CN-121971543-A - Traditional Chinese medicine composition and application thereof in preparation of products for treating allergic rhinitis

Abstract

The invention relates to the technical field of biological medicines, in particular to a traditional Chinese medicine composition and application thereof in preparing a product for treating allergic rhinitis. The traditional Chinese medicine composition comprises glabrous sarcandra herb, ningpo Yam rhizome, cicada slough, earthworm, magnolia flower, angelica dahurica, divaricate saposhnikovia root, honeysuckle, weeping forsythiae capsule, lithospermum, szechuan lovage rhizome, medulla tetrapanacis, semen lepidii and raw liquorice. The invention takes glabrous sarcandra herb and Ningpo Yam rhizome as monarch drugs, takes cicada slough, earthworm, magnolia flower, dahurian angelica root and divaricate saposhnikovia root as ministerial drugs, takes honeysuckle, weeping forsythiae capsule, lithospermum, szechuan lovage rhizome, ricepaper pith and pepperweed seed as adjuvant drugs, and takes raw licorice as conductant drugs. The whole formula has the effects of dispelling wind and eliminating dampness, promoting blood circulation and inducing resuscitation, and can play a comprehensive treatment role for four core symptoms of nasal obstruction, watery nasal discharge, sneeze and nasal itching of allergic rhinitis.

Inventors

• ZHANG XIAOYANG
• SUN QING
• LIAN ZENGLIN
• ZHANG XU

Assignees

• 中国医学科学院北京协和医院

Dates

Publication Date

20260505

Application Date

20260318

Claims (10)

1. 1. The traditional Chinese medicine composition is characterized by comprising, by mass, 9-30 parts of glabrous sarcandra herb, 9-15 parts of Ningpo Yam rhizome, 3-6 parts of cicada slough, 5-10 parts of earthworm, 3-10 parts of magnolia flower, 3-10 parts of radix angelicae, 5-10 parts of radix sileris, 6-15 parts of honeysuckle, 6-15 parts of fructus forsythiae, 5-10 parts of lithospermum, 3-10 parts of ligusticum wallichii, 3-6 parts of medulla tetrapanacis, 3-10 parts of semen lepidii and 2-10 parts of raw liquorice.
2. 2. A traditional Chinese medicine extract, characterized in that the extract is extracted from the traditional Chinese medicine composition of claim 1.
3. 3. The traditional Chinese medicine composition or traditional Chinese medicine extract according to claim 1 or 2, characterized in that it exhibits characteristic ionic peaks corresponding to cimicifuga rhizome glycoside, cimicifuga rhizome essence, 5-O-methylvisamiloride, O-methylpinoresinol, hydrated oxidized peucedanum essence, (3S) -3-butyl-4, 5-dihydro-1 (3H) -isobenzofuranone, imperatorin, artemethrin a, forsythoside 1, eleostearate, isochlorogenic acid C, rosmarinic acid, forsythin in mass spectrometry analysis.
4. 4. A method for preparing the Chinese medicinal extract according to claim 2, which comprises the steps of immersing the Chinese medicinal composition according to claim 1 in water, decocting, and filtering.
5. 5. The method according to claim 4, wherein the soaking time is 30 to 60 minutes.
6. 6. The method according to claim 4, wherein the decocting comprises the steps of decocting for 20-30 min after the soaking, filtering to obtain a first liquid medicine and residue, adding water into the residue, continuously decocting for 20-30 min, filtering to obtain a second liquid medicine, and combining the first liquid medicine and the second liquid medicine.
7. 7. A Chinese medicinal preparation is characterized by comprising the Chinese medicinal composition according to claim 1 or the Chinese medicinal extract according to claim 2 and pharmaceutically acceptable auxiliary materials.
8. 8. The traditional Chinese medicine preparation according to claim 7, wherein the dosage form of the traditional Chinese medicine preparation comprises, but is not limited to, decoction, tablets, capsules, granules, pills, syrups, oral solutions, oral suspensions and oral emulsions.
9. 9. The use of the traditional Chinese medicine composition according to claim 1, or the traditional Chinese medicine extract according to claim 2, or the traditional Chinese medicine preparation according to claim 7 or 8 in the preparation of a product for preventing or/and treating allergic rhinitis.
10. 10. The use according to claim 9, wherein the allergic rhinitis is seasonal allergic rhinitis or perennial allergic rhinitis with syndrome of pathogenic wind invading the nose and dampness blocking the orifices.

