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CN-121971528-A - Sustained-release stick for repairing mammary glands of dairy cows in early period of milk drying and preparation method thereof

CN121971528ACN 121971528 ACN121971528 ACN 121971528ACN-121971528-A

Abstract

The invention provides a sustained-release bar for breast repair in an initial period of milk drying of dairy cows and a preparation method thereof, belonging to the technical field of veterinary pharmaceutical preparations. The invention relates to a slow-release bar for breast repair in the early stage of milk cow dry milk, which comprises the following raw materials, by weight, 6-10 parts of compound plant extracts, 10-15 parts of ferroferric oxide, 8-12 parts of magnesium oxide, 6-10 parts of zinc sulfate, 1-5 parts of barley malt alkali hydrochloride, 1-5 parts of manganese sulfate, 0.05-0.15 part of calcium iodate, 0.05-0.15 part of sodium selenite, 0.5-2 parts of calcium stearate and 3-10 parts of vegetable oil. The slow-release rod for repairing the breast of the dairy cow in the early period of milk drying can effectively promote the breast of the dairy cow in the period of milk drying to empty and recover, obviously shorten the recovery period, reduce the risk of mastitis infection in the period of milk drying, and is better than the repairing effect of natural milk stopping.

Inventors

  • YANG WEI
  • ZHANG BINGBING
  • LI ZHENDONG
  • Wen Jianan
  • CHANG YAQI
  • HUANG YI
  • KUAI XINYUE
  • ZHANG ZEXIN
  • LI XINRUI

Assignees

  • 黑龙江八一农垦大学

Dates

Publication Date
20260505
Application Date
20260306

Claims (10)

  1. 1. The slow-release stick for repairing the mammary gland of the dairy cow in the early stage of milk drying is characterized by comprising, by weight, 6-10 parts of compound plant extracts, 10-15 parts of ferroferric oxide, 8-12 parts of magnesium oxide, 6-10 parts of zinc sulfate, 1-5 parts of barley malt alkali hydrochloride, 1-5 parts of manganese sulfate, 0.05-0.15 part of calcium iodate, 0.05-0.15 part of sodium selenite, 0.5-2 parts of calcium stearate and 3-10 parts of vegetable oil.
  2. 2. The slow release stick for breast repair in the early stage of milk drying of a dairy cow according to claim 1 is characterized by comprising the following raw materials, by weight, 8 parts of a compound plant extract, 12.5 parts of ferroferric oxide, 10 parts of magnesium oxide, 8 parts of zinc sulfate, 3.5 parts of barley malt alkali hydrochloride, 3 parts of manganese sulfate, 0.1 part of calcium iodate, 0.1 part of sodium selenite, 1 part of calcium stearate and 5 parts of vegetable oil.
  3. 3. The delayed release stick for early dry milk mammary gland repair of dairy cows of claim 1, wherein the plant comprises at least two of sage, green pricklyash, nettle, horsetail and parsley.
  4. 4. A method for preparing a slow release stick for breast repair in the early stage of milk drying of dairy cows according to any of claims 1 to 3, comprising the following steps: (1) Crushing and sieving ferroferric oxide, magnesium oxide, zinc sulfate, barley malt alkali hydrochloride, manganese sulfate, calcium iodate and sodium selenite, and mixing to obtain premixed powder; (2) Purifying the mixture of sage, green pricklyash, nettle, scouring rush and parsley by a water extraction and alcohol precipitation process to obtain a compound plant extract, and concentrating the compound plant extract to obtain an extract; (3) Mixing the extract obtained in the step (2) with the premixed powder obtained in the step (1), and granulating to obtain wet granules; (4) Drying the wet particles, spraying vegetable oil after drying, and adding calcium stearate to obtain modified particles; (5) And pressing the modified particles to obtain the sustained-release stick for repairing the mammary glands of the dairy cows in the early stage of milk drying.
  5. 5. The method for preparing the delayed release stick for breast repair in the early stage of milk drying of dairy cows according to claim 4, wherein the ferroferric oxide, magnesium oxide, zinc sulfate, barley malt hydrochloride, manganese sulfate, calcium iodate and sodium selenite in the step (1) are subjected to superfine grinding, pass through a 70-90 mesh sieve, and are mixed for 15-20min.
  6. 6. The method for preparing the slow-release stick for breast repair in the early stage of milk drying of cows according to claim 4, wherein the weight ratio of sage, green pricklyash, nettle, horsetail and parsley in the step (2) is 2-8:2-7:1-4:1-3:1-3.
  7. 7. The method for preparing a delayed release stick for breast repair in the early stage of milk drying of a dairy cow according to claim 4, wherein the relative density of the extract in the step (2) is 1.30+/-0.05.
  8. 8. The method for preparing the sustained-release stick for breast repair in the early stage of milk drying of dairy cows according to claim 4, wherein the drying treatment process in the step (4) comprises the steps of drying for 1-12 hours at 40-50 ℃, heating to 55-60 ℃ and drying to 3-5% of water content.
  9. 9. The method for preparing a slow-release stick for breast repair in the early stage of milk drying of dairy cows according to claim 4, wherein the pressing process in the step (5) comprises the steps of pre-pressing the air at a pressure of 1.5-3 tons, exhausting the air, and maintaining the pressure at a main pressure of 8-12 tons.
  10. 10. The method for preparing the sustained-release stick for breast repair in the initial period of milk drying of the dairy cows according to claim 4, wherein the density of the sustained-release stick for breast repair in the initial period of milk drying of the dairy cows in the step (5) is more than or equal to 1.8g/cm 3 .

