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CN-121971523-A - Radix puerariae laminaria ointment and preparation method thereof

CN121971523ACN 121971523 ACN121971523 ACN 121971523ACN-121971523-A

Abstract

The invention provides kudzuvine root laminaria paste and a preparation method thereof, and relates to the technical field of medicine and food processing. The kudzuvine root laminaria ointment comprises, by weight, 20-60 parts of kudzuvine root, 15-40 parts of laminaria japonica, 5-15 parts of dried orange peel, 5-20 parts of poria cocos, 3-10 parts of liquorice, 10-30 parts of rock candy and 5-20 parts of honey. Compared with the traditional high-temperature water decoction method, the extraction rate of puerarin and total flavone is improved by more than 30%, the extraction rate of brown algae polysaccharide is improved by more than 50%, the utilization rate of raw materials is greatly improved, the production cost is reduced, the extraction rate of active ingredients is greatly improved, meanwhile, the paste stability is excellent, and macromolecular easily-precipitated impurities such as starch, tannins, gum and the like in the paste are precisely removed through an alcohol precipitation refining process, so that the problems of layering and precipitation of the paste after long-term storage are radically solved.

Inventors

  • ZHAO XUELI

Assignees

  • 赵雪利

Dates

Publication Date
20260505
Application Date
20260325

Claims (8)

  1. 1. The kudzuvine root laminaria ointment comprises the following raw materials of, by weight, 20-60 parts of kudzuvine root, 15-40 parts of laminaria japonica, 5-15 parts of dried orange peel, 5-20 parts of poria cocos, 3-10 parts of liquorice, 10-30 parts of rock candy and 5-20 parts of honey.
  2. 2. A preparation method of kudzuvine root laminaria paste is characterized by comprising the following steps: Step 1, raw material pretreatment; cleaning radix Puerariae, thallus laminariae, pericarpium Citri Tangerinae, poria, and Glycyrrhrizae radix respectively, removing impurities, soaking thallus laminariae in clear water, desalting, oven drying all raw materials at low temperature, pulverizing, and sieving to obtain mixed raw material powder; Step 2, compound enzymolysis pretreatment; Adding mixed raw material powder into an extraction tank, adding purified water according to the ratio of feed liquid, adding complex enzyme, regulating the pH value of a system, carrying out constant-temperature enzymolysis, and then heating to inactivate enzyme to obtain enzymolysis feed liquid; step 3, water decoction extraction and refining; Extracting the enzymolysis liquid twice with water, mixing the two filtrates, centrifuging, collecting supernatant, concentrating under reduced pressure to obtain fluid extract, adding ethanol into the fluid extract, precipitating with ethanol, refrigerating, standing, filtering, and recovering ethanol from the filtrate to obtain refined concentrated solution; Step 4, collecting paste at low temperature; Concentrating the refined concentrated solution at low temperature under reduced pressure, adding crystal sugar, stirring to dissolve completely, concentrating to specific relative density, cooling, adding Mel, and stirring to obtain semi-finished paste; step 5, sterilizing and filling; And (3) carrying out sectional sterilization treatment on the paste semi-finished product, then carrying out aseptic filling, sealing, secondary sterilization, cooling and checking to be qualified to obtain the finished product of kudzuvine root laminaria paste.
  3. 3. The preparation method of the pueraria kelp paste according to claim 2, wherein in the pretreatment of the raw materials in the step 1, the kelp is desalted by soaking in normal-temperature clean water for 2-4 hours and changing water for 2-3 times, the low-temperature drying temperature is 40-50 ℃, and the kelp paste is crushed and then is sieved by a 40-60-mesh sieve.
  4. 4. The preparation method of the pueraria kelp paste according to claim 2 is characterized in that in the step 2 of compound enzymolysis pretreatment, the feed liquid ratio is1 (8-15), the compound enzyme is formed by compounding cellulase, pectase and neutral protease according to the mass ratio of 2:1:1, the addition amount of the compound enzyme is 0.2% -0.8% of the total weight of mixed raw material powder, the enzymolysis condition is pH value of 4.5-6.0, the enzymolysis temperature is 45-55 ℃, the enzymolysis time is1-3 h, and the enzyme deactivation condition is 90-95 ℃ and the heat preservation is carried out for 10-15min.
  5. 5. The method for preparing the pueraria kelp paste according to claim 2, wherein in the step 3, water-decocting extraction and refining are carried out for two times, specifically, the first time of extraction is carried out, purified water is added to a feed-liquid ratio of 1 (8-15), heating is carried out for 1-2h, the first filtrate is obtained by filtering, the filter residue is added with the purified water to the feed-liquid ratio of 1 (6-10), heating is carried out for 0.5-1.5h, the second filtrate is obtained by filtering, the centrifugation condition is 4000r/min for 10-15min, and the relative density of the clear paste is 1.05-1.10.
  6. 6. The method according to claim 2, wherein in the step 3 of water decoction and refining, 95% edible ethanol by volume is added into the extract by alcohol precipitation treatment, and the extract is stirred uniformly until the alcohol content of the system reaches 50% -70%, and the extract is refrigerated and kept stand for 12-24 hours at 0-4 ℃, so that the relative density of the refined concentrate is 1.10-1.15.
  7. 7. The method for preparing kudzuvine root laminaria paste according to claim 2, wherein in the step 4, the condition of low-temperature decompression concentration is that the temperature is 50-65 ℃, the vacuum degree is-0.06 to-0.08 MPa, honey is added when the concentration is carried out to the relative density of 1.20-1.25, and the system temperature is less than or equal to 60 ℃ when the honey is added.
  8. 8. The method for preparing the pueraria kelp paste according to claim 2, wherein the step 5 is characterized in that the step of sterilizing and filling is carried out in a sectional manner, wherein the first pasteurization condition is 75-85 ℃ and the temperature is kept for 15-30min, and the second sterilization condition is 80-85 ℃ and the temperature is kept for 10-20min.

