CN-121971574-A - Application of Dan-zedoary Fukang in preparing medicament for treating dysfunctional uterine bleeding

CN121971574ACN 121971574 ACN121971574 ACN 121971574ACN-121971574-A

Abstract

The invention belongs to the technical field of application of traditional Chinese medicines, and in particular relates to application of a Dan-zedoary health preparation in preparation of a medicine for treating dysfunctional uterine bleeding. The pharmacodynamic experiment proves that the danzedoary can shorten the coagulation time and the bleeding time of mice, and improve the uterine coefficient, the estradiol level, the progesterone level and the VEGF protein expression level of the endometrial tissues of the mice of the anovulatory dysfunctional uterine bleeding rats. The medicine has the advantages of providing more medicine selection for clinically treating dysfunctional uterine bleeding diseases, along with good effect, years of clinical experience and high safety.

Inventors

Geng Yuefei
WANG CUNLIN
LIN QINGHUA
SHEN YONGMEI

Assignees

云南圣科药业有限公司

Dates

Publication Date: 20260505
Application Date: 20260331
Priority Date: 20250428

Claims (4)

1. Application of DANzedoary Fukang preparation in preparing medicine for treating dysfunctional uterine bleeding is provided.
2. The use according to claim 1, wherein the Dan E Fu kang preparation is prepared from radix Salviae Miltiorrhizae, rhizoma Curcumae, radix bupleuri, radix Notoginseng, radix Paeoniae Rubra, radix Angelicae sinensis, rhizoma Sparganii, rhizoma Cyperi, rhizoma corydalis, and radix Glycyrrhizae.
3. The use according to claim 1, wherein the dysfunctional uterine bleeding comprises anovulatory dysfunctional uterine bleeding.
4. The method according to claim 1, wherein the dysfunctional uterine bleeding comprises ovulatory dysfunctional uterine bleeding.

Description

Application of Dan-zedoary Fukang in preparing medicament for treating dysfunctional uterine bleeding Technical Field The invention belongs to the technical field of application of traditional Chinese medicines, and in particular relates to application of Dan-zedoary health in preparation of medicines for treating dysfunctional uterine bleeding. Background Dysfunctional uterine bleeding is abnormal uterine bleeding caused by abnormal intraneural dysfunction of hypothalamic-pituitary-ovarian axis affecting in vivo estrogen levels, and is one of the common diseases of gynaecology and obstetrics. The clinical symptoms mainly include dysmenorrhea, abdominal pain, blood concentration, viscera dysfunction, pubertal dysfunctional blood, climacteric dysfunctional blood, bleeding tendency, postmenopausal bleeding, flaviidogenic cyst and diphasic body temperature. Dysfunctional uterine bleeding can cause the following harm to the body that functional uterine bleeding can cause vaginal infection, frequent bleeding, long bleeding time and large bleeding amount, and patients often have anemia symptoms due to blood loss. Long-term bleeding can also adversely affect fertility and other systemic systems. Most of dysfunctional uterine bleeding clinically adopts drug treatment and surgical treatment. The medicine is treated by hormone or antibiotics, but the current medicine treatment can only control the illness state, the long-term administration can lead to the hypoimmunity of human body, the illness state is repeatedly difficult to heal, and meanwhile, the long-term administration of western medicines also causes damage to the body. The operation treatment is carried out for the patients with high bleeding amount. Traditional surgical treatment is highly destructive, and the eradication purpose is not achieved at all. Therefore, a medicine for treating dysfunctional uterine bleeding with good treatment effect and small side effect needs to be searched. The Dan-zedoary Fukang is derived from Yi nationality medical prescription, has the effects of promoting blood circulation to remove blood stasis, soothing liver and regulating qi, regulating menstruation and relieving pain, and softening hard masses and resolving accumulation, can improve menstrual cycle disorder state, and plays an important role in the treatment of regulating menstruation and relieving pain. The report on the aspect of treating dysfunctional uterine bleeding by using the Dan E Fu kang is not yet seen. Disclosure of Invention The invention aims to provide a novel medical application of a Dan-zedoary Fukang preparation. The invention provides an application of a Dan-zedoary health preparation in preparing a medicine for treating dysfunctional uterine bleeding. Further, the Dan-zedoary Fukang preparation is prepared from raw materials of red sage root, zedoary, bupleurum yunnanensis, pseudo-ginseng, red paeony root, angelica, rhizoma sparganii, nutgrass galingale rhizome, rhizoma corydalis and liquorice. Further, the dysfunctional uterine bleeding includes anovulatory dysfunctional uterine bleeding. Further, the dysfunctional uterine bleeding includes ovulatory dysfunctional uterine bleeding. The Dan-zedoary Fukang is prepared from radix Salviae Miltiorrhizae, rhizoma Curcumae, radix bupleuri, radix Notoginseng, radix Paeoniae Rubra, radix Angelicae sinensis, rhizoma Sparganii, rhizoma Cyperi, rhizoma corydalis, and radix Glycyrrhizae. The red sage root has the effects of promoting blood circulation, removing blood stasis, regulating menstruation, relieving pain, clearing heart fire and relieving restlessness, and can improve endometrial blood circulation and promote endomembrane repair. The curcuma zedoary has the effects of promoting qi and breaking blood, removing food retention and relieving pain, inhibiting platelet aggregation, and improving local microcirculation. Bupleurum yunnanense has the functions of soothing liver, relieving depression and regulating endocrine. Notoginseng radix has effects of removing blood stasis, stopping bleeding, relieving swelling and pain, and can be used for treating hemoptysis, hematemesis, epistaxis, hematochezia, metrorrhagia, traumatic hemorrhage, thoracoabdominal pain, and traumatic injury. The red paeony root has the functions of clearing heat and cooling blood, disperse blood stasis and relieve pain. The Chinese angelica root has the effects of replenishing blood, activating blood, regulating menstruation, relieving pain, and relaxing bowel, and is used for treating blood deficiency and sallow complexion, dizziness, palpitation, irregular menstruation, amenorrhea, dysmenorrhea, deficiency-cold abdominal pain, rheumatalgia, traumatic injury, carbuncle, sore and ulcer, and constipation due to intestinal dryness. Rhizoma Sparganii has effects of removing blood stasis, activating qi-flowing, resolving food stagnation, and relieving pain, and can be used for treating abdominal mass, dysmenorrhea, blood stasis amenorr