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CN-121971514-A - Pharmaceutical composition for treating eczema, application thereof and external preparation based on pharmaceutical composition

CN121971514ACN 121971514 ACN121971514 ACN 121971514ACN-121971514-A

Abstract

The invention discloses a pharmaceutical composition for treating eczema, application thereof and an external preparation based on the pharmaceutical composition, and belongs to the technical field of traditional Chinese medicines. The invention takes dandelion, polygonum aviculare and polygonum as raw materials, adopts water and ethanol with different concentrations as extraction solvents, takes the extracted extract as the active ingredients of external preparations such as lotion, cream, gel, cream and the like, can play a role in relieving itching rapidly and effectively through the combination of the active ingredients, is suitable for treating eczema, obviously improves the scab, red swelling and itching symptoms of eczema, and is not easy to repeatedly attack. And the preparation process is simple, and is suitable for industrial production.

Inventors

  • WANG XIAOBO
  • LI XIAOJIE
  • HE JUNTING
  • SU JIANYING
  • CUI LEI
  • LI JUN
  • NI YAHUI

Assignees

  • 陕西医药控股医药研究院有限公司

Dates

Publication Date
20260505
Application Date
20251114

Claims (10)

  1. 1. The pharmaceutical composition for treating eczema is characterized by comprising, by mass, 1-20 parts of dandelion, 1-15 parts of polygonum aviculare and 1-10 parts of hot Liaoao.
  2. 2. The pharmaceutical composition for treating eczema according to claim 1, which is characterized by comprising, by mass, 5-15 parts of dandelion, 5-10 parts of polygonum aviculare and 2-8 parts of peppery Liao.
  3. 3. The pharmaceutical composition for treating eczema according to claim 1, which is characterized by comprising, by mass, 8-12 parts of dandelion, 6-8 parts of polygonum aviculare and 3-5 parts of peppery Liao.
  4. 4. Use of a pharmaceutical composition for treating eczema according to any one of claims 1-3 for the preparation of an external preparation for treating eczema.
  5. 5. The use according to claim 4, wherein the external preparation comprises lotions, creams, gels and creams.
  6. 6. An external preparation for treating eczema, which is characterized by being prepared by taking the pharmaceutical composition for treating eczema as an active ingredient according to any one of claims 1-3, and adding or not adding pharmaceutically acceptable auxiliary materials.
  7. 7. The external preparation for treating eczema according to claim 6, wherein when the external preparation is a lotion, the external preparation comprises, by mass, 1-20 parts of dandelion, 1-15 parts of polygonum aviculare, 1-10 parts of hot Liao and 0-8 parts of preservative.
  8. 8. The external preparation for treating eczema according to claim 6, wherein when the external preparation is a cream, the external preparation comprises, by mass, 1-20 parts of dandelion, 1-15 parts of polygonum aviculare, 1-10 parts of polygonum, 20-60 parts of mineral esters, 10-30 parts of glycerol, 8-15 parts of liquid paraffin, 10-40 parts of stearyl alcohol, 10-50 parts of an emulsifier and 1-8 parts of a preservative.
  9. 9. The external preparation for treating eczema according to claim 6, wherein when the external preparation is a gel, the external preparation comprises, by mass, 1-20 parts of dandelion, 1-15 parts of polygonum aviculare, 1-10 parts of polygonum, 10-30 parts of glycerol, 10-80 parts of gel matrix, 2-11 parts of preservative and 1-8 parts of triethanolamine.
  10. 10. The external preparation for treating eczema according to claim 6, wherein when the external preparation is a cream, the external preparation comprises, by mass, 1-20 parts of dandelion, 1-15 parts of polygonum aviculare, 1-10 parts of polygonum, 10-40 parts of mineral esters, 10-20 parts of glycerol, 1-20 parts of liquid paraffin, 1-30 parts of stearyl alcohol, 4-40 parts of an emulsifying agent, 2-8 parts of triethanolamine and 1-8 parts of a preservative.

