CN-121971536-A - Female qi and blood regulating and tonifying product based on deer uterus and ovary extracts and preparation method thereof

Abstract

The invention relates to a female qi and blood regulating and tonifying product based on deer uterus and ovary extracts and a preparation method thereof, belonging to the technical field of health-care food. The female qi and blood regulating and supplementing product comprises, by weight, 20% -25% of sika deer uterus extract, 15% -20% of sika deer ovary extract, 15% -20% of sika deer antler blood extract, 10% -15% of red ginseng, 8% -12% of Chinese angelica, 8% -12% of cinnamon, 5% -8% of astragalus mongholicus, 5% -8% of fennel, 5% -8% of poria cocos, 3% -5% of wolfberry fruits and 3% -5% of jujube. The deer source extract is scientifically compatible with the traditional Chinese medicine, the effects of tonifying qi and blood, conditioning menstruation, improving endocrine and assisting reproductive health are synergistically exerted, the deer source extract is suitable for women who are pregnant, postpartum or physically weak, the preparation method of various dosage forms is provided, the process is stable and controllable, the retention rate of active ingredients is high, and the use requirements of different crowds are met.

Inventors

• JIAO ANLONG
• ZHANG BAOXU

Assignees

• 张宝旭

Dates

Publication Date

20260505

Application Date

20260205

Claims (6)

