CN-121971563-A - Qisha lily traditional Chinese medicine composition suitable for treating acute lung injury and preparation and application thereof

Abstract

The invention discloses a traditional Chinese medicine composition for treating acute lung diseases, an aqueous extract and an alcohol precipitate thereof and application. The traditional Chinese medicine composition comprises, by mass, 16-20 parts of astragalus membranaceus, 13-17 parts of glehnia root, 13-17 parts of lily, 18-22 parts of reed rhizome, 8-12 parts of coix seed, 8-12 parts of peach kernel, 8-12 parts of liquorice, 8-12 parts of mulberry leaf and 8-12 parts of platycodon grandiflorum. The traditional Chinese medicine composition can obviously reduce the BALF factor level related to ALI inflammation and the inflammatory factor level in serum, obviously improve pathological damage of lung tissues and have no adverse effect on body weight and viscera.

Inventors

• YAO GUANGTAO
• CHEN JIAJING
• LI FENGJIE
• WU XINYANG
• YANG GUIMEI
• XUE JIA
• XU JIARUO
• ZHANG YUJIE

Assignees

• 上海中医药大学

Dates

Publication Date

20260505

Application Date

20260403

Claims (10)

1. 1. The traditional Chinese medicine composition is characterized by comprising, by mass, 16-20 parts of astragalus mongholicus, 13-17 parts of glehnia root, 13-17 parts of lily, 18-22 parts of reed rhizome, 8-12 parts of coix seed, 8-12 parts of peach kernel, 8-12 parts of liquorice, 8-12 parts of mulberry leaf and 8-12 parts of platycodon grandiflorum.
2. 2. The traditional Chinese medicine composition according to claim 1, wherein the traditional Chinese medicine composition comprises, by mass, 17-19 parts of astragalus mongholicus, 14-16 parts of glehnia root, 14-16 parts of lily, 19-21 parts of reed rhizome, 9-11 parts of coix seed, 9-11 parts of peach kernel, 9-11 parts of liquorice, 9-11 parts of mulberry leaf and 9-11 parts of platycodon grandiflorum.
3. 3. The traditional Chinese medicine composition according to claim 1, wherein the traditional Chinese medicine composition comprises, by mass, 18 parts of astragalus mongholicus, 15 parts of glehnia root, 15 parts of lily, 20 parts of reed rhizome, 10 parts of coix seed, 10 parts of peach kernel, 10 parts of liquorice, 10 parts of mulberry leaf and 10 parts of platycodon grandiflorum.
4. 4. A Chinese medicinal extract, which is prepared by extracting the effective components from the Chinese medicinal composition according to any one of claims 1 to 3.
5. 5. Use of the traditional Chinese medicine extract according to claim 4 in the preparation of a medicament for treating acute lung injury.
6. 6. The use according to claim 5, wherein the medicament has at least any one of the following effects: the preparation method comprises the steps of (1) inhibiting lung inflammatory response, (2) relieving lung oxidative stress, and (3) improving lung tissue pathological damage.
7. 7. The use according to claim 5 or 6, wherein the medicament has at least any one of the following effects: (1) decrease the level of interleukin-6, interleukin-1 beta and tumor necrosis factor-alpha in bronchoalveolar lavage fluid and serum, (2) down-regulate abnormal expression of glutathione S-transferase P3 in lung tissue, (3) reduce inflammatory cell infiltration, repair alveolar structural damage, reduce hemorrhagic foci and reduce pulmonary space thickening.
8. 8. The use according to any one of claims 5 to 7, wherein the amount of the Chinese medicinal composition used is a therapeutically effective amount.
9. 9. A Chinese medicinal preparation comprising a therapeutically effective amount of the Chinese medicinal extract of claim 4, and one or more pharmaceutically acceptable excipients.
10. 10. The traditional Chinese medicine preparation according to claim 9, wherein the traditional Chinese medicine preparation is an oral preparation.

