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CN-121971572-A - Traditional Chinese medicine composition for treating diabetes and preparation method and application thereof

CN121971572ACN 121971572 ACN121971572 ACN 121971572ACN-121971572-A

Abstract

The invention discloses a traditional Chinese medicine composition for treating diabetes and a preparation method and application thereof, and relates to the technical field of traditional Chinese medicines. The invention adopts raw materials such as barley flour with skin, rice bran, millet bran and the like to prepare a component A, adopts raw materials such as radix trichosanthis, semen cuscutae, dwarf lilyturf tuber, dried rehamnnia root and the like to prepare a component B, adopts astragalus mongholicus, eupatorium and dried orange peel and the like to prepare a component C, and combines the component A, the component B and the component C to prepare the traditional Chinese medicine composition with the effects of strengthening spleen and nourishing stomach, tonifying qi and nourishing yin, clearing heat and promoting fluid production, and reinforcing kidney and removing food retention. The invention introduces the barley flour with skin, the rice bran and the millet bran into the traditional Chinese medicine composition innovatively, and the cereal hulls contain B vitamins which can participate in metabolism of sugar and fat, thereby not only being beneficial to stabilizing postprandial blood sugar and improving insulin sensitivity, but also providing satiety and having the functions of dietary therapy meal replacement and nutrition balance.

Inventors

  • ZHANG YIFANG

Assignees

  • 湖北中医药大学

Dates

Publication Date
20260505
Application Date
20260313

Claims (10)

  1. 1. A traditional Chinese medicine composition for treating diabetes is characterized by comprising a component A, a component B and a component C in a mass ratio of (230-250): (80-120): (260-265); the component A consists of the following raw materials, by weight, 25-35 parts of lotus root starch, 25-35 parts of kudzuvine root, 25-35 parts of poria cocos, 25-35 parts of water chestnut, 25-35 parts of gorgon euryale seed, 25-35 parts of barley with skin, 25-35 parts of rice oil bran and 25-35 parts of millet oil bran; the component B comprises the following raw materials, by weight, 10-20 parts of radix trichosanthis, 5-15 parts of semen cuscutae, 5-15 parts of radix ophiopogonis, 10-20 parts of radix rehmanniae, 10-20 parts of cortex moutan, 5-15 parts of ootheca mantidis, 5-15 parts of oyster powder, 5-15 parts of endothelium corneum gigeriae galli and 4-6 parts of ginseng; The component C is prepared from (by weight parts) herba Eupatorii 10-20, radix astragali Preparata 10-20, radix Glycyrrhizae Preparata 10-20, radix Codonopsis 10-20, bombyx Bombycis 10-15, herba Euphorbiae Humifusae 5-15, caulis Bambusae in Taenia 10-15, mume fructus 10-20, cornu Betulae Pendulae 5-15, pericarpium Citri Tangerinae 10-15, rhizoma Phragmitis 10-20, rhizoma anemarrhenae 10-20, radix Sophorae Flavescentis 10-15, herba cistanches 10-15, folium Mori 10-15, radix Curcumae 10-15, herba Artemisiae Scopariae 10-15, radix bupleuri 10-15, fructus crataegi Preparata 10-15, malt 10-15, massa Medicata Fermentata 5-7.
  2. 2. The traditional Chinese medicine composition for treating diabetes according to claim 1, wherein the traditional Chinese medicine composition for treating diabetes further comprises auxiliary materials, and the auxiliary materials comprise refined honey and perilla oil in a mass ratio of (2-4).
  3. 3. The traditional Chinese medicine composition for treating diabetes according to claim 1, wherein the dosage form of the traditional Chinese medicine composition for treating diabetes is pill, paste or powder.
  4. 4. A method for preparing a traditional Chinese medicine composition for treating diabetes according to any one of claims 1-3, comprising the following steps: (1) Weighing and mixing the raw materials of the component C according to the weight parts, adding water for decoction twice, and then merging decoction; (2) Weighing the raw materials of the component A and the component B according to parts by weight, uniformly mixing and crushing to obtain a mixture, adding auxiliary materials into the extract, uniformly mixing, adding the mixture, and drying to obtain the traditional Chinese medicine composition for treating diabetes.
  5. 5. The method for preparing the traditional Chinese medicine composition for treating diabetes according to claim 4, wherein in the step (1), water is added to the mixed component C raw material for two times, the specific steps are that water which is 8-12 times of the mixed component C raw material is added, the mixed component C raw material is soaked for 25-35min, the mixed component C raw material is decocted with slow fire for 0.5-1.5h, the mixture is filtered after the decoction, the decoction and filter residues are separated, the filter residues are added with water which is 6-10 times of the mixed component C raw material, the mixture is decocted with slow fire for 30-50min, and the decoction is collected after the filtration.
  6. 6. The method for preparing a traditional Chinese medicine composition for treating diabetes according to claim 4, wherein in the step (1), the vacuum low-temperature concentration condition is that the temperature is 60-70 ℃ and the vacuum degree is-80 to-90 KPa.
  7. 7. The method for preparing a Chinese medicinal composition for treating diabetes according to claim 4, wherein in the step (1), the relative density of the extract at 60 ℃ is 1.10-1.15.
  8. 8. The method for preparing a traditional Chinese medicine composition for treating diabetes according to claim 4, wherein in the step (2), auxiliary materials account for 10-15% of the mass of the traditional Chinese medicine composition for treating diabetes.
  9. 9. The method for preparing a Chinese medicinal composition for treating diabetes according to claim 4, wherein in the step (2), the drying temperature is 60-70 ℃ and the drying time is 10-15h.
  10. 10. Use of a traditional Chinese medicine composition according to any one of claims 1-3 for the preparation of a pharmaceutical product for the treatment of diabetes.

