Search

CN-121971567-A - Composition with function of improving bone mineral density, application thereof and preparation method of related health-care product or food

CN121971567ACN 121971567 ACN121971567 ACN 121971567ACN-121971567-A

Abstract

The composition comprises, by weight, 0.5-4.5 parts of D-glucosamine hydrochloride, 0.5-3 parts of calcium carbonate, 0.1-1.5 parts of chondroitin sulfate sodium, 0.5-2.5 parts of American ginseng extract, 0.2-2 parts of red sage root extract, 0.15-1.5 parts of white peony root extract and 0.1-1 part of turmeric extract. The composition can be made into medicine, health product or food for increasing bone density. The composition provided by the invention adopts green natural and high-quality raw materials and auxiliary materials, and is prepared from the traditional Chinese medicine, modern nutrition and modern pharmacology, and calcium supplement, articular cartilage protection and inflammation relief are integrated, so that the composition plays a comprehensive role in increasing bone density in different links, and the effect of increasing bone density under the condition of three-tube alignment is achieved. The composition can be prepared into medicines, health products or foods, and the preparation process is simple, and the prepared products are green and safe, have obvious curative effects and have good market prospects.

Inventors

  • BAI WEIRONG
  • FANG MING
  • ZHAO LIJUAN
  • ZHANG XIEFENG
  • WU DINGAI

Assignees

  • 宁波中药制药股份有限公司

Dates

Publication Date
20260505
Application Date
20251215

Claims (8)

  1. 1. The composition with the function of improving bone mineral density is characterized by comprising, by weight, 0.5-4.5 parts of D-glucosamine hydrochloride, 0.5-3 parts of calcium carbonate, 0.1-1.5 parts of chondroitin sulfate sodium, 0.5-2.5 parts of American ginseng extract, 0.2-2 parts of red sage root extract, 0.15-1.5 parts of white peony root extract and 0.1-1 part of turmeric extract.
  2. 2. The composition according to claim 1, wherein the composition comprises 1-2 parts by weight of D-glucosamine hydrochloride, 0.5-1.5 parts by weight of calcium carbonate, 0.1-1 part by weight of chondroitin sulfate sodium, 0.5-1 part by weight of American ginseng extract, 0.2-1 part by weight of red sage root extract, 0.15-1 part by weight of white peony root extract and 0.1-0.5 part by weight of turmeric extract.
  3. 3. The composition according to claim 2, wherein the composition comprises 1.5 parts by weight of D-glucosamine hydrochloride, 1.02 parts by weight of calcium carbonate, 0.5 part by weight of chondroitin sulfate sodium, 0.75 part by weight of American ginseng extract, 0.6 part by weight of red sage root extract, 0.45 part by weight of white peony root extract and 0.3 part by weight of turmeric extract.
  4. 4. The use of a composition having a function of improving bone mineral density according to any one of claims 1 to 3, for the preparation of a medicament, health product or food for increasing bone mineral density.
  5. 5. The method according to claim 4, wherein the pharmaceutical, nutraceutical or food is selected from the group consisting of oral tablets, tabletted candies, lozenges, chewable tablets, effervescent tablets, hard capsules, soft capsules, granules, syrups, alcoholic beverages and oral liquids.
  6. 6. The method according to claim 5, wherein the pharmaceutical, nutraceutical or food product comprises pharmaceutically or food acceptable adjuvants or additives, including sorbitol, microcrystalline cellulose, maltodextrin, magnesium stearate or silicon dioxide.
  7. 7. A preparation method of a health product or food with the function of improving bone mineral density is characterized in that the health product or food is a tablet and comprises the following steps: 1) A composition according to any one of claims 1 to 3, wherein D-glucosamine hydrochloride, calcium carbonate, american ginseng extract, red sage root extract, sodium chondroitin sulfate, white peony root extract, turmeric extract are sieved and weighed according to the ratio; 2) Uniformly mixing the sieved and weighed material with sorbitol for 15-40 minutes; 3) Wet granulating the mixed powder with ethanol, and drying until the moisture of the wet granules is below 5%; 4) Finishing and total mixing, namely finishing the dried granules, and mixing magnesium stearate with the finished granules for 10-20 minutes; 5) Tabletting to obtain a sample.
  8. 8. The method of claim 7, wherein the drying temperature is 60+ -5deg.C and the drying time is 60-90 minutes.

