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CN-121971571-A - Traditional Chinese medicine composition for delayed fracture healing

CN121971571ACN 121971571 ACN121971571 ACN 121971571ACN-121971571-A

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and provides a traditional Chinese medicine composition for fracture delayed healing. The traditional Chinese medicine composition is prepared from flos Abelmoschi Manihot, dried alum, leech, centipede, scorpion, hedgehog skin, liquorice, elder, semen oroxyli, uncaria, medlar, safflower, papaya, radix curcumae, stephania tetrandra, stir-fried mustard seed, citron, stir-fried rice sprout, stir-fried malt and fructus polygoni orientalis, and has definite effect when the medicines are combined. The monarch, minister, assistant and guide in the formula of the invention are scientific and reasonable in compatibility, and the raw materials are multiple in flavor, different from the common medicine efficacy of the enhanced single medicine, but are in a synergistic relationship, so that the traditional Chinese medicine composition can effectively reduce swelling and relieve pain, promote blood stasis to dissipate, unblock channels and collaterals, qi and blood circulation, nourish bones, promote fracture delayed healing and reduce pain of patients.

Inventors

  • ZHANG WEIKAI
  • DENG TUO

Assignees

  • 华中科技大学同济医学院附属同济医院

Dates

Publication Date
20260505
Application Date
20260305

Claims (10)

  1. 1. The traditional Chinese medicine composition for fracture delayed healing is characterized by comprising, by weight, 35-45 parts of flos Abelmoschi Manihot, 55-70 parts of dried alum, 4-8 parts of leech, 2-3 parts of centipede, 2-3 parts of scorpion, 10-15 parts of hedgehog skin, 10-15 parts of liquorice, 10-15 parts of elder, 10-15 parts of semen oroxyli, 55-65 parts of uncaria, 4-6 parts of medlar, 6-10 parts of safflower, 15-25 parts of papaya, 10-15 parts of radix curcumae, 10-15 parts of radix stephaniae tetrandrae, 25-35 parts of fried mustard seed, 15-20 parts of citron, 10-15 parts of fried rice sprout, 20-25 parts of fried malt and 15-20 parts of fructus polygoni orientalis.
  2. 2. The traditional Chinese medicine composition for fracture delayed union according to claim 1, which is characterized by comprising, by weight, 40 parts of flos abelmoschus manihot, 63 parts of dried alum, 6 parts of leech, 2 parts of centipede, 3 parts of scorpion, 11 parts of hedgehog skin, 11 parts of liquorice, 13 parts of elder, 12 parts of semen oroxyli, 60 parts of uncaria, 5 parts of medlar, 8 parts of safflower, 20 parts of papaya, 11 parts of radix curcumae, 11 parts of radix stephaniae tetrandrae, 30 parts of stir-fried mustard, 16 parts of citron, 13 parts of stir-fried rice sprout, 21 parts of stir-fried malt and 17 parts of fructus polygoni orientalis.
  3. 3. The traditional Chinese medicine composition for fracture delayed healing according to claim 1, which is characterized by comprising, by weight, 35 parts of flos abelmoschus manihot, 70 parts of dried alum, 4 parts of leech, 3 parts of centipede, 2 parts of scorpion, 10 parts of hedgehog skin, 15 parts of liquorice, 10 parts of elder, 10 parts of oroxylum indicum, 55 parts of uncaria, 4 parts of medlar, 10 parts of safflower, 25 parts of papaya, 10 parts of radix curcumae, 15 parts of stephania tetrandra, 25 parts of fried mustard seed, 20 parts of citron, 10 parts of fried rice sprout, 20 parts of fried malt and 15 parts of fructus polygoni orientalis.
  4. 4. The traditional Chinese medicine composition for fracture delayed union according to claim 1, which is characterized by comprising, by weight, 40 parts of flos abelmoschus manihot, 55 parts of dried alum, 6 parts of leech, 3 parts of centipede, 2 parts of scorpion, 11 parts of hedgehog skin, 10 parts of liquorice, 15 parts of elder, 10 parts of oroxylum indicum, 60 parts of uncaria, 6 parts of medlar, 6 parts of safflower, 25 parts of papaya, 15 parts of radix curcumae, 10 parts of radix stephaniae tetrandrae, 30 parts of stir-fried mustard seed, 15 parts of citron, 15 parts of stir-fried rice sprout, 21 parts of stir-fried malt and 20 parts of fructus polygoni orientalis.
  5. 5. The method for preparing the traditional Chinese medicine composition for delayed fracture healing according to any one of claims 1& # x2011 and 4, which is characterized by comprising the steps of mixing the raw materials, adding purified water according to a liquid medicine ratio of 1:8-10, decocting for 2 times, each time for 60-90min, and combining the filtrates.
  6. 6. The method for preparing a pharmaceutical composition for delayed fracture healing according to claim 5, wherein the method comprises mixing the above raw materials, adding purified water at a liquid medicine ratio of 1:9, decocting for 2 times each for 90min, and mixing the filtrates.
  7. 7. A traditional Chinese medicine preparation of a traditional Chinese medicine composition for fracture delayed union, which is characterized in that the traditional Chinese medicine preparation is prepared by taking the traditional Chinese medicine composition for fracture delayed union as raw materials, wherein the traditional Chinese medicine composition is used for fracture delayed union and is prepared by taking the traditional Chinese medicine composition for fracture delayed union as raw materials.
  8. 8. The traditional Chinese medicine preparation of the traditional Chinese medicine composition for delayed fracture healing according to claim 7, wherein the traditional Chinese medicine preparation further comprises pharmaceutically acceptable auxiliary materials, and the traditional Chinese medicine preparation is in the form of granules, pills, capsules, tablets, powder or oral liquid.
  9. 9. The application of the traditional Chinese medicine composition for delayed fracture healing according to any one of claims 1& # x2011 and 4 in preparing medicines for preventing or treating delayed fracture healing.
  10. 10. The use of a traditional Chinese medicine composition for delayed fracture healing according to claim 9, wherein the delayed fracture healing is diabetic delayed fracture healing or delayed fracture healing caused by glucocorticoid.

