CN-121971556-A - Traditional Chinese medicine composition for improving renal atrophy caused by nutrition and metabolism and application thereof

CN121971556ACN 121971556 ACN121971556 ACN 121971556ACN-121971556-A

Abstract

The invention belongs to the field of traditional Chinese medicines. The invention provides a traditional Chinese medicine composition for improving renal atrophy caused by nutrition and metabolism and application thereof, the Chinese medicinal composition comprises radix rehmanniae Preparata, corni fructus, radix Morindae officinalis, cistanchis herba, rhizoma Polygonati, semen Cuscutae, rubi fructus, fructus Schisandrae, herba Dendrobii, radix rehmanniae, rhizoma Dioscoreae, saviae Miltiorrhizae radix, radix Codonopsis, radix astragali, carapax et Plastrum Testudinis and herba asari. The traditional Chinese medicine composition can effectively fill kidney cell nutrition, achieves kidney volume improvement, has stable effect, is safe in materials, has little or no toxic or side effect, has no damage to human bodies, can synchronously improve other viscera operation capability, and is easy to obtain materials, and simple to apply and operate.

Inventors

ZHANG BOJUN
Yuan Qianyu
Xiao Kuihua
WU YINGYING
LV QI
CHEN LIYING
CHEN XIAOTING

Assignees

诸暨市尚展医学研究有限公司
灵璧县罕见病食品研究院
儋州尚展肿瘤食品研究院

Dates

Publication Date: 20260505
Application Date: 20260303

Claims (8)

1. A Chinese medicinal composition for improving renal atrophy caused by nutrition and metabolism is characterized by comprising the following components in part by weight, The principal drug is prepared from radix rehmanniae Preparata, corni fructus, radix Morindae officinalis, and Cistanchis herba; ministerial drugs including rhizoma Polygonati, semen Cuscutae, rubi fructus, fructus Schisandrae chinensis and herba Dendrobii; Adjuvant materials including radix rehmanniae, rhizoma Dioscoreae, saviae Miltiorrhizae radix, radix Codonopsis, and radix astragali; The preparation comprises carapax et Plastrum Testudinis and herba asari.
2. The Chinese medicinal composition according to claim 1, wherein the components are in parts by mass, The monarch drug is prepared from 10 to 20 parts of rehmannia glutinosa, 15 to 25 parts of dogwood, 10 to 20 parts of morinda officinalis and 10 to 20 parts of cistanche deserticola; Ministerial drugs of 10-20 parts of rhizoma polygonati, 10-20 parts of semen cuscutae, 10-20 parts of raspberry, 5-15 parts of shizandra berry and 5-15 parts of dendrobium candidum; Adjuvant drugs of 10-20 parts of dried rehmannia root, 15-25 parts of Chinese yam, 5-15 parts of red sage root, 5-15 parts of pilose asiabell root and 5-15 parts of astragalus root; the traditional Chinese medicine is 15-25 parts of tortoise plastron and 5-15 parts of asarum.
3. The Chinese medicinal composition according to claim 2, wherein the components are in parts by mass, The monarch drug comprises 15 parts of rehmannia glutinosa, 20 parts of dogwood, 15 parts of morinda officinalis and 15 parts of cistanche deserticola; the ministerial drugs comprise 15 parts of rhizoma polygonati, 15 parts of semen cuscutae, 15 parts of raspberry, 10 parts of shizandra berry and 10 parts of dendrobium candidum; adjuvant drugs including 15 parts of radix rehmanniae, 20 parts of Chinese yam, 10 parts of red sage root, 10 parts of radix codonopsis pilosulae and 10 parts of astragalus; The preparation comprises 20 parts of tortoise plastron and 10 parts of asarum.
4. A method for preparing a Chinese medicinal composition according to any one of claims 1 to 3, comprising the steps of, (1) Mixing the above materials at a certain proportion, adding water 2.5-3.5 times of the traditional Chinese medicine, soaking for 20-50 min, decocting until water is boiled, continuously decocting with medium fire for 15-35 min, and filtering to obtain residue and primary filtrate; (2) Adding water into the filter residue obtained in the step (1) which is 1.5-3.5 times of that of the traditional Chinese medicine, decocting until the water is boiled, continuing decocting for 15-35 minutes by using middle fire, and filtering to obtain a second filtrate; (3) Mixing the first filtrate and the second filtrate to obtain the final product.
5. A method of using a traditional Chinese medicine composition, comprising conditioning the traditional Chinese medicine composition prepared by the preparation method of claim 4.
6. A traditional Chinese medicine preparation for improving renal atrophy caused by nutrition and metabolism, which is characterized by comprising the traditional Chinese medicine composition according to any one of claims 1 and pharmaceutically acceptable auxiliary materials.
7. The traditional Chinese medicine preparation according to claim 6, wherein the preparation comprises powder, pill, tablet, capsule or granule.
8. Use of a traditional Chinese medicine composition according to any one of claims 1-3 or a traditional Chinese medicine preparation according to any one of claims 6-7 for the preparation of a medicament for treating or ameliorating renal atrophy.

