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CN-121971552-A - Chinese medicinal composition for sobering up and dispelling effects of alcohol, and preparation method, application and product thereof

CN121971552ACN 121971552 ACN121971552 ACN 121971552ACN-121971552-A

Abstract

The invention belongs to the field of traditional Chinese medicine compositions, and particularly relates to a traditional Chinese medicine composition for sobering up and dispelling effects, which comprises a component A and a component B, wherein the component A comprises a component a, a component B, a component c and a component d, the component B comprises a component e, a component f, a component g and a component h, the component a is a kudzuvine root and an extract thereof, the component B is a rhizoma polygonati and an extract thereof, the component c is a poria cocos and an extract thereof, the component d is a lily and an extract thereof, the component e is a dwarf lilyturf tuber and an extract thereof, the component f is a medlar and an extract thereof, the component g is a konjak and an extract thereof, and the component h is a orange peel and an extract thereof. The 8 flavors are combined, so that the synergy can be realized, and an excellent sobering-up and anti-alcohol effect can be obtained. The traditional Chinese medicine composition provided by the invention can be based on the combination effect of multiple mechanisms of accelerating metabolism, organ protection and system conditioning, has a better sobering function, and the components of the traditional Chinese medicine composition belong to medicinal and edible safe raw materials.

Inventors

  • LIU XIAOZHONG
  • XIA WENJUAN
  • JIN QIFENG

Assignees

  • 湖南湘源美东医药科技有限公司

Dates

Publication Date
20260505
Application Date
20260205

Claims (10)

  1. 1. The traditional Chinese medicine composition for sobering up and dispelling effects of alcohol is characterized by comprising a component A and a component B, wherein the component A comprises a component a, a component B, a component c and a component d, and the component B comprises a component e, a component f, a component g and a component h; In the component A, the component a is radix puerariae and an extract thereof, the component b is rhizoma polygonati and an extract thereof, the component c is poria cocos and an extract thereof, and the component d is lily and an extract thereof; In the component B, the component e is dwarf lilyturf tuber and an extract thereof, the component f is medlar and an extract thereof, the component g is konjak and an extract thereof, and the component h is orange peel and an extract thereof.
  2. 2. The traditional Chinese medicine composition for sobering up and dispelling effects of alcohol according to claim 1, wherein the weight ratio of the raw materials in the components a-d in the component A meets the requirements of the formulas 1 and 2; Component b/(component c+component d) is less than or equal to 0 and less than or equal to 5; Formula 1; component a/(component b+component c) is 0 to 5; Formula 2; preferably, in the component A, the weight ratio of the raw materials in the components a-d is 1:0.5-2:0.5-2; in the component B, the weight ratio of the raw medicinal materials in the components e-h meets the requirements of the formulas 3 and 4; component e/(component f+component h) is less than or equal to 0 and less than or equal to 5; formula 3; 0< component g/(component e+component f) is less than or equal to 5; formula 4; Preferably, the weight ratio of the raw materials in the components e-h in the component B is 1:0.2-3:1-5:0.5-5.
  3. 3. The traditional Chinese medicine composition for sobering up and dispelling effects of alcohol according to claim 1, wherein the weight ratio of the component A to the component B is 1:0.5-1, preferably 1:0.6-0.9.
  4. 4. The traditional Chinese medicine composition for sobering up and dispelling effects of alcohol according to claim 1, further comprising a component C, wherein the component C comprises raw medicinal materials of at least one of hawthorn, fragrant solomonseal rhizome, chinese yam, cinnamon, astragalus root, angelica, coix seed and lotus leaf and extracts thereof; Preferably, the content of component C is 20wt.%.
  5. 5. The traditional Chinese medicine composition for sobering up and dispelling effects of alcohol according to claim 1, wherein in the traditional Chinese medicine composition, total flavone is not more than 5.0% and not more than 20.0%, total polysaccharide is not more than 10.0% and not more than 30.0%, total saponin is not more than 1.0% and not more than 10.0%, and total polyphenol is not more than 1.0% and not more than 10.0%.
  6. 6. A method for preparing the traditional Chinese medicine composition for sobering up and dispelling effects of alcohol according to any one of claims 1 to 5, which is characterized in that the composition A and the composition B are mixed to prepare; preferably, the traditional Chinese medicine composition is prepared by mixing various single raw medicinal materials in the component A and the component B; or extracting any crude drugs in the component A and the component B to obtain an extract, and mixing the extract with other components to obtain the traditional Chinese medicine composition; or mixing and extracting any raw materials in the component A and the component B.
  7. 7. The method for preparing the anti-hangover Chinese medicinal composition according to claim 6, wherein the extraction mode is one of solvent extraction, enzymolysis extraction, fermentation treatment or supercritical CO 2 extraction; The mixed raw materials of the component A and the component B are subjected to fermentation treatment in advance and then subjected to enzymolysis treatment to prepare the traditional Chinese medicine composition; preferably, the fermentation bacteria are bacillus subtilis, and the inoculation amount of the fermentation bacteria can be 5-15%; fermenting for more than 12 hours; the enzyme for enzymolysis is cellulase-pectase complex enzyme, the use amount of the enzyme can be 0.5-2%, and the enzymolysis treatment time can be more than 1 h.
  8. 8. Use of the traditional Chinese medicine composition for sobering up and dispelling effects of alcohol according to any one of claims 1-5 in preparing a sobering up and dispelling effects product; the anti-hangover product is at least one of medicine, health product and food.
  9. 9. A product for sobering up and dispelling effects of alcohol, which is characterized by comprising the Chinese medicinal composition according to any one of claims 1 to 5.
  10. 10. The anti-hangover product according to claim 9, wherein the product is at least one of a pharmaceutical, a health product, and a food; Preferably, the composition further comprises auxiliary materials; Preferably, the nutritional supplement comprises at least one of amino acid, betaine hydrochloride, curcumin, reduced glutathione, gamma-aminobutyric acid, resveratrol, yeast beta-glucan, polyfructose, galacto-oligosaccharide, xylo-oligosaccharide, chitosan and sodium alginate; preferably, the preparation is substituted tea, granule, capsule, tablet, powder, oral liquid, ointment and other acceptable dosage forms.

