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CN-121971525-A - Traditional Chinese medicine composition with acid-inhibiting and esophagus-protecting effects and preparation method thereof

CN121971525ACN 121971525 ACN121971525 ACN 121971525ACN-121971525-A

Abstract

The invention relates to the technical field of traditional Chinese medicine preparations, and provides a traditional Chinese medicine composition with an acid inhibiting and esophagus protecting effect, which comprises, by weight, 6-12 parts of coptis chinensis, 2-6 parts of fructus evodiae, 15-25 parts of cuttlebone, 10-20 parts of inula flower, 15-25 parts of Haematitum, 12-20 parts of white paeony root, 12-20 parts of dried orange peel, 8-15 parts of dried orange peel, 6-10 parts of liquorice. The traditional Chinese medicine composition realizes the comprehensive effects of acid inhibition, mucous membrane protection and power regulation by the synergistic compatibility of a plurality of raw material medicines, is mild in relieving relevant symptoms, has no adverse reaction and is suitable for long-term conditioning. The standardized preparation process improves the extraction rate of the active ingredients, ensures the stable and consistent curative effect of the product, solves the problems of rough process and unstable quality of the traditional Chinese medicine preparation, adapts to different crowds in various dosage forms, has convenient administration, high compliance, easily available raw materials and controllable cost, and is suitable for industrial production and clinical popularization.

Inventors

  • QIAO WEIFENG

Assignees

  • 新野纳安生物医药科技有限公司

Dates

Publication Date
20260505
Application Date
20260330

Claims (10)

  1. 1. The traditional Chinese medicine composition with the effects of inhibiting acid and protecting esophagus is characterized by comprising the following raw material medicines in parts by weight: 6-12 parts of coptis chinensis; 2-6 parts of fructus evodiae; 15-25 parts of cuttlebone; 10-20 parts of inula flower; 15-25 parts of Haematitum; white peony root, 12-20 parts; 8-15 parts of dried orange peel; 6-10 parts of liquorice.
  2. 2. The traditional Chinese medicine composition with the effects of inhibiting acid and protecting esophagus according to claim 1, wherein the preferred weight ratio of the raw materials is as follows: 9 parts of coptis chinensis, 4 parts of evodia rutaecarpa, 20 parts of cuttlebone, 15 parts of inula flower, 20 parts of ruddle, 15 parts of white paeony root, 12 parts of dried orange peel and 8 parts of liquorice.
  3. 3. The Chinese medicinal composition with the effect of inhibiting acid and protecting esophagus according to claim 1, wherein the coptis chinensis is dried rhizome of coptis chinensis, coptis deltoidea or coptis chinensis of ranunculaceae, impurities are removed through cleaning, and the evodia rutaecarpa is dried near-ripe fruits of evodia rutaecarpa of rutaceae, tiger or evodia rutaecarpa is used after salt roasting.
  4. 4. The traditional Chinese medicine composition with the acid inhibiting and esophagus protecting effects according to claim 1, wherein cuttlebone is dried inner shell of cuttlefish or cuttlefish of cuttlefish animals, crushed and sieved by a 80-mesh sieve, and ruddle is oxide mineral hematite ore, calcined, quenched, crushed and sieved by a 100-mesh sieve.
  5. 5. The Chinese medicinal composition with acid inhibiting and esophagus protecting effects according to claim 1, wherein the inula flower is a dried head-like inflorescence of inula flower or Inula euryales flower of Compositae, impurities such as stems and leaves are removed, and the white peony root is a dried root of Paeonia lactiflora of Ranunculaceae, and is processed by wine-processing.
  6. 6. The Chinese medicinal composition with the effects of inhibiting acid and protecting esophagus according to claim 1, wherein the dried orange peel is dried mature pericarp of Rutaceae plant orange and cultivated variety thereof, the storage life is more than or equal to 1 year, and the licorice is dried root and rhizome of Leguminosae plant licorice, glycyrrhiza distenosa or Glycyrrhiza glabra, and the dried pericarp is processed by honey.
  7. 7. A method for preparing a traditional Chinese medicine composition with acid-inhibiting and esophagus-protecting effects, which is characterized by comprising the following steps of: Weighing the raw materials according to the weight parts, respectively cleaning to remove impurities, mildewed parts and non-medicinal parts, wherein cuttlebone and Haematitum are crushed and sieved, the stem and leaf of the inula flower are removed, and the rest raw materials are cleaned and drained; Adding all the pretreated crude drugs into an extraction tank, adding purified water which is 8-12 times of the total weight of the crude drugs, soaking for 30-60 minutes, heating to boil, keeping the micro-boiling state, decocting for 1-2 hours, filtering, and collecting a first filtrate; combining the two filtrates, concentrating to obtain fluid extract with a relative density of 1.20-1.30 by adopting a reduced pressure concentration mode; Step four, spray drying or vacuum drying the clear paste, crushing the clear paste after drying, and sieving the crushed clear paste with a 100-mesh sieve to obtain dry paste powder; And fifthly, adding pharmaceutically acceptable auxiliary materials into the dry paste powder, uniformly mixing, and preparing capsules, tablets or granules by adopting a conventional preparation process.
  8. 8. The method for preparing the traditional Chinese medicine composition with the acid inhibiting and esophagus protecting effects according to claim 7, wherein a stirring device is adopted in the decoction process in the second step, the stirring speed is 30-50 r/min, the raw material medicine is ensured to be fully contacted with water, and a 120-mesh filter screen is adopted for filtering, so that dregs and insoluble impurities are removed.
  9. 9. The method for preparing a Chinese medicinal composition with acid inhibiting and esophagus protecting effects according to claim 7, wherein the temperature of the air inlet and the air outlet of the spray drying in the fourth step is monitored in real time, so that the moisture absorption or the destruction of active ingredients of the dry paste powder caused by temperature fluctuation is avoided, and the moisture content of the dry paste powder is controlled below 5.0%.
  10. 10. The preparation method of the traditional Chinese medicine composition with the acid inhibiting and esophagus protecting effects, which is characterized in that the auxiliary materials for the traditional Chinese medicine in the fifth step comprise a filler, a disintegrating agent, a binding agent and a lubricant, wherein the filler is starch or lactose when preparing capsules, the lubricant is magnesium stearate, the disintegrating agent is crospovidone when preparing tablets, the binding agent is sucrose aqueous solution when preparing granules, and the drying temperature is 60-70 ℃.