Description

Qisha lily traditional Chinese medicine composition suitable for treating acute lung injury and preparation and application thereof Technical Field The invention belongs to the field of medicines, and in particular relates to a astragalus root-lilium brownii traditional Chinese medicine composition suitable for treating acute lung injury, and preparation and application thereof. Background Acute lung injury (acute lung injury, ALI) is a critical high-risk respiratory system, is characterized by alveolar epithelial and capillary endothelial cell injury as a core pathology, is usually induced by pathogenic infection, trauma or inhalational stimulation, and further causes pulmonary edema, gas exchange disorder and uncontrolled inflammatory reaction, and can progress to acute respiratory distress syndrome (acute respiratory distress syndrome, ARDS) when severe. Because of the complex pathogenesis, the clinical death rate is high, and the medical problems to be solved are urgent. The rapid rise in intensive care pressure brought about by ALI to the medical system has highlighted the urgency of studying ALI and therapeutic strategies. In addition to correcting the primary morbidity and respiratory support, there is currently a lack of effective prophylactic and therapeutic measures for ALI and ARDS developed therefrom. Disclosure of Invention The invention aims to solve the technical problem of providing a astragalus root-lilium brownii traditional Chinese medicine composition suitable for treating acute lung injury, and preparation and application thereof. The invention solves the technical problems by the following technical proposal: The invention provides a traditional Chinese medicine composition, which comprises, by mass, 16-20 parts of astragalus mongholicus, 13-17 parts of glehnia littoralis, 13-17 parts of lily, 18-22 parts of reed rhizome, 8-12 parts of coix seed, 8-12 parts of peach kernel, 8-12 parts of liquorice, 8-12 parts of mulberry leaves and 8-12 parts of platycodon grandiflorum. In the traditional Chinese medicine composition, the mass parts of astragalus membranaceus can be 16 parts, 17 parts, 18 parts, 19 parts or 20 parts. In the traditional Chinese medicine composition, the mass parts of the glehnia root can be 13 parts, 14 parts, 15 parts, 16 parts or 17 parts. In the traditional Chinese medicine composition, the mass parts of lily can be 13 parts, 14 parts, 15 parts, 16 parts or 17 parts. In the traditional Chinese medicine composition, the mass parts of the reed rhizome can be 18 parts, 19 parts, 20 parts, 21 parts or 22 parts. In the traditional Chinese medicine composition, the mass parts of the coix seed can be 8 parts, 9 parts, 10 parts, 11 parts or 12 parts. In the traditional Chinese medicine composition, the mass part of peach kernel can be 8 parts, 9 parts, 10 parts, 11 parts or 12 parts. In the traditional Chinese medicine composition, the mass parts of liquorice can be 8 parts, 9 parts, 10 parts, 11 parts or 12 parts. In the traditional Chinese medicine composition, the mass parts of the mulberry leaves can be 8 parts, 9 parts, 10 parts, 11 parts or 12 parts. In the traditional Chinese medicine composition, the mass part of the platycodon grandiflorum can be 8 parts, 9 parts, 10 parts, 11 parts or 12 parts. In a preferred embodiment, the traditional Chinese medicine composition comprises, by mass, 17-19 parts of astragalus membranaceus, 14-16 parts of glehnia root, 14-16 parts of lily, 19-21 parts of reed rhizome, 9-11 parts of coix seed, 9-11 parts of peach kernel, 9-11 parts of liquorice, 9-11 parts of mulberry leaf and 9-11 parts of platycodon grandiflorum. In a more preferred embodiment, the traditional Chinese medicine composition comprises, by mass, 18 parts of astragalus membranaceus, 15 parts of glehnia root, 15 parts of lily, 20 parts of reed rhizome, 10 parts of coix seed, 10 parts of peach kernel, 10 parts of liquorice, 10 parts of mulberry leaf and 10 parts of platycodon grandiflorum. In a second aspect, the present invention provides a traditional Chinese medicine extract, which is prepared by extracting active ingredients from the traditional Chinese medicine composition in the first aspect. Specifically, the invention provides a traditional Chinese medicine water extract, which is prepared by taking the traditional Chinese medicine composition in the first aspect as a raw material and extracting active ingredients with water. The preparation method comprises the following steps: S1, mixing the traditional Chinese medicine composition in the first aspect with 8-12 times of water, and decocting and extracting for 2-4 times, wherein each time lasts for 50-70 minutes to obtain an extracting solution; s2, removing water in the extracting solution to obtain the extract. In a preferred embodiment, in step S1, the Chinese medicinal composition according to the first aspect is mixed with 10 times of water, and decocted for 3 times, each for 60 minutes, to obtain an extrac