Search

CN-121971561-A - Traditional Chinese medicine composition with anti-tumor function and application thereof

CN121971561ACN 121971561 ACN121971561 ACN 121971561ACN-121971561-A

Abstract

The invention provides a traditional Chinese medicine composition with an anti-tumor function and application thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition comprises, by weight, 8-12 parts of radix scutellariae, 12-18 parts of white peony root, 8-12 parts of officinal magnolia bark, 8-12 parts of fructus aurantii, 8-12 parts of dried orange peel, 8-12 parts of radix puerariae, 8-12 parts of radix bupleuri, 8-12 parts of liquorice, 12-18 parts of radix codonopsis, 25-35 parts of radix astragali, 25-35 parts of radix sophorae flavescentis, 25-35 parts of oldenlandia diffusa, 25-35 parts of Chinese gooseberry root, 25-35 parts of herba patriniae and 25-35 parts of coix seed. The traditional Chinese medicine composition has direct anti-tumor activity, can obviously enhance the treatment effect of chemotherapeutic drugs and/or immune checkpoint inhibitors, and provides an effective means for the comprehensive treatment of tumors.

Inventors

  • SUI XINBING
  • GAO QUAN
  • CHEN MENGTING
  • Zhu Zhitou

Assignees

  • 隋新兵

Dates

Publication Date
20260505
Application Date
20260109

Claims (10)

  1. 1. The traditional Chinese medicine composition is characterized by comprising, by weight, 8-12 parts of radix scutellariae, 12-18 parts of white peony root, 8-12 parts of officinal magnolia bark, 8-12 parts of fructus aurantii, 8-12 parts of dried orange peel, 8-12 parts of kudzuvine root, 8-12 parts of radix bupleuri, 8-12 parts of liquorice, 12-18 parts of radix codonopsis pilosulae, 25-35 parts of astragalus membranaceus, 25-35 parts of radix sophorae flavescentis, 25-35 parts of oldenlandia diffusa, 25-35 parts of Chinese actinidia root, 25-35 parts of herba patriniae and 25-35 parts of coix seed.
  2. 2. The traditional Chinese medicine composition according to claim 1 is characterized by comprising, by weight, 9-11 parts of radix scutellariae, 13-16 parts of white paeony root, 9-11 parts of officinal magnolia bark, 9-11 parts of fructus aurantii, 9-11 parts of dried orange peel, 9-11 parts of radix puerariae, 9-11 parts of radix bupleuri, 9-11 parts of liquorice, 13-16 parts of radix codonopsis, 28-33 parts of radix astragali, 28-33 parts of radix sophorae flavescentis, 28-33 parts of oldenlandia diffusa, 28-32 parts of Chinese gooseberry root, 28-32 parts of herba patriniae and 28-32 parts of coix seed.
  3. 3. The traditional Chinese medicine composition according to claim 1 or 2, which is characterized by comprising the following raw materials, by weight, 10 parts of radix scutellariae, 15 parts of white peony root, 10 parts of officinal magnolia bark, 10 parts of fructus aurantii, 10 parts of dried orange peel, 10 parts of kudzuvine root, 10 parts of radix bupleuri, 10 parts of liquorice, 15 parts of radix codonopsitis, 30 parts of astragalus membranaceus, 30 parts of radix sophorae flavescentis, 30 parts of oldenlandia diffusa, 30 parts of Chinese gooseberry root, 30 parts of herba patriniae and 30 parts of coix seed.
  4. 4. The method for preparing the traditional Chinese medicine composition according to any one of claims 1-3, wherein the traditional Chinese medicine composition is obtained by mixing raw materials, heating, refluxing and extracting the raw materials, and collecting an extracting solution.
  5. 5. The method according to claim 4, wherein the solvent for heat reflux extraction comprises water or an aqueous solution of 70 vol.% to 99 vol.% ethanol; the extraction temperature of the water is 92-102 ℃; The extraction temperature of the 70-99 vol% ethanol water solution is 98-102 ℃ or 78-90 ℃.
  6. 6. The traditional Chinese medicine composition according to any one of claims 1-3, the traditional Chinese medicine composition prepared by the preparation method according to claim 4 or 5, or the application of the traditional Chinese medicine composition in combination with chemotherapeutic drugs and/or immune checkpoint inhibitors in preparation of antitumor drugs.
  7. 7. The use of a traditional Chinese medicine composition according to any one of claims 1-3 or a traditional Chinese medicine composition prepared by the preparation method according to claim 4 or 5 in preparing a medicament for improving the anti-tumor efficacy of a chemotherapeutic medicament and/or an immune checkpoint inhibitor.
  8. 8. The use according to claim 6 or 7, wherein the tumour is selected from at least one of intestinal cancer, lung cancer, gastric cancer, liver cancer, breast cancer, pancreatic cancer, prostate cancer, ovarian cancer, cervical cancer, renal cancer, bladder cancer, oesophageal cancer, brain glioma, melanoma, nasopharyngeal cancer, thyroid cancer, osteosarcoma, gall bladder cancer and soft tissue sarcoma.
  9. 9. An antitumor pharmaceutical composition characterized in that the active ingredient comprises the traditional Chinese medicine composition according to any one of claims 1-3 or the traditional Chinese medicine composition prepared by the preparation method according to claim 4 or 5.
  10. 10. The anti-tumor pharmaceutical composition according to claim 9, wherein the active ingredient further comprises a chemotherapeutic agent and/or an immune checkpoint inhibitor.