Description

Sustained-release stick for repairing mammary glands of dairy cows in early period of milk drying and preparation method thereof Technical Field The invention belongs to the technical field of veterinary pharmaceutical preparations, and particularly relates to a sustained-release bar for breast repair in an early period of milk drying of dairy cows and a preparation method thereof. Background The dry period is an important stage in the production cycle of cows, during which the cows complete their recovery from body conditions, renew mammary epithelial cells, and have important significance for the health and physiology of the cows, animal welfare and sustainability of lactation performance. However, under endocrine physiological regulation such as prolactin, the accumulation of milk in the breast is easy to occur in the early stage of milk drying (i.e. during the final milking), the pressure in the breast is increased, and the formation of a nipple keratin plug is delayed, so that the occurrence of milk leakage and mastitis in the milk drying stage is caused. In recent years, with the rapid increase of dairy cow unit production in China, high-yield cows still have higher yield (15-25 kg/d) at the end of gestation, so that the development of products for effectively relieving the lactation stress of cows in the early stage of milk drying is particularly important for the health of the breasts of the cows and the sustainability of lactation performance. The prior art generally reduces milk yield and promotes mammary repair by single or double daily infusion of dopamine agonist (quinagolide or cabergoline) for several days before and after milk drying, alleviating intramammary hypertension in the early stages of milk drying. However, since the method needs daily injection, the operation is complicated, the stress risk of the dairy cows is increased, and serious adverse events (including death) of using related products are frequent. Therefore, the development of related green, safe and long-acting health products is particularly important. Disclosure of Invention The invention provides a slow-release rod for repairing the mammary gland of a dairy cow in the early stage of milk drying, which comprises, by weight, 6-10 parts of a compound plant extract, 10-15 parts of ferroferric oxide, 8-12 parts of magnesium oxide, 6-10 parts of zinc sulfate, 1-5 parts of barley malt alkali hydrochloride, 1-5 parts of manganese sulfate, 0.05-0.15 part of calcium iodate, 0.05-0.15 part of sodium selenite, 0.5-2 parts of calcium stearate and 3-10 parts of vegetable oil. Further, the compound plant extract comprises, by weight, 8 parts of compound plant extract, 12.5 parts of ferroferric oxide, 10 parts of magnesium oxide, 8 parts of zinc sulfate, 3.5 parts of barley malt alkali hydrochloride, 3 parts of manganese sulfate, 0.1 part of calcium iodate, 0.1 part of sodium selenite, 1 part of calcium stearate and 5 parts of vegetable oil. Further, the plant comprises at least two of sage, green pricklyash, nettle, horsetail and parsley. The invention also provides a preparation method of the slow-release rod for breast repair in the initial period of milk drying of the dairy cows, which comprises the following steps: (1) Crushing and sieving ferroferric oxide, magnesium oxide, zinc sulfate, barley malt alkali hydrochloride, manganese sulfate, calcium iodate and sodium selenite, and mixing to obtain premixed powder; (2) Purifying the mixture of sage, green pricklyash, nettle, scouring rush and parsley by a water extraction and alcohol precipitation process to obtain a compound plant extract, and concentrating the compound plant extract to obtain an extract; (3) Mixing the extract obtained in the step (2) with the premixed powder obtained in the step (1), and granulating to obtain wet granules; (4) Drying the wet particles, spraying vegetable oil after drying, and adding calcium stearate to obtain modified particles; (5) And pressing the modified particles to obtain the sustained-release stick for repairing the mammary glands of the dairy cows in the early stage of milk drying. Further, the ferroferric oxide, magnesium oxide, zinc sulfate, barley malt alkali hydrochloride, manganese sulfate, calcium iodate and sodium selenite in the step (1) are subjected to superfine grinding, and are sieved by a 70-90-mesh sieve and mixed for 15-20min. Further, in the step (2), the weight ratio of the sage to the green pepper to the nettle to the horsetail to the parsley is 2-8:2-7:1-4:1-3:1-3. Further, the relative density of the extract in the step (2) is 1.30+/-0.05. Further, the drying treatment process in the step (4) comprises the steps of drying for 1-12 hours at 40-50 ℃, heating to 55-60 ℃ and drying until the water content is 3-5%. Further, the pressing process in the step (5) comprises the steps of exhausting at the pre-pressing pressure of 1.5-3 tons and maintaining at the main pressure of 8-12 tons. Further, the density of the breast rep