CN-121971524-A - External traditional Chinese medicine composition for promoting intestinal function recovery after thoracic surgery and preparation method and application thereof

CN121971524ACN 121971524 ACN121971524 ACN 121971524ACN-121971524-A

Abstract

The invention relates to the technical field of traditional Chinese medicines, and provides an external traditional Chinese medicine composition for promoting intestinal function recovery after thoracic surgery, which comprises the following components, by weight, 3-40 parts of rheum officinale, 2-36 parts of magnolia officinalis, 1-25 parts of immature bitter orange, 1-25 parts of mirabilite, 1-25 parts of radish seeds, 1-25 parts of fructus cannabis and 1-10 parts of fructus evodiae. The traditional Chinese medicine composition disclosed by the invention is reasonable in compatibility from comprehensive conditioning angles such as clearing viscera and heat, promoting qi circulation and relieving stagnation, relaxing bowel and the like, so that the composition can promote postoperative evacuation and defecation, is favorable for promoting intestinal function recovery, avoids poor nutrition conditions caused by gastrointestinal tract and diaphragm upward lifting caused by intestinal cavity inflation, limits respiratory activity, strengthens pulmonary ventilation disorder, is unfavorable for the harm of pulmonary recovery, has the obvious effects of promoting postoperative evacuation and defecation, improving abdominal distention and promoting digestion, is simple in formula, is derived from classical prescription improvement, and is more suitable for postoperative weak patients.

Inventors

WANG LISHA
WANG FANG
ZHANG GUANGJIAN
LIU BOHAO
QIAO JIN
LIU YUGANG
GAO RUI
GENG QIANQIAN
BAI JIE
WANG QIAN

Assignees

西安交通大学医学院第一附属医院

Dates

Publication Date: 20260505
Application Date: 20260205

Claims (10)

1. A traditional Chinese medicine composition for external use for promoting intestinal function recovery after chest surgery is characterized by comprising the following components in parts by weight: 3-40 parts of rheum officinale; 2-36 parts of magnolia officinalis; 1-25 parts of immature bitter orange; 1-25 parts of mirabilite; 1-25 parts of radish seeds; 1-25 parts of fructus cannabis; 1-10 parts of fructus evodiae.
2. The external traditional Chinese medicine composition for promoting intestinal function recovery after thoracic surgery according to claim 1, further comprising an auxiliary material, wherein the auxiliary material is at least one of a filler, a lubricant, a dispersing agent, a wetting agent, an adhesive, an antioxidant or a preservative.
3. The external traditional Chinese medicine composition for promoting intestinal function recovery after thoracic surgery according to claim 1, further comprising a filling auxiliary material, wherein the filling auxiliary material is any one of an oil type, a starch type, a sugar type, a cellulose type auxiliary material or a filling auxiliary material.
4. The external-use traditional Chinese medicine composition for promoting intestinal function recovery after thoracic surgery according to claim 1, wherein the dosage form of the traditional Chinese medicine composition is any one of powder, granule, decoction, capsule, ointment or suppository.
5. A method for preparing a topical Chinese medicinal composition for promoting intestinal function recovery after thoracic surgery, using the topical Chinese medicinal composition for promoting intestinal function recovery after thoracic surgery as claimed in any one of claims 1 to 4, comprising the steps of: Crushing the prescription medicines to obtain crushed materials; step two, sieving the crushed material obtained in the step one with a 80-120 mesh sieve to obtain powder; and step three, standby.
6. The method for preparing a topical Chinese medicinal composition for promoting intestinal function recovery after thoracic surgery according to claim 5, wherein the powder obtained in the second step is boiled in water, filtered, and concentrated to obtain a Chinese medicinal composition thick paste, and the preparation method of the Chinese medicinal composition thick paste comprises the following steps of: Pouring the powder obtained in the step two into an extraction tank, adding water with the weight being 8-10 times of the total weight of the powder, and soaking for 30-60min; heating, boiling and extracting the soaked powder for 2 hours, filtering, and taking supernatant for later use; thirdly, adding water with the weight being 8-10 times that of the powder after extraction and filtration into the powder again, heating and boiling for 2 hours, filtering, and taking supernatant; transferring the liquid medicine obtained in the second step and the third step into an evaporation tank, and heating and concentrating until the specific gravity is about 1.05-1.20g/cm < 3 >; step five, filtering the concentrated solution in the step four to remove impurities, filtering the concentrated solution through a ceramic membrane, and collecting filtrate; and step six, concentrating the filtrate in the step five to obtain thick paste with the specific gravity of 1.25-1.35g/cm < 3 >, thereby obtaining the thick paste of the traditional Chinese medicine composition.
7. The method for preparing the external traditional Chinese medicine composition for promoting intestinal function recovery after thoracic surgery according to claim 6, wherein the step of preparing the thick paste of the traditional Chinese medicine composition into a dried product after the thick paste of the traditional Chinese medicine composition is obtained in the step six is as follows: Step one, detecting the solid content in the thick paste of the traditional Chinese medicine composition obtained in the step six; Step two, taking a certain weight of Chinese medicinal composition thick paste, and mixing according to the solid content of the thick paste and filling auxiliary materials with the same weight; step three, putting the mixture in the step two into a vacuum drying oven at 60 ℃ for drying; And step four, crushing the dried substance in the step three, and sieving the crushed substance with a 100-mesh sieve to obtain the dried substance of the traditional Chinese medicine composition.
8. The method for preparing the external traditional Chinese medicine composition for promoting intestinal function recovery after thoracic surgery according to claim 6, wherein after the thick paste of the traditional Chinese medicine composition is obtained in the step six, the method for preparing the thick paste of the traditional Chinese medicine composition into a suppository of the traditional Chinese medicine composition is as follows: firstly, taking a predetermined part of Chinese medicinal composition thick paste, and adding a proper amount of oil agent to dilute to a predetermined dosage; Step two, through the process of mixing the medicine with the matrix and injection molding, pouring the molten mixture into a model coated with lubricant until the molten mixture slightly overflows from a die opening; and thirdly, cooling and completely solidifying, cutting off the overflow part by a knife, opening a mould and taking out the suppository to obtain the traditional Chinese medicine composition suppository.
9. The method for preparing a topical Chinese medicinal composition for promoting intestinal function recovery after thoracic surgery according to claim 8, wherein the oil is any one of sesame oil, castor oil, glycerin or paraffin.
10. Use of a Chinese medicinal composition according to any one of claims 1-4 in the preparation of a medicament for treating abdominal distension and constipation or improving intestinal function after thoracic surgery.