Description

Traditional Chinese medicine composition with anti-tumor function and application thereof Technical Field The application belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition with an anti-tumor function and application thereof. Background Malignant tumors are one of the major diseases seriously jeopardizing human health. Currently, the main treatment means of modern medicine include surgery, radiation therapy, chemotherapy, immunotherapy, etc. Among them, chemotherapy and immunotherapy have become core treatment schemes for middle and late stage tumors. However, the chemotherapeutic drugs have the problems of poor selectivity, large toxic and side effects (such as bone marrow suppression, gastrointestinal tract reaction, liver and kidney function injury and the like), easy generation of drug resistance and the like, and seriously influence the survival quality and treatment compliance of patients. In recent years, although immunotherapy typified by an immune checkpoint inhibitor has been progressed in breakthrough, the overall response rate is limited, immune-related adverse reactions may be caused, and primary or secondary drug resistance may occur in some patients. In face of the above challenges, traditional Chinese medicine presents unique advantages in the comprehensive treatment of tumors. A plurality of clinical practices show that the combination of the traditional Chinese medicine and chemotherapy and immunotherapy is expected to have the synergistic effect of attenuation and synergy, namely, the toxic and side effects brought by western medicine treatment are reduced, and the anti-tumor curative effect is enhanced. The Chinese medicinal prescription of baikal skullcap root-magnolia bark Shang Shi in Gujin Yichester is composed of 8 Chinese medicinal materials of baikal skullcap root, white peony root with bran, ginger magnolia bark, bitter orange with bran, dried orange peel, kudzuvine root, bupleurum root and honey-fried licorice root. Up to now, the use of flavored baikal skullcap root and magnolia bark decoction in preparing anti-tumor drugs and enhancing the curative effect of tumor treatment has not been reported. Disclosure of Invention The application aims to provide a traditional Chinese medicine composition with an anti-tumor function, which not only has stronger anti-tumor activity, but also has a synergistic effect on the aspect of anti-tumor with conventional therapies. The invention provides a traditional Chinese medicine composition which is prepared from the following raw materials, by weight, 8-12 parts of radix scutellariae, 12-18 parts of white peony root, 8-12 parts of officinal magnolia bark, 8-12 parts of fructus aurantii, 8-12 parts of dried orange peel, 8-12 parts of kudzuvine root, 8-12 parts of radix bupleuri, 8-12 parts of liquorice, 12-18 parts of radix codonopsis pilosulae, 25-35 parts of astragalus membranaceus, 25-35 parts of radix sophorae flavescentis, 25-35 parts of oldenlandia diffusa, 25-35 parts of Chinese actinidia root, 25-35 parts of herba patriniae and 25-35 parts of coix seed. The traditional Chinese medicine composition is prepared from the following raw materials, by weight, 9-11 parts of radix scutellariae, 13-16 parts of white peony root, 9-11 parts of officinal magnolia bark, 9-11 parts of fructus aurantii, 9-11 parts of dried orange peel, 9-11 parts of kudzuvine root, 9-11 parts of radix bupleuri, 9-11 parts of liquorice, 13-16 parts of codonopsis pilosula, 28-33 parts of astragalus mongholicus, 28-33 parts of radix sophorae flavescentis, 28-33 parts of oldenlandia diffusa, 28-32 parts of Chinese gooseberry root, 28-32 parts of herba patriniae and 28-32 parts of coix seed. Preferably, the Chinese medicinal composition is prepared from the following raw materials, by weight, 10 parts of radix scutellariae, 15 parts of white peony root, 10 parts of officinal magnolia bark, 10 parts of fructus aurantii, 10 parts of dried orange peel, 10 parts of radix puerariae, 10 parts of radix bupleuri, 10 parts of liquorice, 15 parts of radix codonopsis pilosulae, 30 parts of astragalus membranaceus, 30 parts of radix sophorae flavescentis, 30 parts of oldenlandia diffusa, 30 parts of Chinese gooseberry root, 30 parts of herba patriniae and 30 parts of coix seed. The invention provides a preparation method of the traditional Chinese medicine composition, which comprises the steps of mixing raw materials, heating, reflux-extracting, and collecting an extracting solution to obtain the traditional Chinese medicine composition. Preferably, the solvent for heating reflux extraction comprises water or 70-99 vol% ethanol water solution; the extraction temperature of the water is 92-102 ℃; The extraction temperature of the 70-99 vol% ethanol water solution is 98-102 ℃ or 78-90 DEG C The invention provides the application of the traditional Chinese medicine composition, the traditional Chinese