CN-121971555-A - Bletilla striata composition and preparation method and application thereof

Abstract

The invention provides a bletilla striata composition, a preparation method and application thereof, and relates to the technical field of traditional Chinese medicine preparations. The bletilla striata polysaccharide is used as a core active ingredient of the bletilla striata polysaccharide, has the effects of film forming, hemostasis, targeted promotion of wound repair and infection prevention, is compounded with the bletilla striata, and is anti-inflammatory in a synergistic way, and the expression levels of pro-inflammatory factors IL-1 beta, TNF-alpha and IL-6 are reduced by inhibiting NF-kappa B and MAPK signal channels, so that inflammatory cascade reaction is obviously blocked, inflammation-induced red swelling and pain are effectively relieved, and wound healing is accelerated. In addition, the bletilla striata and the tea polyphenol can also produce synergistic antibacterial effect, compared with single bletilla striata component, the wound infection probability is further reduced, excessive deposition of collagen is also inhibited by the compound use of the bletilla striata and the tea polyphenol, the scar area is reduced, the scar hyperplasia degree is reduced, and the blank of 'promoting healing only and preventing scars' aiming at burns and scalds in the prior art is overcome.

Inventors

• ZHAO JUANJUAN
• ZHANG CHUANQIN
• HU YI
• Han Taojian
• XU DELIN
• WU XIAOSONG
• Gan Yiji
• LIU HAIYU
• ZHANG HE

Assignees

• 遵义医科大学

Dates

Publication Date

20260505

Application Date

20260319

Claims (10)

1. 1. The bletilla striata composition is characterized by comprising, by mass, 5-15 parts of bletilla striata, 0.1-1 part of tea polyphenol, 5-18 parts of a fat-soluble penetration enhancer, 25-45 parts of a closed oily matrix and 5-18 parts of a water-soluble humectant; the mass of the bletilla striata is calculated by dry weight.
2. 2. The bletilla striata composition according to claim 1, wherein the fat-soluble penetration enhancer comprises one or more of lanolin, hydrogenated castor oil and polyoxyethylene hydrogenated castor oil.
3. 3. The composition of claim 1, wherein the occlusive oily base comprises one or more of petrolatum, mineral oil, and glyceryl stearate.
4. 4. The bletilla striata composition according to claim 1, wherein the water-soluble humectant comprises one or more of glycerin, propylene glycol, sorbitol and betaine.
5. 5. The bletilla striata composition according to claim 2,3 or 4, wherein the bletilla striata composition comprises, by mass, 5-15 parts of bletilla striata, 0.1-1 part of tea polyphenol, 5-15 parts of lanolin, 30-40 parts of vaseline and 10-15 parts of glycerin.
6. 6. The composition of claim 5, wherein the composition comprises, in parts by weight, 10 parts of bletilla striata, 0.3 part of tea polyphenol, 11.5 parts of lanolin, 32.9 parts of vaseline and 11.4 parts of glycerin.
7. 7. The method for preparing the bletilla striata composition according to any one of claims 1-6, comprising the following steps: thermally mixing the fat-soluble penetration enhancer with the closed oily matrix to obtain an oil-based mixture; Mixing the oil-based mixture with bletilla striata powder to obtain a paste; Mixing the paste, tea polyphenols and water-soluble humectant to obtain rhizoma bletilla composition.
8. 8. The preparation method according to claim 7, wherein the particle size of the bletilla striata powder is more than or equal to 120 meshes; The temperature of the thermal mixing is 50-80 ℃.
9. 9. Use of the bletilla striata composition according to any one of claims 1-6 or the bletilla striata composition prepared by the preparation method according to any one of claims 7-8 in the preparation of a medicament for treating burns and scalds.
10. 10. The use according to claim 9, wherein the dosage form of the medicament comprises an ointment.

