CN-121971542-A - Traditional Chinese medicine composition for treating xerophthalmia and preparation method and application thereof

Abstract

The invention belongs to the technical field of medicines, and particularly relates to a traditional Chinese medicine composition for treating dry eyes, and a preparation method and application thereof, wherein the traditional Chinese medicine composition is prepared from, by weight, 12-18 parts of wolfberry fruit, 8-12 parts of chrysanthemum, 12-18 parts of prepared rehmannia root, 8-12 parts of cornus officinalis, 8-12 parts of tree peony bark, 8-12 parts of Chinese yam, 8-12 parts of poria cocos, 8-12 parts of rhizoma alismatis, 8-12 parts of buddleia officinalis, 8-12 parts of equisetum and 12-18 parts of radix scrophulariae. The traditional Chinese medicine composition provided by the invention has statistically significant effects superior to the traditional classical control medicine "Qiju Dihuang Wan" on the key indexes of directly reflecting curative effects, such as increasing tear secretion, prolonging tear film rupture time, reducing cornea damage score, and the like. The traditional Chinese medicine composition has the advantages that the traditional Chinese medicine composition is subjected to targeted medicine taste increase and decrease and proportion optimization, a synergistic effect is generated, and the technical problems that the pertinence is not strong and the curative effect is not optimal in the prior art are solved.

Inventors

• PENG QINGHUA
• HOU WANJUN
• Tian Sainan
• PENG JUN
• LIU PEI
• LIU GUICHENG
• HUANG YU
• TAN KANG
• CHEN YAO
• WANG HAILAN

Assignees

• 湖南中医药大学

Dates

Publication Date

20260505

Application Date

20260310

Claims (9)

1. 1. The traditional Chinese medicine composition for treating xerophthalmia is characterized by being prepared from the following raw materials in parts by weight: 12-18 parts of medlar, 8-12 parts of chrysanthemum, 12-18 parts of prepared rehmannia root, 8-12 parts of cornus officinalis, 8-12 parts of tree peony bark, 8-12 parts of Chinese yam, 8-12 parts of poria cocos, 8-12 parts of rhizoma alismatis, 8-12 parts of butterflybush flower, 8-12 parts of scouring rush, and 12-18 parts of radix scrophulariae.
2. 2. The traditional Chinese medicine composition according to claim 1, wherein the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 15 parts of medlar, 10 parts of chrysanthemum, 15 parts of prepared rehmannia root, 10 parts of cornus officinalis, 10 parts of tree peony bark, 10 parts of Chinese yam, 10 parts of poria cocos, 10 parts of rhizoma alismatis, 10 parts of buddleja officinalis, 10 parts of scouring rush and 15 parts of radix scrophulariae.
3. 3. The preparation method of the traditional Chinese medicine composition according to claim 1, which is characterized by comprising the following steps: and weighing the raw materials according to the weight parts, drying, mixing and crushing to obtain the traditional Chinese medicine composition.
4. 4. A method according to claim 3, wherein the drying conditions are: All the raw materials are dried at 60 ℃ until the moisture is less than or equal to 8 percent.
5. 5. The use of a traditional Chinese medicine composition according to claim 1, wherein the traditional Chinese medicine composition is used for preparing a preparation for treating xerophthalmia.
6. 6. The use of claim 7, wherein the formulation further comprises a pharmaceutically acceptable adjuvant.
7. 7. The use of claim 6, wherein the pharmaceutically acceptable excipients comprise at least one of excipients, fillers, flavoring agents, binders, disintegrants, lubricants, antacids, and nutritional supplements.
8. 8. The use according to claim 7, wherein the excipient is honey.
9. 9. The use according to claim 8, wherein the weight ratio of honey to the Chinese medicinal composition is 1.05:1.