1. 1. A female qi and blood regulating and supplementing product based on deer uterus and ovary extracts is characterized by comprising, by weight, 20% -25% of a sika deer uterus extract, 15% -20% of a sika deer ovary extract, 15% -20% of a sika deer antler blood extract, 10% -15% of red ginseng, 8% -12% of Chinese angelica, 8% -12% of cinnamon, 5% -8% of astragalus membranaceus, 5% -8% of fennel, 5% -8% of poria cocos, 3% -5% of wolfberry fruit and 3% -5% of Chinese date, wherein the regulating and supplementing product has the effects of replenishing qi and blood, regulating menstruation, improving endocrine and assisting reproductive health, and is suitable for women with pregnancy, postpartum or physical weakness.
2. 2. The qi and blood regulating and supplementing product for women according to claim 1, wherein the dosage form of the regulating and supplementing product is a pill, a capsule, a granule, a tablet or an oral liquid.
3. 3. The qi and blood regulating and tonifying product for women according to claim 1, wherein the red deer uterus extract and the ovary extract are prepared from artificially cultured healthy red deer through cleaning, enzymolysis, concentration and drying, and when the red deer antler blood extract is obtained by cutting healthy red deer antler, fresh deer antler blood is collected by a vacuum pump or a centrifuge, and macromolecule proteins are converted into a micromolecular structure through biotechnological treatment, and then concentrated and dried.
4. 4. A method for preparing a female qi and blood regulating and supplementing product according to any one of claims 1 to 3, which is characterized by comprising the following corresponding processes according to different target dosage forms: (1) Preparation of pills: ① Raw material pretreatment, namely respectively selecting red ginseng, angelica, cinnamon, astragalus, fennel, poria cocos, wolfberry fruit and jujube, removing impurities, cleaning, drying at 60-70 ℃ until the moisture is less than or equal to 10%, mixing, crushing, and sieving with a 80-100-mesh sieve to obtain mixed traditional Chinese medicine powder; ② Preparation of core raw materials: The deer uterus extract is prepared by taking artificially cultured healthy deer uterus, removing fascia and impurities, cleaning, cutting into small blocks of 0.5-1 cm, adding purified water of 3-5 times of the weight, heating to 50-60 ℃, adding compound protease of which the weight is 0.3-0.5% of the weight of the raw materials, carrying out enzymolysis for 2-3 hours, heating to 90-100 ℃ after the enzymolysis is finished, inactivating the enzyme for 15-20 min, filtering to obtain supernatant, concentrating to extract with the relative density of 1.2-1.3 (60 ℃), vacuum drying, crushing, and sieving with a 100-mesh sieve to obtain the deer uterus extract; The deer ovary extract is prepared by taking artificially cultured healthy sika deer ovaries, removing connective tissues and impurities, cleaning, crushing into homogenate, adding 2-4 times of purified water, extracting at a constant temperature of 60-70 ℃ for 2 times, 1.5-2 hours each time, combining extract solutions, filtering, concentrating to obtain extractum with a relative density of 1.2-1.3 (60 ℃), drying in vacuum, crushing, and sieving with a 100-mesh sieve to obtain the deer ovary extract; collecting fresh sika deer antler blood, immediately adding 0.1% -0.2% of antioxidant, uniformly stirring, performing enzymolysis treatment by adopting a biotechnology, converting macromolecular proteins into small molecular structures, concentrating to obtain extractum with the relative density of 1.1-1.2 (60 ℃), freeze-drying, pulverizing, and sieving with a 100-mesh sieve to obtain the sika deer antler blood extract; ③ Mixing, namely adding all the raw materials into a mixer, stirring and mixing until the raw materials are uniform; ④ Preparing pills, namely adding a proper amount of purified water into the mixed materials as an adhesive, regulating the humidity until the mixture is agglomerated by hand and dispersed by light touch, and preparing wet pills with the diameter of 3-5 mm by adopting a pill making method or an extrusion rolling method; ⑤ Drying, namely placing the wet pellets into a drying box at a temperature of 40-50 ℃ for drying at a low temperature until the moisture content is less than or equal to 8%; ⑥ Screening, packaging, namely screening pills with uniform size, removing adhesion, crushing the pills, and aseptically packaging to obtain the medicine; (2) And (3) preparation of capsules: ① Raw material pretreatment and core raw material preparation, wherein the same pill preparation step ①～②; ② Mixing, namely adding all the raw materials into a mixer to be uniformly mixed to obtain mixed powder with the water content less than or equal to 6%; ③ Filling, namely filling the mixed powder into hollow capsules by a capsule filling machine, and controlling the filling amount of each capsule to be 0.3-0.5 g; ④ Polishing and packaging, namely polishing the filled capsules, removing surface powder, and carrying out aseptic packaging; (3) The preparation of the granule comprises the following steps: ① Raw material pretreatment and core raw material preparation, wherein the same pill preparation step ①～②; ② Mixing all the raw materials uniformly, adding a proper amount of 30% -50% ethanol solution as an adhesive, stirring to prepare a soft material which is agglomerated by hand and is dispersed by touching; ③ Granulating, namely extruding and granulating the soft material through a 16-20 mesh screen to obtain wet granules; ④ Drying, namely placing the wet particles into a drying oven at 45-55 ℃ to be dried until the moisture content is less than or equal to 5%; ⑤ Finishing and packaging, namely finishing the granules through a 14-20 mesh screen, removing fine powder and large granules, and carrying out aseptic packaging; (4) Preparation of tablets: ① Raw material pretreatment and core raw material preparation, wherein the same pill preparation step ①～②; ② Mixing, namely mixing all raw materials with microcrystalline cellulose accounting for 5% -10% of the total mass of the raw materials for 20-30 min, adding magnesium stearate accounting for 0.5% -1%, and continuously mixing for 5-10 min to obtain a tabletting material with moisture less than or equal to 5%; ③ Tabletting, namely pressing the tabletting materials into plain tablets with the diameter of 6-8 mm and the tablet weight of 0.5-1.0 g by a tablet press; ④ Coating and packaging, namely coating a tablet with 5% -8% hydroxypropyl methylcellulose aqueous solution serving as a tablet coating solution by a film at 40-50 ℃ until the surface is smooth, drying, checking whether foreign matters are qualified, and packaging in a sterile way; (5) The preparation of the oral liquid comprises the following steps: ① Raw material pretreatment, namely selecting red ginseng, angelica, cinnamon, astragalus, fennel, poria cocos, wolfberry fruit and jujube, removing impurities, cleaning, drying until the moisture is less than or equal to 10%, mixing, crushing and sieving with a 60-80-mesh sieve to obtain mixed traditional Chinese medicine powder; ② The preparation of core raw materials: Taking deer uterus extract concentrate, namely taking artificially cultured healthy deer uterus, removing fascia and impurities, cleaning, cutting into small blocks of 0.5-1 cm, adding purified water of 3-5 times of weight, heating to 50-60 ℃, adding compound protease of which the weight is 0.3-0.5% of the weight of the raw material, carrying out enzymolysis for 2-3 hours, heating to 90-100 ℃ after the enzymolysis is finished, inactivating the enzyme for 15-20 minutes, filtering, taking supernatant, and concentrating under reduced pressure to concentrate with the relative density of 1.1-1.2 (60 ℃); Collecting the ovary extract concentrate of artificially cultured healthy sika deer, removing connective tissues and impurities, cleaning, crushing into homogenate, adding 2-4 times of purified water, extracting at a constant temperature of 60-70 ℃ for 2 times, 1.5-2 hours each time, combining the extract solutions, filtering, and concentrating under reduced pressure to obtain a concentrate with a relative density of 1.1-1.2 (60 ℃); Collecting fresh sika deer antler blood, immediately adding 0.1% -0.2% of antioxidant, uniformly stirring, performing enzymolysis treatment (the enzymolysis temperature is 45-55 ℃ and the enzymolysis time is 1.5-2 hours) by adopting a biotechnology, converting macromolecular proteins into a small molecular structure, and concentrating under reduced pressure to a concentrated solution with the relative density of 1.1-1.2 (60 ℃); ③ Extracting traditional Chinese medicine, namely adding purified water with the weight of 5-8 times of that of the mixed traditional Chinese medicine powder, decocting for 2 times and 1.5 hours each time, mixing decoctions, filtering and concentrating to obtain traditional Chinese medicine concentrated solution with the relative density of 1.05-1.1 (60 ℃); ④ Mixing and blending, namely mixing the deer uterus extract concentrated solution, the deer ovary extract concentrated solution, the deer blood extract concentrated solution and the traditional Chinese medicine concentrated solution for 15-20 min, adding natural sweetener accounting for 0.1% -0.3% of the total liquid weight, stirring and dissolving, adding purified water to fix the volume, and adjusting the pH value to 4.5-6.0; ⑤ Filtering, filling, namely finely filtering the blended solution through a microporous filter membrane with the thickness of 0.22 mu m, filling into oral liquid bottles in a sterile manner, wherein each bottle is 10-20 ml; ⑥ Sterilizing by using 100 ℃ circulating steam for 15-20 min, and cooling to obtain the product.
5. 5. The method of claim 4, wherein the compound protease used for preparing the deer uterus extract and the deer uterus extract concentrate is a compound of neutral protease and papain in a ratio of 1:1, and the antioxidant used for preparing the deer antler blood extract and the deer antler blood extract concentrate is vitamin C or tea polyphenol.
6. 6. The method of claim 4, wherein the natural sweetener added in the mixing stage of the oral liquid is stevioside or fructo-oligosaccharide.