Description

Traditional Chinese medicine composition with acid-inhibiting and esophagus-protecting effects and preparation method thereof Technical Field The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a traditional Chinese medicine composition with acid-inhibiting and esophagus-protecting effects and a preparation method thereof. Background Gastroesophageal reflux disease is a clinically high-frequency digestive system disease, and takes acid regurgitation, heartburn, poststernal pain and the like as typical symptoms, and the long-term attack easily damages the mucosa of the food tube, so that the life quality of patients is seriously influenced. Along with the change of dietary structure and the acceleration of life rhythm, the incidence rate of the disease is continuously increased, and the requirements for safe and effective therapeutic drugs are urgent. The traditional Chinese medicine has the advantages of overall syndrome differentiation and both principal and secondary aspects in the digestive system disease regulation, and the development of the traditional Chinese medicine composition with the effects of inhibiting acid, protecting mucous membrane and regulating motility meets the clinical treatment requirements. At present, the clinical medicines for gastroesophageal reflux are mainly divided into western medicines and traditional Chinese medicines, wherein the western medicines mainly comprise proton pump inhibitors and H2 receptor antagonists, the core functions are to inhibit gastric acid secretion and rapidly relieve symptoms, the traditional Chinese medicines are single-effect preparations or stress acid inhibition or stress mucous membrane restoration, the traditional compatibility of part of the formulas is adopted, the pathological characteristics of gastroesophageal reflux are not optimized, and the preparation process is mainly traditional water decoction and lacks standardized control. The traditional western medicines have the problems of poor compatibility pertinence, difficulty in considering comprehensive requirements of acid suppression, mucosa protection and power regulation of a single effect, unstable content of active ingredients of part of the preparation, rough preparation process, influence on the consistency of clinical curative effect, lack of safety data for long-term conditioning and difficulty in meeting long-term medication requirements of patients. Disclosure of Invention Aiming at the defects of the prior art, the invention provides a traditional Chinese medicine composition with the effects of inhibiting acid and protecting esophagus and a preparation method thereof, which solve the problems that the traditional gastroesophageal reflux treatment medicine has obvious limitation, western medicines can inhibit acid rapidly, but can cause adverse reactions easily after long-term use, and are difficult to repair esophageal mucosa and regulate gastric motility, the traditional Chinese medicine preparation has single multiple effects, the comprehensive treatment requirement is difficult to be considered, meanwhile, the preparation process is extensive, the content of active ingredients is unstable, the curative effect consistency is poor, the safety guarantee of long-term conditioning is lacked, and the clinical treatment and long-term medication requirement of patients can not be met. The traditional Chinese medicine composition with the effects of inhibiting acid and protecting esophagus is characterized by comprising the following raw material medicines in parts by weight: 6-12 parts of coptis chinensis; 2-6 parts of fructus evodiae; 15-25 parts of cuttlebone; 10-20 parts of inula flower; 15-25 parts of Haematitum; white peony root, 12-20 parts; 8-15 parts of dried orange peel; 6-10 parts of liquorice. Preferably, the preferred weight ratio of the raw materials is as follows: 9 parts of coptis chinensis, 4 parts of evodia rutaecarpa, 20 parts of cuttlebone, 15 parts of inula flower, 20 parts of ruddle, 15 parts of white paeony root, 12 parts of dried orange peel and 8 parts of liquorice. Preferably, the Coptidis rhizoma is dried rhizome of Coptidis rhizoma, coptidis rhizoma or herba Clinopodii of Ranunculaceae, and is purified to remove impurities, and the fructus evodiae is dried near-ripe fruit of fructus evodiae of Rutaceae, gekko Swinhonis or fructus evodiae, and is processed with salt. Preferably, the cuttlebone is dried inner shell of cuttlefish or cuttlefish of cuttlefish family, and is crushed and sieved with 80 mesh sieve, and the Haematitum is oxide mineral hematite ore, and is crushed and sieved with 100 mesh sieve after calcining and quenching. Preferably, the inula flower is dried head-like inflorescence of inula flower or Inula europaea of Compositae, the impurities such as stems and leaves are removed, and the white peony root is dried root of Paeonia lactiflora of Ranunculaceae, and is processed by wine-pr