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CN-121971560-A - Plant-source compound oral liquid for promoting discharge of postoperative residual calculus and application thereof

CN121971560ACN 121971560 ACN121971560 ACN 121971560ACN-121971560-A

Abstract

The invention provides a plant-derived compound oral liquid for promoting the discharge of residual calculus after operation and application thereof, the oral liquid is prepared by taking plants such as cattail grass, climbing fern vine, lysimachia christinae and the like as core raw materials, compounding cowberry fruit extract and globe artichoke extract, adding intestinal flora regulator consisting of xylooligosaccharide and inactivated lactobacillus plantarum, and matching with natural sweetener and thickening stabilizer; simultaneously optimizes the purification and extraction process of the extract and the preparation flow of reflux extraction, compound blending, sterilization and filling of the oral liquid. The preparation process is stable and controllable, the dissolution rate of the active ingredients is high, no chemical synthesis additive is used, the safety is good, the preparation method can be widely applied to the preparation of medicines for promoting the discharge of kidney stones, urinary stones and bladder stones after operation, and the clinical application value is remarkable.

Inventors

  • WU CHENGBIN
  • XU YAJUN
  • WEN LI

Assignees

  • 海口市第三人民医院

Dates

Publication Date
20260505
Application Date
20260210

Claims (10)

  1. 1. A plant-derived compound oral liquid for promoting the discharge of residual calculus after operation is characterized by comprising, by weight, 15-35 parts of cattail grass, 10-25 parts of climbing fern vine, 20-40 parts of desmodium, 10-20 parts of desmodium styracifolium, 5-15 parts of chicken's gizzard-skin, 6-10 parts of cogongrass rhizome, 3-8 parts of semen Abutili, 5-15 parts of hawthorn leaves, 1-5 parts of cowberry fruit extract, 2-4 parts of globe artichoke extract and auxiliary materials.
  2. 2. The plant-derived compound oral liquid according to claim 1, which is characterized by comprising the following raw materials, by weight, 25 parts of cattail grass, 15 parts of climbing fern vine, 30 parts of desmodium, 15 parts of desmodium styracifolium, 10 parts of chicken's gizzard-skin, 8 parts of cogongrass rhizome, 5 parts of malva seed, 10 parts of hawthorn leaf, 3 parts of cowberry fruit extract, 3 parts of globe artichoke extract and auxiliary materials.
  3. 3. The plant-derived compound oral liquid according to claim 1, further comprising an intestinal flora regulator, wherein the regulator is xylo-oligosaccharide and inactivated lactobacillus plantarum, and the adding amount is 3-15 parts.
  4. 4. The plant-derived compound oral liquid according to claim 1, wherein the auxiliary materials comprise 1-10 parts of natural sweetener and 0.1-3 parts of thickening stabilizer.
  5. 5. The plant-derived compound oral liquid of claim 4, wherein the natural sweetener is selected from steviol glycosides or erythritol and the thickening stabilizer is selected from pectin or agar.
  6. 6. The plant-derived compound oral liquid of claim 1, wherein the extraction method of the cowberry fruit extract comprises the following steps: (1) Raw material pretreatment, namely crushing cowberry fruits or dried products thereof to obtain fruit pulp or fruit powder; (2) Solvent extraction, namely adding 40-60% v/v of acidified ethanol solution according to the mass volume g/mL ratio of 1:5-10, stirring and extracting for 1-3 hours in a constant-temperature water bath at the temperature of 40-50 ℃, repeating the extraction for 3 times, and combining the extracting solutions; (3) Filtering and concentrating, namely concentrating the extracting solution in the step (2) under reduced pressure at 50-70 ℃ and minus 0.08-minus 0.10 MPa; (4) Purifying by loading the concentrated solution onto macroporous adsorption resin column, eluting impurities with 2-4 times of column volume deionized water and 15-25% v/v ethanol, eluting target component with 60-80% v/v ethanol at flow rate of 1-3BV/h, and collecting eluate; (5) Drying to obtain powder, and spray drying the eluate to obtain powder of Vaccinium myrtillus extract.
  7. 7. The plant-derived compound oral liquid according to claim 1, wherein the extraction method of the artichoke extract comprises the following steps: (1) Raw material pretreatment, namely selecting fresh leaves of globe artichoke, removing impurities, cleaning, drying by blowing at 55-65 ℃ until the moisture content is less than or equal to 8%, crushing, and sieving by a 30-50-mesh sieve to obtain globe artichoke dry powder; (2) Ultrasonic assisted extraction by adding deionized water at a mass/volume g/mL ratio of 1:10-14, adjusting pH to 5.0-6.0, ultrasonic extracting at power of 250-350W and temperature of 55-65deg.C for 30-60 min for 1-3 times, and mixing extractive solutions; (3) Centrifuging the extractive solution at 3500-4500r/min for 10-20 min, collecting supernatant, and passing through 0.20-0.25 μm microfiltration membrane; (4) Nanofiltration concentration, namely adopting a ceramic nanofiltration membrane with the molecular weight cut-off of 250-350Da, and concentrating to 1/4-1/6 of the original volume under the conditions of the pressure of 0.5-0.7MPa and the temperature of 40-50 ℃; (5) Freeze drying, pre-freezing the concentrated solution at-45 to-35 deg.C for 2-4 hr, freeze drying at vacuum degree of 0.008-0.012MPa and sublimation temperature of 30-40 deg.C for 10-14 hr, pulverizing, and sieving with 70-90 mesh sieve to obtain globe artichoke extract.
  8. 8. The method for preparing the plant-derived compound oral liquid according to any one of claims 1 to 7, comprising the steps of: S1, raw material extraction, namely weighing cattail grass, climbing fern vine, desmodium, chicken' S gizzard-membrane, cogongrass rhizome, semen Abutili and hawthorn leaves according to parts by weight, mixing, adding 10-15 times of deionized water, soaking for 30-60 minutes, heating to 80-90 ℃ for reflux extraction for 2-3 times, each time for 1-2 hours, combining the extracting solutions, and concentrating under reduced pressure to obtain clear paste with the relative density of 1.10-1.15; S2, compounding, namely mixing the clear paste obtained in the step S1 with the cowberry extract, the artichoke extract, the intestinal flora regulator, the natural sweetener and the thickening stabilizer, adding deionized water to 1000mL, stirring until the clear paste is completely dissolved, and regulating the pH value to 5.0-6.0; and S3, sterilizing and filling, namely sterilizing and filtering the mixed solution obtained in the step S2 through a microporous filter membrane with the diameter of 0.45 mu m and a microporous filter membrane with the diameter of 0.22 mu m, and filling the obtained filtrate under a sterile condition to obtain the plant source compound oral liquid.
  9. 9. Use of a botanical compound oral liquid as claimed in any of claims 1-7 in the manufacture of a medicament for promoting post-operative urinary system stone removal.
  10. 10. The use according to claim 9, wherein the urinary system stones are kidney stones, urinary stones or bladder stones.