Description

External traditional Chinese medicine composition for promoting intestinal function recovery after thoracic surgery and preparation method and application thereof Technical Field The invention relates to the technical field of traditional Chinese medicines, in particular to an external traditional Chinese medicine composition for promoting intestinal function recovery after thoracic surgery, and a preparation method and application thereof. Background The decline of intestinal function after thoracic surgery is a ubiquitous phenomenon, mainly caused by multiple causes such as nerve and drug effects, respiration and mechanical factors. The combined use of opioid analgesic and anticholinergic agent can further inhibit gastrointestinal peristalsis and secretion function, and remarkably delay postoperative intestinal function recovery. Meanwhile, the operation itself affects the ventilation function, and the oxygen inhalation in the perioperative period and the movement limitation of the bedridden patient lead to the accumulation of gas in the gastrointestinal tract, thereby causing abdominal distention and constipation. In addition, the normal contractile function of intestinal smooth muscle is also affected by local inflammatory reactions, electrolyte disorders, etc. caused by surgical trauma. The postoperative intestinal dysfunction has a serious impact on prognosis. Intestinal cavity flatulence lifts diaphragm, limits respiratory activity, strengthens pulmonary ventilation disorder, slows down intestinal peristalsis to cause qi accumulation and defecation, increases intestinal bacteria shift risk, and induces or aggravates complications such as atelectasis, pulmonary infection and the like. Loss of appetite and impaired digestive function directly affect nutrient intake, and impaired intestinal function as an important immune organ can delay recovery of the body, prolong hospitalization time, and even induce multiple organ dysfunction in severe cases. Traditional Chinese medicine has unique advantages in promoting postoperative intestinal function recovery. According to the theory that the lung and the large intestine are both exterior and interior, postoperative bowel dysfunction belongs to the category of qi obstruction of the viscera, qi stagnation and blood stasis, and the traditional Chinese medicine can promote gastrointestinal peristalsis, shorten the time of evacuation and defecation and effectively relieve symptoms such as abdominal distension and pain through the treatment methods of promoting qi circulation and blood circulation, removing internal obstruction and purgation. Clinical researches show that the traditional Chinese medicine combination therapy based on the conventional western medicine therapy can obviously shorten the postoperative borborygmus restoration time, anus exhaust time and defecation time, and has the characteristics of good safety and good curative effect compared with western medicine promotion medicines. The external treatment of traditional Chinese medicine has more advantages in postoperative intestinal function recovery. The external treatment method can absorb the medicine through skin and mucous membrane, completely avoids the stimulation of oral medicine to gastrointestinal tract, and is especially suitable for patients with postoperative gastrointestinal dysfunction, nausea and vomiting. The external treatment method has rapid onset of drug action, can directly act on focus, and can rapidly relieve symptoms such as abdominal distention and abdominal pain. Meanwhile, the external treatment method belongs to noninvasive or minimally invasive treatment, avoids the burden caused by metabolism of the medicament through the liver and the kidney, and has small side effect and high patient acceptance. The external treatment method of the traditional Chinese medicine is simple and convenient to operate, the patient can operate by himself or with the assistance of nurses, and the external treatment method of the traditional Chinese medicine is particularly suitable for postoperative bedridden patients, and has remarkable effect in promoting postoperative gastrointestinal function recovery. The oral defecation promoting western medicines have the defects that the osmotic cathartic can lead a large amount of water to stay in intestinal tracts, electrolyte such as potassium, sodium and the like can be lost along with feces when the oral defecation promoting western medicines are used, symptoms such as hypodynamia, arrhythmia and the like can occur, and hypokalemia can be induced when the oral defecation promoting western medicines are serious. The long-term use of the laxative can inhibit the autonomous peristaltic function of the intestinal tract, so that the bowel reflex is weakened, and a malignant cycle of 'no drug is used and the bowel is not discharged' is formed. Patients are easy to suffer from intractable constipation and even intestinal blackness after stopping takin