Description

Female qi and blood regulating and tonifying product based on deer uterus and ovary extracts and preparation method thereof Technical Field The invention relates to the technical field of health-care food, in particular to a female qi and blood regulating and tonifying product based on deer uterus and ovary extracts and a preparation method thereof. Background In modern life scenes, women face multiple challenges such as quickening life rhythm, rising working pressure, irregular work and rest, unbalanced diet and the like, and health problems such as qi and blood deficiency, irregular menstruation, dysmenorrhea, endocrine disturbance and the like are increasingly common. These problems not only affect the daily health and quality of life of women, but also may cause hindrance to pregnancy, and postpartum women often suffer from deficiency and weakness, pale complexion, slow recovery of reproductive system and the like due to massive consumption of qi and blood in the childbirth process, so that a targeted qi and blood nourishing and health conditioning product is needed. The theory of traditional Chinese medicine holds that female takes qi and blood as the basis, and reproductive health is closely related to qi and blood filling and endocrine balance. The reproductive organs (uterus and ovary) of deer and deer blood are taken as precious nourishing products in traditional medicine, and have extremely high medicinal value and nutritive value. The deer uterus is rich in nutritional ingredients such as high-quality animal proteins, collagen, various trace elements and the like, can directly tonify qi and blood, improves various discomforts caused by deficiency of qi and blood, has a natural conditioning effect on female reproductive system functions, and the deer ovary serving as a genital gland organ of deer contains active ingredients such as natural estrogen, progesterone and the like, can mildly regulate endocrine, assist in improving irregular menstruation and climacteric symptoms, can tonify kidney and replenish essence, relieve deficiency and weakness, and the deer antler blood has yang-strengthening and blood-replenishing effects, belongs to superior traditional Chinese medicine products, contains active substances such as various amino acids, deer antler blood polysaccharide and the like, is a high-quality raw material for enriching blood and producing, tonifying kidney and strengthening yang, and can provide double support for female qi and blood conditioning. At present, the female qi and blood nourishing foods in the market are various, but most of the foods adopt conventional traditional Chinese medicine compatibility, lack products which take deer uterus and ovary extracts as core raw materials, and are difficult to fully exert the unique nourishing and conditioning advantages of deer reproductive organs. Therefore, the female qi and blood regulating and supplementing product which takes deer uterus and ovary extracts as cores, is matched with traditional Chinese medicines, has scientific process and synergistic effect, and has important market value and application prospect. Disclosure of Invention The invention aims to solve the technical problem of providing a female qi and blood regulating and supplementing product based on deer uterus and ovary extracts and a preparation method thereof, so as to overcome the defects and shortcomings of the prior art and products described in the background art and fill the blank of the industry. The technical scheme for solving the technical problems is that the female qi and blood regulating and tonifying product based on the deer uterus and ovary extracts comprises, by weight, 20% -25% of the deer uterus extract, 15% -20% of the deer ovary extract, 15% -20% of the deer antler blood extract, 10% -15% of red ginseng, 8% -12% of Chinese angelica, 8% -12% of cinnamon, 5% -8% of astragalus membranaceus, 5% -8% of fennel, 5% -8% of poria cocos, 3% -5% of medlar and 3% -5% of jujube, and the regulating and tonifying product has the effects of replenishing qi and blood, regulating menstruation, improving endocrine and assisting reproductive health and is suitable for female with pregnancy, postpartum or physical weakness. Further, the dosage form of the tonic is pill, capsule, granule, tablet or oral liquid. Still further, the red deer uterus extract and the ovary extract are all from artificially cultured healthy red deer, and are prepared by cleaning, enzymolysis, concentration and drying, wherein when the red deer antler blood extract is obtained by cutting healthy red deer antler, fresh deer antler blood is collected by a vacuum pump or a centrifuge, macromolecular proteins are converted into a small molecular structure by biotechnological treatment, and then the small molecular structure is concentrated and dried. The invention also discloses a preparation method of the female qi and blood regulating and tonifying product based on the deer uterus and ovary ex