Description

Traditional Chinese medicine composition for delayed fracture healing Technical Field The invention belongs to the technical field of traditional Chinese medicines, and relates to a traditional Chinese medicine composition for fracture delayed healing. Background Beyond the normal healing time after fracture, the phenomenon of no complete length or no longer holding is called delayed healing or nonunion of fracture. Delayed fracture healing and bone nonunion are different stages in the process of fracture healing disorders. Delayed fracture healing may be considered a precursor to bone nonunion, and treatment of delayed fracture healing where appropriate may prevent the occurrence of bone nonunion. Their etiology is mainly both biological and biomechanical. Modern medicine considers that the slow healing of the fracture mainly comprises systemic, local and medicinal factors, wherein the local factors are the main causes of the slow healing of the fracture, so that the re-reduction of the fracture end and proper internal and external fixation are the treatment keys for thoroughly solving the fundamental problem. Because local blood circulation is not smooth, tissue perfusion is insufficient, and healing is slow due to nutrition loss, so how to promote local blood circulation is an important condition for healing. The effect of diabetes on fracture healing is currently lacking in intensive research, but it is undoubted that diabetics are more prone to delayed fracture healing or even non-healing. Diabetes is a chronic metabolic disease, and causes delayed fracture healing and high non-healing rate of diabetics by causing systemic multisystem and various complications including blood circulation, bone metabolism, nerve function and other factors affecting fracture healing. The glucocorticoid has various effects of anti-inflammatory, antiviral, anti-immune, anti-shock and the like, and because of the good and unique pharmacological effects of the glucocorticoid, many patients must take the glucocorticoid for a long time, and the long-term use of the glucocorticoid with a large dosage can have adverse effects on bones, so that glucocorticoid osteoporosis is caused, and pathological fracture is caused. Currently, glucocorticoids have become the third leading cause of osteoporosis after secondary estrogen deficiency and senile factors. Fracture is one of the most serious side effects of glucocorticoid-induced osteoporosis, and fracture caused by glucocorticoid often delays healing, has extremely high disability rate, and lacks an effective prevention and treatment method. Fracture caused by glucocorticoid osteoporosis is a common clinical disease, and the fracture is urgent in onset and difficult to heal, so that the fracture is a difficult problem in the clinical field of orthopedics. Surgical treatment of delayed union and non-union of fractures is the most prominent treatment today, with the aim of promoting union of fractures and restoring the function of the limb. At present, the traditional Chinese medicine composition with good curative effect and no toxic or side effect is still lacking in the field of treating fracture delayed union. Disclosure of Invention In view of the above, the present invention provides a traditional Chinese medicine composition for fracture delayed healing. The invention also provides a preparation method of the traditional Chinese medicine composition for fracture delayed healing. The invention also provides application of the traditional Chinese medicine composition for fracture delayed healing in preparation of a medicine for fracture delayed healing. The technical scheme adopted by the invention for achieving the purpose is as follows: The first aspect of the invention provides a traditional Chinese medicine composition for fracture delayed healing, which is prepared from the following raw materials, by weight, 35-45 parts of flos Abelmoschi Manihot, 55-70 parts of dried alum, 4-8 parts of leech, 2-3 parts of centipede, 2-3 parts of scorpion, 10-15 parts of hedgehog skin, 10-15 parts of liquorice, 10-15 parts of elder, 10-15 parts of semen oroxyli, 55-65 parts of uncaria, 4-6 parts of medlar, 6-10 parts of safflower, 15-25 parts of papaya, 10-15 parts of radix curcumae, 10-15 parts of radix stephaniae tetrandrae, 25-35 parts of fried mustard seed, 15-20 parts of citron, 10-15 parts of fried rice sprout, 20-25 parts of fried malt and 15-20 parts of safflower seed. In the present invention, when a ratio, equivalent weight, temperature, concentration, time, number of copies, weight ratio, or other value or parameter is expressed as a range, preferred range, or a range bounded by a list of upper preferable values and lower preferable values, this should be understood as specifically disclosing all ranges formed from any pair of any upper range limit or preferred value with any lower range limit or preferred value, regardless of whether ranges are separately disclosed. For example,