Description

Traditional Chinese medicine composition for treating xerophthalmia and preparation method and application thereof Technical Field The invention belongs to the technical field of medicines, and particularly relates to a traditional Chinese medicine composition for treating xerophthalmia as well as a preparation method and application thereof. Background In the field of traditional Chinese medicines for treating liver-kidney yin deficiency type xerophthalmia, the closest prior art is a classical prescription of Qiju Dihuang pills and similar modified prescription, the Qiju Dihuang pills consist of medlar, chrysanthemum, prepared rehmannia root, cornus officinalis, yam, moutan bark, poria cocos and rhizoma alismatis, and the prescription is widely applied to symptoms of dry eyes, blurred vision and the like caused by liver-kidney yin deficiency. When the pill of the Chinese wolfberry, the chrysanthemum and the rehmannia is directly applied to treating the common dry eye in modern clinic, the following defects of insufficient pertinence exist: ① The prescription compatibility is not enough, the classical pill of the Chinese wolfberry, the chrysanthemum and the rehmannia is a basic and broad-spectrum nourishing prescription, and the design is originally aimed at the extensive syndrome of yin deficiency of liver and kidney. Dry eye, especially of the type with longer course and intractable symptoms, often has more specific pathological changes such as "flaming up of deficiency fire", "stasis of the collaterals of the eyes" or "abnormal distribution of body fluids" on the basis of "yin deficiency". The prior art has the defects of insufficient or missing medicine compatibility in the aspects of clearing and reducing deficiency fire, dredging the collaterals, promoting the production of body fluid and moistening dryness, so that the accurate striking capability of the traditional Chinese medicine for dry eye nuclear heart disease machine is limited, and partial patients have slower effects or symptoms are not thoroughly improved. ② The optimization degree of the medicine proportion is insufficient, the proportion of each medicine taste in the pill is fixed, and the pill aims at balancing the relations of tonifying kidney, nourishing liver, strengthening spleen, purging turbidity and the like. However, for dry eyes with "malnutrition" as the prominent manifestation, the weight of the drugs for directly moisturizing and nourishing eyes, guiding drugs upward and improving local functions may not be enough. For example, the critical drug taste ratio for improving eyesight and moisturizing dryness may not reach the optimal efficacy ratio for this disease, resulting in the overall efficacy of treating dry eye being not maximized. Therefore, on the basis of classical formulas, precise compatibility innovation and proportioning optimization aiming at xerophthalmia are necessary to provide a solution with more remarkable effect. Disclosure of Invention The invention aims to provide a traditional Chinese medicine composition for treating xerophthalmia, which solves the problems existing in the prior art. The technical scheme adopted by the invention is as follows: The invention provides a traditional Chinese medicine composition for treating dry eyes, which is prepared from the following raw materials in parts by weight: 12-18 parts of medlar, 8-12 parts of chrysanthemum, 12-18 parts of prepared rehmannia root, 8-12 parts of cornus officinalis, 8-12 parts of tree peony bark, 8-12 parts of Chinese yam, 8-12 parts of poria cocos, 8-12 parts of rhizoma alismatis, 8-12 parts of butterflybush flower, 8-12 parts of scouring rush, and 12-18 parts of radix scrophulariae. Based on the classical theory of traditional Chinese medicine, the traditional Chinese medicine composition takes 'nourishing kidney yin, conserving liver wood and accurately intervening in eye diseases' as a core concept, and aims at treating symptoms such as dry eyes, blurred vision and the like caused by yin deficiency of liver and kidney. The formula further optimizes compatibility on the basis of inheriting classical theory, and accurately intervenes in the local pathological links of the ocular surface, thereby embodying the therapeutic ideas of treating both symptoms and root causes. The relationship of monarch, minister, assistant and guide of the traditional Chinese medicine composition is as follows: (1) Monarch drug. Prepared rehmannia root, radix rehmanniae Preparata, has sweet taste and slightly warm nature, enters liver and kidney meridians, and has the effects of nourishing yin, tonifying kidney, replenishing essence and nourishing marrow. In the formula, the prepared rehmannia root is used as a monarch drug, plays a core role, aims at the main pathogenesis of deficiency of kidney yin, lays a foundation for nourishing kidney yin for the main body of the prescription, and fundamentally improves the whole body symptoms and the internal root causes of o