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CN-121971534-A - Traditional Chinese medicine compound for treating yin-nourishing hard-mass-softening lung nodule

CN121971534ACN 121971534 ACN121971534 ACN 121971534ACN-121971534-A

Abstract

The invention discloses a traditional Chinese medicine compound for treating lung nodules with effects of nourishing yin and softening hard masses, which relates to the technical field of traditional Chinese medicine compounds, is prepared by a formula cooperative logic based on lung collaterals microenvironment metabolic regulation, and accurately plays a role in treating abnormal rising succinic acid metabolites around lung nodule focuses, wherein radix scrophulariae is used for downregulating succinic acid synthase, repairing lung collaterals mucous membranes, concha arcae is used for degrading nodule matrix glycosaminoglycans, and platycodon grandiflorum is used for dredging lung collaterals passages, so that accurate cooperation of yin nourishing components for repairing lung collaterals microenvironment and hardness softening components targeted metabolic abnormality is realized, and lung nodule symptoms are effectively improved.

Inventors

  • CHEN FEI
  • LI WENHAO
  • XIE YING
  • HAN JIERU

Assignees

  • 黑龙江中医药大学

Dates

Publication Date
20260505
Application Date
20260309

Claims (10)

  1. 1. A traditional Chinese medicine compound for treating yin-nourishing hard-hardness-softening lung nodule is characterized by being prepared from the following raw materials in parts by weight: 28% of radix scrophulariae, 22% of concha arcae, 12% of platycodon grandiflorum and the balance of pharmaceutical auxiliary materials, wherein the traditional Chinese medicine compound is prepared based on the formula synergistic logic of the metabolic regulation of the lung collaterals microenvironment, and plays a role in treating abnormal rising succinic acid metabolites around lung nodule lesions, wherein the radix scrophulariae is used for downregulating succinic acid synthase, repairing lung collaterals mucous membrane, the concha arcae is used for degrading nodule matrix glycosaminoglycan, and the platycodon grandiflorum is used for dredging lung collaterals.
  2. 2. The traditional Chinese medicine compound for treating the lung nodules with the effects of nourishing yin and softening hard masses according to claim 1, wherein the radix scrophulariae is a wine-roasted radix scrophulariae, the wine-roasted technological parameters are that a net radix scrophulariae slice is taken, yellow wine accounting for 10% -15% of the weight of the radix scrophulariae slice is added, the mixture is stirred uniformly, the mixture is moistened until the yellow wine is completely absorbed, the mixture is placed in a stir-frying container, the mixture is heated and fried with slow fire until the surface is slightly provided with focal spots, and the mixture is taken out, cooled and filtered to remove scraps.
  3. 3. The traditional Chinese medicine compound for treating the lung nodules with the effects of nourishing yin and softening hardness according to claim 1, wherein the concha arcae are calcined concha arcae, and the calcining technological parameters are that the purified concha arcae are taken out, put into a calcining container, heated with strong fire to be calcined until the concha arcae are crisp, taken out, cooled and crushed to 80-100 meshes.
  4. 4. The traditional Chinese medicine compound for treating lung nodules with yin nourishing and hardness softening effects according to claim 1, wherein the platycodon grandiflorum is stir-fried with honey, the technological parameters of stir-frying with honey are that refined honey is taken, boiled water accounting for 30% -40% of the weight of the refined honey is added for dilution, clean platycodon grandiflorum tablets are added for uniform stirring, the mixture is moistened thoroughly, the mixture is placed in a stir-frying container, stir-fried with slow fire until hands are not sticky, the mixture is taken out for cooling, and the dosage of the refined honey is 20% -25% of the weight of the platycodon grandiflorum tablets.
  5. 5. The traditional Chinese medicine compound for treating the lung nodules with the effects of nourishing yin and softening hard masses, which is characterized in that the proportion of 28 percent to 12 percent is determined by combining lung collaterals microenvironment metabonomics analysis with a weight formula, specifically, a lung tissue sample around a lung nodule focus is collected, the contents of succinic acid and intermediate metabolites thereof are detected by adopting a targeted metabonomics technology, the differential contribution value of each metabolite is calculated by partial least square discriminant analysis, and the proportion of each bulk drug is calculated by the weight formula, wherein the formula is as follows: wherein Is a raw material medicine Is used in the weight ratio of (a), Is a raw material medicine The regulation and control efficiency of the succinic acid metabolites, Is the contribution coefficient of succinic acid metabolites to the lung nodule progression.
  6. 6. The traditional Chinese medicine compound for treating yin-nourishing and hardness-softening lung nodules according to claim 1, wherein the radix scrophulariae downregulated succinic acid synthase is an alpha subtype of succinic acid coenzyme A ligase, and the succinic acid synthesis rate is reduced by 30% -45% by reducing the mRNA expression quantity of the enzyme.
  7. 7. The traditional Chinese medicine compound for treating the lung nodules with the effects of nourishing yin and softening hardness according to claim 1, wherein the nodule matrix glycosaminoglycans degraded by the concha arcae are hyaluronic acid, chondroitin sulfate and dermatan sulfate.
  8. 8. The traditional Chinese medicine compound for treating the lung nodules with the effects of nourishing yin and softening hard masses according to claim 1, wherein the pharmaceutical auxiliary materials comprise one or more of filler dextrin, a flavoring agent stevioside and a disintegrating agent sodium carboxymethyl starch, wherein the additive amount of the filler dextrin is 25% -35% of the weight of the compound clear paste, the additive amount of the flavoring agent stevioside is 0.3% -0.7% of the weight of the compound clear paste, and the additive amount of the disintegrating agent sodium carboxymethyl starch is 2% -5% of the weight of the compound dry paste powder.
  9. 9. The traditional Chinese medicine compound for treating the lung nodules with the effects of nourishing yin and softening hard masses, which is disclosed in claim 1, is characterized in that the extraction process parameters of the traditional Chinese medicine compound are that raw materials are crushed to 60-100 meshes, 70% ethanol is used as an extraction solvent, the ratio of feed to liquid is 1:8-1:12, reflux extraction is carried out for 2-3 times, each time is 1.5-2.5 hours, and the extraction solutions are combined and then concentrated under reduced pressure to obtain clear paste with the relative density of 1.12-1.18.
  10. 10. The traditional Chinese medicine compound for treating the lung nodules with the effects of nourishing yin and softening hard masses, which is disclosed in claim 1, is suitable for benign lung nodule patients with the diameter of less than or equal to 8mm and the increase of succinic acid metabolites around focuses by more than or equal to 2 times compared with normal lung tissues, and is orally taken, wherein the daily raw medicine dosage is 6-12 g, and the administration is divided into 2-3 times.