Description

Chinese medicinal composition for sobering up and dispelling effects of alcohol, and preparation method, application and product thereof Technical Field The invention relates to the field of traditional Chinese medicines, in particular to the field of traditional Chinese medicines for sobering up and dispelling effects of alcohol. Background Excessive drinking can cause accumulation of ethanol and its metabolite acetaldehyde in the body, causing acute or chronic health impairment. The pathological process mainly comprises the steps of metabolizing ethanol into acetaldehyde with stronger toxicity by liver Alcohol Dehydrogenase (ADH), and converting the acetaldehyde into acetic acid under the action of aldehyde dehydrogenase (ALDH). The process not only consumes a large amount of coenzyme to cause metabolic disorder, but also can generate excessive free radicals to cause oxidative stress, directly damage liver cells, gastrointestinal mucosa and nervous system, clinically show symptoms such as headache, nausea, vomiting, dry mouth, hypodynamia and the like, and increase the risks of fatty liver, hepatitis and even cirrhosis for a long time. In view of the above problems, the anti-hangover products on the market today are mainly developed around the following three action paths: promoting alcohol metabolism by adding radix Puerariae extract and semen Hoveniae etc. to promote ADH and ALDH activity and accelerate ethanol decomposition and removal. Protecting liver and resisting oxidation by directly scavenging free radicals with L-cysteine, curcumin, silymarin, etc., and relieving injury of oxidative stress to hepatocytes. Regulating intestinal microecology, namely indirectly relieving liver burden by maintaining intestinal barrier function through probiotics, prebiotics and the like based on the theory of intestinal-liver axis. In the comprehensive view, the prior art scheme focuses on a single or few targets, for example, one type of product takes chemical nutrients (such as glutathione) as a core, has single components and lacks regulation on the whole state of an organism, and the other type of product adopts medicinal and edible raw materials, but is often limited to 1-2 medicinal materials (such as single radix puerariae extract) and fails to form a system formula based on the whole view and monarch, minister, assistant and guide theory of traditional Chinese medicine, and has limited synergistic effect. In addition, some products are required to achieve the instant effect, and the addition of stimulant components such as caffeine can only mask symptoms, and do not fundamentally promote alcohol metabolism and organ protection. Disclosure of Invention Aiming at the problems existing in the prior art, the invention provides a traditional Chinese medicine composition for sobering up and relieving alcoholism, which aims at improving the sobering up and relieving alcoholism effect based on the combined synergy of components. The second aim of the invention is to provide a preparation method of the traditional Chinese medicine composition and application of the traditional Chinese medicine composition in preparation of anti-hangover products. The third object of the present invention is to provide an article comprising the said Chinese medicinal composition. The traditional Chinese medicine scheme for sobering up disclosed in the prior art, although following the principle of monarch, minister, assistant and guide compatibility, generally has the following defects that 1) the formula is based on experience, the synergistic mechanism of each medicinal material in the modern pharmacological level is not clear, 2) the daily dosage is often larger for pursuing the curative effect, and potential safety concerns can exist for long-term use, 3) part of the scheme has complicated medicinal taste, dispersed efficacy targets and the whole medicinal effect needs to be systematically improved. Therefore, it is needed to provide a traditional Chinese medicine composition with high safety based on clear Chinese medical treatment rules and modern pharmacological basis, precise and appropriate compatibility, optimized dosage. A Chinese medicinal composition for relieving hangover comprises component A and component B, wherein component A comprises component a, component B, component c and component d, and component B comprises component e, component f, component g and component h; In the component A, the component a is radix puerariae and an extract thereof, the component b is rhizoma polygonati and an extract thereof, the component c is poria cocos and an extract thereof, and the component d is lily and an extract thereof; In the component B, the component e is dwarf lilyturf tuber and an extract thereof, the component f is medlar and an extract thereof, the component g is konjak and an extract thereof, and the component h is orange peel and an extract thereof. The traditional anti-alcohol liver-protecting composition has two t