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CN-121971562-A - Abdominal anti-inflammatory patch and preparation method thereof

CN121971562ACN 121971562 ACN121971562 ACN 121971562ACN-121971562-A

Abstract

The invention belongs to the technical field of anti-inflammatory patches, and particularly relates to an abdomen anti-inflammatory patch and a preparation method thereof, wherein the abdomen anti-inflammatory patch comprises, by weight, 20-40 parts of raw coix seeds, 25-40 parts of drug-carrying compounds, 10-25 parts of cortex moutan, 8-20 parts of safflower, 25-40 parts of patrinia herb, 25-45 parts of selfheal, 8-15 parts of rheum officinale, 15-30 parts of rhizoma corydalis and 10-30 parts of mirabilite, and hydroxyl active sites fully exposed after impurities are removed by a purification process in the drug-carrying compounds prepared by the invention become core carriers for constructing a supermolecular system, the core carriers react with menthol and borneol to form a stable drug-carrying compound, a core anti-inflammatory prescription is matched, and the external patch is prepared by combining special processes of gradient low-temperature mixing, low Wen Yaogao tempering and the like, so that the targeted anti-inflammatory effect and the stability of a drug are greatly improved on the premise of keeping the safety of the drug.

Inventors

  • SU JUANPING
  • XIN YAN
  • ZHOU XINYUAN
  • SUN SHIYING

Assignees

  • 山西省中医药研究院（山西省中医院）

Dates

Publication Date
20260505
Application Date
20260330

Claims (6)

  1. 1. An anti-inflammatory abdomen patch is characterized by comprising the following raw materials, by weight, 20-40 parts of raw coix seeds, 25-40 parts of drug-carrying compounds, 10-25 parts of cortex moutan, 8-20 parts of safflower, 25-40 parts of herba patriniae, 25-45 parts of selfheal, 8-15 parts of rheum officinale, 15-30 parts of rhizoma corydalis and 10-30 parts of mirabilite; the drug-loaded compound comprises the following raw materials in mass ratio of Sha Haozi:menthol, borneol=100-120:1.5:1; The preparation method of the drug-loaded compound comprises the following steps: (1) Taking sargassum pallidum, rinsing, drying at low temperature, pulverizing, sieving, extracting with water, concentrating under reduced pressure, precipitating crude polysaccharide, centrifuging, collecting precipitate, washing, and freeze drying to obtain crude polysaccharide; (2) Dissolving crude polysaccharide in purified water to form polysaccharide solution, adding Sevage reagent, shaking vigorously, centrifuging, dialyzing, and lyophilizing to obtain Sha Haozi refined polysaccharide; (3) Weighing sargassum pallidum refined polysaccharide, adding purified water, stirring in water bath, filtering to obtain clear solution, mixing menthol and Borneolum Syntheticum, and stirring by ice-separation heating method to obtain mixed oily liquid; (4) And (3) dropwise adding the mixed oily liquid into the clear solution, stirring while dropwise adding, performing ultrasonic-assisted compounding, and then continuing low-temperature stirring, and performing vacuum freeze drying to obtain the drug-loaded compound.
  2. 2. The abdominal anti-inflammatory patch according to claim 1, wherein in step (2), the volume ratio of polysaccharide solution to Sevage reagent is 3:1; in the step (3), the mass ratio of Sha Haozi refined polysaccharide to menthol is 2-5:1, and the mass concentration of the sargassum pallidum refined polysaccharide in the clarified solution is 100-150mg/mL.
  3. 3. The abdominal anti-inflammatory patch according to claim 1, wherein in the step (4), the ultrasonic-assisted compounding condition is that the power is set to 200-300W, the frequency is 40kHz, the temperature is 8-12 ℃, the ultrasonic time is 30min, and the temperature of the low-temperature stirring is 8-12 ℃ for 1 hour.
  4. 4. A method for preparing an abdominal anti-inflammatory patch according to any one of claims 1 to 3, comprising the steps of: s1, mixing raw coix seed, tree peony bark, safflower, herba patriniae, selfheal, rheum officinale and rhizoma corydalis, drying at a low temperature, then crushing and sieving to obtain core medicinal powder; s2, mixing the core powder with mirabilite, adding a medicine carrying compound, and carrying out gradient mixing to obtain composite powder; S3, mixing carbomer matrix, glycerol and purified water, heating, stirring until the carbomer matrix, glycerol and purified water are dissolved to form a transparent gel matrix, and cooling to obtain a cooled gel matrix; s4, adding the composite powder into the cooled gel matrix for multiple times, and stirring while adding to form ointment; s5, preparing and forming the ointment, sealing and packaging in a sterile way to obtain the abdomen anti-inflammatory patch.
  5. 5. The method of claim 4, wherein in step S2, the gradient mixing is performed by mixing the core powder and Natrii sulfas in a three-dimensional motion mixer for 15min at low speed, adding the drug-loaded compound, mixing for 30 min, and controlling the mixing temperature in the whole process.
  6. 6. The method of claim 4, wherein in step S3, the mass ratio of carbomer matrix, glycerin and purified water is 3:5:12.