Description

Plant-source compound oral liquid for promoting discharge of postoperative residual calculus and application thereof Technical Field The invention relates to the technical field of medicine preparation, in particular to a plant-derived compound oral liquid for promoting discharge of postoperative residual stones and application thereof. Background Urinary system stones are common diseases and frequently-occurring diseases of urinary surgery, and the treatment method comprises minimally invasive operations such as extracorporeal shock wave lithotripsy, ureteroscope lithotripsy and lithotripsy, percutaneous nephrolithotripsy and the like. However, residual calculus fragments with smaller diameters often exist after operation, and if the residual calculus fragments cannot be discharged in time, the residual calculus fragments can become cores for calculus recurrence, so that complications such as obstruction and infection are caused, and the final curative effect of the operation and the life quality of patients are seriously affected. At present, drugs are often used clinically to assist in removing urinary calculus, such as alpha receptor blockers or calcium channel antagonists, primarily by relaxing ureteral smooth muscle. However, the medicines have single action targets, have limited comprehensive effects on improving urine environment, inhibiting crystal aggregation, relieving postoperative local edema, inflammatory reaction and the like, and may be accompanied with side effects such as orthostatic hypotension, dizziness and the like. In addition, although some Chinese patent medicines have the effects of promoting urination and treating stranguria, the Chinese patent medicines have complex components and high quality control difficulty, and the research on targeted treatment under the specific physiological and pathological state after operation is insufficient, in particular the comprehensive consideration on the aspects of regulating whole body metabolism, resisting oxidative stress and protecting kidney functions is insufficient. Disclosure of Invention In view of the above, the invention provides a plant-derived compound oral liquid for promoting the discharge of residual calculus after operation and application thereof, and solves the problems. The technical scheme is that the plant-derived compound oral liquid for promoting the discharge of residual calculus after operation is realized by the following raw materials, by weight, 15-35 parts of cattail grass, 10-25 parts of climbing fern vine, 20-40 parts of desmodium, 10-20 parts of desmodium styracifolium, 5-15 parts of chicken's gizzard-skin, 6-10 parts of cogongrass rhizome, 3-8 parts of semen Abutili, 5-15 parts of hawthorn leaves, 1-5 parts of cowberry fruit extract, 2-4 parts of artichoke extract and auxiliary materials. Further, the Chinese medicinal composition comprises the following raw materials, by weight, 25 parts of cattleleaf knotweed herb, 15 parts of climbing fern vine, 30 parts of desmodium, 15 parts of desmodium styracifolium, 10 parts of chicken's gizzard-skin, 8 parts of cogongrass rhizome, 5 parts of semen Abutili, 10 parts of hawthorn leaf, 3 parts of cowberry fruit extract, 3 parts of globe artichoke extract and auxiliary materials. Further, the preparation also comprises an intestinal flora regulator, wherein the regulator is xylooligosaccharide and inactivated lactobacillus plantarum, and the addition amount is 3-15 parts. Further, the auxiliary materials comprise 1-10 parts of natural sweetener and 0.1-3 parts of thickening stabilizer. Further, the natural sweetener is selected from steviol glycoside or erythritol, and the thickening stabilizer is selected from pectin or agar. Further, the extraction method of the bilberry extract comprises the following steps: (1) Raw material pretreatment, namely selecting mature cowberry fruits, screening to remove impurities, washing with deionized water for 3 times, freezing at-20 ℃ for 24 hours, and crushing into pulp with the particle size of 5-8 mm; (2) Extracting with solvent by adding acidified ethanol solution 40-60% v/v at mass volume g/mL of 1:5-10, stirring in 40-50deg.C constant-temperature water bath for 1-3 hr, repeating extraction for 3 times, and mixing extractive solutions; (3) Filtering and concentrating, namely removing residues by adopting plate-and-frame filtration (the pore diameter of a filter membrane is 0.45 μm), and concentrating the extracting solution under reduced pressure at 50-70 ℃ and-0.08-0.10 MPa until the solid content is 25%; (4) Resin purification, namely loading the concentrated solution to an AB-8 macroporous adsorption resin column (diameter to height ratio is 1:8), eluting impurities by using 2-4 times of column volume deionized water and 15-25% v/v ethanol in sequence, eluting target components by using 60-80% v/v ethanol at a flow rate of 1-3BV/h, and collecting eluent; (5) Drying and pulverizing, namely spray drying the eluent to obtain powde