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CN-121971557-A - Composition for assisting in improving memory, application and preparation

CN121971557ACN 121971557 ACN121971557 ACN 121971557ACN-121971557-A

Abstract

The invention relates to the technical field of traditional Chinese medicines and health-care foods, in particular to a composition, application and preparation for assisting in improving memory. The composition for assisting in improving memory comprises, by weight, 2-9 parts of ginseng, 2-9 parts of ligusticum wallichii, 3-10 parts of gastrodia elata and 0.2-0.8 part of ginkgo leaf extract, wherein the preparation method of the composition comprises the steps of extracting gastrodia elata with water, filtering to obtain dregs and extract, concentrating the extract, adding ethanol for fractional precipitation, combining the precipitates to obtain gastrodia elata polysaccharide, adding the dregs, ginseng and ligusticum wallichii into ethanol for extraction, filtering, concentrating under reduced pressure, drying to obtain extract powder, and finally mixing the gastrodia elata polysaccharide, the extract powder and the ginkgo leaf extract. According to the invention, through fumbling on the extraction method of each component, the efficacy experiment proves that the composition finally prepared has the effect of remarkably improving the memory.

Inventors

  • LV YUNYI
  • Wen Gengxin
  • LIU QIANG

Assignees

  • 深圳利孚生物科技有限公司

Dates

Publication Date
20260505
Application Date
20260303

Claims (10)

  1. 1. A composition for assisting in improving memory is characterized by comprising, by weight, 2-9 parts of ginseng, 2-9 parts of ligusticum wallichii, 3-10 parts of gastrodia elata and 0.2-0.8 part of ginkgo leaf extract; The preparation method of the composition comprises the following steps: (1) Extracting rhizoma Gastrodiae with water, filtering to obtain residue and extractive solution, concentrating the extractive solution, sequentially adding ethanol to ethanol concentration of 40-50%, 65-75% and 80-85% respectively, precipitating for three times, and mixing the precipitate to obtain rhizoma Gastrodiae polysaccharide; (2) Extracting the residues, ginseng radix and rhizoma Ligustici Chuanxiong with ethanol solution, filtering, concentrating the filtrate, and drying to obtain extract powder; (3) Mixing rhizoma Gastrodiae polysaccharide, extract powder and folium Ginkgo extract.
  2. 2. The memory-aid composition according to claim 1, wherein in the step (1), the temperature of the extraction is 70-85 ℃ and the time of the extraction is 0.5-1h.
  3. 3. The memory-aid composition according to claim 1, wherein in the step (2), the ethanol solution is an ethanol solution having a concentration of 60 to 75% by volume of soybean lecithin and polyglyceride.
  4. 4. The composition for assisting in improving memory according to claim 3, wherein the mass concentration of the soybean lecithin and the polyglycerol ester in the ethanol solution is 0.1 to 3%; And/or the mass ratio of the soybean lecithin to the polyglycerol ester is 1:0.1-0.5; and/or, the polyglycerol ester is tetrapolyglycerol monolaurate.
  5. 5. The composition for assisting in improving memory according to claim 1, wherein in the step (2), the extraction is reflux extraction, the number of times of extraction is 1 to 3, and each time of extraction is 1 to 2 hours.
  6. 6. The composition for assisting in improving memory according to claim 1, wherein the composition for assisting in improving memory comprises, by weight, 2-5 parts of ginseng, 2-5 parts of ligusticum wallichii, 3-5 parts of gastrodia elata and 0.2-0.5 part of ginkgo leaf extract; Preferably, the composition for improving memory comprises the following components in parts by weight of 3 parts of ginseng, 3 parts of ligusticum wallichii, 5 parts of gastrodia elata and 0.4 part of ginkgo leaf extract.
  7. 7. Use of a composition for assisting in improving memory as claimed in any one of claims 1 to 6 in the manufacture of a health food or medicament for assisting in improving memory.
  8. 8. A preparation for assisting in improving memory, which is characterized by comprising the composition for assisting in improving memory according to any one of claims 1-6 and pharmaceutically or food acceptable auxiliary materials, wherein the preparation is any one of solid beverage, tablet, capsule and tea substitute.
  9. 9. The preparation according to claim 8, wherein the composition for improving memory comprises, by weight, 20-40 parts of a composition for improving memory, 50-70 parts of a filler, 0.01-0.05 parts of a lubricant, and 1-10 parts of a flavoring agent.
  10. 10. The formulation according to claim 9, wherein the filler is tapioca starch and lactose in a mass ratio of 1:1-2; and/or the lubricant is silicon dioxide and/or magnesium stearate; and/or the flavoring agent is any one or more of stevioside, lemon essence, apple essence, strawberry essence, cranberry essence and chamomile essence.