Description

Abdominal anti-inflammatory patch and preparation method thereof Technical Field The invention belongs to the technical field of anti-inflammatory patches, and particularly relates to an abdomen anti-inflammatory patch and a preparation method thereof. Background The abdominal inflammatory diseases are common clinical diseases and frequently encountered diseases, and comprise various diseases such as acute and chronic appendicitis, cholecystitis, gastroenterology chronic intestinal inflammation, gynecological pelvic inflammation, adnexitis and the like, the diseases mostly take damp-heat stasis and qi-blood stasis as core pathogenesis, and the conventional treatment mostly adopts oral antibiotics, anti-inflammatory western medicines or oral traditional Chinese medicine decoction, and has obvious defects that the oral medicines are absorbed by gastrointestinal tracts, metabolized by livers, have poor targeting, easily cause gastrointestinal irritation and liver-kidney metabolism burden, the antibiotics are easy to generate drug resistance after long-term use, partial acute inflammation needs operation treatment, and has large wounds, more postoperative complications and low patient acceptance. The external patch of the traditional Chinese medicine relies on the theory of 'external treatment of internal diseases' of the traditional Chinese medicine, and the medicine is directly absorbed through skin to reach focus, so that the first pass effect of oral administration is avoided, the safety is high, the targeting is strong, and the external patch becomes the preferable scheme of the conservative treatment of abdominal inflammation. The traditional external-use patch for treating the abdominal inflammation has a plurality of short plates with the technology that firstly, the formula is mainly prepared by simply stacking conventional medicinal materials for activating blood and dissolving stasis and clearing heat and detoxicating, the accurate compatibility of monarch, minister, assistant and guide is not carried out on a nuclear heart disease machine for treating the abdominal inflammation, the anti-inflammatory pertinence is insufficient, secondly, most of the patches only depend on the permeation of medicinal components, lack of permeation promoting carrier and heating permeation promoting synergistic technology, the transdermal absorption efficiency is low, the effect is slow, the duration of the medicinal effect is short, and thirdly, the matrix adhesiveness of the conventional patch is poor, the conventional patch is easy to fall off, the conventional patch is easy to be allergic, the medicament release is unstable, and the clinical curative effect is uneven. Therefore, research and development of the transdermal drug delivery device has the advantages of high transdermal absorption efficiency, definite curative effect and safe use, and is a technical problem to be solved in the field. Disclosure of Invention Aiming at the defects of the prior art, the invention provides an abdomen anti-inflammatory patch and a preparation method thereof, wherein the invention takes the Chinese medicine internal disease external treatment theory as basis, uses sargassum pallidum refined polysaccharide as a special medicine carrier, prepares a medicine-carrying compound with a trace amount of Pi Zuo agents through a low-temperature supermolecular inclusion process, matches with a core anti-inflammatory prescription medicine, combines with a special process of gradient low-temperature mixing, low Wen Yaogao tempering and the like, and prepares the external patch. The invention effectively solves the problems of uneven dispersion, serious loss of volatile components and poor transdermal effect of the conventional patch, greatly improves the targeted anti-inflammatory effect and the stability of the preparation on the premise of keeping the safety of medication, avoids the gastrointestinal irritation and liver and kidney metabolism burden caused by oral administration, and is suitable for external treatment of various abdominal inflammatory diseases. Aiming at the defects of the prior art, the invention adopts the following technical scheme: The invention provides an abdomen anti-inflammatory patch which comprises the following raw materials, by weight, 20-40 parts of raw coix seeds, 25-40 parts of drug-carrying compounds, 10-25 parts of tree peony barks, 8-20 parts of safflower, 25-40 parts of patrinia herb, 25-45 parts of selfheal, 8-15 parts of rheum officinale, 15-30 parts of rhizoma corydalis and 10-30 parts of mirabilite; The sargassum pallidum compound comprises the following raw materials in percentage by mass of Sha Haozi:menthol, borneol=100-120:1.5:1; the preparation method of the sargassum pallidum compound comprises the following steps: (1) Taking sargassum pallidum, removing impurities, quickly rinsing with clear water, drying at low temperature of 40 ℃, crushing, sieving with a 60-mesh sieve, adding purified wat