CN-121971554-A - Traditional Chinese medicine fermentation composition for regulating male hormone and preparation method and application thereof

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine fermentation composition for regulating male hormone, and a preparation method and application thereof. The preparation method comprises the steps of (1) mixing ginseng, rhizoma polygonati, cinnamon and wolfberry fruit, crushing to obtain mixed powder, (2) adding water into the mixed powder to obtain a fermentation material, simultaneously adding lactobacillus plantarum and bifidobacterium longum subspecies into the fermentation material, uniformly stirring, carrying out anaerobic fermentation, sterilizing after fermentation, cooling to room temperature to obtain a fermentation product A, (3) continuously adding bifidobacterium lactis and bifidobacterium animalis subspecies into the fermentation product A, carrying out anaerobic fermentation, sterilizing after fermentation, centrifuging, taking supernatant to obtain a fermentation product B, and (4) concentrating the fermentation product B under reduced pressure, drying and crushing. The invention has simple and refined ingredients and high formula cooperativity, and adopts specific strains and fermentation modes aiming at the special formula to realize the maximization of androgen regulation effect.

Inventors

• Jin Qikai
• Heng Peiqiang
• Liu Baogeng
• CHEN XIAOLI
• GU ZHIJING
• JI WENTAO
• Fu Xuena

Assignees

• 北京国华新业中医医学研究院有限公司

Dates

Publication Date

20260505

Application Date

20260325

Claims (10)

1. 1. A preparation method of a traditional Chinese medicine fermentation composition for regulating male hormone is characterized by comprising the following steps: (1) Mixing Ginseng radix, rhizoma Polygonati, cortex Cinnamomi, and fructus Lycii, and pulverizing to obtain mixed powder; (2) Adding water into the mixed powder to obtain a fermentation material, adding lactobacillus plantarum and bifidobacterium longum subspecies into the fermentation material simultaneously, stirring uniformly, carrying out anaerobic fermentation, sterilizing after fermentation, and cooling to room temperature to obtain a fermentation product A; (3) Continuously adding bifidobacterium lactis and bifidobacterium animalis subspecies into the fermentation product A, carrying out anaerobic fermentation, sterilizing after fermentation, centrifuging, and taking supernatant to obtain a fermentation product B; (4) Concentrating the fermentation product B under reduced pressure, drying, and pulverizing to obtain traditional Chinese medicine fermentation composition for regulating male hormone.
2. 2. The method for preparing the traditional Chinese medicine fermentation composition for regulating male hormone according to claim 1, wherein the traditional Chinese medicine fermentation composition comprises the following raw materials, by mass, 5-15 parts of ginseng, 20-30 parts of rhizoma polygonati, 1-10 parts of cinnamon and 30-40 parts of medlar.
3. 3. The method for preparing a traditional Chinese medicine fermentation composition for regulating male hormone according to claim 1, wherein the amount of lactobacillus plantarum is (1-3) x 10 8 CFU/mL fermented material.
4. 4. The method for preparing a traditional Chinese medicine fermentation composition for regulating male hormone according to claim 1, wherein the amount of the long subspecies of bifidobacterium longum is (4-7) multiplied by 10 8 CFU/mL of fermentation material.
5. 5. The method for preparing a traditional Chinese medicine fermentation composition for regulating male hormone according to claim 1, wherein the anaerobic fermentation in the step (2) is carried out under the conditions that the fermentation temperature is 35-40 ℃ and the fermentation time is 17-20h.
6. 6. The method for preparing a traditional Chinese medicine fermentation composition for regulating male hormone according to claim 1, wherein the amount of bifidobacterium lactis is (2-5) x 10 8 CFU/mL fermented material.
7. 7. The method for preparing a traditional Chinese medicine fermentation composition for regulating male hormone according to claim 1, wherein the amount of the bifidobacterium animalis subspecies lactis is (2-5) x10 8 CFU/mL of fermentation material.
8. 8. The method for preparing a traditional Chinese medicine fermentation composition for regulating male hormone according to claim 1, wherein the anaerobic fermentation in the step (3) is carried out under the conditions that the fermentation temperature is 35-40 ℃ and the fermentation time is 13-15h.
9. 9. A fermented composition of traditional Chinese medicine for regulating male hormone prepared by the preparation method of any one of claims 1 to 8.
10. 10. Use of a traditional Chinese medicine fermentation composition for regulating androgens prepared by the preparation method of any one of claims 1-8 in the preparation of a medicament for regulating androgens.