Description

Composition for assisting in improving memory, application and preparation Technical Field The invention belongs to the technical field of traditional Chinese medicines and health-care foods, and particularly relates to a composition, application and preparation for assisting in improving memory. Background Memory itself is a comprehensive function of the nervous system, and any tissue dysfunction in the nervous system affects memory function and reduces memory. The memory center of human body is in the sea horse, if the functions of the inner core and the outer core are not sound, the input and output information of the memory can not be effectively completed, and the control ability including intelligence and memory can be reduced. The neural connection function of the hippocampus with other tissues of the brain can cause serious dysfunction in memory function if a debilitating condition occurs or the development is imperfect. The traditional Chinese medicine theory considers that hypomnesis is related to 'kidney essence deficiency', 'heart-spleen deficiency' or 'phlegm stasis and collateral obstruction', and brain is regulated by means of tonifying heart and spleen, tonifying kidney, replenishing essence and the like. Modern researches have proved that the active ingredients of the traditional Chinese medicine (such as ginseng flavonoid glycoside, ligusticum chuanxiong and ferulic acid) act through multiple channels: (1) ‌ antioxidant and neuroprotection ‌, flavonoid component scavenging free radical, reducing neuron oxidative damage, and delaying brain cell degeneration; (2) ‌ promote neurotransmitter synthesis ‌, such as ginsenoside, can promote acetylcholine level and enhance synaptic transmission efficiency; (3) ‌ improving microcirculation ‌, dilating cerebral vessels, and increasing oxygen supply to Hippocampus. The Chinese patent application CN1135350A discloses a preparation method of a memory pill, which comprises the steps of taking radix rehmanniae, prepared rehmannia root, chinese yam, dogwood, chinese angelica, shizandra berry, asparagus, dwarf lilyturf tuber, polygala tenuifolia, spina date seed, platycladi seed, amur corktree bark, common anemarrhena rhizome, medlar, ginseng, dragon bone, tortoise shell, dragon bone, grassleaf sweetflag rhizome, indian buead, crushing tortoise shell, ginseng, dragon bone and Indian buead into fine powder, adding ethanol into the rest ten five medicines, reflux-extracting for two times, concentrating the clear paste, mixing the clear paste with the fine powder, drying, crushing, sieving, preparing pills with ethanol, coating with dried rehmannia root charcoal, preparing the pills, drying, polishing and packaging. The prescription has complex medicinal taste, is not beneficial to the elucidation of pharmacological actions, and has no outstanding medicinal effect. Another Chinese patent CN106668564B discloses a natural pharmaceutical composition for improving memory function, which is prepared from (by weight portions) cistanche 30-80, gastrodia tuber 18-30 and ginkgo leaf 2-10. The natural pharmaceutical composition plays a role in better improving memory function through the synergistic effect among the components, and has better effect than a single component. The medicinal preparation and the health product prepared from the natural medicinal composition have remarkable curative effect of improving the memory function and are convenient to take. The raw materials have simple flavor, no harm to human body and good safety, but the dosage of the raw materials is large, the active ingredients of the raw materials are not fully extracted, certain waste is caused to traditional Chinese medicine resources, and the effect of improving the memory is still required to be improved. Disclosure of Invention Aiming at the defects in the prior art, the invention provides a composition, application and preparation for assisting in improving memory. The invention aims at realizing the following technical scheme: A composition for assisting in improving memory comprises, by weight, 2-9 parts of ginseng, 2-9 parts of Ligusticum wallichii, 3-10 parts of gastrodia elata and 0.2-0.8 part of ginkgo leaf extract; The preparation method of the composition comprises the following steps: (1) Extracting rhizoma Gastrodiae with water, filtering to obtain residue and extractive solution, concentrating the extractive solution, sequentially adding ethanol to obtain 40-50% ethanol, 65-75% ethanol and 80-85% ethanol, precipitating for three times, and mixing the precipitate to obtain rhizoma Gastrodiae polysaccharide; (2) Extracting the residues, ginseng radix and rhizoma Ligustici Chuanxiong with ethanol solution, filtering, concentrating the filtrate, and drying to obtain extract powder; (3) Mixing rhizoma Gastrodiae polysaccharide, extract powder and folium Ginkgo extract. Preferably, in step (1), the extraction temperature is 70-85 ℃ and the extraction time is 0.5-1h. Preferably, in t