Description

Radix puerariae laminaria ointment and preparation method thereof Technical Field The invention relates to the technical field of medicine and food processing, in particular to kudzuvine root laminaria paste and a preparation method thereof. Background The pueraria is the dried root of the kudzu vine of the leguminous plant, is a medicine and food homologous raw material published by the Committee of China Wei Jian, the core active ingredients of the pueraria and isoflavone compounds are puerarin, the traditional Chinese medicine considers that the pueraria has the effects of relieving muscle and allaying fever, promoting the production of body fluid and quenching thirst, clearing and activating the channels and collaterals, and invigorating yang and relieving diarrhea, modern pharmacological researches prove that the puerarin can improve microcirculation, regulate blood sugar and blood fat and protect cardiovascular, is a natural raw material with great development value, the kelp is a dry leaf body of kelp of laminariaceae or kelp of pterophyceae, is a medicinal and edible raw material, is rich in fucoidan, mannitol, iodine element, dietary fiber and various mineral substances, has the effects of softening hardness to dissipate stagnation, dissolving phlegm and promoting diuresis according to the traditional Chinese medicine records, and modern researches show that fucoidan can regulate lipid metabolism, improve intestinal flora, resist oxidation, and iodine element can maintain normal physiological functions of thyroid and has wide application prospect. At present, the development and application of kudzuvine root and kelp are mainly focused on primary processing of single raw materials, such as kudzuvine root powder, kelp leisure food and the like, and the compound deep processing products of the kudzuvine root and kelp are fewer, especially the paste formula products with scientific formula and advanced process are more scarce, and the existing related paste formula products have the following technical defects: the formula is unreasonable in compatibility, most of raw materials are simply overlapped, the principle of monarch, minister, assistant and guide in traditional Chinese medicine is not followed, the efficacy cooperativity is poor, the taste is not compatible, and the problems of bitter kudzuvine root and heavy kelp fishy taste exist; The second disadvantage is that the extraction process is backward, the traditional high-temperature water decoction method is mostly adopted, the plant cell walls are difficult to fully crush, the extraction rate of core effective components such as puerarin, total flavone, fucoidin and the like is low, and the raw material utilization rate is poor; And thirdly, the paste has insufficient stability, is not subjected to refining impurity removal treatment, has high content of macromolecular impurities such as starch, tannins and the like, is easy to generate layering and precipitation phenomena after long-term storage, needs to be additionally added with a thickening agent and a preservative, and does not accord with the trend of healthy consumption. Therefore, the invention provides the kudzuvine root laminaria ointment which has scientific formula, high extraction rate of active ingredients, good stability of ointment, no additional additive, good taste and suitability for industrial production, and the preparation method thereof, and has important market value and application significance. Disclosure of Invention Aiming at the defects of the prior art, the invention provides the kudzuvine root laminaria ointment and the preparation method thereof, and the formula of the ointment follows the compatibility theory of traditional Chinese medicine, and the preparation process can greatly improve the extraction rate of active ingredients, ensure the stability of the ointment, reduce the loss of active ingredients, has no preservative or thickening agent, has excellent taste and is suitable for long-term administration and industrial production. In order to achieve the above purpose, the invention is realized by the following technical scheme: The kudzuvine root laminaria ointment comprises, by weight, 20-60 parts of kudzuvine root, 15-40 parts of laminaria japonica, 5-15 parts of dried orange peel, 5-20 parts of poria cocos, 3-10 parts of liquorice, 10-30 parts of rock candy and 5-20 parts of honey. A preparation method of kudzuvine root laminaria paste is characterized by comprising the following steps: Step 1, raw material pretreatment; cleaning radix Puerariae, thallus laminariae, pericarpium Citri Tangerinae, poria, and Glycyrrhrizae radix respectively, removing impurities, soaking thallus laminariae in clear water, desalting, oven drying all raw materials at low temperature, pulverizing, and sieving to obtain mixed raw material powder; Step 2, compound enzymolysis pretreatment; Adding mixed raw material powder into an extraction tank, adding purified water accor