CN-121971565-A - Composition for promoting sperm quality improvement and anti-aging as well as preparation method and application thereof

Abstract

The invention belongs to the technical field of traditional Chinese medicine compositions, and discloses a composition for promoting sperm quality improvement and anti-aging, and a preparation method and application thereof, wherein the composition consists of dried ginseng, fructus alpiniae oxyphyllae, dried orange peel, nutmeg, cape jasmine, raspberry, dark plum, papaya and deer blood freeze-dried powder; the preparation formulation of the traditional Chinese medicine composition comprises decoction, powder, superfine powder, pills and the like, the application of the composition in preparing medicines for treating and/or relieving oligospermia and asthenospermia, the principle and recipe medicines of the traditional Chinese medicine composition are through ancient and modern, the preparation process is mature and controllable, and a safe, effective and clear traditional Chinese medicine new choice is provided for clinically treating the oligospermia and related anti-aging.

Inventors

• JIANG XIAO
• LIU GUICHUN
• LI MINGJIE
• ZHANG TIANYAO
• CHENG JIN
• BAO XINYU
• Cao Zimo
• WANG YIXI

Assignees

• 西安翻译学院

Dates

Publication Date

20260505

Application Date

20260225

Claims (10)

1. 1. The composition for promoting sperm quality improvement and anti-aging is characterized by comprising, by mass, 1-18 parts of sun-dried ginseng, 1-9 parts of fructus alpiniae oxyphyllae, 1-27 parts of dried orange peel, 1-9 parts of nutmeg, 1-9 parts of cape jasmine, 1-27 parts of raspberry, 1-18 parts of dark plum, 1-18 parts of papaya and 1-9 parts of deer blood freeze-dried powder.
2. 2. The composition for promoting sperm quality improvement and anti-aging according to claim 1, wherein the composition comprises, by mass, 6 parts of sun-dried ginseng, 3 parts of fructus alpiniae oxyphyllae, 9 parts of dried orange peel, 3 parts of nutmeg, 3 parts of cape jasmine, 9 parts of raspberry, 6 parts of dark plum, 6 parts of papaya and 3 parts of deer blood freeze-dried powder.
3. 3. The composition for promoting sperm quality and resisting aging according to claim 2, further comprising poria cocos, fried Chinese yam, semen euryales and semen allii tuberosi, wherein each 6 parts of sun-dried ginseng comprises 15 parts of poria cocos, 21 parts of fried Chinese yam, 15 parts of semen euryales and 9 parts of semen allii tuberosi by mass.
4. 4. The composition for promoting sperm quality and resisting aging according to claim 2, further comprising poria cocos, fried Chinese yam, semen euryales, semen cassiae and pericarpium arecae, wherein each 6 parts of sun-dried ginseng contains 15 parts of poria cocos, 21 parts of fried Chinese yam, 15 parts of semen euryales, 9 parts of semen cassiae and 12 parts of pericarpium arecae by mass.
5. 5. The composition for promoting sperm quality and resisting aging according to claim 2, further comprising poria cocos, fried Chinese yam, semen euryales, semen cassiae, cortex phellodendri and rhizoma anemarrhenae, wherein each of the 6 parts of sun-dried ginseng contains 15 parts of poria cocos, 21 parts of fried Chinese yam, 15 parts of semen euryales, 9 parts of semen cassiae, 12 parts of pericarpium arecae, 3 parts of cortex phellodendri and 6 parts of rhizoma anemarrhenae by mass.
6. 6. The preparation method of the composition for promoting sperm quality improvement and anti-aging according to claim 1 or 2 is characterized by comprising the steps of weighing raw ginseng, fructus alpiniae oxyphyllae, dried orange peel, nutmeg, cape jasmine fruit, raspberry, dark plum and papaya according to the prescription, soaking in water for 30-60 min, boiling with strong fire, decocting with slow fire for 30-45 min, filtering to obtain a first decoction liquid, adding water into residues again, decocting with slow fire for 20-30 min, filtering to obtain a second decoction liquid, merging the two decoctions for later use, and adding warm water into the two decoctions and deer blood freeze-dried powder according to the amount before taking.
7. 7. The method for preparing the composition for promoting sperm quality improvement and anti-aging according to claim 1 or 2, which is characterized by comprising the steps of weighing sun-dried ginseng, fructus alpiniae oxyphyllae, dried orange peel, nutmeg, cape jasmine, raspberry, dark plum, papaya and deer blood freeze-dried powder according to the prescription amount, cleaning, drying, mixing, crushing by a crusher, and sieving by a 80-120-mesh sieve to obtain powder.
8. 8. The method for preparing a composition for promoting sperm quality and resisting aging according to claim 7, wherein the obtained powder is subjected to superfine grinding to obtain superfine powder with a particle size of D90 less than or equal to 45 μm.
9. 9. The preparation method of the composition for promoting sperm quality improvement and anti-aging according to claim 1 or 2 is characterized by comprising the steps of weighing sun-dried ginseng, fructus alpiniae oxyphyllae, dried orange peel, nutmeg, cape jasmine, raspberry, dark plum, papaya and deer blood freeze-dried powder according to the prescription amount, respectively cleaning and drying, mixing eight medicinal materials except the deer blood freeze-dried powder to obtain mixed powder, crushing the mixed powder and sieving the mixed powder with a 80-120 mesh sieve for later use, fully and uniformly mixing the deer blood freeze-dried powder and the mixed powder according to an equal incremental method, and finally adding warm water or ethanol as an adhesive to prepare pills by adopting a pill making method.
10. 10. Use of a composition for promoting sperm quality improvement and anti-aging according to claim 1 or 2 in the manufacture of a medicament for the treatment and/or alleviation of oligospermia and asthenozoospermia.

