises the following steps: (1) Removing impurities from folium Ginkgo, radix Puerariae, eucommiae cortex, herba Apocyni Veneti, thallus laminariae, and fructus Piperis, and pulverizing to 20-40 mesh respectively; (2) Weighing crushed ginkgo leaves, kudzuvine roots, eucommia ulmoides and peppers according to a formula, adding the ginkgo leaves, the kudzuvine roots, the eucommia ulmoides and the peppers into an ethanol solution for reflux extraction, filtering, discarding filter residues, combining the extracting solutions, and concentrating to a relative density of 1.08-1.16 to obtain an extracting solution 1; (3) Weighing crushed apocynum venetum and kelp according to a formula, adding wat