Description

Composition with function of improving bone mineral density, application thereof and preparation method of related health-care product or food Technical Field The invention relates to a composition with a function of improving bone mineral density, application thereof and a preparation method of related health-care products or foods. Background The market capacity of the health care product for increasing bone mineral density is very large, mainly because of the high incidence rate of osteoporosis. It is reported that the old people in China are about 2 hundred million people at the end of 2013, 2.43 hundred million people are reached in 2020, 3 hundred million people are broken through in 2025, and osteoporosis is a degenerative disease, and the risk of the disease increases with the increase of the age. The 2013 Chinese osteoporosis fracture prevention and treatment blue book issued by the Chinese health promotion foundation indicates that in recent years, the incidence rate of the osteoporosis fracture is high, the total incidence rate of the osteoporosis is 15.7% in people over 50 years old in China, the incidence rate of the osteoporosis is in a rapid growth state along with the acceleration of the aging process, but only about 1/5 of the osteoporosis fracture patients are treated. It is known that China has become the most global osteoporosis patient and its severity is inferior to cardiovascular disease. National large scale epidemiological surveys have also shown that the total prevalence of osteoporosis in China is 12.4%, with the prevalence of senile disease being more than half, with fracture incidence approaching 33%. At present, the medicaments for preventing and treating osteoporosis mainly comprise bisphosphonates, calcium preparations, estrogens, androgens, vitamin D, calcitonin, hormone replacement therapies and the like, but have unsatisfactory effects and larger side effects. In view of the above conditions, experts call for the establishment of an effective and standardized treatment mode for managing osteoporosis throughout the course, and middle-aged and elderly people should perform bone density (BMD) detection once a year for early diagnosis, and secondly, for those who have osteoporosis, have an osteoporotic fracture or have a reduced bone mass and are accompanied by osteoporosis risk factors, the bone loss can be prevented and the fracture risk reduced by calcium supplementation and health care products. The method provides huge market space for large health consumption, especially for health care products for increasing bone mineral density. Thus, a composition having the function of improving bone mineral density has been developed with good market prospect. Disclosure of Invention The first technical problem to be solved by the invention is to provide a composition with the function of improving bone mineral density, which has the characteristics of green and natural raw materials, good use effect, safety and reliability. The second technical problem to be solved by the present invention is to provide an application of a composition with the function of improving bone mineral density. The third technical problem to be solved by the invention is to provide a preparation method of a health care product or food with the function of improving bone mineral density, which has the advantages of simple preparation process, green and safe prepared product and good effect. The technical scheme adopted by the invention for solving the first technical problem is that the composition with the function of improving bone density is characterized by comprising, by weight, 0.5-4.5 parts of D-glucosamine hydrochloride, 0.5-3 parts of calcium carbonate, 0.1-1.5 parts of chondroitin sulfate sodium, 0.5-2.5 parts of American ginseng extract, 0.2-2 parts of red sage root extract, 0.15-1.5 parts of white peony root extract and 0.1-1 part of turmeric extract. Preferably, the composition comprises 1-2 parts by weight of D-glucosamine hydrochloride, 0.5-1.5 parts by weight of calcium carbonate, 0.1-1 part by weight of chondroitin sulfate sodium, 0.5-1 part by weight of American ginseng extract, 0.2-1 part by weight of red sage root extract, 0.15-1 part by weight of white peony root extract and 0.1-0.5 part by weight of turmeric extract. Further preferably, the composition comprises 1.5 parts by weight of D-glucosamine hydrochloride, 1.02 parts by weight of calcium carbonate, 0.5 part by weight of chondroitin sulfate sodium, 0.75 part by weight of American ginseng extract, 0.6 part by weight of red sage root extract, 0.45 part by weight of white peony root extract and 0.3 part by weight of turmeric extract. The technical scheme adopted by the invention for solving the second technical problem is that the composition with the function of improving bone mineral density is applied to preparation of medicines, health-care products or foods so as to increase bone mineral density. As an improvement, the medicin