Description

Composition for promoting sperm quality improvement and anti-aging as well as preparation method and application thereof Technical Field The invention relates to the technical field of traditional Chinese medicine compositions, in particular to a composition for promoting sperm quality improvement and anti-aging, and a preparation method and application thereof. Background Weak sperm disease (asthenospermia) is one of the major factors responsible for male infertility, and its diagnostic criteria is sperm concentration, motility or morphology index lower than World Health Organization (WHO) 5 th edition standard (‌ sperm concentration lower normal reference limit is ‌ ten thousand ‌ per milliliter (15 x 10 6/mL), below which may suggest oligospermia, associated with cryptorchism, varicocele, etc., ‌ sperm motility ‌ (forward motile sperm ratio) lower normal reference limit is ‌% ‌, below 32% may be associated with genital tract infection, seminal plasma abnormality or oxidative stress, ‌ normal morphology sperm ratio lower normal reference limit is ‌% below 4% diagnosed as teratospermia, possibly affecting fertility). Modern medical research has shown that the occurrence of this disease is closely related to hypothalamic-pituitary-gonadal axis (HPG axis) dysfunction, oxidative stress damage, genital tract infection, varicocele and genetic factors. Of particular concern, the HPG axis is central to neuroendocrine regulation of reproduction and development, and its dysfunction directly leads to imbalance in gonadotropin releasing hormone (GnRH), follicle Stimulating Hormone (FSH), luteinizing Hormone (LH) and testosterone (T), resulting in oligospermia, and is more widely associated with functional decline in the systemic multisystem. Clinical statistics show that patients with asthenozoospermia often have reduced bone density (osteoporosis), dyslipidemia, early lesions of atherosclerosis, depression-like mood, and cognitive decline. This suggests that the decline of male reproductive function is not an isolated event, but rather the general aging or dysfunction of the body is manifested in the prominence of the reproductive system, one of the common underlying pathological basis being dysfunction of the HPG axis. Currently, modern medicine mainly comprises 1) hormone medicines (such as clomiphene, tamoxifen, HCG/HMG and the like) aiming at adjusting the HPG axis, but having the risks of large individual response difference and possibly aggravating endocrine disturbance or generating other endocrine side effects, 2) antioxidants (such as vitamin C, E, coenzyme Q10 and the like) used for removing excessive active oxygen and having limited regulation effect on the existing structural injury and complicated neuroendocrine network, and 3) surgical treatment (such as varicocele ligation) only applicable to patients with specific etiology. In general, existing western medicine protocols focus on single-target interventions or symptomatic treatments, with significant limitations in restoring fine HPG axis regulation, improving systemic concomitant symptoms and long-term safety maintenance. The traditional Chinese medicine differentiation of male infertility mainly belongs to the categories of 'oligospermia', 'cold sperm', 'infertility' and the like, the core pathogenesis is usually due to deficiency of kidney essence and kidney yang, the treatment method mainly comprises tonifying kidney and replenishing essence, warming kidney and strengthening yang, and the treatment method represents prescriptions such as five-seed yanzong pills, golden-deficiency kidney qi pills and the like. The prescription has a certain curative effect on simple deficiency syndrome, however, the traditional prescription can not be arrested in the interactive state of deficiency, stagnation, dryness and stasis of qi-releasing machine, body fluid distribution and collaterals astringency on the basis of deficiency and deficiency of primordial qi and deficiency of kidney essence, which are more common complex pathogenesis of deficiency and stasis caused by factors such as long-term pressure, fatigue, improper diet and the like in modern society. The disadvantage is that it is easy to block qi movement, and it is difficult to reach collaterals by pure tonifying method, so that the efficacy of the medicine cannot be effectively distributed to the affected parts (such as collaterals of reproduction and Ren Ji meridians), thereby affecting the curative effect and possibly even causing "deficiency is not compensated". The 'Xin Runtong collaterals' method and the 'long-term disease entering collaterals' theory and 'extra meridians' theory proposed by Qing dynasty traditional Chinese medicine leaf Tianshi provide a valuable thought for breaking the above-mentioned treatment dilemma. The theory system considers that chronic deficiency diseases can be deeply entered into nutrient-blood collaterals and eight extra-channels by pathogenic factors after long t