Description

Traditional Chinese medicine compound for treating yin-nourishing hard-mass-softening lung nodule Technical Field The invention relates to the technical field of traditional Chinese medicine compounds, in particular to a traditional Chinese medicine compound for treating yin-nourishing hard mass lung nodules. Background With the aggravation of environmental pollution and the change of life style, the incidence of pulmonary nodules has risen year after year, and is one of the important problems affecting public health, and the pulmonary nodules are a common lesion of the lung, and the formation of the pulmonary nodules is related to various factors including, but not limited to, smoking, air pollution, occupational exposure, genetic factors and the like, and the pulmonary nodules are mostly benign but have a part of malignant risks, so that early intervention and treatment have important significance for preventing disease progression. When the traditional Chinese medicine is used for treating lung nodules, the traditional Chinese medicine depends on empirical formulas, and is lack of deep research and scientific proportion on pathogenesis of the lung nodules. On one hand, the empirical prescription often adopts a fixed prescription, is difficult to carry out personalized adjustment aiming at specific illness states of different patients, so that the treatment effect is uneven, on the other hand, the processing technology and the extraction method of the traditional Chinese medicine are rough, the extraction rate and the bioavailability of active ingredients are low, the curative effect of the medicine is affected, in addition, the traditional Chinese medicine compound lacks scientific basis in the selection and the addition amount of medicinal auxiliary materials, the compound stability is poor, even adverse reaction is generated, and the wide clinical application of the traditional Chinese medicine compound is limited. Aiming at the defects of the traditional Chinese medicine in the aspect of treating lung nodules, the invention provides a traditional Chinese medicine compound for treating lung nodules, which is particularly important. Disclosure of Invention The invention aims to make up the defects of the prior art, provides a traditional Chinese medicine compound for treating yin-nourishing hard-hardness-softening lung nodule, can be prepared by a formula synergic logic based on metabolism regulation of lung collaterals microenvironment, and provides a more reliable and effective treatment option for lung nodule patients by scientifically proportioning raw material medicines such as radix scrophulariae, concha arcae, platycodon grandiflorum and the like, optimizing a processing technology and an extraction method, and accurately acting on succinic acid metabolites abnormally increased around the lung nodule focus. The invention provides a traditional Chinese medicine compound for treating yin-nourishing hard-hardness-softening lung nodules, which is prepared from the following raw materials in parts by weight: 28% of radix scrophulariae, 22% of concha arcae, 12% of platycodon grandiflorum and the balance of pharmaceutical auxiliary materials, wherein the traditional Chinese medicine compound is prepared based on the formula synergic logic of the lung meridian microenvironment metabolic regulation, and plays a role in treating abnormal rising succinic acid metabolites around lung nodule lesions, wherein the radix scrophulariae is used for down-regulating succinic acid synthase and repairing lung meridian mucous membrane, the concha arcae is used for degrading nodule matrix glycosaminoglycan, and the platycodon grandiflorum is used for dredging lung meridian passages, so that the accurate synergic effect of yin nourishing components in repairing lung meridian microenvironment and softening hardness components in targeting metabolic abnormality is realized. Further, the radix scrophulariae is stir-fried with wine, and the technological parameters of stir-frying with wine are that the radix scrophulariae slices are taken out, yellow wine accounting for 10% -15% of the weight of the radix scrophulariae slices is added, and stirred uniformly, the mixture is moistened until the yellow wine is completely absorbed, the mixture is placed into a stir-frying container, the mixture is heated and fried with slow fire until the surface is slightly provided with focal spots, and the mixture is taken out, cooled and the chips are removed by sieving. Further, the corrugated seeds are calcined corrugated seeds, and the calcining process parameters are that the calcined corrugated seeds are taken out and put into a calcining container, heated by strong fire until the calcined corrugated seeds are crisp, taken out and cooled, and crushed to 80-100 meshes. Further, the radix platycodi is stir-fried with honey, and the stir-frying process comprises the steps of taking refined honey, adding boiled water accounting for 30% -40%