Description

Traditional Chinese medicine composition for improving renal atrophy caused by nutrition and metabolism and application thereof Technical Field The invention belongs to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for improving renal atrophy caused by nutrition and metabolism and application thereof. Background Kidneys are located on both sides of the spine, cling to the back wall of the abdomen, and are hidden behind the peritoneum, one on each of the left and right sides. Is one of the important viscera of human body. The basic structural unit is nephron, and each side has about millions of units, so that metabolic wastes and redundant substances in blood are efficiently removed. Meanwhile, the compound vitamin D compound is a key regulator for maintaining stable environment in a human body, precisely regulates and controls water, electrolyte and acid-base balance, and has important endocrine functions of secreting renin to regulate blood pressure, generating erythropoietin to promote hematopoiesis and activating vitamin D to maintain bone health. Thus, the functional status of the kidneys directly affects blood circulation, bone metabolism, and general multisystem health. In the theory of traditional Chinese medicine, kidneys are known as the congenital root and the visceral manifestation of Tibetan essence, which govern the ability of storing essence to grow, develop and reproduce, govern water, govern and regulate the metabolism of water and fluid throughout the body, govern qi and assist in maintaining depth of breath. The traditional Chinese medicine considers that the kidney essence is directly related to the states of bones, bone marrow, brain, hair and hearing. This holistic aspect, in combination with the delicate anatomic physiology of western medicine, underscores the basic stone effects of kidneys on life health. The adult kidney has a long diameter of 10-12 cm, a wide diameter of 5-6 cm, a thick diameter of 3-5 cm and a cortex thickness of >1.5 cm. The volume is related to genetics, age, sex and height (Chinese kidney development guidance attached table). In combination with the theory of traditional Chinese medicine, the greater the volume of the kidney which has no pathology and is complete in structure, the stronger the vitality (the reference value table for the kidney measurement of the children is attached, as shown in figure 21). Common causes of renal atrophy are chronic kidney disease, renal artery stenosis, obstructive nephropathy, infection or inflammation, congenital anomalies, and the like. The nutrition and blood required by the kidneys cannot be supplied due to nutrition and metabolism problems, and the tendency of renal atrophy is also caused. Renal atrophy refers to a state in which the essential tissue of the kidney is reduced and the volume is reduced. This process means that the renal function units (nephrons) are lost in large amounts and that a decline in renal function generally occurs. The prior art does not specify a method for treating renal atrophy. The core of the current means for treating renal atrophy is to control the etiology, protect the residual renal function, treat related complications, delay the progression of the disease and improve the quality of life. For the problem of renal atrophy, it is necessary to more clearly define the problem of kidney regrowth that helps atrophy. Disclosure of Invention Aiming at the defects of the prior art, the invention provides a traditional Chinese medicine composition for improving renal atrophy caused by nutrition and metabolism and application thereof. The traditional Chinese medicine composition can effectively fill kidney cell nutrition, and can improve kidney volume. The invention aims to provide a traditional Chinese medicine composition for improving renal atrophy caused by nutrition and metabolism, which comprises the following components, The principal drug is prepared from radix rehmanniae Preparata, corni fructus, radix Morindae officinalis, and Cistanchis herba; ministerial drugs including rhizoma Polygonati, semen Cuscutae, rubi fructus, fructus Schisandrae chinensis and herba Dendrobii; Adjuvant materials including radix rehmanniae, rhizoma Dioscoreae, saviae Miltiorrhizae radix, radix Codonopsis, and radix astragali; The preparation comprises carapax et Plastrum Testudinis and herba asari. Further, the traditional Chinese medicine composition comprises the following components in parts by mass, The monarch drug is prepared from 10 to 20 parts of rehmannia glutinosa, 15 to 25 parts of dogwood, 10 to 20 parts of morinda officinalis and 10 to 20 parts of cistanche deserticola; Ministerial drugs of 10-20 parts of rhizoma polygonati, 10-20 parts of semen cuscutae, 10-20 parts of raspberry, 5-15 parts of shizandra berry and 5-15 parts of dendrobium candidum; Adjuvant drugs of 10-20 parts of dried rehmannia root, 15-25 parts of Chinese yam,