Description

Traditional Chinese medicine composition for treating diabetes and preparation method and application thereof Technical Field The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating diabetes and a preparation method and application thereof. Background Diabetes mellitus is a metabolic disease characterized by a long-term excessive blood glucose level, and its incidence rate continues to rise, and the age of onset shows a tendency to be younger. Modern medicine considers that the etiology is insufficient secretion or reduced activity of islets, resulting in abnormal regulation of blood sugar. Current methods of treatment for diabetes include diet control, delayed carbohydrate absorption, exogenous insulin injection, and the like. Although these methods can control blood sugar levels to some extent, they are focused on symptomatic management, and do not fundamentally improve the constitution of patients and restore the body's own regulatory function. In traditional Chinese medicine, diabetes belongs to the category of diabetes in traditional Chinese medicine, and ancient doctors divide diabetes into upper-level diabetes (lung diabetes), middle-level diabetes (spleen diabetes) and lower-level diabetes (kidney diabetes) according to symptoms and disease process stages, which correspond to three-more-one-less manifestations of polyphagia, polydipsia, polyuria and body wasting induced by modern medicine respectively. For the more abundant type II diabetes, improving insulin secretion and activity is central to the treatment, and insulin must bind to insulin receptors that are closely related to liver status to exert glycemic regulation. Clinical studies have demonstrated that insulin resistance is one of the most important, fundamental causes of inducing and driving the development of diabetes and hyperlipidemia. According to the theory of traditional Chinese medicine, the wood is used for removing the earth, the liver and gall are used for removing the earth, the spleen is used for removing the earth and the spleen is used for removing the four limbs. The occurrence of diabetes is considered to be closely related to the dysfunction of liver, spleen, kidney and other viscera by the traditional Chinese medicine. It is clear that diabetes is not caused by pathological changes of a single viscera, but is closely related to dysfunction of a plurality of viscera such as liver, spleen, kidney, etc., and the dysfunction of viscera is one of the nuclear heart disease mechanisms. Based on the pathogenesis cognition, the traditional Chinese medicine treatment of diabetes is mainly performed on soothing liver and relieving depression, strengthening spleen and replenishing qi, nourishing yin and promoting the production of body fluid, and the intervention is implemented through comprehensive means such as medicine conditioning, meridian intervention, diet therapy and nursing, and finally the aims of improving the physique of a patient and recovering the normal physiological functions of an organism are achieved. Among them, polydipsia and diuresis are typical symptoms of diabetes, and the essence is that body fluids in the body cannot be normally kept, so that blood sugar is relatively raised. Therefore, replenishing body water and restoring body fluid balance by nourishing yin and promoting fluid production is a key link of traditional Chinese medicine for conditioning diabetes. The Chinese medicine yin nourishing and diet therapy combined mode can effectively optimize the internal environment of a human body, relieve polydipsia and diuresis symptoms, enable body fluid to recover to a reasonable steady state, further reduce the dissolution concentration of blood sugar in the body, promote normal transportation of nutrient substances and discharge of metabolic wastes, and provide guarantee for body function recovery. Therefore, development of a traditional Chinese medicine composition for treating diabetes with homology of medicine and food is particularly necessary to realize effective treatment of diabetes by nourishing yin and promoting fluid production. Disclosure of Invention Aiming at the prior art, the invention aims to provide a traditional Chinese medicine composition for treating diabetes, and a preparation method and application thereof. In order to achieve the above purpose, the invention adopts the following technical scheme: the invention provides a traditional Chinese medicine composition for treating diabetes, which comprises a component A, a component B and a component C in a mass ratio of (230-250): (80-120): (260-265); the component A consists of the following raw materials, by weight, 25-35 parts of lotus root starch, 25-35 parts of kudzuvine root, 25-35 parts of poria cocos, 25-35 parts of water chestnut, 25-35 parts of gorgon euryale seed, 25-35 parts of barley with skin, 25-35 parts of rice oil bran and 25-35