Description

Pharmaceutical composition for treating eczema, application thereof and external preparation based on pharmaceutical composition Technical Field The invention belongs to the technical field of traditional Chinese medicine compositions, and in particular relates to a pharmaceutical composition for treating eczema and an external preparation. Background Eczema is an inflammatory skin disease mainly comprising itch, skin damage and cumulus herpes, which is caused by the comprehensive influence of endogenous factors (hereditary, endocrine and chronic diseases) and exogenous factors (environmental, chemical substance stimulation and physical factors) on human bodies, has a relatively complex pathogenesis, and is not yet thoroughly studied clinically. According to global epidemic investigation data, the number of eczema patients accounts for more than 10% of the total number of people worldwide, has higher morbidity and has an annual rising trend. Because of the characteristics of severe itching, skin polymorphic damage, repeated disease attacks, disunion in the past, and the like, the life quality and physical and mental health of patients are seriously affected. How to effectively treat eczema is always one of the problems which need to be clinically solved. At present, the external medicine is usually combined with oral medicine for clinical eczema treatment. The clinical Western medicine adopts oral antihistamine medicine, such as chlorphenamine, loratadine, cetirizine, olopatadine hydrochloride, terfenadine, etc., and the topical medicine adopts glucocorticoid, such as prednisone, compound dexamethasone acetate cream, 3% boric acid solution lotion, etc. Although the western medicines have obvious clinical effects in a short period, the western medicines are easy to relapse after being taken off, and can cause a plurality of adverse reactions such as skin atrophy, pigmentation, addiction and the like after being repeatedly used for a long time and a large area. The traditional Chinese medicine is usually taken orally, and the traditional Chinese medicine comprises dryness-moistening itching-relieving capsules, wind-dispelling itching-relieving particles, cicada itching-relieving capsules, tinea and summer tower heat tablets, psoriasis capsules, compound glycyrrhizin tablets and the like, and the external medicine comprises dehumidifying itching-relieving cream, paeonol ointment, centipede and calamine lotion, local irritation symptoms such as itching, skin injury aggravation and stinging easily occur when the external medicine is used, the centipede ointment is used for a long time, the symptoms of skin stratum corneum thickening can be accompanied, the paeonol ointment can cause local skin anaphylactic reaction, and the local skin dryness and desquamation can be caused when the paeonol ointment is used for a long time or the external medicine is used excessively. Therefore, external medicines with reliable curative effect, less adverse reaction and difficult recurrence are urgently needed clinically for eczema. Disclosure of Invention In order to overcome the defects of the prior art, the invention aims to provide a pharmaceutical composition and an external preparation for treating eczema, so as to solve the technical problems of easy recurrence and large adverse drug reaction in the prior art. In order to achieve the above purpose, the invention is realized by adopting the following technical scheme: The application discloses a pharmaceutical composition for treating eczema, which comprises, by mass, 1-20 parts of dandelion, 1-15 parts of polygonum aviculare and 1-10 parts of hot Liao. The dandelion is a dried whole herb of a compositae plant, the adding amount of the dandelion is 1-20 parts, and the dandelion is realized in the form of dandelion powder or dandelion water extract in the specific application process, and the dandelion is mainly used for providing the effects of clearing heat and detoxicating to inhibit skin inflammatory reaction. The addition of 1-20 parts ensures that the active ingredient reaches an effective anti-inflammatory concentration locally on the skin, thus inhibiting inflammatory reactions and alleviating itching symptoms, while avoiding the risk of skin irritation caused by excessive doses. The polygonum aviculare is a dry stem and leaf of a Polygonaceae plant, the addition amount of which is 1-15 parts, and in practical application, the polygonum aviculare is realized in a dry product or an alcohol extract form of polygonum aviculare, and the polygonum aviculare is mainly used for exerting the efficacy of promoting diuresis and relieving itching so as to improve eczema symptoms. The amount of 1-15 parts optimizes the effect of removing damp heat in vivo and prevents skin dryness or horny layer abnormality caused by excessive use. The spicy Liao is a Chinese herbal medicine with the characteristics of dispelling wind and removing toxicity, the addition amount of the spicy Liao