CN-121971547-A - Application of Yindan Xinnaotong soft capsule in preparation of acute lung injury prevention and treatment medicines

Abstract

The invention discloses application of Yindan Xinnaotong soft capsules in preparation of medicines for preventing and treating acute lung injury, and experimental researches show that the Yindan Xinnaotong soft capsules can remarkably improve lung histopathological injury of a mouse model of acute lung injury induced by alternative complement activation and relieve inflammatory cell infiltration. The mechanism of action is that the Yindan Xinnaotong can effectively inhibit the expression of key inflammatory mediators (TNF-alpha, IL-6) and adhesion molecules (ICAM-1, P-selectin) in lung tissues and serum. Meanwhile, the medicine can down regulate mRNA transcription level of NF-kappa B p, JNK, p38 MAPK and STAT3 signal channel related genes in lung tissues and inhibit phosphorylation activation of corresponding proteins. The results comprehensively show that the Yindan Xinnaotong compound medicine can intervene in inflammatory signal paths through multiple targets, plays roles in resisting inflammation and protecting lung tissues, and can be used for preparing medicines for preventing and/or treating acute lung injury.

Inventors

• LU QINGYU
• SUN QIANYUN
• ZHOU SHUTING
• ZHANG QIYUN
• GUO LI
• YANG FUMEI

Assignees

• 贵州省天然产物研究中心

Dates

Publication Date

20260505

Application Date

20260327

Claims (2)

1. 1. Application of YINDANXINNAOTONG Soft Capsule in preparing medicine for preventing and treating acute lung injury is provided.
2. 2. The application of the Yindan Xinnaotong soft capsule of claim 1 in preparing medicines for preventing and treating acute lung injury is characterized in that the dosage form of the medicines is any one of oral liquid, injection, tablet, capsule, granule and dripping pill.

Description

Application of Yindan Xinnaotong soft capsule in preparation of acute lung injury prevention and treatment medicines Technical Field The invention belongs to the technical field of novel application of traditional Chinese medicine compounds, and in particular relates to application of Yindan Xinnaotong soft capsules in preparation of medicines for preventing and treating acute lung injury. Background Acute lung injury (acute lung injury, ALI) is a clinically common critical illness with a global mortality rate of over 50% and presents a serious hazard to human health. Acute lung injury is characterized by excessive lung inflammation, and can further develop into acute respiratory distress syndrome and multiple organ dysfunction syndrome if timely and effective treatment cannot be achieved in early stage. At present, the clinical treatment modes mainly comprise support treatment such as oxygen supply, mechanical ventilation and the like, and glucocorticoid medicaments are also adopted to relieve ALI pulmonary inflammation, but the medicaments have great side effects, and no effective treatment medicament exists clinically at present. Therefore, the exploration and development of effective control drugs remains an important direction in ALI treatment research. Considering the variety of ALI causes and complex pathogenesis, searching for a medicine for interfering lung inflammation by multiple ways and multiple targets is a key way for preventing and treating ALI. The traditional Chinese medicine is used as traditional medicine of China, has the unique advantages of 'overall concept' and 'dialectical treatment', has huge application potential in the treatment of a plurality of diseases, has the characteristics of multiple components, multiple targets, multiple links, multiple ways and small toxic and side effects, and provides a new thought for the treatment of ALI. Therefore, the discovery and excavation of the medicines for treating ALI from the traditional Chinese medicine compound preparation are important ways for preventing and treating acute lung injury. The Yindan Xinnaotong soft capsule is a Guizhou ethnic medicine which is marketed, and mainly comprises ginkgo leaf, erigeron breviscapus, gynostemma pentaphylla, hawthorn, garlic, pseudo-ginseng and blumea balsamifera tablet, wherein the content is brown to tan paste, is spicy and has slightly bitter taste. The traditional medicine has the main functions of promoting blood circulation to remove blood stasis, promoting qi circulation to relieve pain, promoting digestion to remove stagnation, can be used for treating coronary heart disease, angina pectoris, hyperlipidemia, cerebral arteriosclerosis, apoplexy and the like, and has no research report on the aspect of preventing and treating acute lung injury at present. Based on the above, the application of the Yindan Xinnaotong soft capsule in treating acute lung injury has important practical significance, and can provide clinical medicines for preventing and treating acute lung injury. Disclosure of Invention The invention aims to find out a new drug with obvious effect of treating acute lung injury aiming at the defect of treating acute lung injury by the traditional Chinese medicine compound preparation. In order to achieve the aim, the invention provides application of the Yindan Xinnaotong soft capsule in preparing medicines for preventing and treating acute lung injury. The Yindan Xinnaotong soft capsule can be directly prepared into a preparation for treating acute lung injury or can be prepared into a compound preparation for treating acute lung injury by being compounded with other medicines for treating acute lung injury. The preparation is any one of oral liquid, injection, tablet, capsule, granule and dripping pill. The beneficial effects of the invention are as follows: The invention discloses that the Yindan Xinnaotong soft capsule can be used for preparing the medicine for preventing and treating the acute lung injury for the first time, expands the clinical application range of the known medicine, and lays a solid experimental foundation for developing the medicine into a potential new medicine for treating the acute lung injury. In an acute lung injury animal model, the Yindan Xinnaotong soft capsule can obviously relieve pathological injury of lung tissues, including the lung interstitial broadening, alveolar dilatation and inflammatory cell infiltration, and intuitively proves the protective effect of the Yindan Xinnaotong soft capsule on lung structures. Pharmacological experiments prove that the Yindan Xinnaotong soft capsule can obviously reduce the level of core pro-inflammatory factors (TNF-alpha and IL-6) in alveolar lavage fluid and serum, reduce inflammatory cascade reaction from the source, effectively down regulate the expression of ICAM-1 and P-selectin, inhibit the adhesion and migration of leukocytes and endothelial cells, reduce the aggregation of inflammatory cells in l