Description

Traditional Chinese medicine fermentation composition for regulating male hormone and preparation method and application thereof Technical Field The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine fermentation composition for regulating male hormone, and a preparation method and application thereof. Background Androgens (mainly testosterone) are key hormones for maintaining normal physiological functions of human bodies, and particularly play an important role in male reproductive system development, sexual function maintenance, muscle strength, bone density regulation and metabolic balance, and are involved in human body immune function regulation and mental state maintenance. With the increasing age, increasing life pressure, bad life habit and influence of chronic diseases, the population with insufficient androgen secretion is increased, and the clinical symptoms of hyposexuality, physical performance decline, memory decline, muscle relaxation, osteoporosis and the like are mainly represented, the life quality is seriously influenced, and even complications such as prostate diseases, hypogonadism and the like can be possibly caused, so that the health of human bodies is obviously endangered. At present, the clinic treatment modes aiming at androgen hyposecretion mainly comprise androgen replacement treatment and drug intervention, wherein the androgen replacement treatment mainly comprises preparations such as testosterone undecanoate capsules, testosterone patches and the like, can rapidly promote serum androgen level, but can easily cause side effects such as water retention, erythrocytosis, sleep apnea, male mammary gland development and the like after long-term use, and has potential risks for patients with prostate diseases, and the safety is required to be improved. Therefore, the development of safe, mild and natural source regulating preparation without side effect becomes a research hotspot in the current medical field, for example, CN 116392567B discloses a traditional Chinese medicine composition for improving testis dysfunction, and a preparation method and application thereof, and can improve testis dysfunction, improve hormone secretion and regulate the male reproductive endocrine environment of an organism. The traditional Chinese medicine has unique advantages in the aspects of regulating endocrine and improving hormone secretion abnormality due to the advantages of homology of medicine and food, mildness and nourishing and small side effect, however, the traditional Chinese medicine preparation mostly adopts conventional preparation methods such as crushing, decoction, extraction and the like, has the problems that active ingredients are difficult to sufficiently dissolve out, the human body absorption and utilization rate is low, the effect is slow and the like, and the effect of regulating androgen cannot be fully exerted. In order to solve the problem, the prior art begins to process the traditional Chinese medicine by adopting a probiotic fermentation technology, and macromolecular active ingredients in the traditional Chinese medicine are degraded into substances easy to absorb, such as small molecular peptides, oligosaccharides and the like through the metabolism of probiotics. However, the prior art still has a plurality of problems to be solved, firstly the prior art does not aim at the traditional Chinese medicine fermentation for regulating the male hormone, the fermentation effect is unknown, most of the prior art uses the probiotic fermentation technology for processing various traditional Chinese medicines, the specific efficacy requirement for regulating the male hormone is not combined, secondly the strains used for fermenting the traditional Chinese medicines in the prior art are single strains or compound strains matched randomly, the synergism among the strains is not deeply researched, the fermentation is not thorough according to the characteristic design science of traditional Chinese medicine raw materials, the problem of low conversion efficiency of active ingredients exists, thirdly the traditional Chinese medicine fermentation raw materials in the prior art are complex in composition, the raw material proportion is not optimized according to the efficacy requirement for regulating the male hormone, the content of the active ingredients is unbalanced, the mild and efficient regulation effect cannot be realized, the stability of the fermentation process is influenced even due to the improper proportion of the raw materials, the quality difference among product batches is large, and standardized production is difficult to realize. Therefore, developing a traditional Chinese medicine fermentation composition and a preparation method thereof which are specially aimed at regulating male hormone, simple and scientific raw material proportion, reasonable fermentation process and stabl