Description

Bletilla striata composition and preparation method and application thereof Technical Field The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a bletilla striata composition, a preparation method and application thereof. Background Burns and scalds are a common acute accidental injury disease, which means skin or mucous membrane injury caused by flame, hot fluid, high-heat gas, electricity, chemical corrosive or radioactive rays acting on the body, and serious people may injure deep subcutaneous tissues such as muscles, bones, joints and even viscera, and even may cause life hazard when serious people are serious. After burns and scalds, strong inflammatory reaction can be immediately initiated locally, moderate inflammation is a necessary process for clearing necrotic tissues and starting repair, but if the inflammatory reaction is excessive, out-of-control or lasting too long, the wound surface of the burns and scalds is not degraded, is difficult to heal, and aggravates pain and discomfort of the burns and scalds. The treatment method for burns and scalds mainly comprises western medicine therapy and traditional Chinese medicine therapy, wherein the western medicine therapy mainly utilizes chemical synthetic medicines for resisting bacteria, resisting inflammation, easing pain and the like, but the western medicine therapy possibly brings certain irritation, has poor regeneration promoting capability on the wounds of the deep burns and scalds, has obvious scar tissues after healing, and can generate obvious toxic and side effects on human bodies due to the low specificity of part of the chemical synthetic medicines. In the traditional Chinese medicine therapy, burn and scald are diseases caused by yin impairment caused by fire heat, and the balance of the organism can be restored by treating the burn and scald through natural treatment medicines. The rhizoma bletillae is a dry tuber of rhizoma bletillae (Bletillastriata) of Orchidaceae, and has wide medicinal value, such as rhizoma bletillae, radix Caulophylli, rhizoma coptidis, and the like. It contains a large amount of mucilage, has bitter, astringent and sweet taste, is slightly cold in nature, enters lung, liver and stomach meridians, and has the effects of astringing to stop bleeding, clearing heat and promoting diuresis, and relieving swelling and promoting granulation. Can be used for treating hemoptysis, epistaxis, hemorrhage due to golden sore, carbuncle, swelling and toxin, ulcer pain, burn due to scalding fire, rhagadia manus et pedis, anal fissure, and nipple fissure. The related art discloses a bletilla striata burn and scald medicine, which is prepared by mixing bletilla striata ultrafine powder obtained by drying and crushing the bletilla striata with an oil matrix or a paste matrix, and treats the burn and scald through physical protection and basic repair effects of bletilla striata colloid. However, the bletilla striata burn and scald medicine has poor anti-inflammatory effect, so that the wound surface of the burn and scald is slow to heal, and the inflammation is not degraded, thereby aggravating the pain and discomfort of the burn and scald. Disclosure of Invention In view of the above, the present invention aims to provide a bletilla striata composition, a preparation method and an application thereof. The bletilla striata composition provided by the invention can obviously block inflammatory cascade reaction and has excellent anti-inflammatory effect. In order to achieve the above object, the present invention provides the following technical solutions: The invention provides a bletilla striata composition which comprises, by mass, 5-15 parts of bletilla striata, 0.1-1 part of tea polyphenol, 5-18 parts of a fat-soluble penetration enhancer, 25-45 parts of a closed oily matrix and 5-18 parts of a water-soluble humectant; the mass of the bletilla striata is calculated by dry weight. Preferably, the fat-soluble penetration enhancer comprises one or more of lanolin, hydrogenated castor oil and polyoxyethylene hydrogenated castor oil. Preferably, the closed oily matrix comprises one or more of vaseline, mineral oil and glyceryl stearate. Preferably, the water-soluble humectant comprises one or more of glycerin, propylene glycol, sorbitol and betaine. Preferably, the bletilla striata composition comprises, by mass, 5-15 parts of bletilla striata, 0.1-1 part of tea polyphenol, 5-15 parts of lanolin, 30-40 parts of vaseline and 10-15 parts of glycerin. Preferably, the bletilla striata composition comprises, by mass, 10 parts of bletilla striata, 0.3 part of tea polyphenol, 11.5 parts of lanolin, 32.9 parts of Vaseline and 11.4 parts of glycerin. The invention provides a preparation method of the bletilla striata composition, which comprises the following steps: thermally mixing the fat-soluble penetration enhancer with the closed oily matrix to obtain an oil-based mixture; Mixing t