Description

Traditional Chinese medicine composition and application thereof in preparation of products for treating allergic rhinitis Technical Field The invention relates to the technical field of biological medicines, in particular to a traditional Chinese medicine composition and application thereof in preparing a product for treating allergic rhinitis. Background Allergic rhinitis (ALLERGIC RHINITIS, AR) is a non-infectious chronic inflammatory disease of the nasal mucosa mediated mainly by immunoglobulin E (immunoglobulin E, igE) after exposure to allergens in atopic individuals, frequently combined with bronchial asthma, chronic sinusitis, etc. With industrialization and urbanization, the prevalence of AR is increased year by year, the global prevalence is 10-30%, the total prevalence is over 5 hundred million, the prevalence of adults in China is increased from 11.1% in 2005 to 17.6% in 2011, the prevalence is about 2.4 hundred million, and the prevalence becomes a serious public health problem, and the high prevalence of the prevalence remarkably reduces the quality of life of patients and increases the social and economic burden. The international guidelines recommend treatment with nasal glucocorticoids, antihistamines and leukotriene receptor antagonists, which can alleviate symptoms in a short period of time, but face clinical bottlenecks such as easy recurrence of withdrawal (chemical drugs), high cost (biological agents), limited application (immunotherapy is only applicable to a single allergen and requires 3-5 years of treatment course), etc. Therefore, developing a new multi-target intervention strategy which combines short-term symptom control and long-term immune remodeling becomes a key direction for breaking through the existing treatment dilemma. From the pathogenesis cognition, the occurrence of AR is an immune imbalance result caused by the combined action of inheritance and environmental factors, which is highly in agreement with the theory of yin-yang imbalance in traditional Chinese medicine. According to the theory of "allergic patients with allergic rhinitis and clear nasal discharge and sneeze with itching in the nose" it can be seen that AR belongs to the category of "allergic rhinitis" in traditional Chinese medicine. The traditional Chinese medicine has long history of AR treatment, namely takes the whole view as the core, combines disease identification and differentiation, whole and partial treatment, internal treatment and external treatment, has the unique advantages of multi-target immunoregulation, relapse delay, low toxic and side effects and the like, gradually forms special characteristics in clinical application, and becomes an important supplement system of AR treatment. The meta-analysis shows that the traditional Chinese medicine can significantly improve the quality of life of AR patients compared with placebo, and that compared with antihistamines, the traditional Chinese medicine has better performance in improving total nasal symptom score (Total Nasal Symptom Score, TNSS), single symptom score, quality of life and reducing recurrence rate. Therefore, the traditional Chinese medicine has definite AR treatment effect, the recurrence rate is low, and the patient can obtain better treatment effect and experience. Therefore, the development of an effective Chinese medicinal prescription for treating AR has important clinical significance. Disclosure of Invention The invention aims to provide a traditional Chinese medicine composition and application thereof in preparing a product for treating allergic rhinitis. The technical problems to be solved are not limited to the described technical subject matter, and other technical subject matter not mentioned herein will be clearly understood by those skilled in the art from the following description. Wind disease is a disease caused by exogenous pathogenic wind, or with pathogenic wind. The professor Zhang Xiaoyang to Beijing co-ordination hospital as early as 2001, according to the ancient books of scattered Chinese medicine, the clinical characteristics of the system summary wind-outlet disease are that four parts (skin, head, joints and orifices) and eight symptoms (acute, dynamic, spastic, paralysis, itching, tingling, pain and swelling) are found to be highly coincident with the symptoms of AR. The pathological changes of AR are head, orifice (nose, eye, upper jaw, ear), skin mucosa, and have the characteristics of acute onset (sudden onset sneeze), itching (nose, eye, upper jaw, throat, ear), swelling (nasal mucosa edema, nasal obstruction), etc. The invention discovers that the wind medicine is a core component for treating the AR compound through data mining. The investigation of the symptoms of the subsequent open-spread proves that the external wind syndrome, the dampness-trapped syndrome and the blood stasis syndrome are the main symptoms of the AR, and congeal the core pathogenesis of the wind evil invading the nose